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1. 发明申请

US20140298893A1 METHOD FOR TESTING THE INTEGRITY OF A HYDROPHOBIC POROUS DIAPHRAGM FILTER 审中-公开
标题翻译：用于测试疏水性多孔透膜过滤器的完整性的方法
公开(公告)号：US20140298893A1
公开(公告)日：2014-10-09
申请号：US14240645
申请日：2012-06-26
申请人： Michael Laubstein , Juergen Van Den Boogaard , Dirk Leiser
发明人： Michael Laubstein , Juergen Van Den Boogaard , Dirk Leiser
IPC分类号： G01N15/08
CPC分类号： G01N15/0826 , B01D65/102
摘要： A method for testing integrity of a hydrophobic, porous diaphragm filter (42) includes arranging the filter (42) in a non-wetted state in a test housing (30) so that the filter (42) divides an upstream housing region (30a) from a downstream housing region (30b), completely filling the upstream housing region (30a) with a test liquid that does not wet the hydrophobic diaphragm filter (42), incompletely filling a reservoir (12) that is connected to a liquid feed line (16) of the test housing (30), charging the reservoir (12) with compressed air at a constant pressure below the intrusion pressure of the filter, and determining a substance flow at the reservoir (12). The substance flow to be determined is a mass flow out of the reservoir (12) determined as a decrease in the overall weight of the reservoir (12).
摘要翻译：一种用于测试疏水性多孔膜过滤器（42）的完整性的方法包括将过滤器（42）以非润湿状态布置在测试壳体（30）中，使得过滤器（42）将上游壳体区域（30a）从下游壳体区域（30b）中，用不会使疏水膜过滤器（42）不润湿的测试液体完全填充上游壳体区域（30a），不完全地填充连接到液体供给管线的储存器（12） 16），其中压缩空气在低于过滤器的入侵压力的恒定压力下对储存器（12）进行充电，并且确定储存器（12）处的物质流。要确定的物质流量是由储存器（12）排出的质量流量，其确定为储存器（12）的总重量的减小。

2. 发明授权

US06829551B2 Test device for filter systems, method for testing filter systems, and computer program therefor 有权
标题翻译：过滤系统的测试装置，过滤系统的测试方法及其计算机程序
公开(公告)号：US06829551B2
公开(公告)日：2004-12-07
申请号：US10198075
申请日：2002-07-19
申请人： Jochen Von Der Hardt , Reinhard Baumfalk , Oscar-Werner Reif , Juergen Van Den Boogaard
发明人： Jochen Von Der Hardt , Reinhard Baumfalk , Oscar-Werner Reif , Juergen Van Den Boogaard
IPC分类号： G01L2300
CPC分类号： B01D65/102 , G01N15/08 , G01N2015/084
摘要： A test device (10) for filter systems comprising at least two test units (14), a management unit (12) for managing and controlling the at least two test units (14), and signal links via a bi-directional or multi-directional network (16) between the management unit (12) and the at least two test units (14), particularly for transmitting test program instructions and test results. The invention further relates to a method for testing filter systems and a computer readable storage device with a computer program stored therein for testing filter systems.
摘要翻译：一种用于过滤器系统的测试装置（10），包括至少两个测试单元（14），用于管理和控制所述至少两个测试单元（14）的管理单元（12），以及经由双向或多在管理单元（12）和至少两个测试单元（14）之间的方向网络（16），特别是用于发送测试程序指令和测试结果。本发明还涉及一种用于测试过滤器系统的方法以及其中存储有用于测试过滤器系统的计算机程序的计算机可读存储设备。

3. 发明申请

US20110058448A1 MIXING SYSTEM 有权
标题翻译：混合系统
公开(公告)号：US20110058448A1
公开(公告)日：2011-03-10
申请号：US12991466
申请日：2009-05-07
申请人： Oscar-Werner Reif , Gerhard Greller , Juergen Van Den Boogaard , Karl-Heinz Kompart , Marco Lohrengel
发明人： Oscar-Werner Reif , Gerhard Greller , Juergen Van Den Boogaard , Karl-Heinz Kompart , Marco Lohrengel
IPC分类号： B01F7/16
CPC分类号： B01F7/16 , B01F11/0082 , B01F13/045 , B01F15/00071 , B01F15/00831 , B01F15/0085
摘要： A mixing system has a single-use container (1) with flexible walls and a mixing device. The mixing device has at least one encapsulated drive (5) and a mixer shaft (3). The drive (5) can be disposed of after use together with the mixer shaft (3) and the single-use container (1). The mixing system can be used in biotechnology and the pharmaceutical industry for mixing liquids, dissolving solids or cultivating cells and microorganisms.
摘要翻译：混合系统具有具有柔性壁的一次性容器（1）和混合装置。混合装置具有至少一个封装的驱动器（5）和混合器轴（3）。驱动器（5）可以与混合器轴（3）和一次性容器（1）一起使用后被处理。混合系统可用于生物技术和制药工业用于混合液体，溶解固体或培养细胞和微生物。

4. 发明授权

US07198053B2 Cleaning method for filter testing device, computer program product for implementing said method and filter testing device 有权
标题翻译：过滤器检测装置的清洗方法，实现所述方法和过滤器检测装置的计算机程序产品
公开(公告)号：US07198053B2
公开(公告)日：2007-04-03
申请号：US10762553
申请日：2004-01-23
申请人： Jochen Von Der Hardt , Juergen Van Den Boogaard , Reinhard Baumfalk , Oscar-Werner Reif
发明人： Jochen Von Der Hardt , Juergen Van Den Boogaard , Reinhard Baumfalk , Oscar-Werner Reif
IPC分类号： B08B3/00
CPC分类号： B01D46/46 , B01D2273/18
摘要： A cleaning method for a filter testing device (10) including switching devices (V1–V6), external connections (12, 14, 16, 18, 20) and internal volumes (24, 26, 28, 30, VV1–VV5) that can come into contact with a fluid from a filter device that is to be tested. The cleaning method involves the steps of: selecting one or more internal volumes (24, 26, 28, 30, VV1–VV5) to be cleaned, cleaning the selected internal volumes (24, 26, 28, 30, VV1–VV5) with a cleaning fluid by correspondingly switching the switching devices (V1–V6), and removing the cleaning fluid contained in the internal volumes (24, 26, 28, 30, VV1–VV5) from the internal volumes. Also a computer program product with program parts for implementing the method of the invention or a preferred embodiment thereof, and a filter testing device adapted to be cleaned by the method of the invention.
摘要翻译：一种用于包括开关装置（V 1 -V 6），外部连接（12,14,16,18,20）和内部容积（24,26,28,30，V

5. 发明授权

US09669366B2 Mixing system 有权
公开(公告)号：US09669366B2
公开(公告)日：2017-06-06
申请号：US12991466
申请日：2009-05-07
申请人： Oscar-Werner Reif , Gerhard Greller , Juergen Van Den Boogaard , Karl-Heinz Kompart , Marco Lohrengel
发明人： Oscar-Werner Reif , Gerhard Greller , Juergen Van Den Boogaard , Karl-Heinz Kompart , Marco Lohrengel
IPC分类号： B01F7/16 , B01F11/00 , B01F13/04 , B01F15/00
CPC分类号： B01F7/16 , B01F11/0082 , B01F13/045 , B01F15/00071 , B01F15/00831 , B01F15/0085
摘要： A mixing system has a single-use container (1) with flexible walls and a mixing device. The mixing device has at least one encapsulated drive (5) and a mixer shaft (3). The drive (5) can be disposed of after use together with the mixer shaft (3) and the single-use container (1). The mixing system can be used in biotechnology and the pharmaceutical industry for mixing liquids, dissolving solids or cultivating cells and microorganisms.

6. 发明授权

US10294447B2 Bioreactor with condenser 有权
公开(公告)号：US10294447B2
公开(公告)日：2019-05-21
申请号：US12994270
申请日：2009-05-07
申请人： Oscar-Werner Reif , Gerid Hellwig , Juergen Van Den Boogaard , Ute Noack
发明人： Oscar-Werner Reif , Gerid Hellwig , Juergen Van Den Boogaard , Ute Noack
IPC分类号： C12M1/00 , C12M1/107
摘要： Bioreactor with a vessel having at least one gas dissipation duct for gas discharge, the orifice of the gas dissipation duct being connected to a hydrophobic sterile filter and to a condenser arranged between them and having condensation surfaces, a turbulence generator for generating a turbulent flow is arranged in the gas dissipation duct in the region of the condenser.

7. 发明授权

US09255244B2 Bioreactor 有权
标题翻译：生物反应器
公开(公告)号：US09255244B2
公开(公告)日：2016-02-09
申请号：US12867647
申请日：2009-02-12
申请人： Juergen Van Den Boogaard , Gerhard Greller , Jens Ludwig , Oscar-Werner Reif
发明人： Juergen Van Den Boogaard , Gerhard Greller , Jens Ludwig , Oscar-Werner Reif
IPC分类号： C12M1/00 , C12M3/00 , C12M1/06 , B01F7/16 , B01F15/00 , C12M1/12 , F16C33/76
CPC分类号： C12M27/02 , B01F7/1695 , B01F15/00831 , B01F15/0085 , C12M23/26 , C12M37/04 , F16C33/76
摘要： A bioreactor (1) having a container (2), a shaft housing (3) for guiding a shaft (5) through a wall (7), a stirrer (6) connected to the shaft (5) in the interior (9) of the container (2), and a drive (4) arranged outside the container (2) and connectable to the shaft (5). The shaft (5) is mounted in the shaft housing (3) via at least one ball bearing (23) and is sealed in relation to the shaft housing (3) by at least one seal (11, 20). The seal (11, 20) is configured as a radial shaft seal (28) having two sealing lips (30, 31) that are arranged one behind the other in the longitudinal direction of the shaft (5) and are able to run on the shaft (5) without lubricant.
摘要翻译：具有容器（2）的生物反应器（1），用于通过壁（7）引导轴（5）的轴壳体（3），与内部（9）中的轴（5）连接的搅拌器（6）和位于所述容器（2）的外部并且可连接到所述轴（5）的驱动器（4）。轴（5）经由至少一个滚珠轴承（23）安装在轴壳体（3）中，并通过至少一个密封件（11,20）相对于轴壳体（3）密封。密封件（11,20）被构造为具有两个密封唇（30,31）的径向轴密封件（28），所述密封唇缘（30,31）沿轴（5）的纵向方向一个接一个地布置，并且能够在轴（5）无润滑剂。

8. 发明申请

US20110076759A1 BIOREACTOR WITH CONDENSER 审中-公开
标题翻译：具有冷凝器的生物反应器
公开(公告)号：US20110076759A1
公开(公告)日：2011-03-31
申请号：US12994270
申请日：2009-05-07
申请人： Oscar-Werner Reif , Gerid Hellwig , Juergen Van Den Boogaard , Ute Noack
发明人： Oscar-Werner Reif , Gerid Hellwig , Juergen Van Den Boogaard , Ute Noack
IPC分类号： C12M1/12
CPC分类号： C12M21/04 , C12M23/14 , C12M23/28 , C12M23/36 , C12M47/18 , C12M47/20
摘要： Bioreactor with a vessel having at least one gas dissipation duct for gas discharge, the orifice of the gas dissipation duct being connected to a hydrophobic sterile filter and to a condenser arranged between them and having condensation surfaces, a turbulence generator for generating a turbulent flow is arranged in the gas dissipation duct in the region of the condenser.
摘要翻译：具有容器的生物反应器具有至少一个用于气体放电的气体消散管道，气体消散管道的孔口连接到疏水性无菌过滤器和布置在它们之间并具有冷凝表面的冷凝器，用于产生湍流的湍流发生器是布置在冷凝器区域中的气体消散管道中。

9. 发明申请

US20110058447A1 MIXING SYSTEM 有权
标题翻译：混合系统
公开(公告)号：US20110058447A1
公开(公告)日：2011-03-10
申请号：US12991461
申请日：2009-05-07
申请人： Oscar-Werner Reif , Gerhard Greller , Juergen Van Den Boogaard , Sven Luehmann , Marco Lohrengel
发明人： Oscar-Werner Reif , Gerhard Greller , Juergen Van Den Boogaard , Sven Luehmann , Marco Lohrengel
IPC分类号： B01F7/16
CPC分类号： C12M23/14 , B01F7/1695 , B01F13/0827 , B01F13/0836 , B01F15/00071 , B01F15/00831 , B01F15/0085 , B01F2015/00084 , B01F2215/0032 , B01F2215/0073 , C12M27/02
摘要： A mixing system has a container with flexible walls (1), a fluid-tight drive space (6) and a mixing device. The container with flexible walls (1) has at least one head plate (5). The fluid-tight drive space (6) is outside of the container interior (2), and is enclosed by the head plate (5) and a cap (7) attached to the head plate (5). The mixing device has a stirrer shaft (3), onto which stirrer elements (4, 4′) are attached. The stirrer shaft (3) is guided from the container interior (2) through an opening in the head plate (5) and the section of the stirrer shaft (3) in the drive space (6) is guided by bearings (9, 10). A seal (8) is fit into the opening of the head plate, and encloses the stirrer shaft (3) and seals the container interior (2) from the drive space (6).
摘要翻译：混合系统具有容器，该容器具有柔性壁（1），流体密封的驱动空间（6）和混合装置。具有柔性壁（1）的容器具有至少一个头板（5）。流体密封的驱动空间（6）位于容器内部（2）的外部，并由头板（5）和盖（7）封闭，盖帽（7）附接到头板（5）。混合装置具有搅拌器轴（3），搅拌器元件（4,4'）安装在搅拌轴上。搅拌器轴（3）从容器内部（2）通过头板（5）中的开口引导，并且驱动空间（6）中的搅拌器轴（3）的部分由轴承（9,10 ）。密封件（8）装配在头板的开口中，并包围搅拌器轴（3）并将容器内部（2）与驱动空间（6）密封。

10. 发明授权

US09045722B2 Mixing system 有权
标题翻译：混合系统
公开(公告)号：US09045722B2
公开(公告)日：2015-06-02
申请号：US12991461
申请日：2009-05-07
申请人： Oscar-Werner Reif , Gerhard Greller , Juergen Van Den Boogaard , Sven Luehmann , Marco Lohrengel
发明人： Oscar-Werner Reif , Gerhard Greller , Juergen Van Den Boogaard , Sven Luehmann , Marco Lohrengel
IPC分类号： B01F7/16 , B01F13/02 , B01F15/00 , C12M1/00 , B01F13/08 , C12M1/06
CPC分类号： C12M23/14 , B01F7/1695 , B01F13/0827 , B01F13/0836 , B01F15/00071 , B01F15/00831 , B01F15/0085 , B01F2015/00084 , B01F2215/0032 , B01F2215/0073 , C12M27/02
摘要： A mixing system has a container with flexible walls (1), a fluid-tight drive space (6) and a mixing device. The container with flexible walls (1) has at least one head plate (5). The fluid-tight drive space (6) is outside of the container interior (2), and is enclosed by the head plate (5) and a cap (7) attached to the head plate (5). The mixing device has a stirrer shaft (3), onto which stirrer elements (4, 4′) are attached. The stirrer shaft (3) is guided from the container interior (2) through an opening in the head plate (5) and the section of the stirrer shaft (3) in the drive space (6) is guided by bearings (9, 10). A seal (8) is fit into the opening of the head plate, and encloses the stirrer shaft (3) and seals the container interior (2) from the drive space (6).
摘要翻译：混合系统具有容器，该容器具有柔性壁（1），流体密封的驱动空间（6）和混合装置。具有柔性壁（1）的容器具有至少一个头板（5）。流体密封的驱动空间（6）位于容器内部（2）的外部，并由头板（5）和盖（7）封闭，盖帽（7）附接到头板（5）。混合装置具有搅拌器轴（3），搅拌器元件（4,4'）安装在搅拌轴上。搅拌器轴（3）从容器内部（2）通过头板（5）中的开口引导，并且驱动空间（6）中的搅拌器轴（3）的部分由轴承（9,10 ）。密封件（8）装配在头板的开口中，并包围搅拌器轴（3）并将容器内部（2）与驱动空间（6）密封。

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