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1. 发明授权

US08697155B2 Treatment of obesity and related disorders 有权
标题翻译：治疗肥胖及相关疾病
公开(公告)号：US08697155B2
公开(公告)日：2014-04-15
申请号：US13055009
申请日：2009-07-20
申请人： Michael J. Levy , Mark D. Topazian , Steven P. Petrou
发明人： Michael J. Levy , Mark D. Topazian , Steven P. Petrou
IPC分类号： A61K35/00 , A61K38/48 , A61M29/00 , A61K38/00 , A61P3/04
CPC分类号： A61K9/0053 , A61K9/0095 , A61K38/10 , A61K38/4886 , A61K45/06 , A61K47/24 , A61M31/00 , A61K2300/00
摘要： This disclosure provides a method of treating obesity and related disorders through the administration of a composition comprising a neurotoxin and a mucosal permeabilizing agent. Methods for making and using the described compositions are also provided.
摘要翻译：本公开提供了通过施用包含神经毒素和粘膜渗透剂的组合物来治疗肥胖症和相关疾病的方法。还提供了制备和使用所述组合物的方法。

2. 发明申请

US20130317390A1 CYTOLOGICAL SAMPLE ACQUISITION DEVICE AND METHOD 审中-公开
标题翻译：细胞学样本获取装置和方法
公开(公告)号：US20130317390A1
公开(公告)日：2013-11-28
申请号：US13982137
申请日：2012-01-25
申请人： Michael J. Levy , Christopher J. Gostout
发明人： Michael J. Levy , Christopher J. Gostout
IPC分类号： A61B10/04
CPC分类号： A61B10/04 , A61B10/02 , A61B17/22032 , A61B2010/0074 , A61B2010/0216 , F04C2270/0421
摘要： A tissue collection device and method. One embodiment of the device includes a body formed by an elongated member, a pair of inflatable balloons at spaced-apart locations on the body, and one or more collection structures on the body. Inflation lumens extending through the body and coupled to the balloons cause the balloons to move between collapsed and expanded states. The collection structures collect a tissue sample from a collection region between the balloons. In another embodiment the collection structures include one or more of an irrigation lumen and an aspiration lumen having one or more ports opening into the collection region.
摘要翻译：一种组织收集装置和方法。该装置的一个实施例包括由细长构件形成的主体，身体上间隔开的位置处的一对可充气气囊，以及身体上的一个或多个收集结构。通过身体延伸并与球囊联接的充气流体导致气囊在收缩和膨胀状态之间移动。收集结构从气球之间的收集区域收集组织样本。在另一个实施例中，收集结构包括一个或多个冲洗管腔和具有通向收集区域的一个或多个端口的抽吸腔。

3. 发明授权

US08226575B2 Biopsy needle assemblies 有权
标题翻译：活检针组件
公开(公告)号：US08226575B2
公开(公告)日：2012-07-24
申请号：US12780596
申请日：2010-05-14
申请人： Michael J. Levy
发明人： Michael J. Levy
IPC分类号： A61B10/00 , A61B17/32
CPC分类号： A61B10/0283 , A61B10/06 , A61B2010/045
摘要： This document provides needle biopsy systems and methods for obtaining tissue biopsies. In various embodiments, the systems and methods provided can inhibit needle contamination by unwanted tissue or cells and/or regulate a negative pressure to assist sampling of target tissue or cells.
摘要翻译：本文件提供用于获得组织活组织检查的针活检系统和方法。在各种实施方案中，所提供的系统和方法可以抑制不想要的组织或细胞的针污染和/或调节负压以辅助对靶组织或细胞的取样。

4. 发明申请

US20110190660A1 Biopsy Devices 审中-公开
标题翻译：活组织检查装置
公开(公告)号：US20110190660A1
公开(公告)日：2011-08-04
申请号：US12990853
申请日：2009-04-27
申请人： Michael J. Levy
发明人： Michael J. Levy
IPC分类号： A61B10/00
CPC分类号： A61B10/0275 , A61B10/0283 , A61B10/04 , A61B2010/0208 , A61B2090/3925
摘要： Tissue biopsy devices having improved safety, adaptability, and firing power and speed.
摘要翻译：具有改进的安全性，适应性和发射功率和速度的组织活组织检查装置。

5. 发明申请

US20090054905A1 Embolization coil delivery systems and methods 有权
标题翻译：栓塞线圈输送系统及方法
公开(公告)号：US20090054905A1
公开(公告)日：2009-02-26
申请号：US12154331
申请日：2008-05-22
申请人： Michael J. Levy
发明人： Michael J. Levy
IPC分类号： A61B17/12 , A61B17/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/1215 , A61B17/12163 , A61B17/1219 , A61B90/39 , A61B2017/12054 , A61B2017/12059 , A61B2090/3925
摘要： A system and method for ultrasonically guided endoscopic (EUS) delivery of one or more embolization coils to an internal body site. The embolization coil delivery devices are preferably ultrasonically guided to the selected internal body site after being advanced through the working channel of an endoscope with its distal end located near the selected internal body site. In one aspect, the system and method may be utilized to deploy an embolization coil into a lesion to promote thrombosis and/or prevent bleeding.
摘要翻译：一种用于超声引导内窥镜（EUS）将一个或多个栓塞线圈递送到内部身体部位的系统和方法。栓塞线圈输送装置优选地在通过内窥镜的工作通道前进后被超声波引导到所选择的内部身体部位，其远端位于选定的内部身体部位附近。在一个方面，该系统和方法可用于将栓塞线圈部署到病变部分以促进血栓形成和/或预防出血。

6. 发明授权

US06913721B2 Process of making a charging member 失效
标题翻译：制造充电部件的工序
公开(公告)号：US06913721B2
公开(公告)日：2005-07-05
申请号：US10228877
申请日：2002-08-27
申请人： Michael F. Zona , John S. Facci , Michael J. Levy , Rachael L. McGrath
发明人： Michael F. Zona , John S. Facci , Michael J. Levy , Rachael L. McGrath
IPC分类号： G03G15/02 , B05D5/12 , B29C37/00 , B29C41/00 , B29C41/20 , B29C41/22 , F16C13/00
CPC分类号： B29C41/006 , B29C37/0082 , B29C41/20 , B29C41/22 , B29K2995/0005 , B29K2995/0046 , B29L2031/767
摘要： Apparatus for charging a substrate, including: an elongated charging member having a crowned surface; an elongated pressure member having the pressure member being supported for pressure engagement with the charging member to form a nip therebetween adapted to receive the substrate. There is also disclosed a method for making the apparatus.
摘要翻译：用于对基板充电的装置，包括：具有凸面的细长充电部件; 一个细长的压力构件，其具有被支撑用于与充电构件压力接合的压力构件，以在它们之间形成适于容纳衬底的压区。还公开了一种制造该装置的方法。

7. 发明授权

US06807389B2 Bias charge roller with optimally induced AC corona 失效
公开(公告)号：US06807389B2
公开(公告)日：2004-10-19
申请号：US10319201
申请日：2002-12-13
申请人： John S. Facci , Michael J. Levy , Paul W. Morehouse, Jr. , Rachael L. McGrath
发明人： John S. Facci , Michael J. Levy , Paul W. Morehouse, Jr. , Rachael L. McGrath
IPC分类号： G03G1500
CPC分类号： G03G15/0283 , G03G15/0291 , G03G2215/021
摘要： An apparatus and process for applying an electrical charge to a photoreceptor wherein a bias charge roll member is situated in contact or in close proximity with a surface of a member to be charged such as a photoreceptor. The bias charge roll member is supplied with an electrical bias having a variable voltage waveform onto which a DC bias is superimposed. The amount of DC bias is selected to set the signal voltage such that a minimally acceptable amount of AC corona is created sufficient for uniform photoreceptor charging while avoiding unnecessary excessive positive corona that causes excessive photoreceptor wear.

8. 发明授权

US5668439A High voltage power supply 失效
标题翻译：高压电源
公开(公告)号：US5668439A
公开(公告)日：1997-09-16
申请号：US538659
申请日：1995-10-03
申请人： Christopher R. Snelling , John S. Facci , Michael J. Levy , Dale R. Mashtare , Michael S. Smith
发明人： Christopher R. Snelling , John S. Facci , Michael J. Levy , Dale R. Mashtare , Michael S. Smith
IPC分类号： G03G15/02 , G03G15/00 , G03G21/00 , H01L41/113 , H02N2/00 , H02N2/18 , H01L41/08
CPC分类号： G03G15/80 , H02N2/18 , Y10S310/80
摘要： A power supply for transmitting voltage to a device, including a web having a piezoelectric exterior layer for generating a voltage on the surface thereof in response to being deformed. The web is entrained about a roller arrangement to deform the piezoelectric exterior layer. Commutation brushes transfers the voltage generated on the surface of the piezoelectric exterior layer to the device. The roller arrangement in combination with the placement of commutation brushes and neutralization brushes are used to adjust the voltage to the device.
摘要翻译：一种用于向装置传送电压的电源，包括具有压电外层的卷材，用于响应于变形而在其表面上产生电压。卷筒纸被卷入关于使压电外层变形的辊布置。换向电刷将压电外层的表面上产生的电压传递到器件。使用辊布置与放置刷子和中和刷的布置来调节装置的电压。

9. 发明授权

US5602626A Ionically conductive liquid charging apparatus 失效
标题翻译：离子导电液体充电装置
公开(公告)号：US5602626A
公开(公告)日：1997-02-11
申请号：US497987
申请日：1995-07-03
申请人： John S. Facci , Michael J. Levy , Joseph Mammino , Richard B. Lewis , Martin A. Abkowitz , James M. Markovics
发明人： John S. Facci , Michael J. Levy , Joseph Mammino , Richard B. Lewis , Martin A. Abkowitz , James M. Markovics
IPC分类号： G03G13/02 , G03G15/02
CPC分类号： G03G13/025 , G03G15/0208
摘要： An apparatus for applying an electrical charge to a charge retentive surface by transporting ions through an ionically conductive liquid and transferring the ions to the member to be charged across the liquid/charge retentive surface interface. The ionically conductive liquid is contacted with the charge retentive surface for depositing ions onto the charge retentive surface via a wetted donor blade supported within a conductive housing, wherein the housing is coupled to an electrical power supply for applying an electrical potential to the ionically conductive liquid. In one specific embodiment, the charging apparatus includes a support blade for urging the donor blade into contact with the charge retentive surface and a wiping blade for wiping any liquid from the surface of the charge retentive surface as may have been transferred to the surface at the donor blade/charge retentive surface interface.
摘要翻译：一种用于通过将离子传送通过离子导电液体并将离子转移到待充电的构件穿过液体/电荷保持性表面界面而将电荷施加到电荷保持性表面的装置。离子导电液体与电荷保持表面接触，用于通过支撑在导电壳体内的润湿供体叶片将离子沉积到电荷保持性表面上，其中壳体耦合到电源以将电位施加到离子导电液体。在一个具体实施例中，充电装置包括用于推动供体叶片与充电保持性表面接触的支撑刀片和用于擦拭来自充电保持性表面的任何液体的擦拭刀片，这可能已经被传送到表面供体叶片/电荷保持性表面界面。

10. 发明授权

US5424129A Composite metal oxide particle processes and toners thereof 失效
标题翻译：复合金属氧化物颗粒工艺及其调色剂
公开(公告)号：US5424129A
公开(公告)日：1995-06-13
申请号：US976597
申请日：1992-11-16
申请人： Richard B. Lewis , Michael J. Levy
发明人： Richard B. Lewis , Michael J. Levy
IPC分类号： G03G9/08 , G03G9/097 , B32B5/00
CPC分类号： G03G9/09708 , G03G9/09716 , G03G9/09725 , Y10T428/2991 , Y10T428/2993 , Y10T428/2995 , Y10T428/3154 , Y10T428/31663
摘要： A composite metal oxide charge enhancing additive composition comprised of a first metal oxide forming a core particle, and a second metal oxide forming an outer layer on the first metal oxide core particle of the formula [(M.sup.1 O.sub.n)x]-[(M.sup.2 O.sub.n).sub.y ] wherein M.sup.1 represents the first metal oxide metal, M.sup.2 represents the second metal oxide metal, n is an integer representing the number of oxygen atoms and is determined by the valence of the metal M to which the oxygen atoms are bonded, x and y represent the relative molar ratios of the first and second metal oxides, and wherein M.sup.1 is different from M.sup.2.Another embodiment is a composite metal oxide toner charge enhancing additive composition comprising an organosilane outer layer or coating covalently bonded on the outer surface of the second metal oxide layer of the formula {(M.sup.1 O.sub.n).sub.x }-{M.sup.2 O.sub.n).sub.y }-{Si R.sub.4-n).sub.z } wherein (Si R.sub.4-n).sub.z represents the covalently bonded organosilane outer layer surface coating where Si is the silicon atom of the organosilane linking or coupling agent; R is a member of the group of alkyl, alkenyl, alkynyl, aryl, alkaryl, aralkyl having between 1 to 25 carbon atoms or halogenated and oxygenated derivatives thereof; m is an integer with a value of at least one; n of the organosilane is an integer having a value of 1 to 3 and z is determined from the molar ratio of the silane component relative to the first and second metal oxides.
摘要翻译：复合金属氧化物电荷增强添加剂组合物由形成核心颗粒的第一金属氧化物和形成式[（M1On）x] - [（M2On）y）的第一金属氧化物核心颗粒上的外层形成的第二金属氧化物组成 ]其中M1表示第一金属氧化物金属，M2表示第二金属氧化物金属，n表示氧原子数，并且由氧原子键合的金属M的化合价决定，x和y表示第一和第二金属氧化物的相对摩尔比，其中M1不同于M2。另一个实施方案是复合金属氧化物调色剂电荷增强添加剂组合物，其包含有机硅烷外层或共价键合在式{（M1On）x} - {M2On）y} - {SiR4（R）的第二金属氧化物层的外表面上的涂层 -n）z}其中（Si 4-n）z表示共价键合的有机硅烷外层表面涂层，其中Si是有机硅烷连接或偶联剂的硅原子; R是具有1至25个碳原子的烷基，烯基，炔基，芳基，烷芳基，芳烷基或其卤化和氧化衍生物的基团的成员; m是至少为1的整数; 有机硅烷的n为1〜3的整数，z由硅烷成分相对于第1及第2金属氧化物的摩尔比决定。

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