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1. 发明授权

US5961469A Spectrophotometric assay for cyanide 失效
标题翻译：氰化物分光光度法
公开(公告)号：US5961469A
公开(公告)日：1999-10-05
申请号：US749032
申请日：1996-11-14
申请人： Michael F. Roizen , Jon Moss
发明人： Michael F. Roizen , Jon Moss
IPC分类号： A61B5/00 , A61N5/00 , G01N33/84
CPC分类号： G01N33/84 , G01N2800/40
摘要： A method of detecting and quantifying cyanide concentration in a patient, by monitoring photometric changes resulting from the transformation of methemoglobin to cyanomethemoglobin. The present invention provides for a means of cyanide poisoning assessment in patients using the affinity of methemoglobin for cyanide to assess the photometric changes resulting from methemoglobin converting to cyanomethemoglobin, as an indicator of cyanide concentration in a patient. Appropriate corrective action can then be promptly taken.
摘要翻译：通过监测由高铁血红蛋白转化为氰氯高血红蛋白而产生的光度变化来检测和定量患者中氰化物浓度的方法。本发明提供了使用高铁血红蛋白对氰化物的亲合力来评估由高铁血红蛋白转化成氰氯高血红蛋白的光度变化作为患者中氰化物浓度指示剂的患者中氰化物中毒评估的方法。然后可以及时采取适当的纠正措施。

2. 发明申请

US20090285938A1 Nutritional Supplement Product to Suppress Age-Related Decline in Cognitive Capacity and Other Aging Functions 有权
标题翻译：营养补品产品抑制与年龄相关的认知能力下降和其他老化功能
公开(公告)号：US20090285938A1
公开(公告)日：2009-11-19
申请号：US12508277
申请日：2009-07-23
申请人： Michael F. Roizen
发明人： Michael F. Roizen
IPC分类号： A23L1/303 , A23L1/302 , A23G1/00 , A23L1/36
CPC分类号： A61K8/97 , A23G1/30 , A23G1/56 , A23G3/34 , A23G3/36 , A23G3/368 , A23G3/48 , A23L2/02 , A23L2/52 , A23L25/30 , A23L33/10 , A23L33/15 , A23L33/155 , A23L33/16 , A23V2002/00 , A23V2200/302 , A61K2800/92 , A61Q19/08 , A23V2250/702 , A23V2250/704 , A23V2250/708 , A23V2250/71 , A23V2250/712 , A23V2250/1578 , A23V2250/161 , A23V2250/1626 , A23V2250/1642 , A23V2250/2108 , A23V2250/0606 , A23V2250/0652 , A23V2250/0612 , A23V2250/214 , A23V2250/213 , A23V2250/314 , A23V2200/30
摘要： A product and method for administering daily micronutrient requirements (DMRs) comprising vitamins, minerals and essential fatty acids targeted to reduce appetite and/or the risks associated with aging and associated cognitive impairment. The DMRs are administered to individuals via food products. In an embodiment of the present invention, the DMRs are offered in the form of a health bar, smoothie, or drink. The DMRs may be incorporated into other forms without departing from the scope of the present invention. By way of illustration and not as a limitation, the constituents may be incorporated into a fruit or yogurt “smoothie,” a frozen desert such as an ice cream or sorbet, and a beverage.
摘要翻译：一种用于管理每日微量营养素要求（DMR）的产品和方法，其包含维生素，矿物质和必需脂肪酸，以减少食欲和/或与老化和相关的认知障碍相关的风险。 DMR通过食品给个人服用。在本发明的一个实施方案中，DMR以健康酒吧，冰沙或饮料的形式提供。在不脱离本发明的范围的情况下，DMR可以并入其他形式。作为说明而不是限制，组分可以并入水果或酸奶“冰沙”，冰冻的沙漠如冰淇淋或冰糕，以及饮料。

3. 发明授权

US06559158B1 Use of methylnaltrexone and related compounds to treat chronic opioid use side affects 有权
标题翻译：使用甲基纳曲酮及其相关化合物治疗慢性阿片类药物使用方面的影响
公开(公告)号：US06559158B1
公开(公告)日：2003-05-06
申请号：US09669358
申请日：2000-09-26
申请人： Joseph F. Foss , Michael F. Roizen , Jonathan Moss , Chun-Su Yuan , William Drell
发明人： Joseph F. Foss , Michael F. Roizen , Jonathan Moss , Chun-Su Yuan , William Drell
IPC分类号： A61K31485
CPC分类号： A61K31/485
摘要： A method of preventing or treating an opioid-induced side effect in a patient who has been chronically taking opioids, the method comprising administering a quaternary derivative of noroxymorphone in an amount sufficient to prevent or treat the side effect in the patient, but which amount would be insufficient to treat a patient with the same opioid-induced side effect who had not chronically been administered opioids.
摘要翻译：一种在长期摄取阿片样物质的患者中预防或治疗阿片样物质诱导的副作用的方法，所述方法包括以足以防止或治疗患者副作用的量施用去甲吗啡酮的季衍生物，不足以治疗没有长期服用阿片类药物的相同阿片样物质诱导的副作用的患者。

4. 发明授权

US06497658B2 Alarm upon detection of impending sleep state 有权
标题翻译：在检测即将到来的睡眠状态时发出报警
公开(公告)号：US06497658B2
公开(公告)日：2002-12-24
申请号：US09737682
申请日：2000-12-15
申请人： Michael F. Roizen , Lawrence J. Gottlieb , Avery Tung
发明人： Michael F. Roizen , Lawrence J. Gottlieb , Avery Tung
IPC分类号： A61B500
CPC分类号： A61M21/02 , A61B5/0402 , A61B5/0476 , A61B5/18 , A61B5/4809 , A61M2021/0022 , A61M2021/0027 , A61M2021/0044 , A61M2230/10 , A61M2230/60
摘要： The present invention monitors a physiological process intrinsic to humans and which measures directly the approach of a sleep state. When sleep onset is detected, the subject is restored to a fully awake state by an alert mechanism. Sleep onset is determined by monitoring EEG and EMG signals of the subject with a bispectral index monitor and applying an analysis algorithm to the index values output by the monitor. As a person tires, the value of their bispectral index begins to drop and then oscillate back and forth between two discrete levels. This pattern is consistent among various subjects and indicates an early warning of impending sleep, before a dangerous loss of vigilance has occurred.
摘要翻译：本发明监测人类固有的生理过程，并且直接测量睡眠状态的方法。当检测到睡眠开始时，通过警报机制将被摄体恢复到完全清醒状态。通过用双谱指数监测器监测受试者的EEG和EMG信号并将分析算法应用于由监测器输出的指数值来确定睡眠发作。作为一个人，轮胎的双轴指数的价值开始下降，然后在两个离散的水平之间来回摆动。这种模式在各种主题之间是一致的，并且表示在即将发生睡眠之前提前警告即将发生的警觉。

5. 发明授权

US07976879B2 Nutritional supplement product to suppress age-related decline in cognitive capacity and other aging functions 有权
标题翻译：营养补品可以抑制年龄相关的认知能力下降等衰老功能
公开(公告)号：US07976879B2
公开(公告)日：2011-07-12
申请号：US12508277
申请日：2009-07-23
申请人： Michael F. Roizen
发明人： Michael F. Roizen
IPC分类号： A61K36/00 , A61K31/455 , A61K36/82 , A61K38/43 , A61K36/20 , A61K9/48 , A61K33/42 , A61K33/06 , A61K8/26 , A23L1/30 , A23L1/36 , A23C21/00 , A23G1/00 , A23B7/157
CPC分类号： A61K8/97 , A23G1/30 , A23G1/56 , A23G3/34 , A23G3/36 , A23G3/368 , A23G3/48 , A23L2/02 , A23L2/52 , A23L25/30 , A23L33/10 , A23L33/15 , A23L33/155 , A23L33/16 , A23V2002/00 , A23V2200/302 , A61K2800/92 , A61Q19/08 , A23V2250/702 , A23V2250/704 , A23V2250/708 , A23V2250/71 , A23V2250/712 , A23V2250/1578 , A23V2250/161 , A23V2250/1626 , A23V2250/1642 , A23V2250/2108 , A23V2250/0606 , A23V2250/0652 , A23V2250/0612 , A23V2250/214 , A23V2250/213 , A23V2250/314 , A23V2200/30
摘要： A product and method for administering daily micronutrient requirements (DMRs) comprising vitamins, minerals and essential fatty acids targeted to reduce appetite and/or the risks associated with aging and associated cognitive impairment. The DMRs are administered to individuals via food products. In an embodiment of the present invention, the DMRs are offered in the form of a health bar, smoothie, or drink. The DMRs may be incorporated into other forms without departing from the scope of the present invention. By way of illustration and not as a limitation, the constituents may be incorporated into a fruit or yogurt “smoothie,” a frozen desert such as an ice cream or sorbet, and a beverage.
摘要翻译：一种用于管理每日微量营养素要求（DMR）的产品和方法，其包含维生素，矿物质和必需脂肪酸，以减少食欲和/或与老化和相关的认知障碍相关的风险。 DMR通过食品给个人服用。在本发明的一个实施方案中，DMR以健康酒吧，冰沙或饮料的形式提供。在不脱离本发明的范围的情况下，DMR可以并入其他形式。作为说明而不是限制，组分可以并入水果或酸奶“冰沙”，冰冻的沙漠如冰淇淋或冰糕，以及饮料。

6. 发明申请

US20090287506A1 Methods and Systems for Improving Human Health Using Targeted Probiotics 有权
标题翻译：使用目标益生菌改善人类健康的方法和系统
公开(公告)号：US20090287506A1
公开(公告)日：2009-11-19
申请号：US12466750
申请日：2009-05-15
申请人： Michael F. Roizen , Mehmet C. Oz
发明人： Michael F. Roizen , Mehmet C. Oz
IPC分类号： G06Q50/00 , G06Q90/00
CPC分类号： G06F19/322 , G06F19/00 , G06F19/326 , G06F19/3456 , G06Q50/22 , G06Q50/24 , G06Q99/00 , G16H10/60 , Y02A90/22 , Y02A90/26
摘要： Methods and systems enable healthcare providers to identify metabolites that may cause a medical condition in a patient. The healthcare providers may then use the identified metabolite to identify a probiotic that may affect the regulation of that metabolite. Patient information, such as medical history and diagnosis data may then be used in combination with the identified probiotic to create a personalized medicament for that patient.
摘要翻译：方法和系统使医疗保健提供者能够识别可能导致患者医疗状况的代谢物。医疗保健提供者然后可以使用鉴定的代谢物来鉴定可能影响该代谢物调节的益生菌。然后可以将患者信息（例如病史和诊断数据）与所鉴定的益生菌组合使用以为该患者创建个性化药物。

7. 发明授权

US06608075B2 Use of methylnaltrexone and related compounds 有权
标题翻译：使用甲基纳曲酮及其相关化合物
公开(公告)号：US06608075B2
公开(公告)日：2003-08-19
申请号：US09862169
申请日：2001-05-21
申请人： Joseph F. Foss , Michael F. Roizen , Jonathan Moss , Chun-Su Yuan , William Drell
发明人： Joseph F. Foss , Michael F. Roizen , Jonathan Moss , Chun-Su Yuan , William Drell
IPC分类号： A61K31485
CPC分类号： A61K31/485
摘要： A method for preventing or treating opioid induced changes in gastrointestinal motility. The method comprises administering methylnaltrexone or another quaternary derivative of noroxymorphone to a patient prior to the administration of an opioid or after the onset of side effects induced by the administration of an opioid, wherein the methylnaltrexone or quaternary derivative is administered orally in an enterically coated form.
摘要翻译：一种预防或治疗阿片样物质诱导胃肠蠕动变化的方法。所述方法包括在施用阿片样物质之前或在施用阿片样物质引起的副作用开始之后向患者施用甲氧基纳曲酮或其他季戊四醇衍生物，其中所述甲基纳曲酮或季衍生物以肠溶包衣形式口服给药。

8. 发明授权

US06274591B1 Use of methylnaltrexone and related compounds 失效
标题翻译：使用甲基纳曲酮及其相关化合物
公开(公告)号：US06274591B1
公开(公告)日：2001-08-14
申请号：US09120703
申请日：1998-07-22
申请人： Joseph F. Foss , Michael F. Roizen , Jonathan Moss , Chun-Su Yuan , William Drell
发明人： Joseph F. Foss , Michael F. Roizen , Jonathan Moss , Chun-Su Yuan , William Drell
IPC分类号： A61K31448
CPC分类号： A61K31/485
摘要： A method for preventing or treating the opioid induced side effect, inhibition of gastrointestinal motility is disclosed. The method comprises administering methylnaltrexone or another quaternary derivative of noroxymorphone to a patient prior to the administration of an opioid or after the onset of side effects induced by the administration of an opioid, wherein the methylnaltrexone or quaternary derivative is administered orally in an enterically coated form.
摘要翻译：公开了一种预防或治疗阿片样物质诱导的副作用，抑制胃肠蠕动的方法。所述方法包括在施用阿片样物质之前或在施用阿片样物质引起的副作用开始之后向患者施用甲氧基纳曲酮或其他季戊四醇衍生物，其中所述甲基纳曲酮或季衍生物以肠溶包衣形式口服给药。

9. 发明申请

US20120277260A1 USE OF METHYLNALTREXONE AND RELATED COMPOUNDS TO TREAT CONSTIPATION IN CHRONIC OPIOID USERS 审中-公开
公开(公告)号：US20120277260A1
公开(公告)日：2012-11-01
申请号：US13533578
申请日：2012-06-26
申请人： Joseph F. Foss , Michael F. Roizen , Jonathan Moss , Chun-Su Yuan , William Drell
发明人： Joseph F. Foss , Michael F. Roizen , Jonathan Moss , Chun-Su Yuan , William Drell
IPC分类号： A61K31/485 , A61P1/00
CPC分类号： A61K31/485
摘要： A method of preventing or treating constipation in a patient who has been chronically taking opioids, the method comprising administering a quaternary derivative of noroxymorphone in an amount sufficient to prevent or treat the side effect in the patient, but which amount would be insufficient to treat a patient with the same opioid-induced side effect who had not chronically been administered opioids.

10. 发明申请

US20120215790A1 System and Method for Determining an Objective Measure of Human Quality of Life 有权
标题翻译：确定人类生活质量目标度的系统和方法
公开(公告)号：US20120215790A1
公开(公告)日：2012-08-23
申请号：US13214945
申请日：2011-08-22
申请人： Michael F. Roizen , Mehmet C. Oz , Jennifer L. Roizen , Jeffrey D. Roizen
发明人： Michael F. Roizen , Mehmet C. Oz , Jennifer L. Roizen , Jeffrey D. Roizen
IPC分类号： G06F17/30
CPC分类号： A45D44/005
摘要： An objective measure of human QOL is determined by a QOL quantification system. The QOL quantification system comprises a QOL rules engine, a QOL measure datastore, a score data archive, a user computing device, and a network. The QOL measure datastore comprises quantifiable measures of QOL of a QOL factor. The QOL rules engine comprises instructions for receiving user data indicative of a plurality of attributes of a selected QOL factor of the user, obtaining measures of QOL from the QOL measures datastore associated with the selected QOL factor, evaluating the user data against the QOL measures of the selected QOL factor, determining a user score indicative of the QOL of the selected QOL factor of the user, storing the user score in the score data archive, and comparing the user score to a score stored in the score data archive. The QOL rules engine may also suggest change options to one or more QOL factors to improve the user score. The suggested change options may be presented as an ordered listed organized by a relative cost benefit measure.
摘要翻译：人类生活质量的客观量度由生活质量系统确定。 QOL量化系统包括QOL规则引擎，QOL测量数据存储，分数数据归档，用户计算设备和网络。生活质量测量数据存储区包括生活质量因子的可量化度量标准。 QOL规则引擎包括用于接收指示用户选择的生活质量因子的多个属性的用户数据的指令，从与选择的生活质量因子相关联的生活质量度量数据存储区获得生活质量的度量，所选择的生活质量因子，确定指示用户选择的生活质量因子的生活质量的用户分数，将用户分数存储在分数数据归档中，以及将用户分数与存储在分数数据归档中的得分进行比较。 QOL规则引擎还可以针对一个或多个生活质量因素建议更改选项，以改善用户分数。建议的变更选项可以按相关的成本效益计量方式列出。

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