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1. 发明授权

US09848843B2 Dynamic perfusion imaging 有权
公开(公告)号：US09848843B2
公开(公告)日：2017-12-26
申请号：US14112047
申请日：2012-04-17
申请人： Michael Grass , Holger Schmitt
发明人： Michael Grass , Holger Schmitt
IPC分类号： A61B6/00
CPC分类号： A61B6/481 , A61B6/00 , A61B6/486 , A61B6/503 , A61B6/507 , A61B6/5217 , A61B6/542 , A61B6/545 , F04C2270/0421
摘要： A method includes scanning a region of interest, during a contrast agent based perfusion scan, at a predetermined temporal sampling rate during contrast agent uptake in the region of interest, and generating time frame data indicative of the scanned region of interest. The method further includes identifying a predetermined change in an amount of the contrast agent in the region of interest from the time frame data. The method further includes scanning the region of interest at a lower temporal sampling rate, which is lower than the temporal sampling rate during the contrast agent uptake, in response to identifying the predetermined change in the amount of the contrast agent in the region of interest.

2. 发明申请

US20130279783A1 COMPUTED TOMOGRAPHY SYSTEM AND METHOD FOR TRACKING A BOLUS 有权
标题翻译：计算机图像系统和追踪玻璃的方法
公开(公告)号：US20130279783A1
公开(公告)日：2013-10-24
申请号：US13977042
申请日：2012-01-04
申请人： Holger Schmitt , Michael Grass
发明人： Holger Schmitt , Michael Grass
IPC分类号： G06T11/00
CPC分类号： G06T11/008 , A61B6/032 , A61B6/469 , A61B6/481 , A61B6/488 , A61B6/504
摘要： The present invention relates to a computed tomography system (10) and a corresponding method which enable tracking of a contrast material bolus and which involve a reduced radiation dose. The proposed computed tomography system (10) comprises an acquisition unit including an X-ray source (18) and an X-ray detector (30) for acquiring projection data sets (42, 44, 46), a reconstruction unit (41) for reconstructing a planning image (48) from a first projection data set (42), an identification unit (52) for identifying a region of interest (40) in the planning image (48), a selection unit (54) for selecting a projection angle (60) through the region of interest (40), a calculator (62) for calculating a target projection value (64) for a projection of said region of interest (40) with the selected projection angle (60), a control unit (32) for controlling said acquisition unit to acquire a second, reduced projection data set (44) including projection data from projections of said region of interest (40) with the selected projection angle (60), and a comparator (68) for comparing projection values of the second projection data set (44) with the target projection value (64), wherein the control unit (32) is adapted to control the acquisition unit to initiate the acquisition of a third projection data set (46) based on the comparison result (70) and to reconstruct a diagnostic image (50) from the third projection data set (46).
摘要翻译：本发明涉及计算机断层摄影系统（10）和相应的方法，其能够跟踪造影剂推注并涉及降低的辐射剂量。所提出的计算机断层摄影系统（10）包括：采集单元，包括用于获取投影数据组（42,44,46）的X射线源（18）和X射线检测器（30）;重建单元（41），用于从第一投影数据集（42）重建规划图像（48）;识别单元（52），用于识别所述规划图像（48）中的感兴趣区域（40）;选择单元（54），用于选择投影通过感兴趣区域（40）的角度（60）;计算器（62），用于计算用于所选择的投影角度（60）的所述感兴趣区域（40）的投影的目标投影值（64）;控制单元（32），用于控制所述获取单元以选择的投影角度（60）获取包括来自所述感兴趣区域（40）的投影的投影数据的第二缩小投影数据集（44），以及比较器第二投影数据集（44）的投影值与目标投影值（64），w 这里，控制单元（32）适于控制采集单元基于比较结果（70）开始获取第三投影数据集（46），并且从第三投影数据集重建诊断图像（50）（46）。

3. 发明申请

US20130261439A1 INTERVENTIONAL APPARATUS ACTIVATED COMPUTED TOMOGRAPHY (CT) 有权
标题翻译：传统装置激活计算机断层扫描（CT）
公开(公告)号：US20130261439A1
公开(公告)日：2013-10-03
申请号：US13992421
申请日：2011-11-25
申请人： Holger Schmitt , Michael Grass
发明人： Holger Schmitt , Michael Grass
IPC分类号： A61B6/03 , A61B5/055 , A61B8/00 , A61B5/00 , A61B6/00 , A61M25/01 , A61B8/08
CPC分类号： A61B6/032 , A61B5/0084 , A61B5/055 , A61B5/742 , A61B6/037 , A61B6/12 , A61B6/4423 , A61B6/463 , A61B6/542 , A61B6/547 , A61B8/0841 , A61B8/463 , A61B34/20 , A61B90/98 , A61B2034/2055 , A61B2034/2059 , A61B2034/2065 , A61B2090/3945 , A61M25/0108 , A61M25/0113 , A61M25/0127 , A61M2025/0008 , A61M2025/0166
摘要： A system (100) includes an interventional apparatus (102) and an imaging scanner (101). The interventional apparatus includes a interventional instrument (204) configured to perform an image-guided interventional procedure for a patient. The interventional apparatus includes a position detector (122) that detects a position of the interventional instrument within a region of the patient at which the image-guided interventional procedure is performed from outside of the region of interest and generates a signal indicative of the detected position. The imaging scanner includes a controller (114) that activates the imaging scanner to scan the region of interest and the interventional instrument therein for one or more data acquisition cycles based on the movement signal.
摘要翻译：系统（100）包括介入装置（102）和成像扫描器（101）。介入装置包括被配置为对患者执行图像引导介入手术的介入器械（204）。介入装置包括位置检测器（122），其检测介入器械在患者的区域内的位置，在该区域内从感兴趣区域外部执行图像引导的介入程序，并产生指示检测位置的信号。成像扫描器包括控制器（114），其基于移动信号激活成像扫描器以扫描感兴趣区域和其中的介入仪器用于一个或多个数据采集周期。

4. 发明申请

US20110002444A1 MODEL BASED SELF-POSITIONING PATIENT TABLE FOR X-RAY SYSTEMS 审中-公开
标题翻译：基于模型的X射线系统自定位患者表
公开(公告)号：US20110002444A1
公开(公告)日：2011-01-06
申请号：US12920333
申请日：2009-03-09
申请人： Holger Schmitt , Udo Van Stevendaal , Peter Forthmann , Michael Grass
发明人： Holger Schmitt , Udo Van Stevendaal , Peter Forthmann , Michael Grass
IPC分类号： A61B6/04 , G01N23/04
CPC分类号： A61B6/0457 , A61B6/4441 , A61B6/465 , A61B6/469 , A61B6/488 , A61B6/547
摘要： A System (24) for positioning a carrier (9) of an object (10) within a field of view of an imaging unit (7b), the system comprising: an imaging receiving interface unit (14) for receiving image data (22) representing an image (9) of the object (10) from an imaging unit (7b), an object components position determination unit (15) for determining object components (11, 12) position data (25) representing positions of components (11, 12) of the object (10), a memory (16) with anatomic model data stored therein, the anatomic model data representing anatomic model (9*) component positions of anatomic model components (11*, 12*) of an atomic model (10*), a matching unit (17) designed to match object components (11, 12) positions and anatomic model components (11*, 12*) positions based on object components position data and anatomic model data, an input receiving unit (19) for receiving input data (23) representing a selected component (11) of interest, a positioning planning unit (18) for determining position shift data representing a direction and a distance by which the carrier (8) is to be shifted, considering the input data, anatomic model data and object components position data, an interface (20) to a positioning system (21) for shifting the carrier (8) based on the position shift data (27).
摘要翻译：一种用于将物体（10）的载体（9）定位在成像单元（7b）的视野内的系统（24），所述系统包括：用于接收图像数据（22）的成像接收接口单元（14）从成像单元（7b）表示对象（10）的图像（9）;对象分量位置确定单元（15），用于确定表示分量（11,12）的位置的对象分量（11,12）（10）的存储器（16），存储有解剖模型数据的存储器（16），所述解剖模型数据表示原子模型的解剖模型组件（11 *，12 *）的解剖模型（9 *）组件位置 10 *），匹配单元（17），其被设计为基于对象分量位置数据和解剖模型数据来匹配对象分量（11,12）位置和解剖模型分量（11 *，12 *）位置;输入接收单元），用于接收表示所选择的所选择的组件（11）的输入数据（23）;定位计划单元（18）考虑到输入数据，解剖模型数据和对象分量位置数据，表示载体（8）要移动的方向和距离的位置移位数据，到定位系统（21）的接口（20），用于移位载体（8）基于位置偏移数据（27）。

5. 发明授权

US07539529B2 Apparatus for angiographic X-ray photography 失效
标题翻译：用于血管造影X射线摄影的装置
公开(公告)号：US07539529B2
公开(公告)日：2009-05-26
申请号：US10553770
申请日：2004-04-21
申请人： Holger Schmitt , Michael Grass , Volker Rasche
发明人： Holger Schmitt , Michael Grass , Volker Rasche
IPC分类号： A61B6/00 , A61B6/02
CPC分类号： A61B6/481 , A61B6/4441 , A61B6/504
摘要： The invention relates to an X-ray imaging device for visualizing the blood flow in a coronary vascular tree of a patient. According to the invention a first set (1) of X-ray projection images of the vascular tree is recorded during various phases of the heart cycle with simultaneous recording of the ECG (2) of the patient. By means of a suitable program control, computer means (17) of the device according to the invention a reconstruction then follows of the three-dimensional structure of the vascular tree during the various phases of the heart cycle. The invention proposes, to determine the time-dependent concentration of contrast agent within the reconstructed three-dimensional structure of the vascular tree, that local image areas within the X-ray projection images of the second set (6) assigned to individual vascular segments (5, 8) are located in accordance with the spatial positions of the vascular segments (5, 8) in the relevant phase of the heart cycle. The concentration of contrast agent in the area of the vascular segments (5, 8) is then determined by evaluation of the X-ray absorption within the local image areas found.
摘要翻译：本发明涉及用于使患者的冠状动脉血管树中的血流可视化的X射线成像装置。根据本发明，在心脏周期的各个阶段记录血管树的X射线投影图像的第一组（1），同时记录患者的ECG（2）。通过合适的程序控制，根据本发明的装置的计算机装置（17）在心脏周期的各个阶段期间重建血管树的三维结构。本发明提出，为了确定造影剂在血管树的重建三维结构内的时间依赖性浓度，将第二组（6）的X射线投影图像内的局部图像区域分配给各个血管节段 5,8）根据心脏周期的相关阶段中血管段（5,8）的空间位置来定位。然后通过评估所发现的局部图像区域内的X射线吸收来确定血管片段（5,8）区域中造影剂的浓度。

6. 发明申请

US20140037046A1 DYNAMIC PERFUSION IMAGING 有权
标题翻译：动态灌注成像
公开(公告)号：US20140037046A1
公开(公告)日：2014-02-06
申请号：US14112047
申请日：2012-04-17
申请人： Michael Grass , Holger Schmitt
发明人： Michael Grass , Holger Schmitt
IPC分类号： A61B6/00
CPC分类号： A61B6/481 , A61B6/00 , A61B6/486 , A61B6/503 , A61B6/507 , A61B6/5217 , A61B6/542 , A61B6/545 , F04C2270/0421
摘要： A method includes scanning a region of interest, during a contrast agent based perfusion scan, at a predetermined temporal sampling rate during contrast agent uptake in the region of interest, and generating time frame data indicative of the scanned region of interest. The method further includes identifying a predetermined change in an amount of the contrast agent in the region of interest from the time frame data. The method further includes scanning the region of interest at a lower temporal sampling rate, which is lower than the temporal sampling rate during the contrast agent uptake, in response to identifying the predetermined change in the amount of the contrast agent in the region of interest.
摘要翻译：一种方法包括在造影剂基于灌注扫描期间以感兴趣区域中造影剂摄取期间的预定时间采样率扫描感兴趣区域，以及生成指示所扫描的感兴趣区域的时间帧数据。所述方法还包括从所述时间帧数据中识别所述感兴趣区域中的造影剂的量的预定变化。该方法还包括响应于识别感兴趣区域中的造影剂的量的预定变化，以较低的时间采样速率扫描感兴趣区域，其低于造影剂摄取期间的时间采样率。

7. 发明申请

US20080192997A1 Image Processing Device and Method for Blood Flow Imaging 有权
标题翻译：血流成像图像处理装置及方法
公开(公告)号：US20080192997A1
公开(公告)日：2008-08-14
申请号：US11910477
申请日：2006-04-03
申请人： Michael Grass , Holger Schmitt
发明人： Michael Grass , Holger Schmitt
IPC分类号： G06K9/00
CPC分类号： G06T11/008 , G06T2211/404 , G06T2211/412
摘要： The present invention relates to image processing device (5) for generating a time series of 3D volume images showing the blood flow in a vascular tree of an object (40), based on a first series of X-ray projection images (D) of the object acquired from different projection directions and a second and a third series of X-ray projections images (E, F) of the object acquired alternately at a first or second fixed projection plane, respectively, during inflow of contrast agent into the vascular tree of the object. In order to allow image reconstruction of unambiguous structures in the object of interest, and, in particular, the generation of 3D volume images showing the blood flow in a vascular tree of an object even if that vascular tree comprises non-tubular structures, such as aneurysms, an image processing device is proposed comprising: a reconstruction unit (51) for reconstruction of a 3D volume image of said object from said first series of X-ray projection images (D), a segmentation unit (52) for segmentation of the vessel tree from said 3D volume image, —a forward projection unit (54) for forward projection of the segmented vessel tree onto said first and projection plane (R1, R2), respectively, and a mapping unit (55) for mapping of the image values of pixels of the vessel tree in said second and third, respectively, series of X-ray projection images onto corresponding voxels of said 3D volume image to obtain said time series of 3D volume images showing the blood flow in the vascular tree of the object.
摘要翻译：本发明涉及一种图像处理装置（5），用于基于第一系列X射线投影图像（D）产生示出物体（40）的血管树中的血流的3D体积图像的时间序列，在造影剂流入维管束期间，分别在第一或第二固定投影平面上交替地获取的物体从不同的投影方向获取的物体和第二和第三系列的X射线投影图像（E，F）的对象。为了允许感兴趣对象中的明确结构的图像重建，并且特别地，生成显示血液流在物体的血管树中的3D体积图像，即使该血管树包括非管状结构，例如动脉瘤，提出了一种图像处理装置，包括：重建单元（51），用于从所述第一系列X射线投影图像（D）重建所述物体的3D体积图像，分割单元（52），用于分割所述3D体积图像的容器树， - 用于将分割的血管树向前投影到所述第一和投影平面（R 1，R 2）上的前向投影单元（54））和映射单元（55），用于将所述第二和第三分支X射线投影图像中的血管树的像素的图像值映射到所述3D体积图像的相应体素上，以获得所述时间系列3D体积图像显示血液中血液流动的物体血管。

8. 发明申请

US20060293579A1 Apparatus for angiographic x-ray photography 失效
标题翻译：血管造影X线摄影仪
公开(公告)号：US20060293579A1
公开(公告)日：2006-12-28
申请号：US10553770
申请日：2004-04-21
申请人： Holger Schmitt , Michael Grass , Volker Rasche
发明人： Holger Schmitt , Michael Grass , Volker Rasche
IPC分类号： A61B5/05 , A61B6/00
CPC分类号： A61B6/481 , A61B6/4441 , A61B6/504
摘要： The invention relates to an X-ray imaging device for visualizing the blood flow in a coronary vascular tree of a patient. According to the invention a first set (1) of X-ray projection images of the vascular tree is recorded during various phases of the heart cycle with simultaneous recording of the ECG (2) of the patient. By means of a suitable program control, computer means (17) of the device according to the invention a reconstruction then follows of the three-dimensional structure of the vascular tree during the various phases of the heart cycle. The invention proposes, to determine the time-dependent concentration of contrast agent within the reconstructed three-dimensional structure of the vascular tree, that local image areas within the X-ray projection images of the second set (6) assigned to individual vascular segments (5, 8) are located in accordance with the spatial positions of the vascular segments (5, 8) in the relevant phase of the heart cycle. The concentration of contrast agent in the area of the vascular segments (5, 8) is then determined by evaluation of the X-ray absorption within the local image areas found.
摘要翻译：本发明涉及用于使患者的冠状动脉血管树中的血流可视化的X射线成像装置。根据本发明，在心脏周期的各个阶段记录血管树的X射线投影图像的第一组（1），同时记录患者的ECG（2）。通过合适的程序控制，根据本发明的装置的计算机装置（17）在心脏周期的各个阶段期间重建血管树的三维结构。本发明提出，为了确定造影剂在血管树的重建三维结构内的时间依赖性浓度，将第二组（6）的X射线投影图像内的局部图像区域分配给各个血管节段 5,8）根据心脏周期的相关阶段中血管段（5,8）的空间位置来定位。然后通过评估所发现的局部图像区域内的X射线吸收来确定血管片段（5,8）区域中造影剂的浓度。

9. 发明授权

US09439606B2 Interventional apparatus activated computed tomography (CT) 有权
标题翻译：介入装置激活计算机断层扫描（CT）
公开(公告)号：US09439606B2
公开(公告)日：2016-09-13
申请号：US13992421
申请日：2011-11-25
申请人： Holger Schmitt , Michael Grass
发明人： Holger Schmitt , Michael Grass
IPC分类号： A61B6/03 , A61B6/00 , A61B5/00 , A61B5/055 , A61B8/08 , A61B8/00 , A61B6/12 , A61M25/01 , A61M25/00
CPC分类号： A61B6/032 , A61B5/0084 , A61B5/055 , A61B5/742 , A61B6/037 , A61B6/12 , A61B6/4423 , A61B6/463 , A61B6/542 , A61B6/547 , A61B8/0841 , A61B8/463 , A61B34/20 , A61B90/98 , A61B2034/2055 , A61B2034/2059 , A61B2034/2065 , A61B2090/3945 , A61M25/0108 , A61M25/0113 , A61M25/0127 , A61M2025/0008 , A61M2025/0166
摘要： A system (100) includes an interventional apparatus (102) and an imaging scanner (101). The interventional apparatus includes a interventional instrument (204) configured to perform an image-guided interventional procedure for a patient. The interventional apparatus includes a position detector (122) that detects a position of the interventional instrument within a region of the patient at which the image-guided interventional procedure is performed from outside of the region of interest and generates a signal indicative of the detected position. The imaging scanner includes a controller (114) that activates the imaging scanner to scan the region of interest and the interventional instrument therein for one or more data acquisition cycles based on the movement signal.
摘要翻译：系统（100）包括介入装置（102）和成像扫描器（101）。介入装置包括被配置为对患者执行图像引导介入手术的介入器械（204）。介入装置包括位置检测器（122），其检测介入器械在患者的区域内的位置，在该区域内从感兴趣区域外部执行图像引导的介入程序，并产生指示检测位置的信号。成像扫描器包括控制器（114），其基于移动信号激活成像扫描器以扫描感兴趣区域和其中的介入仪器用于一个或多个数据采集周期。

10. 发明授权

US09047702B2 Computed tomography system and method for tracking a bolus 有权
标题翻译：计算机断层扫描系统和跟踪推注的方法
公开(公告)号：US09047702B2
公开(公告)日：2015-06-02
申请号：US13977042
申请日：2012-01-04
申请人： Holger Schmitt , Michael Grass
发明人： Holger Schmitt , Michael Grass
IPC分类号： G06K9/00 , G06T11/00 , A61B6/03 , A61B6/00
CPC分类号： G06T11/008 , A61B6/032 , A61B6/469 , A61B6/481 , A61B6/488 , A61B6/504
摘要： The present invention relates to a computed tomography system (10) and a corresponding method which enable tracking of a contrast material bolus and which involve a reduced radiation dose. The proposed computed tomography system (10) comprises an acquisition unit including an X-ray source (18) and an X-ray detector (30) for acquiring projection data sets (42, 44, 46), a reconstruction unit (41) for reconstructing a planning image (48) from a first projection data set (42), an identification unit (52) for identifying a region of interest (40) in the planning image (48), a selection unit (54) for selecting a projection angle (60) through the region of interest (40), a calculator (62) for calculating a target projection value (64) for a projection of said region of interest (40) with the selected projection angle (60), a control unit (32) for controlling said acquisition unit to acquire a second, reduced projection data set (44) including projection data from projections of said region of interest (40) with the selected projection angle (60), and a comparator (68) for comparing projection values of the second projection data set (44) with the target projection value (64), wherein the control unit (32) is adapted to control the acquisition unit to initiate the acquisition of a third projection data set (46) based on the comparison result (70) and to reconstruct a diagnostic image (50) from the third projection data set (46).
摘要翻译：本发明涉及计算机断层摄影系统（10）和相应的方法，其能够跟踪造影剂推注并涉及降低的辐射剂量。所提出的计算机断层摄影系统（10）包括：采集单元，包括用于获取投影数据组（42,44,46）的X射线源（18）和X射线检测器（30）;重建单元（41），用于从第一投影数据集（42）重建规划图像（48）;识别单元（52），用于识别所述规划图像（48）中的感兴趣区域（40）;选择单元（54），用于选择投影通过感兴趣区域（40）的角度（60）;计算器（62），用于计算用于所选择的投影角度（60）的所述感兴趣区域（40）的投影的目标投影值（64）;控制单元（32），用于控制所述获取单元以选择的投影角度（60）获取包括来自所述感兴趣区域（40）的投影的投影数据的第二缩小投影数据集（44），以及比较器第二投影数据集（44）的投影值与目标投影值（64），w 这里，控制单元（32）适于控制采集单元基于比较结果（70）开始获取第三投影数据集（46），并且从第三投影数据集重建诊断图像（50）（46）。

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