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1. 发明申请

US20190102850A1 SMART CITY COMMODITY EXCHANGE WITH SMART CONTRACTS 审中-公开
公开(公告)号：US20190102850A1
公开(公告)日：2019-04-04
申请号：US15720305
申请日：2017-09-29
申请人： David McMakin Wheeler , Ned M. Smith , Thimas Barnes Abels , Michael John Reed , Clair Michael Bowman , Thomas John Barnes
发明人： David McMakin Wheeler , Ned M. Smith , Thimas Barnes Abels , Michael John Reed , Clair Michael Bowman , Thomas John Barnes
IPC分类号： G06Q50/18 , G06Q30/06 , G06Q20/12
摘要： Embodiments involve using smart contracts in a decentralized network as a framework for a smart city commodity exchange. In at least one embodiment, consumers and service providers negotiate terms and conditions of a smart contract for providing goods or services to the consumer. The service provider may provide all requested goods and services or bundle goods and services provided from multiple vendors. Verification of smart contract fulfillment may be assisted by information from sensors or other independent data collection. The service provider may provide discounted services in exchange for information to provide to a third party. Resources of both the consumer and service provide are committed during smart contract negotiations until completion of the smart contract, or rejection of the offered terms. Resource commitments, smart contract generation, performance of the smart contract and intermediate transactions are recorded in public ledgers according to Blockchain protocols. Other embodiments are described and claimed.

2. 发明授权

US08093279B2 Compound 有权
标题翻译：复合
公开(公告)号：US08093279B2
公开(公告)日：2012-01-10
申请号：US12555342
申请日：2009-09-08
申请人： Lok Wai Lawrence Woo , Toby Jackson , Atul Purohit , Michael John Reed , Gillian Reed, legal representative , Barry Victor Lloyd Potter
发明人： Lok Wai Lawrence Woo , Toby Jackson , Atul Purohit , Michael John Reed , Barry Victor Lloyd Potter
IPC分类号： A61K31/44 , C07D249/00
CPC分类号： C07D249/08 , C07D405/10
摘要： There is provided a compound of Formula I wherein R3, R4, R5, R6 and R7 are independently selected from H and —Y—R8; wherein each R8 is independently selected from —OH, hydrocarbyl groups, oxyhydrocarbyl groups, cyano (—CN), nitro (—NO2), H-bond acceptors, and halogens; wherein at least one of R3, R4, R5, R6 and R7 is —Y—R8 wherein R8 is selected from substituted and unsubstituted heterocyclic rings and amino substituted phenyl groups, wherein X is a bond or a linker group; wherein Y is an optional linker group; and wherein ring A is optionally further substituted; wherein R9 is selected from H, —OH and —OSO2NR1R2; wherein R1 and R2 are independently selected from H and hydrocarbyl; wherein (a) X is a bond and at least one of R3, R4, R5, R6 and R7 is —Y—R8; OR (b) R9 is —OSO2NR1R2 or —OH and four of R3, R4, R5, R6 and R7 are H and one of R3, R4, R5, R6 and R7 is —Y—R8.
摘要翻译：提供式I的化合物，其中R 3，R 4，R 5，R 6和R 7独立地选自H和-Y-R 8; 其中每个R 8独立地选自-OH，烃基，羟基烃基，氰基（-CN），硝基（-NO 2），H-键受体和卤素; 其中R 3，R 4，R 5，R 6和R 7中的至少一个是-Y-R 8，其中R 8选自取代和未取代的杂环和氨基取代的苯基，其中X是键或连接基团; 其中Y是任选的连接基团; 并且其中环A任选进一步被取代; 其中R9选自H，-OH和-OSO2NR1R2; 其中R1和R2独立地选自H和烃基; 其中（a）X是键，并且R 3，R 4，R 5，R 6和R 7中的至少一个是-Y-R 8; 或（b）R9为-OSO2NR1R2或-OH，R3，R4，R5，R6和R7中的4个为H，R3，R4，R5，R6和R7之一为-Y-R8。

3. 发明授权

US07968561B2 Steroidal compounds as steroid sulphatase inhibitors 失效
标题翻译：甾类化合物作为类固醇硫酸酯酶抑制剂
公开(公告)号：US07968561B2
公开(公告)日：2011-06-28
申请号：US12200252
申请日：2008-08-28
申请人： Barry Victor Lloyd Potter , Michael John Reed , Lok Wai Lawrence Woo , Atul Purohit , Paul Foster
发明人： Barry Victor Lloyd Potter , Michael John Reed , Lok Wai Lawrence Woo , Atul Purohit , Paul Foster
IPC分类号： A01N43/42 , A61K31/44 , C07D221/18 , C07D221/22
CPC分类号： C07J63/00
摘要： There is provided a compound having Formula I wherein G is a fluorocarbyl group, and wherein R1 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group.
摘要翻译：提供具有式I的化合物，其中G是氟代羰基，其中R 1是氨基磺酸酯基，膦酸酯基，硫代膦酸酯基，磺酸酯基或磺酰胺基中的任何一个。

4. 发明授权

US07893284B2 Oestrogen derivatives as inhibitors of steroid sulphatase 失效
标题翻译：雌激素衍生物作为类固醇硫酸酯酶的抑制剂
公开(公告)号：US07893284B2
公开(公告)日：2011-02-22
申请号：US11233945
申请日：2005-09-23
申请人： Matthew Leese , Atul Purohit , Michael John Reed , Simon Paul Newman , Surinder Kuman Chander , Fabrice Jourdan , Barry Victor Lloyd Potter
发明人： Matthew Leese , Atul Purohit , Michael John Reed , Simon Paul Newman , Surinder Kuman Chander , Fabrice Jourdan , Barry Victor Lloyd Potter
IPC分类号： C07J3/00 , C07J1/00
CPC分类号： C07J43/00 , C07J41/00
摘要： The present invention provides a compound comprising a steroidal ring system and an optional group R1 selected from any one of —OH, a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; wherein the D ring of the steroidal ring system is substituted by a group R2 of the formula -L-R3, wherein L is an optional linker group and R3 is selected from groups which are or which comprise one of a nitrite group, an alcohol, an ester, an ether, an amine and an alkene, provided that when R3 is or comprises an alcohol, L is present; and wherein the A ring of the steroidal ring system is substituted at position 2 or 4 with a group R4, wherein R4 is a hydrocarbyl group.
摘要翻译：本发明提供了包含甾族环系统和选自-OH，氨基磺酸盐基团，膦酸盐基团，硫代膦酸盐基团，磺酸盐基团或磺酰胺基团中的任何一个的任选基团R1的化合物; 其中甾族环体系的D环被式-L-R3的基团R 2取代，其中L是任选的连接基团，并且R 3选自亚硝酸根基团，醇，酯，醚，胺和烯烃，条件是当R3是或包含醇时，存在L; 并且其中所述甾族环系统的A环在位置2或4与基团R 4取代，其中R 4是烃基。

5. 发明授权

US07745472B2 Compound 有权
标题翻译：复合
公开(公告)号：US07745472B2
公开(公告)日：2010-06-29
申请号：US12056920
申请日：2008-03-27
申请人： Barry Victor Lloyd Potter , Lok Wai Lawrence Woo , Atul Purohit , Michael John Reed , Oliver Brook Sutcliffe , Christian Bubert
发明人： Barry Victor Lloyd Potter , Lok Wai Lawrence Woo , Atul Purohit , Michael John Reed , Oliver Brook Sutcliffe , Christian Bubert
IPC分类号： A61K31/4196 , C07D249/08
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07D413/12 , C07D417/12
摘要： There is provided a compound of Formula I wherein each T is independently selected from H, hydrocarbyl, —F—R, and a bond with one of D, E, P or Q, or together with one of P and Q forms a ring; Z is a suitable atom the valency of which is m; D, E and F are each independently of each other an optional linker group, wherein when Z is nitrogen E is other than CH2 and C═O; P, Q and R are independently of each other a ring system; and at least Q comprises a sulphamate group.
摘要翻译：提供式I的化合物，其中每个T独立地选自H，烃基，-F-R和与D，E，P或Q之一的键，或与P和Q中的一个形成环; Z是一个合适的原子，其化合价是m; D，E和F各自独立地为任选的连接基团，其中当Z为氮时，E不是CH 2且C = O; P，Q和R彼此独立地是环系; 并且至少Q包含氨基磺酸酯基团。

6. 发明申请

US20080312266A1 Steroidal Compounds For Inhibiting Steroid Sulphatase 失效
标题翻译：用于抑制类固醇硫酸酶的甾体化合物
公开(公告)号：US20080312266A1
公开(公告)日：2008-12-18
申请号：US11855603
申请日：2007-09-14
申请人： Barry Victor Lloyd Potter , Michael John Reed , Lok Wai Lawrence Woo
发明人： Barry Victor Lloyd Potter , Michael John Reed , Lok Wai Lawrence Woo
IPC分类号： A61K31/435 , C07D221/18 , C12Q1/34 , A61P35/00
CPC分类号： C07J1/0051 , C07J63/00 , C07J63/008
摘要： There is provided a compound having Formula (I) wherein G is H or a substituent, and wherein R1 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group, capable of inhibiting steroid sulphatase.
摘要翻译：提供了具有式（I）的化合物，其中G是H或取代基，并且其中R 1是能够抑制类固醇硫酸酯酶的氨基磺酸酯基，膦酸酯基，硫代膦酸酯基，磺酸酯基或磺酰胺基中的任何一种。

7. 发明授权

US07067503B2 17-aryl linker derivatised estrogen 3-sulphamates as inhibitors of steroid sulphatase 失效
标题翻译： 17-芳基连接体衍生化的雌激素3-磺酰胺酸酯作为类固醇硫酸酯酶的抑制剂
公开(公告)号：US07067503B2
公开(公告)日：2006-06-27
申请号：US10367622
申请日：2003-02-14
申请人： Barry Victor Lloyd Potter , Michael John Reed , Bertrand Leblond , Matthew Paul Leese
发明人： Barry Victor Lloyd Potter , Michael John Reed , Bertrand Leblond , Matthew Paul Leese
IPC分类号： A61K31/58 , C07J1/00 , C07J43/00
CPC分类号： A61K31/565 , A61K31/37
摘要： There is provided a compound comprising a steroidal ring system and a group R1 selected from any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; wherein the D ring of the steroidal ring system is substituted by a group R2 of the formula —L-R3, wherein L is an optional linker group and R3 is an aromatic hydrocarbyl group.
摘要翻译：提供了包含选自氨基磺酸盐基团，膦酸盐基团，硫代膦酸盐基团，磺酸盐基团或磺酰胺基团中的任何一个的甾体环系统和基团R 1的化合物; 其中所述甾体环体系的D环被式-LR 3 SO 2的基团R 2取代，其中L是任选的连接基团，R 3 芳香族烃基。

8. 发明授权

US06677325B2 Steroid sulphatase inhibitors 失效
标题翻译：类固醇硫酸酶抑制剂
公开(公告)号：US06677325B2
公开(公告)日：2004-01-13
申请号：US10082007
申请日：2002-02-21
申请人： Michael John Reed , Barry Victor Lloyd Potter
发明人： Michael John Reed , Barry Victor Lloyd Potter
IPC分类号： A61K3135
CPC分类号： A61K31/37 , C07D311/16 , C07D311/30 , C07D311/32 , C07D311/36 , C07J41/0072
摘要： A method for controlling estrone or estrodiol production comprising administering a ring system compound comprising a sulphamic acid ester group; wherein said compound is an inhibitor of an enzyme having steroid sulphatase activity (EC 3.1.6.2); and wherein if the sulphamic acid ester group of said compound is replaced with a sulphate group to form a sulphate compound and incubated with a steroid sulphatase enzyme (EC 3.1.6.2) at a pH 7.4 and 37° C. it provides a Km value of less than 50 &mgr;M. A method to target the estrogen metabolic pathway comprising administering a ring system compound comprising a sulphamic acid ester group; wherein said compound is an inhibitor of an enzyme having steroid sulphatase activity (EC 3.1.6.2); and wherein if the sulphamic acid ester group of said compound is replaced with a sulphate group to form a sulphate compound and incubated with a steroid sulphatase enzyme (EC 3.1.6.2) at a pH 7.4 and 37° C. it provides a Km value of less than 50 &mgr;M.
摘要翻译：用于控制雌酮或雌二醇生产的方法，包括施用包含氨基磺酸酯基团的环系化合物; 其中所述化合物是具有类固醇硫酸酯酶活性的酶的抑制剂（EC 3.1.6.2）; 并且其中如果所述化合物的氨基磺酸酯基团被硫酸根基团替代以形成硫酸盐化合物，并在pH 7.4和37℃下与类固醇硫酸酶（EC 3.1.6.2）温育，则其提供Km值小于50亩。靶向雌激素代谢途径的方法，包括施用包含氨基磺酸酯基团的环系化合物; 其中所述化合物是具有类固醇硫酸酯酶活性的酶的抑制剂（EC 3.1.6.2）; 并且其中如果所述化合物的氨基磺酸酯基团被硫酸根基团替代以形成硫酸盐化合物，并在pH 7.4和37℃下与类固醇硫酸酶（EC 3.1.6.2）温育，则其提供Km值小于50亩。

9. 发明授权

US06670353B2 Oxime-group containing oestrone sulphatase inhibitors 失效
标题翻译：含肟基的磺胺类化合物抑制剂
公开(公告)号：US06670353B2
公开(公告)日：2003-12-30
申请号：US09572237
申请日：2000-05-17
申请人： Michael John Reed , Barry Victor Lloyd Potter
发明人： Michael John Reed , Barry Victor Lloyd Potter
IPC分类号： A61K3156
CPC分类号： A61K31/565
摘要： A sulphamate compound suitable for use as an inhibitor of oestrone sulphatase (E.C.3.1.6.2) is described. The compound is a polycyclic compound comprising at least two ring components, wherein the polycyclic compound comprises at least one sulphamate group attached to at least one of the ring components, and wherein at least one oxime group is attached to or is part of at least one of the ring components.
摘要翻译：描述了适合用作奥斯汀硫酸酯酶抑制剂（E.C.3.1.6.2）的氨基磺酸盐化合物。化合物是包含至少两个环组分的多环化合物，其中多环化合物包含至少一个连接至至少一个环组分的氨基磺酸酯基团，并且其中至少一个肟基团连接至至少一个的环组件。

10. 发明授权

US06476011B1 Methods for introducing an estrogenic compound 失效
标题翻译：引入雌激素化合物的方法
公开(公告)号：US06476011B1
公开(公告)日：2002-11-05
申请号：US09193970
申请日：1998-11-18
申请人： Michael John Reed , Barry Victor Lloyd Potter
发明人： Michael John Reed , Barry Victor Lloyd Potter
IPC分类号： A61K3156
CPC分类号： A61K31/37 , C07D311/16 , C07D311/30 , C07D311/32 , C07D311/36 , C07J41/0072
摘要： The invention pertains to methods for introducing an estrogenic compound into a subject in need thereof involving administering an effective amount of a ring system compound having the formula (II) wherein each of R1 and R2 is independently selected from H, alkyl, alkenyl, cycloalkyl and aryl, and at least one of R1 and R2 is H, or together represent alkylene optionally containing one or more hetero atoms or groups in the alkylene chain; and the ring system ABCD represents a substituted or unsubstituted, saturated or unsaturated steroid nucleus selected from the group consisting of oestrones, dehydroepiandrosterones, substituted oestrones, oestradiols, substituted oestradiols, oestriols, substituted dehydroepiandrosterones, or substituted oestriols; wherein the compound is an inhibitor of an enzyme having steroid sulphatase activity (EC 3,1,6,2), or a pharmceutically acceptable salt thereof.
摘要翻译：本发明涉及向有需要的受试者中引入雌激素化合物的方法，包括给予有效量的具有式（II）的环系化合物，其中R 1和R 2各自独立地选自H，烷基，烯基，环烷基和芳基，并且R 1和R 2中的至少一个为H，或一起表示亚烷基链中任选含有一个或多个杂原子或基团的亚烷基; 环系ABCD代表选自以下组中的取代或未取代的饱和或不饱和类固醇核：地塞米松，脱氢表雄酮，取代的雌二醇，雌二醇，取代的雌二醇，雌三醇，取代的脱氢表雄甾酮或取代的雌三醇; 其中所述化合物是具有类固醇硫酸酯酶活性的酶的抑制剂（EC 3,1,6,2）或其药学上可接受的盐。

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