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1. 发明授权

US08084028B2 Antibodies to VLA-1 有权
标题翻译： VLA-1的抗体
公开(公告)号：US08084028B2
公开(公告)日：2011-12-27
申请号：US13017919
申请日：2011-01-31
申请人： Michael Karpusas , Paul D. Lyne , Jose William Saldanha , Ellen A. Garber
发明人： Michael Karpusas , Paul D. Lyne , Jose William Saldanha , Ellen A. Garber
IPC分类号： A61K39/395
CPC分类号： C07K16/2842 , A61K2039/505 , C07K2299/00 , C07K2317/24 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , Y02A90/26
摘要： Antibodies that specifically bind to VLA-1 integrin and methods of using these antibodies to treat immunological disorders in a subject. Also included are crystal structures of complexes formed by VLA-1 antibodies and their ligands, and VLA-1 antagonists and agonists identified by using the structure coordinates of these structures.
摘要翻译：特异性结合VLA-1整联蛋白的抗体以及使用这些抗体治疗受试者的免疫学障碍的方法。还包括由VLA-1抗体及其配体形成的复合物的晶体结构，以及通过使用这些结构的结构坐标鉴定的VLA-1拮抗剂和激动剂。

2. 发明申请

US20110189177A1 ANTIBODIES TO VLA-1 有权
标题翻译： VLA-1的抗体
公开(公告)号：US20110189177A1
公开(公告)日：2011-08-04
申请号：US13017919
申请日：2011-01-31
申请人： Michael Karpusas , Paul D. Lyne , Jose William Saldanha , Ellen A. Garber
发明人： Michael Karpusas , Paul D. Lyne , Jose William Saldanha , Ellen A. Garber
IPC分类号： A61K39/395 , A61P17/00 , A61P19/04 , A61P1/00 , A61P37/06 , A61P17/06
CPC分类号： C07K16/2842 , A61K2039/505 , C07K2299/00 , C07K2317/24 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , Y02A90/26
摘要： Antibodies that specifically bind to VLA-1 integrin and methods of using these antibodies to treat immunological disorders in a subject. Also included are crystal structures of complexes formed by VLA-1 antibodies and their ligands, and VLA-1 antagonists and agonists identified by using the structure coordinates of these structures.
摘要翻译：特异性结合VLA-1整联蛋白的抗体以及使用这些抗体治疗受试者的免疫学障碍的方法。还包括由VLA-1抗体及其配体形成的复合物的晶体结构，以及通过使用这些结构的结构坐标鉴定的VLA-1拮抗剂和激动剂。

3. 发明申请

US20100272716A1 Antibodies to VLA-1 有权
公开(公告)号：US20100272716A1
公开(公告)日：2010-10-28
申请号：US12727965
申请日：2010-03-19
申请人： Michael Karpusas , Paul D. Lyne , Jose William Saldanha , Ellen A. Garber
发明人： Michael Karpusas , Paul D. Lyne , Jose William Saldanha , Ellen A. Garber
IPC分类号： A61K39/395 , A61P1/00 , A61P17/06 , A61P25/00 , A61P19/02
CPC分类号： C07K16/2842 , A61K2039/505 , C07K2299/00 , C07K2317/24 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , Y02A90/26
摘要： Antibodies that specifically bind to VLA-1 integrin and methods of using these antibodies to treat immunological disorders in a subject. Also included are crystal structures of complexes formed by VLA-1 antibodies and their ligands, and VLA-1 antagonists and agonists identified by using the structure coordinates of these structures.

4. 发明申请

US20090010930A1 ANTIBODIES TO VLA-1 有权
标题翻译： VLA-1的抗体
公开(公告)号：US20090010930A1
公开(公告)日：2009-01-08
申请号：US12015213
申请日：2008-01-16
申请人： Michael Karpusas , Paul D. Lyne , Jose William Saldanha , Ellen A. Garber
发明人： Michael Karpusas , Paul D. Lyne , Jose William Saldanha , Ellen A. Garber
IPC分类号： A61K39/395 , C07K16/18 , A61P37/00 , C07H21/00
CPC分类号： C07K16/2842 , A61K2039/505 , C07K2299/00 , C07K2317/24 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , Y02A90/26
摘要： Antibodies that specifically bind to VLA-1 integrin and methods of using these antibodies to treat immunological disorders in a subject. Also included are crystal structures of complexes formed by VLA-1 antibodies and their ligands, and VLA-1 antagonists and agonists identified by using the structure coordinates of these structures.
摘要翻译：特异性结合VLA-1整联蛋白的抗体以及使用这些抗体治疗受试者的免疫学障碍的方法。还包括由VLA-1抗体及其配体形成的复合物的晶体结构，以及通过使用这些结构的结构坐标鉴定的VLA-1拮抗剂和激动剂。

5. 发明申请

US20120177638A1 ANTIBODIES TO VLA-1 审中-公开
标题翻译： VLA-1的抗体
公开(公告)号：US20120177638A1
公开(公告)日：2012-07-12
申请号：US13297124
申请日：2011-11-15
申请人： Michael Karpusas , Paul D. Lyne , Jose William Saldanha , Ellen A. Garber
发明人： Michael Karpusas , Paul D. Lyne , Jose William Saldanha , Ellen A. Garber
IPC分类号： A61K39/395 , A61P17/06 , A61P17/00
CPC分类号： C07K16/2842 , A61K2039/505 , C07K2299/00 , C07K2317/24 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , Y02A90/26
摘要： Antibodies that specifically bind to VLA-1 integrin and methods of using these antibodies to treat immunological disorders in a subject. Also included are crystal structures of complexes formed by VLA-1 antibodies and their ligands, and VLA-1 antagonists and agonists identified by using the structure coordinates of these structures.
摘要翻译：特异性结合VLA-1整联蛋白的抗体以及使用这些抗体治疗受试者的免疫学障碍的方法。还包括由VLA-1抗体及其配体形成的复合物的晶体结构，以及通过使用这些结构的结构坐标鉴定的VLA-1拮抗剂和激动剂。

6. 发明授权

US07910099B2 Antibodies to VLA-1 有权
公开(公告)号：US07910099B2
公开(公告)日：2011-03-22
申请号：US12727965
申请日：2010-03-19
申请人： Michael Karpusas , Paul D. Lyne , Jose William Saldanha , Ellen A. Garber
发明人： Michael Karpusas , Paul D. Lyne , Jose William Saldanha , Ellen A. Garber
IPC分类号： A61K39/395
CPC分类号： C07K16/2842 , A61K2039/505 , C07K2299/00 , C07K2317/24 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , Y02A90/26
摘要： Antibodies that specifically bind to VLA-1 integrin and methods of using these antibodies to treat immunological disorders in a subject. Also included are crystal structures of complexes formed by VLA-1 antibodies and their ligands, and VLA-1 antagonists and agonists identified by using the structure coordinates of these structures.

7. 发明授权

US07723073B2 Antibodies to VLA-1 有权
标题翻译： VLA-1的抗体
公开(公告)号：US07723073B2
公开(公告)日：2010-05-25
申请号：US12015213
申请日：2008-01-16
申请人： Michael Karpusas , Paul D. Lyne , Jose William Saldanha , Ellen A. Garber
发明人： Michael Karpusas , Paul D. Lyne , Jose William Saldanha , Ellen A. Garber
IPC分类号： C12P21/06 , C12N15/87 , C12N5/20 , C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： C07K16/2842 , A61K2039/505 , C07K2299/00 , C07K2317/24 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , Y02A90/26
摘要： Antibodies that specifically bind to VLA-1 integrin and methods of using these antibodies to treat immunological disorders in a subject. Also included are crystal structures of complexes formed by VLA-1 antibodies and their ligands, and VLA-1 antagonists and agonists identified by using the structure coordinates of these structures.
摘要翻译：特异性结合VLA-1整联蛋白的抗体以及使用这些抗体治疗受试者的免疫学障碍的方法。还包括由VLA-1抗体及其配体形成的复合物的晶体结构，以及通过使用这些结构的结构坐标鉴定的VLA-1拮抗剂和激动剂。

8. 发明授权

US07358054B2 Antibodies to VLA-1 有权
标题翻译： VLA-1的抗体
公开(公告)号：US07358054B2
公开(公告)日：2008-04-15
申请号：US10474832
申请日：2002-04-12
申请人： Paul D Lyne , Ellen A Garber , Jose W Saldanha , Michael Karpusas
发明人： Paul D Lyne , Ellen A Garber , Jose W Saldanha , Michael Karpusas
IPC分类号： G01N33/53 , C12N5/20 , C07K16/46 , C07K16/28
CPC分类号： C07K16/2842 , A61K2039/505 , C07K2299/00 , C07K2317/24 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , Y02A90/26
摘要： Antibodies that specifically bind to VLA-1 integrin and methods of using these antibodies to treat immunological disorders in a subject. Also included are crystal structures of complexes formed by VLA-1 antibodies and their ligands, and VLA-1 antagonists and agonists identified by using the structure coordinates of these structures.
摘要翻译：特异性结合VLA-1整联蛋白的抗体以及使用这些抗体治疗受试者的免疫学障碍的方法。还包括由VLA-1抗体及其配体形成的复合物的晶体结构，以及通过使用这些结构的结构坐标鉴定的VLA-1拮抗剂和激动剂。

9. 发明申请

US20060136136A1 Crystal structure of baff, and use thereof in drug design 审中-公开
标题翻译：挡板的晶体结构及其在药物设计中的应用
公开(公告)号：US20060136136A1
公开(公告)日：2006-06-22
申请号：US10794755
申请日：2004-03-05
申请人： Michael Karpusas
发明人： Michael Karpusas
IPC分类号： G06F19/00 , C07K14/535
CPC分类号： C07K14/70575 , C07K2299/00 , G16B15/00
摘要： The present invention relates to crystallizable compositions and crystals of BAFF. In addition, this invention relates to the high resolution structure of a BAFF polypeptide as obtained by X-ray crystallography. This invention also relates to a computer (machine) comprising a machine-readable data storage medium comprising a data storage material encoded with machine-readable data comprising the structure coordinates provided by this invention. This invention also relates to methods of using the structure coordinates of BAFF to solve the structure of similar or homologous molecules or molecular complexes and methods of determining the homology model of a similar or homologous molecule, such as APRIL. This invention also provides a computer capable of producing a three-dimensional representation of APRIL based on the homology model structure coordinates. This invention also relates to methods using the structure coordinates of BAFF to design chemical entities or compounds, including agonists or antagonists of BAFF, that specifically bind BAFF, as well as to design variants of BAFF agonists or antagonists, with improved properties (such as increased or decreased binding affinity for BAFF). This invention also provides variants of BAFF. This invention also relates to compositions comprising said chemical entities, compounds, including agonists or antagonists of BAFF, or variants.
摘要翻译：本发明涉及BAFF的可结晶组合物和晶体。此外，本发明涉及通过X射线晶体学获得的BAFF多肽的高分辨率结构。本发明还涉及一种计算机（机器），其包括机器可读数据存储介质，其包括用包括由本发明提供的结构坐标的机器可读数据编码的数据存储材料。本发明还涉及使用BAFF的结构坐标来解决类似或同源分子或分子复合物的结构的方法以及确定类似或同源分子如APRIL的同源性模型的方法。本发明还提供一种能够基于同源模型结构坐标产生APRIL的三维表示的计算机。本发明还涉及使用BAFF的结构坐标来设计化学实体或化合物的方法，所述化学实体或化合物包括特异性结合BAFF的BAFF的激动剂或拮抗剂，以及设计BAFF激动剂或拮抗剂的变体，具有改善的性质（例如增加或降低对BAFF的结合亲和力）。本发明还提供BAFF的变体。本发明还涉及包含所述化学实体，化合物，包括BAFF的激动剂或拮抗剂或变体的组合物。

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