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1. 发明申请

US20120329820A1 Pyridinoylpiperidines As 5-HT1F Agonists 有权
标题翻译：吡啶基哌啶作为5-HT1F激动剂
公开(公告)号：US20120329820A1
公开(公告)日：2012-12-27
申请号：US13363895
申请日：2012-02-01
申请人： Michael P. Cohen , Daniel T. Kohlman , Sidney X. Liang , Frantz Victor , Yao-Chang Xu , Bai-Ping Ying , Deanna P. Zacherl , Deyi Zhang
发明人： Michael P. Cohen , Daniel T. Kohlman , Sidney X. Liang , Frantz Victor , Yao-Chang Xu , Bai-Ping Ying , Deanna P. Zacherl , Deyi Zhang
IPC分类号： A61K31/4545 , C07D409/14 , A61K31/506 , C07D405/14 , C07D417/14 , A61P25/06 , C07D401/06 , C07D401/14
CPC分类号： C07D401/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要： The present invention relates to compounds of formula I: or pharmaceutically acceptable acid addition salts thereof, where; R1 is C1-C6 alkyl, substituted C1-C6 alkyl, C3-C7 cycloalkyl, substituted C3-C7 cycloalkyl, C3-C7 cycloalkyl-C1-C3 alkyl, substituted C3-C7 cycloalkyl-C1-C3 alkyl, phenyl, substituted phenyl, heterocycle, or substituted heterocycle; R2 is hydrogen, C1-C3 alkyl, C3-C6 cycloalkyl-C1-C3 alkyl, or a group of formula II R3 is hydrogen or C1-C3 alkyl; R4 is hydrogen, halo, or C1-C3 alkyl; R5 is hydrogen or C1-C3 alkyl; R6 is hydrogen or C1-C6 alkyl; and n is an integer from 1 to 6 inclusively. The compounds of the present invention are useful for activating 5-HT1F receptors, inhibiting neuronal protein extravasation, and for the treatment or prevention of migraine in a mammal. The present invention also relates to a process for the synthesis of intermediates in the synthesis of compounds of Formula I.
摘要翻译：本发明涉及式I化合物或其药学上可接受的酸加成盐，其中： R 1是C 1 -C 6烷基，取代的C 1 -C 6烷基，C 3 -C 7环烷基，取代的C 3 -C 7环烷基，C 3 -C 7环烷基-C 1 -C 3烷基，取代的C 3 -C 7环烷基-C 1 -C 3烷基，苯基，取代的苯基，杂环或取代的杂环; R 2是氢，C 1 -C 3烷基，C 3 -C 6环烷基-C 1 -C 3烷基或式II的基团R 3是氢或C 1 -C 3烷基; R4是氢，卤素或C1-C3烷基; R5是氢或C1-C3烷基; R6是氢或C1-C6烷基; n为1〜6的整数。本发明的化合物可用于激活5-HT1F受体，抑制神经元蛋白质外渗，以及治疗或预防哺乳动物偏头痛。本发明还涉及合成式I化合物中的中间体的方法。

2. 发明授权

US07096511B2 Article of clothing 失效
标题翻译：服装文章
公开(公告)号：US07096511B2
公开(公告)日：2006-08-29
申请号：US10480877
申请日：2003-04-09
申请人： Michael P. Cohen
发明人： Michael P. Cohen
IPC分类号： A42B1/18
CPC分类号： A41D15/00 , A41D23/00 , A42B1/041 , A42B1/066 , Y10S2/11
摘要： A clothing garment is formed in two loops or bands as unitary garment. A first of the two loops is an elongated member and the second is an elongated, non-rectangular member, having a wide central region. The two loops can be in the form of two pieces of fabric sewn or otherwise bonded together to form two joined loops. The loops can be elongated pieces of fabric formed into loops by a releasable closure member, such as a hook and loop connector. The connector can provide size adjustment to accommodate various head sizes. The loop with the wide central region is shorter than the essentially rectangular loop.
摘要翻译：衣服在两个圈或带中形成为单一服装。两个环中的第一个是细长构件，第二个是细长的非矩形构件，具有宽的中心区域。两个环可以是两个缝合的织物的形式或以其他方式结合在一起以形成两个连接的环。环可以是通过可释放的关闭构件（例如钩环连接器）形成为环的细长织物。连接器可以提供尺寸调节以适应各种头部尺寸。具有宽中心区域的环路比基本上矩形的环路短。

3. 发明授权

US5028693A Urethane-protected amino acid-N-carboxyanhydrides 失效
标题翻译：聚氨酯保护的氨基酸-N-羧酸酐
公开(公告)号：US5028693A
公开(公告)日：1991-07-02
申请号：US379111
申请日：1989-07-13
申请人： William D. Fuller , Michael P. Cohen , Fred R. Naider , Murray Goodman
发明人： William D. Fuller , Michael P. Cohen , Fred R. Naider , Murray Goodman
IPC分类号： C07D263/44 , C07D277/34 , C07K1/02 , C07K1/04
CPC分类号： C07D263/44 , C07D277/34 , C07K1/023 , C07K1/04
摘要： Urethane-protected NCAs and MTAs are prepared by reacting an NCA or NTA with a haloformate in an inert diluent, under anhydrous conditions and in the presence of a tertiary nitrogen-containing base having an atom or functional group sufficiently electron rich and positioned relative to the nitrogen of said base so as to render said atom or group capable of complexing with the H--N
摘要翻译：氨基甲酸酯保护的NCA和MTA通过使NCA或NTA与卤代甲酸酯在惰性稀释剂中在无水条件下和在具有足够电子富集的原子或官能团的叔氮基的存在下，相对于所述碱的氮气使所述原子或基团能够与所述N-羧酸酐或N-硫代羧酸酐的HN基团络合，但能够产生能够与卤代甲酸酯反应的N-羧酸酐或N-硫代羧酸酐阴离子络合物。

4. 发明授权

US4946942A Urethane-protected amino acid-N-carboxyanhydrides 失效
标题翻译：聚氨酯保护的氨基酸-N-羧酸酐
公开(公告)号：US4946942A
公开(公告)日：1990-08-07
申请号：US168087
申请日：1988-03-11
申请人： William D. Fuller , Michael P. Cohen , Fred R. Naider , Murray Goodman
发明人： William D. Fuller , Michael P. Cohen , Fred R. Naider , Murray Goodman
IPC分类号： C07D277/20 , C07D263/16 , C07D263/44 , C07D265/06 , C07D267/06 , C07D269/02 , C07D277/34 , C07D279/06 , C07D281/02 , C07D283/02 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07K1/00 , C07K1/02 , C07K1/04 , C07K1/06 , C07K1/113 , C07K5/06 , C07K5/062 , C07K5/08 , C07K5/083
CPC分类号： C07D263/44 , C07D277/34 , C07K1/023 , C07K1/04
摘要： The invention relates to urethane-protected amino acid-N-carboxyanhydride and N-thiocarboxyanhydride compounds which are useful in peptide, polypeptide and protein synthesis. Disclosed herein is the preparation and use of these novel compounds.
摘要翻译：本发明涉及可用于肽，多肽和蛋白质合成的氨基甲酸酯保护的氨基酸-N-羧酸酐和N-硫代羧酸酐化合物。本文公开了这些新化合物的制备和用途。

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