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1. 发明授权

US06876880B2 Automated reapplication of atrial pacing therapies 有权
标题翻译：心房起搏治疗的自动再次应用
公开(公告)号：US06876880B2
公开(公告)日：2005-04-05
申请号：US10034060
申请日：2001-12-20
申请人： Michael F. Hess , Rahul Mehra , Eduardo N. Warman , Nirav V. Sheth , Mark L. Brown , David Ritscher
发明人： Michael F. Hess , Rahul Mehra , Eduardo N. Warman , Nirav V. Sheth , Mark L. Brown , David Ritscher
IPC分类号： A61N1/365 , A61N1/362 , A61N1/39
CPC分类号： A61N1/3622 , A61N1/3624
摘要： The invention relates to the use of atrial pacing therapies to treat atrial tachycardia (AT). When an AT episode is detected, an implantable medical device applies an ATP therapy. If the AT episode persists, the ATP therapy may be automatically reapplied at a later time during the course of the same AT episode. In particular, previously used ATP therapies are reapplied when episodic conditions, such as cycle length or cycle regularity, change. Although a particular ATP therapy initially may be unsuccessful in terminating the AT, it may prove successful when the cycle length or regularity of the atrial rhythm changes. As the rhythm slows down, the AT may be more responsive to ATP therapies that were previously unsuccessful. As a result, potentially efficacious ATP therapies can be reapplied to terminate AT episodes, and reduce the number of episodes that require more aggressive termination by painful, atrial shocks.
摘要翻译：本发明涉及心房起搏疗法用于治疗房性心动过速（AT）的用途。当检测到AT发作时，可植入医疗装置应用ATP疗法。如果AT发作持续存在，ATP疗法可能会在相同的AT发作过程中的较晚时间自动重新应用。特别是，当诸如循环长度或循环规律性等情况时，先前使用的ATP疗法将被重新应用。尽管特定的ATP疗法最初可能不能终止AT，但是当心房节律的周期长度或规律性发生变化时，可能会成功。随着节奏减慢，AT可能对以前不成功的ATP疗法更有反应。因此，可以重新应用潜在有效的ATP疗法来终止AT发作，并通过痛苦的心房休克减少需要更积极终止的发作次数。

2. 发明授权

US07076290B2 Method and apparatus for detecting and discriminating arrhythmias 有权
标题翻译：用于检测和鉴别心律失常的方法和装置
公开(公告)号：US07076290B2
公开(公告)日：2006-07-11
申请号：US10682982
申请日：2003-10-10
申请人： Nirav V. Sheth , Eduardo N. Warman , Michael F. Hess
发明人： Nirav V. Sheth , Eduardo N. Warman , Michael F. Hess
IPC分类号： A61B5/04
CPC分类号： A61B5/046 , A61B5/0464 , A61B5/7264 , A61N1/3622 , A61N1/3962
摘要： An apparatus and method for discriminating arrhythmias that includes sensing a heart rate indicative of an arrhythmia associated with a first portion of a heart, determining regularity of the sensed heart rate, determining an event interval variability associated with a second portion of the heart, and classifying the arrhythmia in response to the determined event interval variability.
摘要翻译：一种用于区分心律失常的装置和方法，包括感测指示与心脏的第一部分相关联的心律失常的心率，确定感测心率的规律性，确定与心脏的第二部分相关联的事件间隔变异性，以及分类响应于确定的事件间隔变异性的心律失常。

3. 发明授权

US07366570B2 Method and a system for using implanted medical device data for accessing therapies 有权
标题翻译：用于使用植入的医疗装置数据进行治疗的方法和系统
公开(公告)号：US07366570B2
公开(公告)日：2008-04-29
申请号：US10376061
申请日：2003-02-26
申请人： Kenneth M. Riff , Patrick M. Mahoney , Clifton W. Owens , Rahul Mehra , Michael F. Hess , Nirav V. Sheth , Nancy Perry Pool , Michael R. Ujhelyi
发明人： Kenneth M. Riff , Patrick M. Mahoney , Clifton W. Owens , Rahul Mehra , Michael F. Hess , Nirav V. Sheth , Nancy Perry Pool , Michael R. Ujhelyi
IPC分类号： A61N1/08
CPC分类号： A61N1/37258 , A61B5/0031 , A61N1/37252 , G06F19/00 , G06F19/3418 , G06F19/3456 , G16H10/60 , G16H15/00 , G16H40/63
摘要： A method and system facilitates the access by a patient of implanted medical device related data for patient participation in their own clinical care and therapy. In an example embodiment, the method includes establishing a communications link between an implanted medical device and a data processor via an implanted medical device interface. Access to a secured database is obtained via the implanted device data processor using a set of patient identification data. A query is then submitted via the data processor to the secured database in response to input patient diagnostic data. Data received from the secured database is then displayed for use in a patient evaluation.
摘要翻译：一种方法和系统便于患者接触植入的医疗装置相关数据，以使患者参与其自身临床护理和治疗。在示例实施例中，该方法包括经由植入的医疗设备接口在植入的医疗设备和数据处理器之间建立通信链路。通过使用一组患者识别数据的植入装置数据处理器获得对安全数据库的访问。然后，响应于输入的患者诊断数据，通过数据处理器将查询提交到安全数据库。然后显示从安全数据库接收到的数据以用于患者评估。

4. 发明授权

US08332030B2 Device and method for providing atrial-synchronized ventricular pacing with selective atrial tracking 有权
标题翻译：用于提供心房同步心室起搏和选择性心房跟踪的装置和方法
公开(公告)号：US08332030B2
公开(公告)日：2012-12-11
申请号：US11115597
申请日：2005-04-27
申请人： Michael F. Hess , Eduardo N. Warman
发明人： Michael F. Hess , Eduardo N. Warman
IPC分类号： A61N1/00
CPC分类号： A61N1/3622 , A61N1/3627 , A61N1/3684
摘要： A device for delivering pacing therapy includes an atrial and ventricular leads, sensing circuitry connected to the leads for detecting depolarizations, and pulse generation circuitry for delivering ventricular pacing pulses based on sensed atrial depolarizations. The device includes control circuitry for controlling the pulse generation circuitry in a first mode in which the pulse generation circuitry delivers atrial synchronized pulses to both the right and left ventricular leads in response to each atrial depolarization sensed. In response to a detected atrial arrhythmia, the control circuitry causes the pulse generation circuitry to deliver atrial synchronized ventricular pacing pulses in response only to selected atrial depolarizations.
摘要翻译：用于输送起搏治疗的装置包括心房和心室引线，连接到用于检测去极化的引线的感测电路以及用于基于感测的心房去极化来输送心室起搏脉冲的脉冲产生电路。该装置包括用于在第一模式中控制脉冲发生电路的控制电路，其中脉冲发生电路响应于感测到的每个心房去极化而将心房同步脉冲输送到右心室和左心室引线。响应于检测到的心房心律失常，控制电路使得脉冲发生电路仅响应于所选择的心房去极化来递送心房同步心室起搏脉冲。

5. 发明授权

US06195584B1 Method and apparatus for determining atrial lead dislocation 有权
标题翻译：用于确定心房铅脱位的方法和装置
公开(公告)号：US06195584B1
公开(公告)日：2001-02-27
申请号：US09303279
申请日：1999-04-30
申请人： Michael R. S. Hill , Rahul Mehra , Michael F. Hess , Raylene Pitschneider
发明人： Michael R. S. Hill , Rahul Mehra , Michael F. Hess , Raylene Pitschneider
IPC分类号： A61N137
CPC分类号： A61N1/371 , A61N2001/083
摘要： A method and apparatus for determining the occurrence of a mis-location of an atrial electrode in a cardiac stimulation device having an atrial pulse generator coupled with the atrial electrode and a ventricular sense amplifier coupled to a ventricular electrode. The device paces the atrium in a first pacing mode employing atrial pacing pulses at a first energy level and in a test mode employs higher energy atrial pacing pulses. In the test mode the device measures PR intervals between atrial pacing pulses following sensed ventricular depolarizations and determines that the atrial electrode is mis-located responsive to occurrence of a threshold number of short PR intervals or that the atrial electrode is appropriately located responsive to occurrence of a threshold number of long PR intervals. Operation of the device in the test mode may be pre-conditioned on an absence of atrial tachyarrhythmia.
摘要翻译：一种用于确定在具有与心房电极耦合的心房脉冲发生器和耦合到心室电极的心室感应放大器的心脏刺激装置中心房电极错位的发生的方法和装置。该装置以第一起搏模式采用心房起搏脉冲在第一能级进行起搏，并且在测试模式中采用更高能量的心房起搏脉冲。在测试模式中，该装置测量感测到的心室去极化之后的心房起搏脉冲之间的PR间隔，并且确定心房电极响应于出现阈值数量的短PR间期而错位，或者心房电极适当地位于响应于长PR间隔的阈值数。在测试模式下的装置的操作可以在没有心房快速性心律失常的情况下进行预处理。

6. 发明授权

US08634926B2 Clinic based instrument system for remote processing and access to implanted systems information 有权
标题翻译：基于诊所的仪器系统，用于远程处理和获取植入系统信息
公开(公告)号：US08634926B2
公开(公告)日：2014-01-21
申请号：US10936153
申请日：2004-09-08
申请人： Michael F. Hess , Christopher M. Manrodt
发明人： Michael F. Hess , Christopher M. Manrodt
IPC分类号： A61N1/372
CPC分类号： A61N1/37282 , A61N1/37247
摘要： A system for accessing implantable medical device (IMD) data is provided including an interrogation appliance to retrieve data from an IMD and transfer the data to a processor. The processor converts the device data to a viewable form that is transferred by the processor to a data destination. The data destination may be an electronic mail address, a secure web site, a facsimile number or the interrogation appliance. The data is presented in a viewable form at the data destination either on a display or by printing. Any number of interrogation appliances may be communicatively coupled to the processor for converting IMD data and providing the IMD data back to a data destination in a viewable form for use by a clinician.
摘要翻译：提供了一种用于访问植入式医疗设备（IMD）数据的系统，其包括用于从IMD检索数据并将数据传送到处理器的询问设备。处理器将设备数据转换为由处理器传送到数据目的地的可视窗体。数据目的地可以是电子邮件地址，安全网站，传真号码或询问设备。在显示器上或通过打印在数据目的地以可视形式呈现数据。任何数量的询问设备可以通信地耦合到处理器，用于转换IMD数据，并以可视形式将IMD数据提供给数据目的地，供临床医生使用。

7. 发明授权

US07319898B2 Self-adapting defibrillator induction feature 有权
标题翻译：自适应除颤器感应功能
公开(公告)号：US07319898B2
公开(公告)日：2008-01-15
申请号：US10423073
申请日：2003-04-25
申请人： Michael F. Hess
发明人： Michael F. Hess
IPC分类号： A61N1/39
CPC分类号： A61N1/3712 , A61N1/385 , A61N1/3943
摘要： A system that includes a programming device and a defibrillator provides a self-adapting defibrillator induction feature to test the effectiveness of the defibrillator in detecting and terminating fibrillation of a heart, such as ventricular fibrillation. A fibrillation induction protocol and values for parameters of the protocol are selected. The defibrillator attempts to induce fibrillation according to the selected protocol and parameter values. Parameter values are modified and new protocols are selected until fibrillation is successfully induced, detected and terminated.
摘要翻译：包括编程设备和去纤颤器的系统提供自适应去纤颤器诱导特征，以测试除颤器在检测和终止心脏纤颤的有效性，例如心室颤动。选择原纤维诱导方案和参数参数值。除颤器试图根据选定的方案和参数值诱发颤动。参数值被修改，并且选择新的协议，直到成功诱发，检测和终止颤动。

8. 发明授权

US5928271A Atrial anti-arrhythmia pacemaker and method using high rate atrial and backup ventricular pacing 失效
标题翻译：心房抗心律失常起搏器及方法采用高速心房起搏和备用心室起搏
公开(公告)号：US5928271A
公开(公告)日：1999-07-27
申请号：US30312
申请日：1998-02-25
申请人： Michael F. Hess , Kathleen A. Prieve
发明人： Michael F. Hess , Kathleen A. Prieve
IPC分类号： A61N1/362 , A61N1/368 , A61N1/365
CPC分类号： A61N1/3622
摘要： An atrial and ventricular pacemaker including an atrial pulse generator having the capability of delivering high rate atrial pacing pulses for electrophysiologic study and having the capability of delivering ventricular pacing pulses as a backup, during delivery of high rate atrial pacing pulses. Delivery of backup ventricular pacing pulses may be preconditioned upon the occurrence of a desired number, proportion or pattern of occurrences of paced ventricular beats preceding delivery of high rate atrial pacing pulses. Timing of ventricular backup pulses is synchronized to delivered atrial pacing pulses which occur closely timed to expiration of a defined ventricular escape interval for backup pacing. The defined escape interval for ventricular backup pacing may be set as a function of the average interval separating ventricular events preceding initiation of high rate atrial pacing.
摘要翻译：一种心房起搏器，包括心房脉搏发生器，其具有递送高速率心房起搏脉搏用于电生理学研究的能力，并且具有在递送高速率心房起搏脉冲期间提供心室起搏脉冲作为备用的能力。备用心室起搏脉冲的传送可以在出现高速率心房起搏脉冲之前出现所需数量，比例或出现的起搏心室搏动的情况下进行预处理。心室备用脉冲的定时与递送的心房起搏脉冲同步，其发生紧密定时到定义的心室逃逸间隔到达用于后备起搏。定义的心室起搏起搏间隔可以设置为在高速率心房起搏开始之前分隔心室事件的平均间隔的函数。

9. 发明授权

US5643326A Dual chamber pacing with atrial and ventricular independence 失效
标题翻译：双室起搏与心房和心室独立
公开(公告)号：US5643326A
公开(公告)日：1997-07-01
申请号：US568440
申请日：1995-12-07
申请人： Henry L. Weiner , H. Toby Markowitz , Michael F. Hess
发明人： Henry L. Weiner , H. Toby Markowitz , Michael F. Hess
IPC分类号： A61N1/368
CPC分类号： A61N1/368
摘要： A rate-responsive cardiac pacemaker implements a novel pacing mode, identified as ADIR/VVIR, which is especially effective for patients with Sick Sinus Syndrome and only intermittent atrioventricular block. Within the same pacemaker circuitry, an AAIR pacemaker and a VVI pacemaker (with an escape rate below that of the AAIR pacemaker) are provided with atrial blanking following both atrial and ventricular events. Ventricular blanking after atrial pacing is minimized for better detection of R-waves following an atrial paced event.
摘要翻译：速率响应心脏起搏器实现了一种新颖的起搏模式，被认为是ADIR / VVIR，其对于患有窦性窦综合征的患者和仅间歇性房室传导阻滞特别有效。在相同的起搏器电路中，AAIR起搏器和VVI起搏器（逃逸率低于AAIR起搏器）在心房和心室事件之后都提供心房消隐。心房起搏后的心室消隐最小化，以便更好地检测心房起搏事件后的R波。

10. 发明授权

US08442627B2 Advanced thoracic fluid monitoring capability with impedance 有权
标题翻译：先进的胸腔液监测能力与阻抗
公开(公告)号：US08442627B2
公开(公告)日：2013-05-14
申请号：US11322700
申请日：2005-12-30
申请人： Michael F. Hess
发明人： Michael F. Hess
IPC分类号： A61B5/05 , A61B5/02 , A61B5/08 , A61B5/103 , A61B5/117
CPC分类号： A61B5/0537 , A61B5/053 , A61B5/0538 , A61N1/36521 , A61N1/36535
摘要： An implantable medical device used for thoracic fluid monitoring by detection of changes in impedance in a patient. The device measures impedances of the patient in a supine position and in an upright position. The device determines impedance differences between the supine and upright positions which correspond to a diurnal delta value, which may in turn be employed as a diagnostic parameter.
摘要翻译：用于通过检测患者的阻抗变化而用于胸部流体监测的可植入医疗装置。该装置测量患者在仰卧位和直立位置的阻抗。该装置确定对应于日间Δ值的仰卧位置和垂直位置之间的阻抗差异，其可以用作诊断参数。

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