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1. 发明授权

US08962548B2 Multi-component biological transport systems 有权
公开(公告)号：US08962548B2
公开(公告)日：2015-02-24
申请号：US10591485
申请日：2005-03-03
申请人： Jacob M. Waugh , Michael D. Dake
发明人： Jacob M. Waugh , Michael D. Dake
IPC分类号： A61K49/14 , A61K47/48 , A61K9/00 , A61K47/34 , A61K49/00 , A61K49/12 , B82Y5/00 , A61K38/00
摘要： Compositions and methods are provided that are useful for the delivery, including transdermal delivery, of biologically active agents, including nucleic acids and therapeutic proteins including insulin, larger therapeutic proteins such as botulinum toxin and other biologically active agents such as a therapeutic protein which does not therapeutically alter blood glucose levels, a therapeutic nucleic acid-based agent, a non-protein non-nucleic acid therapeutic agent such as an antifungal agent or alternately an agent for immunization. The compositions can be prepared with components useful for targeting the delivery of the compositions as well as imaging components.

2. 发明授权

US08022179B2 Compositions and methods for topical application and transdermal delivery of an oligopeptide 有权
标题翻译：用于局部应用和透皮递送寡肽的组合物和方法
公开(公告)号：US08022179B2
公开(公告)日：2011-09-20
申请号：US11368198
申请日：2006-03-03
申请人： Michael D. Dake , Jacob M. Waugh
发明人： Michael D. Dake , Jacob M. Waugh
IPC分类号： A61K38/08 , A61K38/10 , A61K31/74 , A61K39/08 , C07K4/00
CPC分类号： A61K9/7023 , A61K8/64 , A61K38/08 , A61Q7/00 , A61Q15/00 , C07K14/33
摘要： The invention relates to the transdermal application of oligopeptides for reducing synaptic transmission in tissues of an animal. In one aspect, this invention relates to compositions comprising an oligopeptide and optionally a carrier comprising a positively charged “backbone” having positively charged branching or “efficiency” groups, as described herein. Most preferably the positively charged carrier is a long-chain positively charged polypeptide or a positively charged nonpeptidyl polymer, for example, a polyalkyleneimine. The invention further relates methods for producing a biologic effect of reducing synaptic transmission in a tissue by topically applying an effective amount of such a composition, preferably to the skin, of a subject or patient in need of such treatment. This invention also provides kits for preparing or formulating a composition that comprises the oligopeptide and optionally a carrier, as well as such additional items that are needed to produce a usable formulation, or a premix that may in turn be used to produce such a formulation.
摘要翻译：本发明涉及用于减少动物组织中突触传递的寡肽的透皮应用。一方面，本发明涉及包含寡肽和任选的载体的组合物，其包含具有带正电荷的支化或“效率”基团的带正电荷的“骨架”，如本文所述。最优选地，带正电荷的载体是长链带正电荷的多肽或带正电荷的非肽基聚合物，例如聚亚烷基亚胺。本发明还涉及用于通过局部施用有效量的这种组合物，优选给予需要这种治疗的受试者或患者的皮肤来产生减少组织中突触传递的生物学效应的方法。本发明还提供用于制备或配制包含寡肽和任选的载体的组合物的试剂盒，以及产生可用制剂所需的其它物质，或可以依次用于制备这种制剂的预混物。

3. 发明申请

US20150320781A1 Compositions and Methods for Topical Diagnostic and Therapeutic Transport 审中-公开
标题翻译：局部诊断和治疗运输的组成和方法
公开(公告)号：US20150320781A1
公开(公告)日：2015-11-12
申请号：US14642580
申请日：2015-03-09
申请人： Michael D. Dake , Jacob M. Waugh
发明人： Michael D. Dake , Jacob M. Waugh
IPC分类号： A61K31/7048 , A61K31/513 , A61K31/496 , A61K31/4164 , A61K9/00 , A61K31/4418 , A61K38/17 , A61K31/7076 , A61K38/48 , C07K16/32 , A61K31/4196 , A61K31/343
CPC分类号： A61K31/7048 , A61K9/0014 , A61K31/343 , A61K31/4164 , A61K31/4196 , A61K31/4418 , A61K31/496 , A61K31/513 , A61K31/7076 , A61K38/1767 , A61K38/4893 , A61K47/59 , A61K47/6455 , A61K49/0041 , A61K49/0043 , A61K49/0045 , A61K49/0054 , A61K49/0063 , C07K16/32 , C12Y304/24069
摘要： Compositions and methods are provided that are useful for the delivery, including transdermal delivery, of biologically active agents, such as non-protein non-nucleotide therapeutics and protein-based therapeutics excluding insulin, botulinum toxins, antibody fragments, and VEGF. The compositions and methods are particularly useful for topical delivery of antifungal agents and antigenic agents suitable for immunization. Alternatively, the composition can be prepared with components useful for targeting the delivery of the compositions as well as imaging components.
摘要翻译：提供了可用于递送（包括经皮递送）生物活性剂（例如非蛋白质非核苷酸治疗剂）和基于蛋白质的治疗剂（不包括胰岛素，肉毒杆菌毒素，抗体片段和VEGF）的组合物和方法。组合物和方法特别适用于局部递送抗真菌剂和适合免疫的抗原剂。或者，组合物可以用用于靶向组合物递送以及成像组分的组分制备。

4. 发明授权

US08092788B2 Compositions and methods for topical diagnostic and therapeutic transport 有权
标题翻译：用于局部诊断和治疗性运输的组合物和方法
公开(公告)号：US08092788B2
公开(公告)日：2012-01-10
申请号：US11073307
申请日：2005-03-03
申请人： Michael D. Dake , Jacob M. Waugh
发明人： Michael D. Dake , Jacob M. Waugh
IPC分类号： A61K31/74 , A61K39/00 , C07K14/00 , C07K7/00
CPC分类号： A61K31/7048 , A61K9/0014 , A61K31/343 , A61K31/4164 , A61K31/4196 , A61K31/4418 , A61K31/496 , A61K31/513 , A61K31/7076 , A61K38/1767 , A61K38/4893 , A61K47/59 , A61K47/6455 , A61K49/0041 , A61K49/0043 , A61K49/0045 , A61K49/0054 , A61K49/0063 , C07K16/32 , C12Y304/24069
摘要： Compositions and methods are provided that are useful for the delivery, including transdermal delivery, of biologically active agents, such as non-protein non-nucleotide therapeutics and protein-based therapeutics excluding insulin, botulinum toxins, antibody fragments, and VEGF. The compositions and methods are particularly useful for topical delivery of antifungal agents and antigenic agents suitable for immunization. Alternately, the compositions can be prepared with components useful for targeting the delivery of the compositions as well as imaging components.
摘要翻译：提供了可用于递送（包括经皮递送）生物活性剂（例如非蛋白质非核苷酸治疗剂）和基于蛋白质的治疗剂（不包括胰岛素，肉毒杆菌毒素，抗体片段和VEGF）的组合物和方法。组合物和方法特别适用于局部递送抗真菌剂和适合免疫的抗原剂。或者，组合物可以用用于靶向组合物递送以及成像组分的组分制备。

5. 发明申请

US20080038203A1 Compositions and Methods for Topical Diagnostic and Therapeutic Transport 有权
标题翻译：局部诊断和治疗运输的组成和方法
公开(公告)号：US20080038203A1
公开(公告)日：2008-02-14
申请号：US10591486
申请日：2005-03-03
申请人： Michael D. Dake , Jacob M. Waugh
发明人： Michael D. Dake , Jacob M. Waugh
IPC分类号： A61B5/055 , A61K38/00 , A61P35/00
CPC分类号： A61K31/7048 , A61K9/0014 , A61K31/343 , A61K31/4164 , A61K31/4196 , A61K31/4418 , A61K31/496 , A61K31/513 , A61K31/7076 , A61K38/1767 , A61K38/4893 , A61K47/59 , A61K47/6455 , A61K49/0041 , A61K49/0043 , A61K49/0045 , A61K49/0054 , A61K49/0063 , C07K16/32 , C12Y304/24069
摘要： Compositions and therapeutic methods are provided that are useful agent for the delivery, including transdermal delivery, of biologically active agents, such as non-protein non-nucleotide therapeutics and protein-based therapeutics excluding insulin, botulinum toxins, antibody fragments, and VEGE The compositions and methods are particularly useful for topical delivery of antifungal agents and antigenic agents suitable for immunization. Alternately, the compositions can be prepared with components useful for targeting the delivery of the compositions as well as imaging components.
摘要翻译：提供了组合物和治疗方法，其是用于递送的有用试剂，包括经皮递送，生物活性剂，例如非蛋白质非核苷酸治疗剂和基于蛋白质的治疗剂，不包括胰岛素，肉毒杆菌毒素，抗体片段和VEGE。组合物并且方法对于适于免疫的抗真菌剂和抗原剂的局部递送特别有用。或者，组合物可以用用于靶向组合物递送以及成像组分的组分制备。

6. 发明授权

US08398997B2 Compositions and methods for topical application and transdermal delivery of botulinum toxins 有权
标题翻译：用于局部应用和经皮递送肉毒杆菌毒素的组合物和方法
公开(公告)号：US08398997B2
公开(公告)日：2013-03-19
申请号：US10591732
申请日：2005-03-03
申请人： Michael D. Dake , Jacob M. Waugh
发明人： Michael D. Dake , Jacob M. Waugh
IPC分类号： A61K39/08 , A61K45/00 , A61K39/02 , A61K31/74 , A61K39/00 , A61K33/32 , A01N59/16
CPC分类号： A61Q19/08 , A61K8/64 , A61K9/0014 , A61K47/34 , A61K47/42 , A61K47/645 , Y02A50/469
摘要： A composition for topical application of a botulinum toxin (including botulinum toxin derivatives) comprises a botulinum toxin and a carrier comprising a polymeric backbone comprising a long-chain polypeptide or nonpeptidyl polymer having attached positively charged branching or “efficiency” groups. The invention also relates to methods for reducing muscle paralysis and other conditions that may be treated with a botulinum toxin, particularly paralysis of subcutaneous, and most particularly, facial, muscles, by topically applying an effective amount of the botulinum toxin and carrier, in conjunction, to the subject's skin or epithelium. Kits for administration are also described.
摘要翻译：用于局部施用肉毒杆菌毒素（包括肉毒杆菌毒素衍生物）的组合物包含肉毒毒素和包含聚合物主链的载体，所述载体包含长链多肽或具有带正电荷的支化或效率基团的非肽基聚合物。本发明还涉及通过局部施用有效量的肉毒杆菌毒素和载体，减少肌肉麻痹和其它可用肉毒杆菌毒素治疗的病症，特别是皮下，尤其是面部肌肉麻痹的方法。，对受试者的皮肤或上皮。还描述了用于给药的试剂盒。

7. 发明申请

US20120065131A1 COMPOSITIONS AND METHODS FOR TOPICAL APPLICATION AND TRANSDERMAL DELIVERY OF AN OLIGOPEPTIDE 审中-公开
标题翻译：用于局部应用和寡核苷酸转运的组合物和方法
公开(公告)号：US20120065131A1
公开(公告)日：2012-03-15
申请号：US13220569
申请日：2011-08-29
申请人： Michael D. Dake , Jacob M. Waugh
发明人： Michael D. Dake , Jacob M. Waugh
IPC分类号： A61K38/08 , A61P25/00 , A61P17/10 , A61Q7/00 , A61P35/00 , A61K8/64 , A61K38/10 , A61P25/16 , A61P25/08 , A61P27/16 , A61P43/00 , A61P17/06 , A61P17/02 , A61P5/00 , A61P13/00 , A61P7/00 , A61P21/00
CPC分类号： A61K9/7023 , A61K8/64 , A61K38/08 , A61Q7/00 , A61Q15/00 , C07K14/33
摘要： The invention relates to the transdermal application of oligopeptides for reducing synaptic transmission in tissues of an animal. In one aspect, this invention relates to compositions comprising an oligopeptide and optionally a carrier comprising a positively charged “backbone” having positively charged branching or “efficiency” groups, as described herein. Most preferably the positively charged carrier is a long-chain positively charged polypeptide or a positively charged nonpeptidyl polymer, for example, a polyalkyleneimine. The invention further relates methods for producing a biologic effect of reducing synaptic transmission in a tissue by topically applying an effective amount of such a composition, preferably to the skin, of a subject or patient in need of such treatment. This invention also provides kits for preparing or formulating a composition that comprises the oligopeptide and optionally a carrier, as well as such additional items that are needed to produce a usable formulation, or a premix that may in turn be used to produce such a formulation.
摘要翻译：本发明涉及用于减少动物组织中突触传递的寡肽的透皮应用。一方面，本发明涉及包含寡肽和任选的载体的组合物，其包含具有带正电荷的支化或“效率”基团的带正电荷的“骨架”，如本文所述。最优选地，带正电荷的载体是长链带正电荷的多肽或带正电荷的非肽基聚合物，例如聚亚烷基亚胺。本发明还涉及用于通过局部施用有效量的这种组合物，优选给予需要这种治疗的受试者或患者的皮肤来产生减少组织中突触传递的生物学效应的方法。本发明还提供用于制备或配制包含寡肽和任选的载体的组合物的试剂盒，以及产生可用制剂所需的其它物质，或可以依次用于制备这种制剂的预混物。

8. 发明申请

US20090087457A1 Compositions and Methods for Topical Application and Transdermal Delivery of Botulinum Toxins 有权
标题翻译：肉毒毒素的局部应用和透皮输送的组合物和方法
公开(公告)号：US20090087457A1
公开(公告)日：2009-04-02
申请号：US11816602
申请日：2006-03-03
申请人： Michael D. Dake , Jacob M. Waugh
发明人： Michael D. Dake , Jacob M. Waugh
IPC分类号： A61K39/08 , A61P17/00
CPC分类号： A61K38/4893 , A61K8/64 , A61K9/00 , A61K9/0014 , A61K9/0019 , A61K47/34 , A61K2800/56 , A61Q19/08 , C12Y304/24069
摘要： Improved formulations for transdermal delivery of botulinum toxin are disclosed. The formulations include, for example, botulinum toxin non-covalently associated with a positively charged backbone having branching or efficiency groups. The formulations also include a partitioning agent, oligo-bridge, or polyanion bridge, and may optionally contain a viscosity modifying agent. The formulations are designed for topical application onto the skin of a patient and may be used to treat wrinkles, hyperhidrosis, and other health-related problems. Kits for administration are also described.
摘要翻译：公开了用于肉毒杆菌毒素透皮递送的改进制剂。制剂包括例如与带有支链或效能基团的带正电的骨架非共价结合的肉毒杆菌毒素。制剂还包括分配剂，寡桥或聚阴离子桥，并且可任选地含有粘度调节剂。该制剂被设计用于局部施用于患者的皮肤上，并且可以用于治疗皱纹，多汗症和其他与健康有关的问题。还描述了用于给药的试剂盒。

9. 发明授权

US10172877B2 Compositions and methods for topical diagnostic and therapeutic transport 有权
公开(公告)号：US10172877B2
公开(公告)日：2019-01-08
申请号：US14642580
申请日：2015-03-09
申请人： Michael D. Dake , Jacob M. Waugh
发明人： Michael D. Dake , Jacob M. Waugh
IPC分类号： A61K47/64 , A61K47/59 , A61K9/00 , A61K31/343 , A61K31/4164 , A61K31/4196 , A61K31/4418 , A61K31/496 , A61K31/513 , A61K31/7076 , A61K49/00 , A61K31/7048 , A61K38/17 , A61K38/48 , C07K16/32
摘要： Compositions and methods are provided that are useful for the delivery, including transdermal delivery, of biologically active agents, such as non-protein non-nucleotide therapeutics and protein-based therapeutics excluding insulin, botulinum toxins, antibody fragments, and VEGF. The compositions and methods are particularly useful for topical delivery of antifungal agents and antigenic agents suitable for immunization. Alternatively, the composition can be prepared with components useful for targeting the delivery of the compositions as well as imaging components.

10. 发明授权

US09180081B2 Compositions and methods for topical application and transdermal delivery of botulinum toxins 有权
标题翻译：用于局部应用和经皮递送肉毒杆菌毒素的组合物和方法
公开(公告)号：US09180081B2
公开(公告)日：2015-11-10
申请号：US11367642
申请日：2006-03-03
申请人： Michael D. Dake , Jacob M. Waugh
发明人： Michael D. Dake , Jacob M. Waugh
IPC分类号： A61K38/48 , A61K39/08 , A61K8/64 , A61Q19/08 , A61K9/00
CPC分类号： A61K38/4893 , A61K8/64 , A61K9/00 , A61K9/0014 , A61K9/0019 , A61K47/34 , A61K2800/56 , A61Q19/08 , C12Y304/24069
摘要： Improved formulations for transdermal delivery of botulinum toxin are disclosed. The formulations include, for example, botulinum toxin non-covalently associated with a positively charged backbone having branching or efficiency groups. The formulations also include a partitioning agent, oligo-bridge, or polyanion bridge, and may optionally contain a viscosity modifying agent. The formulations are designed for topical application onto the skin of a patient and may be used to treat wrinkles, hyperhidrosis, and other health-related problems. Kits for administration are also described.
摘要翻译：公开了用于肉毒杆菌毒素透皮递送的改进制剂。制剂包括例如与带有支链或效能基团的带正电的骨架非共价结合的肉毒杆菌毒素。制剂还包括分配剂，寡桥或聚阴离子桥，并且可任选地含有粘度调节剂。该制剂被设计用于局部施用于患者的皮肤上，并且可以用于治疗皱纹，多汗症和其他与健康有关的问题。还描述了用于给药的试剂盒。

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