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1. 发明授权

US6133251A Combination compound for contraception based on natural estrogen 失效
标题翻译：基于天然雌激素的避孕组合化合物
公开(公告)号：US6133251A
公开(公告)日：2000-10-17
申请号：US738314
申请日：1996-10-25
申请人： Michael Dittgen , Sabine Fricke , Herbert Hoffmann , Claudia Moore , Michael Oettel , Monika Ostertag
发明人： Michael Dittgen , Sabine Fricke , Herbert Hoffmann , Claudia Moore , Michael Oettel , Monika Ostertag
IPC分类号： A61K31/565 , A61K31/57 , A61P15/00 , A61P15/18 , C07J1/00 , C07J7/00 , A61K31/56
CPC分类号： A61K31/57 , Y10S514/843
摘要： The combination preparation for contraception includes a first stage of 2 to 4 first stage daily dosage portions, a second stage of two groups of second stage daily dosage portions, a third stage of 2 to 4 third stage daily dosage portions and an additional stage of 2 to 4 additional stage daily dosage portions. The first stage daily dosage portion is an effective amount of natural estrogen, the second stage daily dosage portion is an effective amount of a combination of natural estrogen and natural or synthetic gestogen, the third stage daily dosage portion is another effective amount of natural estrogen and an additional stage daily dosage portion consists of a placebo. The first group of the second stage consists of 3 to 5 daily dosage portions and the second group, 13 to 17 daily dosage portions. More of the gestogen is included in the effective amount in the second group of the second stage than in the first group. The effective amount of the natural estrogen is constant in both the first and third stages, but smaller in the third stage than in the first stage.
摘要翻译：用于避孕的组合制剂包括第一阶段的2至4个第一阶段每日剂量部分，第二阶段的两组第二阶段日剂量部分，第三阶段的2至4个第三阶段每日剂量部分和另外的阶段2 至4个额外的阶段日剂量部分。第一阶段日剂量是天然雌激素的有效量，第二阶段日剂量是天然雌激素和天然或合成gestogen的组合的有效量，第三阶段日剂量是另一有效量的天然雌激素，额外的阶段每日剂量部分由安慰剂组成。第一组第一组由3〜5个日剂量组成，第二组为每日13〜17次。第二组的第二组中有更多的gestogen包含在第一组中。天然雌激素的有效量在第一和第三阶段都是恒定的，但在第三阶段中比在第一阶段更小。

2. 发明授权

US06884793B2 Combination preparation for contraception based on natural estrogens 失效
标题翻译：基于天然雌激素的避孕组合制剂
公开(公告)号：US06884793B2
公开(公告)日：2005-04-26
申请号：US09950915
申请日：2001-09-12
申请人： Michael Dittgen , Sabine Fricke , Herbert Hoffmann , Claudia Moore , Michael Oettel , Monika Ostertag
发明人： Michael Dittgen , Sabine Fricke , Herbert Hoffmann , Claudia Moore , Michael Oettel , Monika Ostertag
IPC分类号： A61K31/565 , A61K31/57 , A61P15/00 , A61P15/18 , C07J1/00 , C07J7/00 , A61K33/56
CPC分类号： A61K31/57 , Y10S514/843 , A61K31/565 , A61K2300/00
摘要： The combination preparation for contraception includes from 2 to 4 first stage daily dosage portions each including an effective amount of at least one natural estrogen as sole active ingredient, from 16 to 22 second stage daily dosage portions each including an effective amount of a combination of at least one natural estrogen and at least one natural or synthetic gestogen as active ingredient; from 2 to 4 third stage daily dosage portions each including an effective amount of at least one natural estrogen as sole active ingredient; and from 2 to 4 final stage daily dosage portions containing a pharmaceutically acceptable placebo. The estrogen may be estradiol, an estradiol compound that is metabolized to estradiol when taken into the body, a conjugated equine estrogen or a phytoestrogen. The natural or synthetic gestogen can be natural progesterone or a synthetic gestogens, such as medroxyprogesterone acetate.
摘要翻译：用于避孕的组合制剂包括2至4个第一阶段每日剂量部分，每个剂量部分包含有效量的至少一种天然雌激素作为唯一活性成分，16至22个第二阶段日剂量部分，每个包含有效量的组合至少一种天然雌激素和至少一种天然或合成的Gestogen作为活性成分; 2至4个第三阶段每日剂量部分，每个包含有效量的至少一种天然雌激素作为唯一活性成分; 和含有药学上可接受的安慰剂的2至4个最终阶段每日剂量部分。雌激素可以是雌二醇，当被摄入体内时被代谢为雌二醇的雌二醇化合物，共轭马雌激素或植物雌激素。天然或合成的gestogen可以是天然孕酮或合成的gestogens，如醋酸甲羟孕酮。

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