专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5700681A Selection of cells having increased cell adhesion properties 失效
标题翻译：选择具有增加的细胞粘附性质的细胞
公开(公告)号：US5700681A
公开(公告)日：1997-12-23
申请号：US359956
申请日：1994-12-20
申请人： Michael D. Pierschbacher , Erkki I. Ruoslahti , Shoukat Dedhar
发明人： Michael D. Pierschbacher , Erkki I. Ruoslahti , Shoukat Dedhar
IPC分类号： G01N33/53 , C12N5/00 , C12N5/02 , C12N5/09 , C12Q1/04 , C12N5/06 , C07K14/00
CPC分类号： C12N5/0693 , C12N5/0018 , C12N2501/58 , C12N2501/998
摘要： A method for selecting cell lines expressing increased cell adhesion properties or promoting cell differentiation by culturing cells in increasing concentrations of adhesion ligand containing media. Cell lines produced by such method.
摘要翻译：通过增加浓度的粘附配体的培养基来选择表达增加的细胞粘附性或促进细胞分化的细胞系的方法。通过这种方法生产的细胞系。

2. 发明授权

US5952224A Selection of cells having increased cell adhesion properties 失效
标题翻译：选择具有增加的细胞粘附性质的细胞
公开(公告)号：US5952224A
公开(公告)日：1999-09-14
申请号：US915315
申请日：1997-08-20
申请人： Michael D. Pierschbacher , Erkki I. Ruoslahti , Shoukat Dedhar
发明人： Michael D. Pierschbacher , Erkki I. Ruoslahti , Shoukat Dedhar
IPC分类号： G01N33/53 , C12N5/00 , C12N5/02 , C12N5/09 , C12Q1/04
CPC分类号： C12N5/0693 , C12N5/0018 , C12N2501/58 , C12N2501/998
摘要： A method for selecting cell lines expressing increased cell adhesion properties or promoting cell differentiation by culturing cells in increasing concentrations of adhesion ligand containing media. Cell lines produced by such method.
摘要翻译：通过增加浓度的粘附配体的培养基来选择表达增加的细胞粘附性或促进细胞分化的细胞系的方法。通过这种方法生产的细胞系。

3. 发明授权

US5985827A Conformationally stabilized cell adhesion peptides 失效
公开(公告)号：US5985827A
公开(公告)日：1999-11-16
申请号：US458638
申请日：1995-06-02
申请人： Michael D. Pierschbacher , Erkki I. Ruoslahti
发明人： Michael D. Pierschbacher , Erkki I. Ruoslahti
IPC分类号： A61K38/00 , C07K14/47 , C07K14/78
CPC分类号： C07K7/06 , C07K14/47 , C07K14/78 , C07K7/08 , C07K7/50 , C07K7/64 , A61K38/00
摘要： Novel synthetic Arg-Gly-Asp containing peptides which have high affinity and specificity for their receptors by virtue of restrictions on their stereochemical conformation. Such restrictions can be provided by cyclization, by inclusion into a constraining conformational structure such as a helix, by providing an additional chemical structure such as an amide or an enantiomer of a naturally occurring amino acid, or by other methods. In particular, there are provided cyclic peptides having increased affinity and selectivity for the certain receptors over that of linear, Arg-Gly-Asp-containing synthetic peptides.

4. 发明授权

US5906975A Conformationally stabilized cell adhesion peptides 失效
公开(公告)号：US5906975A
公开(公告)日：1999-05-25
申请号：US292568
申请日：1994-08-19
申请人： Michael D. Pierschbacher , Erkki I. Ruoslahti
发明人： Michael D. Pierschbacher , Erkki I. Ruoslahti
IPC分类号： A61K38/00 , C07K14/47 , C07K14/78 , C07K7/64
CPC分类号： C07K7/06 , C07K14/47 , C07K14/78 , C07K7/08 , C07K7/50 , C07K7/64 , A61K38/00
摘要： Novel synthetic Arg-Gly-Asp containing peptides which have high affinity and specificity for their receptors by virtue of restrictions on their stereochemical conformation. Such restrictions can be provided by cyclization, by inclusion into a constraining conformational structure such as a helix, by providing an additional chemical structure such as an amide or an enantiomer of a naturally occurring amino acid, or by other methods. In particular, there are provided cyclic peptides having increased affinity and selectivity for the certain receptors over that of linear, Arg-Gly-Asp-containing synthetic peptides.

5. 发明授权

US5880092A Conformationally stabilized cell adhesion peptides 失效
公开(公告)号：US5880092A
公开(公告)日：1999-03-09
申请号：US459441
申请日：1995-06-02
申请人： Michael D. Pierschbacher , Erkki I. Ruoslahti
发明人： Michael D. Pierschbacher , Erkki I. Ruoslahti
IPC分类号： A61L27/00 , A61K38/00 , B31B50/06 , B65H3/06 , B65H7/18 , C07K1/02 , C07K5/08 , C07K5/10 , C07K7/06 , C07K7/08 , C07K7/56 , C07K14/00 , C07K14/47 , C07K14/705 , C07K14/78 , A61K38/12
CPC分类号： C07K14/001 , B65H3/063 , C07K14/47 , C07K14/78 , A61K38/00 , B65H2406/30
摘要： Novel synthetic Arg-Gly-Asp containing peptides which have high affinity and specificity for their receptors by virtue of restrictions on their stereochemical conformation. Such restrictions can be provided by cyclization, by inclusion into a constraining conformational structure such as a helix, by providing an additional chemical structure such as an amide or an enantiomer of a naturally occurring amino acid, or by other methods. In particular, there are provided cyclic peptides having increased affinity and selectivity for the certain receptors over that of linear, Arg-Gly-Asp-containing synthetic peptides.

6. 发明授权

US5547936A Inhibition of cell migration with synthetic peptides 失效
标题翻译：用合成肽抑制细胞迁移
公开(公告)号：US5547936A
公开(公告)日：1996-08-20
申请号：US169743
申请日：1993-12-17
申请人： Erkki I. Ruoslahti , Michael D. Pierschbacher , Kurt R. Gehlsen
发明人： Erkki I. Ruoslahti , Michael D. Pierschbacher , Kurt R. Gehlsen
IPC分类号： A61K38/07 , A61K38/08 , A61L27/22 , C07K14/78 , A61K38/04 , A61K38/16
CPC分类号： C07K14/78 , A61K38/07 , A61K38/08 , A61L27/227
摘要： A method of inhibiting the invasion of cells, particularly malignant cells through an extracellular membrane by contacting the membrane-cell interface with synthetic Arg-Gly-Asp-containing peptides. In one embodiment, the invention provides peptides containing the amino acid sequence Arg-Gly-Asp-Thr, more specifically Gly-Arg-Gly-Asp-Thr-Pro, which inhibits the attachment of cells to type I collagen in addition to fibronectin and vitronectin, and a method of inhibiting the attachment of cells to type I collagen. The invention further provides an assay for quantitating the invasive quality of cells by determining the amount of such peptides necessary to prevent the cells from penetrating an extracellular membrane, such as an amniotic membrane, in vitro.
摘要翻译：通过使膜 - 细胞界面与合成的含有Arg-Gly-Asp的合成肽接触来抑制细胞侵入的方法，特别是恶性细胞通过细胞外膜。在一个实施方案中，本发明提供了含有氨基酸序列Arg-Gly-Asp-Thr，更特别地Gly-Arg-Gly-Asp-Thr-Pro的肽，其除了纤连蛋白以外还抑制细胞与I型胶原的连接，玻连蛋白，以及抑制细胞对I型胶原的附着的方法。本发明进一步提供了一种用于通过确定在体外测定防止细胞穿透细胞外膜（例如羊膜）所必需的这种肽的量来量化细胞侵入性质量的测定法。

7. 发明授权

US07030213B2 Conformationally stabilized cell adhesion peptides 失效
公开(公告)号：US07030213B2
公开(公告)日：2006-04-18
申请号：US09892071
申请日：2001-06-26
申请人： Michael D. Pierschbacher , Erkki I. Ruoslahti
发明人： Michael D. Pierschbacher , Erkki I. Ruoslahti
IPC分类号： A61K38/00
CPC分类号： C07K7/06 , A61K38/00 , C07K7/08 , C07K7/50 , C07K7/64 , C07K14/47 , C07K14/78
摘要： Novel synthetic Arg-Gly-Asp containing peptides which have high affinity and specificity for their receptors by virtue of restrictions on their stereochemical conformation. Such restrictions can be provided by cyclization, by inclusion into a constraining conformational structure such as a helix, by providing an additional chemical structure such as an amide or an enantiomer of a naturally occurring amino acid, or by other methods. In particular, there are provided cyclic peptides having increased affinity and selectivity for the certain receptors over that of linear, Arg-Gly-Asp-containing synthetic peptides.

8. 发明授权

US5827821A Conformationally stabilized cell adhesion peptides 失效
公开(公告)号：US5827821A
公开(公告)日：1998-10-27
申请号：US914643
申请日：1992-07-16
申请人： Michael D. Pierschbacher , Erkki I. Ruoslahti
发明人： Michael D. Pierschbacher , Erkki I. Ruoslahti
IPC分类号： A61K38/00 , C07K14/47 , C07K14/78
CPC分类号： C07K7/06 , C07K14/47 , C07K14/78 , C07K7/08 , C07K7/50 , C07K7/64 , A61K38/00
摘要： Novel synthetic Arg-Gly-Asp containing peptides which have high affinity and specificity for their receptors by virtue of restrictions on their stereochemical conformation. Such restrictions can be provided by cyclization, by inclusion into a constraining conformational structure such as a helix, by providing an additional chemical structure such as an amide or an enantiomer of a naturally occurring amino acid, or by other methods. In particular, there are provided cyclic peptides having increased affinity and selectivity for the certain receptors over that of linear, Arg-Gly-Asp-containing synthetic peptides.

9. 发明授权

US5695997A Tetrapeptide 失效
标题翻译：四肽
公开(公告)号：US5695997A
公开(公告)日：1997-12-09
申请号：US459641
申请日：1995-06-02
申请人： Erkki I. Ruoslahti , Michael D. Pierschbacher
发明人： Erkki I. Ruoslahti , Michael D. Pierschbacher
IPC分类号： A61K38/07 , A61K38/08 , A61L27/22 , C07K14/78 , C12N5/02 , C07K4/00 , C07K5/10 , C07K14/00
CPC分类号： A61K38/07 , A61K38/08 , A61L27/227 , C07K14/78
摘要： The peptide X-Arg-Gly-Asp-R-Y wherein X is H or at least one amino acid and Y is OH or at least one amino acid, and R is an amino acid selected from Thr or Cys, or other amino acid, having the same cell-attachment activity as fibronectin and the peptide X-Arg-Gly-Asp-Ser-Y, wherein X and Y, having said activity are disclosed.
摘要翻译：肽X-Arg-Gly-Asp-RY，其中X是H或至少一个氨基酸，Y是OH或至少一个氨基酸，R是选自Thr或Cys的氨基酸或其它氨基酸，其具有具有与纤连蛋白相同的细胞附着活性和肽X-Arg-Gly-Asp-Ser-Y，其中X和Y具有所述活性。

10. 发明授权

US4661111A Polypeptide 失效
标题翻译：多肽
公开(公告)号：US4661111A
公开(公告)日：1987-04-28
申请号：US735816
申请日：1985-05-17
申请人： Erkki I. Ruoslahti , Michael D. Pierschbacher
发明人： Erkki I. Ruoslahti , Michael D. Pierschbacher
IPC分类号： C07K14/78 , A61F1/00 , A61K37/00 , C07C103/52 , C07G7/00
CPC分类号： C07K14/78 , Y10S530/813 , Y10S530/815
摘要： A polypeptide having the cell-attaching activity of fibronectin. The polypeptide has 108 amino acid residues and the formula: H-Ile-Gly-Gln-Gln-Ser-Thr-Val-Ser-Asp-Val-Pro-Arg-Asp-Leu-Glu-Val-Val-Ala-Ala-Thr-Pro-Thr-Ser-Leu-Leu-Ile-Ser-Trp-Asp-Ala-Pro-Ala-Val-Thr-Val-Arg-Tyr-Tyr-Arg-Ile-Thr-Tyr-Gly-Glu-Thr-Gly-Gly-Asn-Ser-Pro-Val-Gln-Glu-Phe-Thr-Val-Pro-Gly-Ser-Lys-Ser-Thr-Ala-Thr-Ile-Ser-Gly-Leu-Lys-Pro-Gly-Val-Asp-Tyr-Thr-Ile-Thr-Val-Tyr-Ala-Val-Thr-Gly-Arg-Gly-Asp-Ser-Pro-Ala-Ser-Ser-Lys-Pro-Ile-Ser-Ile-Asn-Tyr-Arg-Thr-Glu-Ile-Asp-Lys-Pro-Ser-Gln-Met-OH. The polypeptide or a biologically active fragment thereof can be employed in the preparation of substrate designed for the attachment of cells thereto. It can be linked to the surface of a prosthetic device to particularly attract endothelial cells and fibroblastic cells.
摘要翻译：具有纤连蛋白的细胞附着活性的多肽。该多肽具有108个氨基酸残基，并且具有下式：H-Ile-Gly-Gln-Gln-Ser-Thr-Val-Ser-Asp-Val-Pro-Arg-Asp-Leu-Glu-Val-Val-Ala-Ala -Thr-Pro-Thr-Ser-Leu-Leu-Ile-Ser-Trp-Asp-Ala-Pro-Ala-Val-Thr-Val-Arg-Tyr-Tyr-Arg-Ile-Thr-Tyr-Gly- Glu-Thr-Gly-Gly-Asn-Ser-Pro-Val-Gln-Glu-Phe-Thr-Val-Pro-Gly-Ser-Lys-Ser-Thr-Ala-Thr-Ile-Ser-Gly-Leu- Lys-Pr-Gly-Val-Asp-Tyr-Thr-Ile-Thr-Val-Tyr-Ala-Val-Thr-Gly-Arg-Gly-Asp-Ser-Pro-Ala-Ser-Ser-Lys-Pro -Ile-Ser-Ile-Asn-Tyr-Arg-Thr-Glu-Ile-Asp-Lys-Pr-Ser-Gln-Met-OH。多肽或其生物活性片段可以用于制备用于连接细胞的底物。它可以连接到假体装置的表面以特别吸引内皮细胞和成纤维细胞。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式