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1. 发明申请

US20120171095A1 LIQUID CARBON DIOXIDE ABSORBENTS, METHODS OF USING THE SAME, AND RELATED SYSTEMS 有权
标题翻译：液体二氧化碳吸收剂，使用其的方法和相关系统
公开(公告)号：US20120171095A1
公开(公告)日：2012-07-05
申请号：US13332843
申请日：2011-12-21
申请人： Michael Joseph O'Brien , Robert James Perry , Tunchiao Hubert Lam , Grigorii Lev Soloveichik , Sergei Kniajanski , Larry Neil Lewis , Malgorzata Iwona Rubinsztajn , Dan Hancu
发明人： Michael Joseph O'Brien , Robert James Perry , Tunchiao Hubert Lam , Grigorii Lev Soloveichik , Sergei Kniajanski , Larry Neil Lewis , Malgorzata Iwona Rubinsztajn , Dan Hancu
IPC分类号： B01D53/62 , C09K3/00
CPC分类号： B01D53/1475 , B01D53/1493 , B01D2252/20 , B01D2252/202 , B01D2252/2025 , B01D2252/2028 , B01D2252/20405 , B01D2252/2041 , B01D2252/20415 , B01D2252/20421 , B01D2252/20426 , B01D2252/20468 , B01D2252/205 , B01D2252/2056 , B01D2252/504 , B01D2258/0283 , F23J2215/50 , F23J2219/40 , Y02C10/04 , Y02C10/06
摘要： A carbon dioxide absorbent composition is described, including (i) a liquid, nonaqueous silicon-based material, functionalized with one or more groups that either reversibly react with CO2 or have a high-affinity for CO2; and (ii) a hydroxy-containing solvent that is capable of dissolving both the silicon-based material and a reaction product of the silicon-based material and CO2. The absorbent may be utilized in methods to reduce carbon dioxide in an exhaust gas, and finds particular utility in power plants.
摘要翻译：描述了一种二氧化碳吸收剂组合物，其包括（i）液体，非水性硅基材料，其被一个或多个与CO 2可逆地反应或对CO 2具有高亲和力的基团官能化; 和（ii）能够溶解硅系材料和硅系材料与CO 2的反应产物的含羟基溶剂。吸收剂可用于减少废气中的二氧化碳的方法，并且在发电厂中具有特殊的用途。

2. 发明申请

US20100154639A1 LIQUID CARBON DIOXIDE ABSORBENT AND METHODS OF USING THE SAME 审中-公开
标题翻译：液体二氧化碳吸收剂及其使用方法
公开(公告)号：US20100154639A1
公开(公告)日：2010-06-24
申请号：US12512577
申请日：2009-07-30
申请人： Robert James Perry , Michael Joseph O'Brien , Tunchiao Hubert Lam , Grigorii Lev Soloveichik , Sergei Kniajanski , Larry Neil Lewis , Malgorzata Iwona Rubinsztajn , Dan Hancu
发明人： Robert James Perry , Michael Joseph O'Brien , Tunchiao Hubert Lam , Grigorii Lev Soloveichik , Sergei Kniajanski , Larry Neil Lewis , Malgorzata Iwona Rubinsztajn , Dan Hancu
IPC分类号： B01D53/14 , C09K3/00
CPC分类号： B01D53/1493 , B01D53/1475 , B01D2252/202 , B01D2252/2025 , B01D2252/2026 , B01D2252/2028 , B01D2252/2041 , B01D2252/20415 , B01D2252/20421 , B01D2252/2056 , B01D2252/504 , F23J2215/50 , F23J2219/40 , Y02A50/2342 , Y02C10/04 , Y02C10/06
摘要： A carbon dioxide absorbent comprising (i) a liquid, nonaqueous silicon-based material, functionalized with one or more groups that either reversibly react with CO2 or have a high-affinity for CO2 is provided and (ii) a hydroxy-containing solvent. The absorbent may be utilized in methods to reduce carbon dioxide in an exhaust gas, and finds particular utility in power plants.
摘要翻译：提供二氧化碳吸收剂，其包含（i）液态非水性硅基材料，其被一个或多个与CO 2可逆地反应或对CO 2具有高亲和力的基团官能化，并且（ii）含羟基溶剂。吸收剂可用于减少废气中的二氧化碳的方法，并且在发电厂中具有特殊的用途。

3. 发明授权

US09440182B2 Liquid carbon dioxide absorbents, methods of using the same, and related systems 有权
标题翻译：液体二氧化碳吸收剂，使用方法及相关系统
公开(公告)号：US09440182B2
公开(公告)日：2016-09-13
申请号：US13332843
申请日：2011-12-21
申请人： Michael Joseph O'Brien , Robert James Perry , Tunchiao Hubert Lam , Grigorii Lev Soloveichik , Sergei Kniajanski , Larry Neil Lewis , Malgorzata Iwona Rubinsztajn , Dan Hancu
发明人： Michael Joseph O'Brien , Robert James Perry , Tunchiao Hubert Lam , Grigorii Lev Soloveichik , Sergei Kniajanski , Larry Neil Lewis , Malgorzata Iwona Rubinsztajn , Dan Hancu
IPC分类号： C07F7/08 , C07F7/18 , C07C215/06 , B01D53/14
CPC分类号： B01D53/1475 , B01D53/1493 , B01D2252/20 , B01D2252/202 , B01D2252/2025 , B01D2252/2028 , B01D2252/20405 , B01D2252/2041 , B01D2252/20415 , B01D2252/20421 , B01D2252/20426 , B01D2252/20468 , B01D2252/205 , B01D2252/2056 , B01D2252/504 , B01D2258/0283 , F23J2215/50 , F23J2219/40 , Y02C10/04 , Y02C10/06
摘要： A carbon dioxide absorbent composition is described, including (i) a liquid, nonaqueous silicon-based material, functionalized with one or more groups that either reversibly react with CO2 or have a high-affinity for CO2; and (ii) a hydroxy-containing solvent that is capable of dissolving both the silicon-based material and a reaction product of the silicon-based material and CO2. The absorbent may be utilized in methods to reduce carbon dioxide in an exhaust gas, and finds particular utility in power plants.
摘要翻译：描述了一种二氧化碳吸收剂组合物，其包括（i）液体，非水性硅基材料，其被一个或多个与CO 2可逆地反应或对CO 2具有高亲和力的基团官能化; 和（ii）能够溶解硅系材料和硅系材料与CO 2的反应产物的含羟基溶剂。吸收剂可用于减少废气中的二氧化碳的方法，并且在发电厂中具有特殊的用途。

4. 发明申请

US20100158777A1 CARBON DIOXIDE ABSORBENT AND METHOD OF USING THE SAME 有权
标题翻译：二氧化碳吸收剂及其使用方法
公开(公告)号：US20100158777A1
公开(公告)日：2010-06-24
申请号：US12512105
申请日：2009-07-30
申请人： Robert James Perry , Larry Neil Lewis , Michael Joseph O'Brien , Grigorii Lev Soloveichik , Sergei Kniajanski , Tunchiao Hubert Lam , Julia Lam Lee , Malgorzata Iwona Rubinsztajn
发明人： Robert James Perry , Larry Neil Lewis , Michael Joseph O'Brien , Grigorii Lev Soloveichik , Sergei Kniajanski , Tunchiao Hubert Lam , Julia Lam Lee , Malgorzata Iwona Rubinsztajn
IPC分类号： B01D53/14 , C07F7/10 , C07F7/00
CPC分类号： B01D53/1475 , B01D53/1493 , F23J2215/50 , Y02C10/04 , Y02C10/06 , Y02C10/08
摘要： In accordance with one aspect, the present invention provides an amino-siloxane composition comprising at least one of structures I, II, III, IV or V said compositions being useful for the capture of carbon dioxide from gas streams such as power plant flue gases. In addition, the present invention provides methods of preparing the amino-siloxane compositions are provided. Also provided are methods for reducing the amount of carbon dioxide in a process stream employing the amino-siloxane compositions of the invention as species which react with carbon dioxide to form an adduct with carbon dioxide. The reaction of the amino-siloxane compositions provided by the present invention with carbon dioxide is reversible and thus, the method provides for multicycle use of said compositions.
摘要翻译：根据一个方面，本发明提供了包含结构I，II，III，IV或V中的至少一种的氨基硅氧烷组合物，所述组合物可用于从诸如发电厂烟道气体的气流捕获二氧化碳。此外，本发明提供了制备氨基硅氧烷组合物的方法。还提供了减少使用本发明的氨基 - 硅氧烷组合物的工艺流中二氧化碳的量作为与二氧化碳反应以与二氧化碳形成加合物的物质的方法。本发明提供的氨基硅氧烷组合物与二氧化碳的反应是可逆的，因此该方法提供所述组合物的多周期使用。

5. 发明授权

US08030509B2 Carbon dioxide absorbent and method of using the same 有权
标题翻译：二氧化碳吸收剂及其使用方法
公开(公告)号：US08030509B2
公开(公告)日：2011-10-04
申请号：US12512105
申请日：2009-07-30
申请人： Robert James Perry , Larry Neil Lewis , Michael Joseph O'Brien , Grigorii Lev Soloveichik , Sergei Kniajanski , Tunchiao Hubert Lam , Julia Lam Lee , Malgorzata Iwona Rubinsztajn
发明人： Robert James Perry , Larry Neil Lewis , Michael Joseph O'Brien , Grigorii Lev Soloveichik , Sergei Kniajanski , Tunchiao Hubert Lam , Julia Lam Lee , Malgorzata Iwona Rubinsztajn
IPC分类号： C07F7/10 , C07D303/02 , B01D53/14 , B01D53/34 , B01D53/62
CPC分类号： B01D53/1475 , B01D53/1493 , F23J2215/50 , Y02C10/04 , Y02C10/06 , Y02C10/08
摘要： In accordance with one aspect, the present invention provides an amino-siloxane composition comprising at least one of structures I, II, III, IV or V said compositions being useful for the capture of carbon dioxide from gas streams such as power plant flue gases. In addition, the present invention provides methods of preparing the amino-siloxane compositions are provided. Also provided are methods for reducing the amount of carbon dioxide in a process stream employing the amino-siloxane compositions of the invention as species which react with carbon dioxide to form an adduct with carbon dioxide. The reaction of the amino-siloxane compositions provided by the present invention with carbon dioxide is reversible and thus, the method provides for multicycle use of said compositions.
摘要翻译：根据一个方面，本发明提供了包含结构I，II，III，IV或V中的至少一种的氨基硅氧烷组合物，所述组合物可用于从诸如发电厂烟道气体的气流捕获二氧化碳。此外，本发明提供了制备氨基硅氧烷组合物的方法。还提供了减少使用本发明的氨基 - 硅氧烷组合物的工艺流中二氧化碳的量作为与二氧化碳反应以与二氧化碳形成加合物的物质的方法。本发明提供的氨基硅氧烷组合物与二氧化碳的反应是可逆的，因此该方法提供所述组合物的多周期使用。

6. 发明申请

US20110305635A9 MYELIN DETECTION USING BENZOFURAN DERIVATIVES 有权
标题翻译：使用苯唑嘌呤衍生物进行MYELIN检测
公开(公告)号：US20110305635A9
公开(公告)日：2011-12-15
申请号：US12211854
申请日：2008-09-17
申请人： Christina Abucay Tan Hehir , Stephen Johnson Lomnes , Kenneth Michael Fish , Tiberiu Mircea Siclovan , Michael Christopher Montalto , Tunchiao Hubert Lam
发明人： Christina Abucay Tan Hehir , Stephen Johnson Lomnes , Kenneth Michael Fish , Tiberiu Mircea Siclovan , Michael Christopher Montalto , Tunchiao Hubert Lam
IPC分类号： A61K51/04
CPC分类号： G01N33/60 , A61K49/10 , A61K51/0419 , G01N33/6896 , G01N2800/285 , Y10T436/14 , Y10T436/20 , Y10T436/200833
摘要： The present invention relates to methods for the detection of myelin and a quantitative measurement of its local concentration in a sample using a benzofuran compound or its radioisotope derivatives. In one embodiment a method of myelin detection comprises identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, parenterally administering to the subject the benzofuran compound, or a derivative of the compound, and determining myelination in the subject by detecting binding in the sample. In one embodiment, the invention provides a method of imaging myelinated tissue in a surgical field of mammalian tissue comprising the steps of contacting the surgical site with the benzofuran compound or a radioisotope derivative of the compound, and detecting binding in the surgical site. In yet another embodiment, a method of imaging spinal cord and spinal nerve root tissue is provided comprising the steps of parenteral administration of a radioisotope derivative of the benzofuran compound and detecting the radioisotope derivative within the spinal canal and intervertebral foramen. Methods of quantification of binding of the benzofuran compound or its derivatives are also provided.
摘要翻译：本发明涉及使用苯并呋喃化合物或其放射性同位素衍生物检测髓磷脂的方法及其在样品中的局部浓度的定量测量。在一个实施方案中，髓鞘蛋白检测的方法包括鉴定患有髓磷脂相关神经病的风险或被诊断患有髓磷脂相关神经病的受试者，所述苯并呋喃化合物或所述化合物的衍生物肠胃外给药，以及通过检测受试者中的结合来确定受试者的髓鞘形成例子。在一个实施方案中，本发明提供了一种在哺乳动物组织的手术领域中成像有髓组织的方法，包括使手术部位与化合物的苯并呋喃化合物或放射性同位素衍生物接触并检测手术部位的结合的步骤。在另一个实施方案中，提供了一种脊髓和脊髓神经根组织成像方法，其包括非肠道给药苯并呋喃化合物的放射性同位素衍生物和检测椎管内的放射性同位素衍生物和椎间孔的步骤。还提供了定量苯并呋喃化合物或其衍生物的结合方法。

7. 发明申请

US20090162280A1 DETECTING SOLUBLE A-BETA 审中-公开
标题翻译：检测可溶性A-BETA
公开(公告)号：US20090162280A1
公开(公告)日：2009-06-25
申请号：US11961460
申请日：2007-12-20
申请人： Cristina Abucay Tan Hehir , Tiberiu Mircea Siclovan , Tunchiao Hubert Lam , Michael Christopher Montalto , Richard Waltz Harper , Warren Jaye Porter
发明人： Cristina Abucay Tan Hehir , Tiberiu Mircea Siclovan , Tunchiao Hubert Lam , Michael Christopher Montalto , Richard Waltz Harper , Warren Jaye Porter
IPC分类号： A61K51/04 , G01N33/53 , A61K49/00 , C07C229/00
CPC分类号： G01N33/6896 , A61K51/0402 , A61K51/0419 , A61K51/0453 , C07C233/81 , G01N33/60 , G01N2333/4709 , G01N2800/2821
摘要： Agents, methods, and kits for qualitatively or quantitatively determining the presence of soluble A-beta in source of A-beta are provided, wherein the agents comprise the compound of formula III or the compound of formula III labeled with a signal generator.
摘要翻译：提供用于定性或定量测定A-β源中可溶性A-β存在的试剂，方法和试剂盒，其中所述试剂包含用信号发生器标记的式III化合物或式III化合物。

8. 发明授权

US08114382B2 Myelin detection using benzofuran derivatives 有权
标题翻译：使用苯并呋喃衍生物的髓磷脂检测
公开(公告)号：US08114382B2
公开(公告)日：2012-02-14
申请号：US12211854
申请日：2008-09-17
申请人： Cristina Abucay Tan Hehir , Stephen Johnson Lomnes , Kenneth Michael Fish , Tiberiu Mircea Siclovan , Michael Christopher Montalto , Tunchiao Hubert Lam
发明人： Cristina Abucay Tan Hehir , Stephen Johnson Lomnes , Kenneth Michael Fish , Tiberiu Mircea Siclovan , Michael Christopher Montalto , Tunchiao Hubert Lam
IPC分类号： A61K49/00
CPC分类号： G01N33/60 , A61K49/10 , A61K51/0419 , G01N33/6896 , G01N2800/285 , Y10T436/14 , Y10T436/20 , Y10T436/200833
摘要： The present invention relates to methods for the detection of myelin and a quantitative measurement of its local concentration in a sample using a benzofuran compound or its radioisotope derivatives. In one embodiment a method of myelin detection comprises identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, parenterally administering to the subject the benzofuran compound, or a derivative of the compound, and determining myelination in the subject by detecting binding in the sample. In one embodiment, the invention provides a method of imaging myelinated tissue in a surgical field of mammalian tissue comprising the steps of contacting the surgical site with the benzofuran compound or a radioisotope derivative of the compound, and detecting binding in the surgical site. In yet another embodiment, a method of imaging spinal cord and spinal nerve root tissue is provided comprising the steps of parenteral administration of a radioisotope derivative of the benzofuran compound and detecting the radioisotope derivative within the spinal canal and intervertebral foramen. Methods of quantification of binding of the benzofuran compound or its derivatives are also provided.
摘要翻译：本发明涉及使用苯并呋喃化合物或其放射性同位素衍生物检测髓磷脂的方法及其在样品中的局部浓度的定量测量。在一个实施方案中，髓鞘蛋白检测的方法包括鉴定患有髓磷脂相关神经病的风险或被诊断患有髓磷脂相关神经病的受试者，所述苯并呋喃化合物或所述化合物的衍生物肠胃外给药，以及通过检测受试者中的结合来确定受试者的髓鞘形成例子。在一个实施方案中，本发明提供了一种在哺乳动物组织的手术领域中成像有髓组织的方法，包括使手术部位与化合物的苯并呋喃化合物或放射性同位素衍生物接触并检测手术部位的结合的步骤。在另一个实施方案中，提供了一种脊髓和脊髓神经根组织成像方法，其包括非肠道给药苯并呋喃化合物的放射性同位素衍生物和检测椎管内的放射性同位素衍生物和椎间孔的步骤。还提供了定量苯并呋喃化合物或其衍生物的结合方法。

9. 发明申请

US20100068140A1 MYELIN DETECTION USING BENZOFURAN DERIVATIVES 有权
标题翻译：使用苯唑嘌呤衍生物进行MYELIN检测
公开(公告)号：US20100068140A1
公开(公告)日：2010-03-18
申请号：US12211854
申请日：2008-09-17
申请人： Christina Abucay Tan Hehir , Stephen Johnson Lomnes , Kenneth Michael Fish , Tiberiu Mircea Siclovan , Michael Christopher Montalto , Tunchiao Hubert Lam
发明人： Christina Abucay Tan Hehir , Stephen Johnson Lomnes , Kenneth Michael Fish , Tiberiu Mircea Siclovan , Michael Christopher Montalto , Tunchiao Hubert Lam
IPC分类号： A61K51/04
CPC分类号： G01N33/60 , A61K49/10 , A61K51/0419 , G01N33/6896 , G01N2800/285 , Y10T436/14 , Y10T436/20 , Y10T436/200833
摘要： The present invention relates to methods for the detection of myelin and a quantitative measurement of its local concentration in a sample using a benzofuran compound or its radioisotope derivatives. In one embodiment a method of myelin detection comprises identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, parenterally administering to the subject the benzofuran compound, or a derivative of the compound, and determining myelination in the subject by detecting binding in the sample. In one embodiment, the invention provides a method of imaging myelinated tissue in a surgical field of mammalian tissue comprising the steps of contacting the surgical site with the benzofuran compound or a radioisotope derivative of the compound, and detecting binding in the surgical site. In yet another embodiment, a method of imaging spinal cord and spinal nerve root tissue is provided comprising the steps of parenteral administration of a radioisotope derivative of the benzofuran compound and detecting the radioisotope derivative within the spinal canal and intervertebral foramen. Methods of quantification of binding of the benzofuran compound or its derivatives are also provided.
摘要翻译：本发明涉及使用苯并呋喃化合物或其放射性同位素衍生物检测髓磷脂的方法及其在样品中的局部浓度的定量测量。在一个实施方案中，髓鞘蛋白检测的方法包括鉴定患有髓磷脂相关神经病的风险或被诊断患有髓磷脂相关神经病的受试者，所述苯并呋喃化合物或所述化合物的衍生物肠胃外给药，以及通过检测受试者中的结合来确定受试者的髓鞘形成例子。在一个实施方案中，本发明提供了一种在哺乳动物组织的手术领域中成像有髓组织的方法，包括使手术部位与化合物的苯并呋喃化合物或放射性同位素衍生物接触并检测手术部位的结合的步骤。在另一个实施方案中，提供了一种脊髓和脊髓神经根组织成像方法，其包括非肠道给药苯并呋喃化合物的放射性同位素衍生物和检测椎管内的放射性同位素衍生物和椎间孔的步骤。还提供了定量苯并呋喃化合物或其衍生物的结合方法。

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