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    • 5. 发明授权
    • Method and apparatus for screening catalyst libraries
    • 用于筛选催化剂文库的方法和装置
    • US06242262B1
    • 2001-06-05
    • US08957191
    • 1997-10-24
    • James P. MorkenSteven J. Taylor
    • James P. MorkenSteven J. Taylor
    • G01N3110
    • G01N33/54373B01J19/0046B01J2219/005B01J2219/00572B01J2219/0059B01J2219/00596B01J2219/00707B01J2219/00738C07B2200/11C07K1/045C07K1/047C40B70/00G01N31/10G01N33/52
    • A method for isolating an active catalyst from a library of compounds that are potential catalysts is disclosed. The method involves providing a library which comprises a plurality of discrete solid supports, each solid support having a different organic compound bound thereto; and providing a reaction solution in a reaction vessel, the reaction solution containing the reactant or reactants necessary for a chemical reaction to occur in the presence of a catalyst for that reaction. The library and the reaction solution are then combined in the reaction vessel, and then one of the discrete solid supports is detected that is characterized by a temperature change in said solution greater than the temperature change of a plurality of other of said discrete solid supports in said solution. The detected solid support carries an active catalyst for the chemical reaction. Continuous flow apparatus for carrying out the method is also disclosed.
    • 公开了一种从潜在的催化剂化合物文库分离活性催化剂的方法。 该方法包括提供包含多个离散的固体支持物的文库,每个固体支持物具有与其结合的不同的有机化合物; 并在反应容器中提供反应溶液,所述反应溶液含有在该反应催化剂存在下发生化学反应所需的反应物或反应物。 然后将文库和反应溶液合并在反应容器中,然后检测离散固体载体之一,其特征在于所述溶液中的温度变化大于多个其它所述离散固体载体的温度变化 说解决方案 检测到的固体载体携带用于化学反应的活性催化剂。 还公开了用于执行该方法的连续流动装置。