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1. 发明授权

US06615075B2 QRST subtraction using an adaptive template for analysis of TU wave obscured atrial activity 有权
标题翻译： QRST减法使用自适应模板分析T波波模糊心房活动
公开(公告)号：US06615075B2
公开(公告)日：2003-09-02
申请号：US09809719
申请日：2001-03-14
申请人： Michael D. Mlynash , Arne Sippens Groenewegen , Michael D. Lesh
发明人： Michael D. Mlynash , Arne Sippens Groenewegen , Michael D. Lesh
IPC分类号： A61B50452
CPC分类号： A61B5/061 , A61B5/04085 , A61B5/04525 , A61B5/6831 , A61B5/7232 , A61B5/7264
摘要： The present invention provides a noninvasive localization, characterization and classification apparatus and method for cardiac arrhythmias. The invention enables discrete isolation of the intricate spatial and temporal detail in morphology of the atrial activity of interest from superimposed ventricular activity of a preceding heartbeat in a particular arrhythmia. An adaptive QRST subtraction template is used that is modulated for discrepancies in voltage and rate between the QRST template and arrhythmia signal. The QRST template modulation is accomplished by using one or more fiducial points and windows that are annotated in both the QRST template and the arrhythmia signal. The invention includes, but is not limited to, the isolation of atrial activity that are commonly known as: (1) P waves in case of focal atrial fibrillation, atrial tachycardia, and orthodromic AV reentrant tachycardia; (2) fibrillation waves in case of chronic atrial fibrillation; and (3) flutter waves in case of atrial flutter.
摘要翻译：本发明提供了用于心律失常的非侵入性定位，表征和分类装置和方法。本发明使得在特定心律不齐中的前一心跳的叠加心室活动的兴趣心房活动的形态学上的错综复杂的空间和时间细节的离散分离。使用自适应QRST减法模板，其被调制为QRST模板和心律失常信号之间的电压和速率的差异。 QRST模板调制是通过使用在QRST模板和心律失常信号中注释的一个或多个基准点和窗口来实现的。本发明包括但不限于通常所述的心房活动的分离：（1）在局灶性房颤，心房心动过速和正畸AV折返性心动过速的情况下的P波; （2）慢性心房颤动的原纤维颤动波; 和（3）在心房颤动的情况下的颤动波。

2. 发明授权

US06931273B2 Database of body surface ECG P wave integral maps for localization of left-sided atrial arrhythmias 失效
标题翻译：左心房心律失常定位的体表心电图P波积分图
公开(公告)号：US06931273B2
公开(公告)日：2005-08-16
申请号：US09835125
申请日：2001-04-11
申请人： Arne Sippens Groenewegen , Michael D. Mlynash
发明人： Arne Sippens Groenewegen , Michael D. Mlynash
IPC分类号： A61B5/0402 , A61B5/0452 , A61B5/04
CPC分类号： A61B5/7264 , A61B5/04023 , A61B5/04525 , A61B5/7242
摘要： A system and method are provided for developing a database of body surface ECG P-wave maps for classification and localization of left-sided atrial arrhythmias. The system and method include generating and receiving P-wave data in a subject by left atrial pacing or receiving P-wave data in a subject during spontaneously occurring or induced left atrial arrhythmias; computing (e.g. potential or integral) maps of the P-wave data; classifying the maps specific to a left atrial ectopic origin; verifying the classification procedure; averaging the classified maps into mean maps; and storing and accessing the mean maps in the database. The mean maps of the P-wave data in the database can be used to automatically classify and localize P-wave data from a patient obtained during a left atrial arrhythmia such as atrial tachycardia, focal atrial fibrillation, or orthodromic atrioventricular reentrant tachycardia.
摘要翻译：提供了一种用于开发体表ECG P波图数据库的系统和方法，用于左侧心房心律失常的分类和定位。该系统和方法包括在自发发生或诱发的左心房心律失常期间通过左心房起搏或在受试者中接收P波数据在受试者中产生和接收P波数据; 计算P波数据的（例如，电位或积分）图; 对特定于左心房异位起源的地图进行分类; 验证分类程序; 将分类地图平均为均值图; 并存储和访问数据库中的均值图。可以使用数据库中P波数据的平均图来自左心房心律失常如房性心动过速，局灶性心房颤动或正常房室折返性心动过速中获得的患者自动分类和定位P波数据。

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