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1. 发明授权

US08412348B2 Intravascular self-anchoring integrated tubular electrode body 失效
标题翻译：血管内自我锚定一体化管状电极体
公开(公告)号：US08412348B2
公开(公告)日：2013-04-02
申请号：US10841069
申请日：2004-05-06
申请人： Michael P. Wallace , Robert J. Garabedian , John Eric Peckham
发明人： Michael P. Wallace , Robert J. Garabedian , John Eric Peckham
IPC分类号： A61N1/05
CPC分类号： A61N1/057 , A61N1/3787 , A61N2001/0585
摘要： An expandable intravascular medical device is provided. The medical device comprises an expandable tubular body that includes an integrated resilient support structure that forms a plurality of electrically conductive regions to which the lead(s) is coupled. The tubular body further includes at least one electrically insulative element disposed between the conductive regions. In one embodiment, the support structure is skeletal in nature, e.g., it can be formed of a mesh, braid, or coil. The conductive regions can be variously formed by the support structure. For example, the support structure may comprise electrically conductive sub-structures that form the conductive regions. In this case, the sub-structures may be mechanically linked together by the insulative element(s), or they can be directly linked together, and the insulative element(s) can take the form of insulative layer(s) disposed on one or more of the conductive sub-structures. As another example, the support structure can have a conductive core and insulative material disposed over portions of the conductive core. In this case, the exposed core portions form the conductive regions, and the unexposed core portions form the insulative element(s).
摘要翻译：提供可扩张血管内医疗装置。医疗装置包括可扩张的管状体，其包括形成多个导电区域的集成的弹性支撑结构，引线与该多个导电区域相连。管状体还包括设置在导电区域之间的至少一个电绝缘元件。在一个实施例中，支撑结构本质上是骨架的，例如，其可以由网，编织物或线圈形成。导电区域可以由支撑结构各种形成。例如，支撑结构可以包括形成导电区域的导电子结构。在这种情况下，子结构可以通过绝缘元件机械地连接在一起，或者它们可以直接连接在一起，并且绝缘元件可以采取设置在一个或多个绝缘元件上的绝缘层的形式，更多的导电子结构。作为另一示例，支撑结构可以具有设置在导电芯的部分上方的导电芯和绝缘材料。在这种情况下，露出的芯部形成导电区域，未曝光的芯部形成绝缘元件。

2. 发明授权

US07295875B2 Method of stimulating/sensing brain with combination of intravascularly and non-vascularly delivered leads 有权
标题翻译：通过血管内和非血管输送导联组合刺激/感觉脑的方法
公开(公告)号：US07295875B2
公开(公告)日：2007-11-13
申请号：US10783679
申请日：2004-02-20
申请人： Michael P. Wallace , Robert J. Garabedian
发明人： Michael P. Wallace , Robert J. Garabedian
IPC分类号： A61N1/36
CPC分类号： A61N1/36025 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/36017 , A61N1/36064 , A61N1/36067 , A61N1/36082
摘要： A method of treating a neurological disorder in a patient is provided. The method comprises intravascularly delivering a first electrical lead within the head of the patient, and non-vascularly delivering a second electrical lead within the head the patient. The vascular and intravascular leads are placed adjacent brain tissue (e.g., cortical brain tissue or deep brain tissue). Optionally, the method comprises implanting a source of stimulation and/or recorder within the patient's body, and then electrically coupling the proximal ends of the electrical leads to the implanted device. Using the electrical leads, the brain tissue can then be stimulated and/or recorded in order to treat the neurological disorder.
摘要翻译：提供了治疗患者神经障碍的方法。该方法包括血管内传递患者头部内的第一电引线，并且在患者的头部内非血管输送第二电引线。血管和血管内引线被放置在脑组织（例如皮质脑组织或深部脑组织）附近。可选地，该方法包括在患者体内植入刺激源和/或记录器源，然后将电引线的近端电连接到植入装置。使用电引线，然后可以刺激和/或记录脑组织以治疗神经障碍。

3. 发明授权

US07937160B2 Methods for delivering cortical electrode leads into patient's head 有权
标题翻译：将皮质电极导入患者头部的方法
公开(公告)号：US07937160B2
公开(公告)日：2011-05-03
申请号：US11010232
申请日：2004-12-10
申请人： Robert J. Garabedian , Michael P. Wallace , Gary Heit
发明人： Robert J. Garabedian , Michael P. Wallace , Gary Heit
IPC分类号： A61N1/05
CPC分类号： A61N1/0531 , A61N1/0539 , A61N1/36082
摘要： Methods and kits for delivering an electrode lead into the head of a patient are provided. A burr hole is formed within the cranium of the patient, and an electrode lead is threaded through the burr hole. The electrode lead is then placed in a pre-shaped two-dimensional geometry between the cranium and cortical brain tissue of the patient. An access anchor may be mounted into the burr hole to facilitate introduction and removal of the electrode lead and other devices. In some circumstances, it may be desirable to separate the dura mater overlying the cortical brain tissue from the cortical brain tissue to create a pocket in which the electrode lead may be manipulated. In this case, a tissue layer dissection device can be introduced through the burr hole, operated to separate the dura mater from the cranium, and then removed from the burr hole. In one embodiment, the dissection device comprises a balloon that can be inflated to separate the dura mater and cranium, and then deflated prior to removing the dissection device from the burr hole.
摘要翻译：提供了用于将电极引线输送到患者头部的方法和套件。在患者的颅骨内形成有钻孔，电极引线穿过毛刺孔。然后将电极引线置于患者的颅骨和皮质脑组织之间的预先形状的二维几何形状中。可以将入口锚固件安装到钻孔中以便于引入和移除电极引线和其它装置。在某些情况下，可能需要将覆盖皮质脑组织的硬膜与皮层脑组织分离，以产生可以操纵电极引线的口袋。在这种情况下，可以通过毛刺孔引入组织层解剖装置，操作以将硬脑膜与头颅分开，然后从毛刺孔中取出。在一个实施例中，解剖装置包括可以充气以分离硬脑膜和颅骨的气囊，然后在从毛刺孔移除解剖装置之前放气。

4. 发明申请

US20100286655A1 Targeted Drug Delivery Device and Method 有权
标题翻译：目标药物输送装置及方法
公开(公告)号：US20100286655A1
公开(公告)日：2010-11-11
申请号：US12838934
申请日：2010-07-19
申请人： Michael P. Wallace , Robert J. Garabedian
发明人： Michael P. Wallace , Robert J. Garabedian
IPC分类号： A61M5/00
CPC分类号： A61M25/10 , A61M25/0141 , A61M25/0147 , A61M2025/0163 , A61M2025/105 , A61M2025/1086
摘要： A targeted drug delivery device is provided. The device comprises an elongated member with proximal and distal ends, a plurality of infusion ports associated with the distal end of the elongated member, and a selector mechanism for selectively placing an introducer port into fluid communication with at least one infusion port. A method for treating tissue is also provided. The method comprises introducing a medical device into the tissue, selecting a region of the tissue to treat, positioning the medical device in proximity to the region, and introducing a medicament through the device to treat only that region.
摘要翻译：提供了靶向药物递送装置。该装置包括具有近端和远端的细长构件，与细长构件的远端相关联的多个输注端口以及用于选择性地将引导器端口与至少一个输注端口流体连通的选择器机构。还提供了一种治疗组织的方法。该方法包括将医疗装置引入组织中，选择组织的区域以治疗，将医疗装置定位在该区域附近，以及通过该装置引入药物以仅治疗该区域。

5. 发明授权

US08206346B2 Targeted drug delivery device and method 有权
标题翻译：靶向药物输送装置及方法
公开(公告)号：US08206346B2
公开(公告)日：2012-06-26
申请号：US12838934
申请日：2010-07-19
申请人： Michael P. Wallace , Robert J. Garabedian
发明人： Michael P. Wallace , Robert J. Garabedian
IPC分类号： A61M29/00
CPC分类号： A61M25/10 , A61M25/0141 , A61M25/0147 , A61M2025/0163 , A61M2025/105 , A61M2025/1086
摘要： A targeted drug delivery device is provided. The device comprises an elongated member with proximal and distal ends, a plurality of infusion ports associated with the distal end of the elongated member, and a selector mechanism for selectively placing an introducer port into fluid communication with at least one infusion port. A method for treating tissue is also provided. The method comprises introducing a medical device into the tissue, selecting a region of the tissue to treat, positioning the medical device in proximity to the region, and introducing a medicament through the device to treat only that region.
摘要翻译：提供了靶向药物递送装置。该装置包括具有近端和远端的细长构件，与细长构件的远端相关联的多个输注端口以及用于选择性地将引导器端口与至少一个输注端口流体连通的选择器机构。还提供了一种治疗组织的方法。该方法包括将医疗装置引入组织中，选择组织的区域以治疗，将医疗装置定位在该区域附近，以及通过该装置引入药物以仅治疗该区域。

6. 发明授权

US08060207B2 Method of intravascularly delivering stimulation leads into direct contact with tissue 失效
标题翻译：血管内传递刺激的方法导致与组织直接接触
公开(公告)号：US08060207B2
公开(公告)日：2011-11-15
申请号：US10744853
申请日：2003-12-22
申请人： Michael P. Wallace , Kamal Ramzipoor , Robert J. Garabedian , Robert M. Abrams
发明人： Michael P. Wallace , Kamal Ramzipoor , Robert J. Garabedian , Robert M. Abrams
IPC分类号： A61N1/00
CPC分类号： A61N1/0529 , A61N1/0531 , A61N1/0534
摘要： A method of treating a disorder in a patient is provided. The method comprises delivering a stimulation lead within a blood vessel, intralumenally puncturing a wall of the blood vessel to create an exit point, and then introducing the stimulation lead through the exit point into direct contact with tissue the stimulation of which treats the disorder. Optionally, the method comprises implanting a source of stimulation within the patient's body, and then electrically coupling the proximal end of the stimulation lead to the implanted stimulation source. Using the stimulation lead, the tissue can then be stimulated in order to treat the disorder.
摘要翻译：提供了一种治疗患者疾病的方法。该方法包括在血管内递送刺激引线，腔内穿刺血管的壁以产生出口点，然后将刺激引线通过出口点直接接触组织，其刺激治疗病症。可选地，该方法包括将刺激源植入患者体内，然后将刺激引线的近端电耦合到植入的刺激源。使用刺激铅，然后可以刺激组织以治疗该疾病。

7. 发明授权

US08019441B2 Collapsible/expandable tubular electrode leads 有权
标题翻译：可折叠/可扩展管状电极引线
公开(公告)号：US08019441B2
公开(公告)日：2011-09-13
申请号：US11459618
申请日：2006-07-24
申请人： Michael P. Wallace , Robert J. Garabedian
发明人： Michael P. Wallace , Robert J. Garabedian
IPC分类号： A61N1/05
CPC分类号： A61N1/0553
摘要： A medical lead and method of treating a patient are provided. The medical lead comprises an electrically insulative tubular membrane, a resilient spring element associated with the insulative membrane, and at least one electrode associated with the insulative membrane. The medical lead is configured to be collapsed into a compact form for percutaneous delivery into the patient, thereby obviating the need to perform an invasive surgical procedure on the patient. The body formed by these elements, when expanded, can be sized to fit within the epidural space of a patient. The patient can be treated by placing the medical lead into a collapsed state by applying a compressive force to the medical lead, percutaneously delivering the collapsed medical lead into the patient adjacent tissue to be treated, and placing the medical lead into an expanded state by releasing the compressive force. In one preferred method, the stimulation lead is used to stimulate tissue, such as spinal cord tissue.
摘要翻译：提供医疗用铅和治疗患者的方法。医用引线包括电绝缘管状膜，与绝缘膜相关联的弹性弹簧元件以及与绝缘膜相关联的至少一个电极。医疗用引线被构造成塌缩成紧密形式用于经皮输送到患者体内，从而避免了对患者执行侵入性外科手术的需要。由这些元件形成的身体，当扩张时，其尺寸可以适合于患者的硬膜外腔内。可以通过向医用引线施加压缩力将医用引线置于折叠状态来将患者放置在患者身体中，将经塌陷的医用导管经皮递送到邻近被治疗组织的患者中，并通过释放将医用引线放入扩张状态压缩力。在一种优选的方法中，刺激引线用于刺激组织，例如脊髓组织。

8. 发明授权

US07758541B2 Targeted drug delivery device and method 失效
标题翻译：靶向药物输送装置及方法
公开(公告)号：US07758541B2
公开(公告)日：2010-07-20
申请号：US10920735
申请日：2004-08-17
申请人： Michael P. Wallace , Robert J. Garabedian
发明人： Michael P. Wallace , Robert J. Garabedian
IPC分类号： A61M31/00
CPC分类号： A61M25/10 , A61M25/0141 , A61M25/0147 , A61M2025/0163 , A61M2025/105 , A61M2025/1086
摘要： A targeted drug delivery device is provided. The device comprises an elongated member with proximal and distal ends, a plurality of infusion ports associated with the distal end of the elongated member, and a selector mechanism for selectively placing an introducer port into fluid communication with at least one infusion port. A method for treating tissue is also provided. The method comprises introducing a medical device into the tissue, selecting an region of the tissue to treat, positioning the medical device in proximity to the region, and introducing a medicament through the device to treat only that region.
摘要翻译：提供了靶向药物递送装置。该装置包括具有近端和远端的细长构件，与细长构件的远端相关联的多个输注端口以及用于选择性地将引导器端口与至少一个输注端口流体连通的选择器机构。还提供了一种治疗组织的方法。该方法包括将医疗装置引入组织中，选择组织的区域以治疗，将医疗装置定位在该区域附近，以及通过该装置引入药物以仅对该区域进行治疗。

9. 发明授权

US07231260B2 Intravascular self-anchoring electrode body with arcuate springs, spring loops, or arms 有权
标题翻译：血管内自身锚定电极主体具有弧形弹簧，弹簧环或手臂
公开(公告)号：US07231260B2
公开(公告)日：2007-06-12
申请号：US10841070
申请日：2004-05-06
申请人： Michael P. Wallace , Robert J. Garabedian , Wendelin C. Maners , Robert Abrams
发明人： Michael P. Wallace , Robert J. Garabedian , Wendelin C. Maners , Robert Abrams
IPC分类号： A61N1/00
CPC分类号： A61N1/057 , A61N1/3787 , A61N2001/0585
摘要： An expandable intravascular medical device comprises an arcuate spring configured to be expanded into contact with the inner surface of a blood vessel. Another medical device comprises an electrode support structure, e.g., a non-tubular arcuate structure or a cylindrical member, and a plurality of resilient spring loops laterally extending from the support structure. The contact created between the loops and a blood vessel is sufficient to anchor the medical device within the blood vessel. In another embodiment, the medical device comprises an elongated member and two resilient spring arms extending distally from the elongated member. The arms are configured to be laterally moved towards each other to place the medical device in a collapsed geometry, and configured to be laterally moved away from each into contact with an inner surface of a blood vessel to place the medical device an expanded geometry.
摘要翻译：可扩张血管内医疗装置包括弓形弹簧，其被构造成膨胀成与血管的内表面接触。另一医疗装置包括电极支撑结构，例如非管状弓形结构或圆柱形构件，以及从支撑结构横向延伸的多个弹性弹簧环。在环和血管之间产生的接触足以将医疗装置锚定在血管内。在另一个实施例中，医疗装置包括细长构件和从细长构件向远侧延伸的两个弹性弹簧臂。臂被配置为朝向彼此横向移动以将医疗装置放置在折叠的几何形状中，并且被构造成横向移动远离每个与血管的内表面接触，以将医疗装置放置成扩展的几何形状。

10. 发明授权

US07177702B2 Collapsible/expandable electrode leads 有权
标题翻译：可折叠/可扩展电极引线
公开(公告)号：US07177702B2
公开(公告)日：2007-02-13
申请号：US10799270
申请日：2004-03-12
申请人： Michael P. Wallace , Robert J. Garabedian , Alex Leynov
发明人： Michael P. Wallace , Robert J. Garabedian , Alex Leynov
IPC分类号： A61N1/00
CPC分类号： A61N1/0553 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/0558
摘要： A medical lead and method of treating a patient are provided. The medical lead comprises an electrically insulative membrane, a resilient spring element associated with the insulative membrane, and at least one electrode associated with the insulative membrane. The spring layer is configured to urge that insulative membrane into an expanded geometry. The medical lead is configured to be collapsed into a compact form for percutaneous delivery into the patient, thereby obviating the need to perform an invasive surgical procedure on the patient. The patient can be treated by placing the medical lead into a collapsed state by applying a compressive force to the medical lead, percutaneously delivering the collapsed medical lead into the patient adjacent tissue to be treated, and placing the medical lead into an expanded state by releasing the compressive force.
摘要翻译：提供医疗用铅和治疗患者的方法。医用引线包括电绝缘膜，与绝缘膜相关联的弹性弹簧元件，以及与绝缘膜相关联的至少一个电极。弹簧层构造成将绝缘膜推动成扩展的几何形状。医疗用引线被构造成塌缩成紧密形式用于经皮输送到患者体内，从而避免了对患者执行侵入性外科手术的需要。可以通过向医用引线施加压缩力将医用引线置于折叠状态来将患者放置在患者身体中，将经塌陷的医用导管经皮递送到邻近被治疗组织的患者中，并通过释放将医用引线放入扩张状态压缩力。

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