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1. 发明申请

US20080064049A1 Compositions and methods for treating and diagnosing cancer 有权
标题翻译：用于治疗和诊断癌症的组合物和方法
公开(公告)号：US20080064049A1
公开(公告)日：2008-03-13
申请号：US11591019
申请日：2006-10-31
申请人： Michael Clarke , Tim Hoey , Xinhao Wang , Scott Dylla , Austin Gumey , Pierro Dalerba , Grace Chen , Mark Prince
发明人： Michael Clarke , Tim Hoey , Xinhao Wang , Scott Dylla , Austin Gumey , Pierro Dalerba , Grace Chen , Mark Prince
IPC分类号： G01N33/574 , C12N5/06
CPC分类号： C12N5/0695 , C12N5/0093 , Y10S435/968 , Y10S435/971
摘要： The present invention relates to compositions and methods for characterizing, treating and diagnosing cancer. In particular, the present invention provides a cancer stem cell profile, as well as novel stem cell cancer markers useful for the diagnosis, characterization, prognosis and treatment of cancer and in particular the targeting of solid tumor stem cells.
摘要翻译：本发明涉及用于表征，治疗和诊断癌症的组合物和方法。特别地，本发明提供癌症干细胞概况，以及用于癌症的诊断，表征，预后和治疗的新型干细胞癌标记物，特别是固体肿瘤干细胞的靶向。

2. 发明申请

US20100169990A1 COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING CANCER 审中-公开
标题翻译：用于治疗和诊断癌症的组合物和方法
公开(公告)号：US20100169990A1
公开(公告)日：2010-07-01
申请号：US12650873
申请日：2009-12-31
申请人： Michael F. Clarke , Tim Hoey , Xinhao Wang , Scott Dylla , Austin Gurney , Piero Dalerba , Grace Chen , Mark Prince
发明人： Michael F. Clarke , Tim Hoey , Xinhao Wang , Scott Dylla , Austin Gurney , Piero Dalerba , Grace Chen , Mark Prince
IPC分类号： A01K67/00 , C12N5/00
CPC分类号： C12N5/0695 , C12N5/0093 , Y10S435/968 , Y10S435/971
摘要： The present invention relates to compositions and methods for characterizing, treating and diagnosing cancer. In particular, the present invention provides a cancer stem cell profile, as well as novel stem cell cancer markers useful for the diagnosis, characterization, prognosis and treatment of cancer and in particular the targeting of solid tumor stem cells.
摘要翻译：本发明涉及用于表征，治疗和诊断癌症的组合物和方法。特别地，本发明提供癌症干细胞概况，以及用于癌症的诊断，表征，预后和治疗的新型干细胞癌标记物，特别是固体肿瘤干细胞的靶向。

3. 发明授权

US07723112B2 Compositions and methods for treating and diagnosing cancer 有权
标题翻译：用于治疗和诊断癌症的组合物和方法
公开(公告)号：US07723112B2
公开(公告)日：2010-05-25
申请号：US11591019
申请日：2006-10-31
申请人： Michael F. Clarke , Tim Hoey , Xinhao Wang , Scott Dylla , Austin Gurney , Piero Dalerba , Mark Prince , Grace Chen
发明人： Michael F. Clarke , Tim Hoey , Xinhao Wang , Scott Dylla , Austin Gurney , Piero Dalerba , Mark Prince , Grace Chen
IPC分类号： G01N33/53
CPC分类号： C12N5/0695 , C12N5/0093 , Y10S435/968 , Y10S435/971
摘要： The present invention relates to compositions and methods for characterizing, treating and diagnosing cancer. In particular, the present invention provides a cancer stem cell profile, as well as novel stem cell cancer markers useful for the diagnosis, characterization, prognosis and treatment of cancer and in particular the targeting of solid tumor stem cells.
摘要翻译：本发明涉及用于表征，治疗和诊断癌症的组合物和方法。特别地，本发明提供癌症干细胞概况，以及用于癌症的诊断，表征，预后和治疗的新型干细胞癌标记物，特别是固体肿瘤干细胞的靶向。

4. 发明申请

US20140030788A1 MICROSCALE AND NANOSCALE STRUCTURES FOR MANIPULATING PARTICLES 有权
标题翻译：用于操作颗粒的微结构和纳米结构
公开(公告)号：US20140030788A1
公开(公告)日：2014-01-30
申请号：US13812934
申请日：2011-07-29
申请人： Grace Chen , Fabio Fachin , Mehmet Toner , Brian Wardle
发明人： Grace Chen , Fabio Fachin , Mehmet Toner , Brian Wardle
IPC分类号： C12M1/12
CPC分类号： C12M25/16 , B01L3/502707 , B01L3/502746 , B01L3/502761 , B01L2200/0652 , B01L2200/0668 , B01L2300/0896 , B01L2400/086 , G01N15/1404 , G01N2015/1413
摘要： The devices and systems described herein include one or more fluid paths, e.g., channels, and one or more selectively permeable obstacles arranged in the fluid path(s), each including a plurality of aligned nanostructures, e.g., nanotubes or nanorods, defining an outer surface of the obstacle and an internal network of voids. The obstacle(s) can further include binding moieties applied to the outer surface and/or to the surfaces of the individual nanostructures within the obstacle(s). The devices can be manufactured by forming the dense groupings of nanostructures to extend outwards and upwards from a substrate; forming a fluidic channel, bonding the fluidic channel to the substrate; and optionally applying binding moieties to the obstacles. The devices can be used to manipulate cells within fluid samples.
摘要翻译：本文描述的装置和系统包括一个或多个流体路径，例如通道和布置在流体路径中的一个或多个选择性渗透的障碍物，每个包括多个对准的纳米结构，例如纳米管或纳米棒，限定外部障碍物的表面和内部的空隙网络。障碍物还可包括施加到障碍物内的各个纳米结构的外表面和/或表面的结合部分。可以通过形成从衬底向外和向上延伸的纳米结构的致密分组来制造器件; 形成流体通道，将流体通道粘合到基底上; 并且任选地将结合部分施加到障碍物上。这些装置可用于操纵流体样品中的细胞。

5. 发明申请

US20130295588A1 COUNTING PARTICLES USING AN ELECTRICAL DIFFERENTIAL COUNTER 有权
标题翻译：使用电气差分计数器计数颗粒
公开(公告)号：US20130295588A1
公开(公告)日：2013-11-07
申请号：US13884580
申请日：2011-11-09
申请人： Nicholas Watkins , Rashid Bashir , William Rodriguez , Xuanhong Cheng , Mehmet Toner , Grace Chen , Aaron Oppenheimer
发明人： Nicholas Watkins , Rashid Bashir , William Rodriguez , Xuanhong Cheng , Mehmet Toner , Grace Chen , Aaron Oppenheimer
IPC分类号： G01N27/02
CPC分类号： G01N27/02 , B01L2200/0652 , B01L2300/0877 , C12M41/36 , G01N15/12 , G01N15/1245 , G01N33/56972 , G01N2015/1006 , G01N2015/1486
摘要： This disclosure relates to methods and devices to count particles of interest, such as cells. The methods include obtaining a fluid sample that may contain particles of interest; counting all types of particles in a portion of the sample using a first electrical differential counter to generate a first total; removing any particles of interest from the portion of the fluid sample; counting any particles remaining in the portion of the fluid sample using a second electrical differential counter after the particles of interest are removed to generate a second total; and calculating a number of particles of interest originally in the fluid sample by subtracting the second total from the first total, wherein the difference is the number of particles of interest in the sample. These methods and related devices can be used, for example, to produce a robust, inexpensive diagnostic kit for CD4+ T cell counting in whole blood samples.
摘要翻译：本公开涉及计算感兴趣的颗粒例如细胞的方法和装置。所述方法包括获得可含有感兴趣的颗粒的流体样品; 使用第一电差分计数器对样品的一部分中的所有类型的颗粒计数以产生第一总数; 从流体样品的一部分去除任何感兴趣的颗粒; 在除去感兴趣的颗粒之后，使用第二电差速器计数器在流体样品的部分中剩余的任何颗粒计数以产生第二总数; 以及通过从第一个总计中减去第二个总计来计算最初在流体样品中的感兴趣的颗粒数，其中差值是样品中的感兴趣的颗粒数。这些方法和相关装置可用于例如在全血样品中产生用于CD4 + T细胞计数的稳健且廉价的诊断试剂盒。

6. 发明申请

US20130055409A1 DYNAMIC REDEMPTION CODES 有权
标题翻译：动态赎回代码
公开(公告)号：US20130055409A1
公开(公告)日：2013-02-28
申请号：US13220312
申请日：2011-08-29
申请人： Grace Chen , Jennifer Woldman
发明人： Grace Chen , Jennifer Woldman
IPC分类号： G06F21/24
CPC分类号： G06Q30/0225 , G06Q30/0207
摘要： Information regarding a redemption code may include at least one parameter associated with certain redeemable content. Requests may be received from a user. The request may concern access to redeemable content associated with a redemption code. The applicability of parameters is determined as is the redeemable content associated with the identified parameter. The user may then be granted access to the identified redeemable content. The determination of applicable parameters may include identifying an associated modification and applying the modification to the redemption code in order to identify the redeemable content.
摘要翻译：关于兑换代码的信息可以包括与某些可兑换内容相关联的至少一个参数。可以从用户接收请求。该请求可能涉及访问与兑换代码相关联的可兑换内容。确定参数的适用性以及与所识别的参数相关联的可兑换内容。然后可以向用户授予对所识别的可兑换内容的访问权限。确定适用的参数可以包括识别相关联的修改并将修改应用于兑换代码，以便识别可兑换内容。

7. 发明申请

US20130054689A1 REDEEMABLE CONTENT SPECIFIC TO GROUPS 审中-公开
标题翻译：特定的重要内容
公开(公告)号：US20130054689A1
公开(公告)日：2013-02-28
申请号：US13220315
申请日：2011-08-29
申请人： Jennifer Woldman , Cindy De Guzman , Grace Chen
发明人： Jennifer Woldman , Cindy De Guzman , Grace Chen
IPC分类号： G06F15/16
CPC分类号： H04N21/25866 , H04N21/4781 , H04N21/4784 , H04N21/6581
摘要： Information regarding a user may be indicative of membership in a group. Such information may be maintained for every user associated with a particular system or title. In instances, redeemable content may be offered exclusively to a group. Requests for such content may therefore be received and evaluated to determine whether the requesting user is a member of the particular group. The determination includes an evaluation of information associated with the requesting user. In some instances, the information associated with the requesting user is a user identifier that is indicative of the group membership, and the user identifier may be included in the request. If the user is indeed determined to be a member of the group, access to the redeemable content is granted. Alternatively, if the user is not determined to be a member of the group, access to the redeemable content is denied.
摘要翻译：关于用户的信息可以指示组中的成员资格。可以为与特定系统或标题相关联的每个用户维护这样的信息。在实例中，可兑换内容可以专门提供给组。因此，可以接收并评估对这些内容的请求以确定请求用户是否是特定组的成员。确定包括对与请求用户相关联的信息的评估。在一些情况下，与请求用户相关联的信息是指示组成员身份的用户标识符，并且用户标识符可以被包括在请求中。如果确实确定用户是该组的成员，则授予对可兑换内容的访问权限。或者，如果用户未被确定为该组的成员，则拒绝对可兑换内容的访问。

8. 发明授权

US08744971B2 Dynamic redemption codes 有权
标题翻译：动态兑换代码
公开(公告)号：US08744971B2
公开(公告)日：2014-06-03
申请号：US13220312
申请日：2011-08-29
申请人： Grace Chen , Jennifer Woldman
发明人： Grace Chen , Jennifer Woldman
IPC分类号： G06F21/00 , G06Q20/00
CPC分类号： G06Q30/0225 , G06Q30/0207
摘要： Information regarding a redemption code may include at least one parameter associated with certain redeemable content. Requests may be received from a user. The request may concern access to redeemable content associated with a redemption code. The applicability of parameters is determined as is the redeemable content associated with the identified parameter. The user may then be granted access to the identified redeemable content. The determination of applicable parameters may include identifying an associated modification and applying the modification to the redemption code in order to identify the redeemable content.
摘要翻译：关于兑换代码的信息可以包括与某些可兑换内容相关联的至少一个参数。可以从用户接收请求。该请求可能涉及访问与兑换代码相关联的可兑换内容。确定参数的适用性以及与所识别的参数相关联的可兑换内容。然后可以向用户授予对所识别的可兑换内容的访问权限。确定适用的参数可以包括识别相关联的修改并将修改应用于兑换代码，以便识别可兑换内容。

9. 发明授权

US08370494B1 System and method for customized I/O fencing for preventing data corruption in computer system clusters 有权
公开(公告)号：US08370494B1
公开(公告)日：2013-02-05
申请号：US12558697
申请日：2009-09-14
申请人： Grace Chen , Bob Schatz , Shardul Divatia
发明人： Grace Chen , Bob Schatz , Shardul Divatia
IPC分类号： G06F15/177 , G06F15/16 , G06F13/28 , G06F11/00
CPC分类号： G06F11/004 , G06F11/2023
摘要： Systems, methods, apparatus and software can implement a flexible I/O fence mechanism framework allowing clustered computer systems to conveniently use one or more I/O fencing techniques. Various different fencing techniques can be used, and fencing mechanism can be customized.

10. 外观设计

USD875137S1 Display screen with a graphical user interface 有权
公开(公告)号：USD875137S1
公开(公告)日：2020-02-11
申请号：US29666823
申请日：2018-10-16
申请人： Jennifer F. Bickerstaff , Shawna Marie Kirby , Kylie Tuosto , John Davidge , Danilo Bangit , Rajeev Goonewardene , Scott Hang Ng , Clayton Yan , Jasmine Woo , Hetal A. Soni , Grace Chen
设计人： Jennifer F. Bickerstaff , Shawna Marie Kirby , Kylie Tuosto , John Davidge , Danilo Bangit , Rajeev Goonewardene , Scott Hang Ng , Clayton Yan , Jasmine Woo , Hetal A. Soni , Grace Chen
摘要： The FIGURE is a front view of a display screen with a graphical user interface showing our new design.
The broken dot-dashed lines showing a perimeter of a display screen are included for purposes of illustrating an interface environment, and form no part of the claimed design. The remaining broken lines show elements of the graphical user interface and form no part of the claimed design.

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