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1. 发明申请

US20060115808A1 Microarrays of functional biomolecules, and uses therefor 审中-公开
公开(公告)号：US20060115808A1
公开(公告)日：2006-06-01
申请号：US11238245
申请日：2005-09-29
申请人： Michael Cardone , Ulrik Nielsen , Gavin MacBeath , James Marks , Peter Sorger , Anthony Sinskey
发明人： Michael Cardone , Ulrik Nielsen , Gavin MacBeath , James Marks , Peter Sorger , Anthony Sinskey
IPC分类号： C12Q1/70 , G01N33/542 , C12M1/34 , G01N33/53
CPC分类号： C40B30/04 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00619 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00707 , B01J2219/00725 , C07K17/06 , C40B40/10 , G01N33/5079 , G01N33/54353 , G01N33/68 , G01N33/6842 , G01N33/6845 , G01N33/6848 , G01N33/6851
摘要： Disclosed are products and methods to facilitate the identification of compounds that are capable of interacting with biological macromolecules of interest, especially when such macromolecules are attached to a support surface in microarray. Aspects of the invention concern attachment chemistry, peptide labeling, antibody preparation, applications and so on.

2. 发明申请

US20060115810A1 Microarrays of functional biomolecules, and uses therefor 审中-公开
公开(公告)号：US20060115810A1
公开(公告)日：2006-06-01
申请号：US11239652
申请日：2005-09-29
申请人： Michael Cardone , Ulrik Nielsen , Gavin MacBeath , James Marks , Peter Sorger , Anthony Sinskey
发明人： Michael Cardone , Ulrik Nielsen , Gavin MacBeath , James Marks , Peter Sorger , Anthony Sinskey
IPC分类号： C12Q1/70 , G01N33/542 , C12M1/34 , G01N33/543 , G01N33/53
CPC分类号： C40B30/04 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00619 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00707 , B01J2219/00725 , C07K17/06 , C40B40/10 , G01N33/5079 , G01N33/54353 , G01N33/68 , G01N33/6842 , G01N33/6845 , G01N33/6848 , G01N33/6851
摘要： Disclosed are products and methods to facilitate the identification of compounds that are capable of interacting with biological macromolecules of interest, especially when such macromolecules are attached to a support surface in microarray. Aspects of the invention concern attachment chemistry, peptide labeling, antibody preparation, applications and so on.

3. 发明申请

US20060115809A1 Microarrays of functional biomolecules, and uses therefor 审中-公开
标题翻译：功能性生物分子的微阵列及其用途
公开(公告)号：US20060115809A1
公开(公告)日：2006-06-01
申请号：US11238683
申请日：2005-09-29
申请人： Michael Cardone , Ulrik Nielsen , Gavin MacBeath , James Marks , Peter Sorger , Anthony Sinskey
发明人： Michael Cardone , Ulrik Nielsen , Gavin MacBeath , James Marks , Peter Sorger , Anthony Sinskey
IPC分类号： C12Q1/70 , G01N33/542 , G01N33/543 , G01N33/53
CPC分类号： C40B30/04 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00619 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00707 , B01J2219/00725 , C07K17/06 , C40B40/10 , G01N33/5079 , G01N33/54353 , G01N33/68 , G01N33/6842 , G01N33/6845 , G01N33/6848 , G01N33/6851
摘要： Disclosed are products and methods to facilitate the identification of compounds that are capable of interacting with biological macromolecules of interest, especially when such macromolecules are attached to a support surface in microarray. Aspects of the invention concern attachment chemistry, peptide labeling, antibody preparation, applications and so on.
摘要翻译：公开了促进鉴定能够与感兴趣的生物大分子相互作用的化合物的产物和方法，特别是当这种大分子连接到微阵列中的支持物表面时。本发明的方面涉及附着化学，肽标记，抗体制备，应用等。

4. 发明申请

US20060263801A1 Methods of high-throughput screening for internalizing antibodies 审中-公开
公开(公告)号：US20060263801A1
公开(公告)日：2006-11-23
申请号：US11361312
申请日：2006-02-24
申请人： James Marks , Ulrik Nielsen , Dimitri Kirpotin
发明人： James Marks , Ulrik Nielsen , Dimitri Kirpotin
IPC分类号： C12Q1/70 , C12Q1/68
CPC分类号： G01N33/5011 , C40B30/04 , G01N33/5008 , G01N33/5432 , G01N33/566 , G01N33/6845 , G01N33/6854 , G01N33/6863
摘要： This invention provides methods of identifying ligands that are internalized into a cell. The methods typically involve i) contacting the cell with a reporter non-covalently coupled to a ligand; ii) dissociating the reporter from the ligand and removing dissociated reporter from the surface of the cell; and iii) detecting the reporter within said cell (if any is present) where the presence of the reporter within said cell indicates that the ligand binds to an internalizing receptor and is internalized.

5. 发明申请

US20100063868A1 SYSTEM AND METHOD FOR TARGETING RETAIL INVESTOR COMMUNICATIONS 审中-公开
标题翻译：零售投资者通信的系统与方法
公开(公告)号：US20100063868A1
公开(公告)日：2010-03-11
申请号：US12398902
申请日：2009-03-05
申请人： Matthew Bird , James Marks
发明人： Matthew Bird , James Marks
IPC分类号： G06Q40/00 , G06Q10/00
CPC分类号： G06Q40/06 , G06Q30/0201
摘要： Real time market surveillance systems and methods are described that provide or timely communicate actionable intelligence to market investors. The system and methods employ Internet-based surveillance and push technologies to survey multiple market intelligence sources and engage in market analytics to provide updated, actionable intelligence to assist and enhance transactional decisions by market investors.
摘要翻译：描述了实时市场监控系统和方法，向市场投资者提供或及时传达可操作的智能。该系统和方法采用基于互联网的监控和推动技术来调查多个市场情报来源，并从事市场分析，提供更新，可操作的情报，以协助和加强市场投资者的交易决策。

6. 发明授权

US09492569B2 Antibodies that bind integrin alpha-V beta-8 有权
标题翻译：结合整合素α-Vβ-8的抗体
公开(公告)号：US09492569B2
公开(公告)日：2016-11-15
申请号：US14239124
申请日：2012-08-17
申请人： Stephen Nishimura , Jianlong Lou , Jody Lynn Baron , James Marks
发明人： Stephen Nishimura , Jianlong Lou , Jody Lynn Baron , James Marks
IPC分类号： A61K38/00 , A61K39/00 , C07K16/18 , A61K49/00 , C07K14/705 , C07K16/28
CPC分类号： A61K49/00 , A01K2207/15 , A01K2217/075 , A61K2039/505 , C07K14/70546 , C07K16/2839 , C07K2317/24 , C07K2317/30 , C07K2317/34 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： Provided herein are antibodies with high affinity for the β8 subunit of αvβ8.
摘要翻译：本文提供了对αvβ8的β8亚基具有高亲和力的抗体。

7. 发明申请

US20050186214A1 Prostate cancer specific internalizing human antibodies 有权
标题翻译：前列腺癌特异性内化人抗体
公开(公告)号：US20050186214A1
公开(公告)日：2005-08-25
申请号：US11021438
申请日：2004-12-21
申请人： Bin Liu , James Marks
发明人： Bin Liu , James Marks
IPC分类号： A61K39/395 , C07K16/30 , C12P21/08 , G01N33/574
CPC分类号： C07K16/3069 , A61K2039/505 , C07K2317/622 , C07K2317/73 , C07K2317/77
摘要： This invention provides novel prostate cancer specific internalizing human antibodies. The antibodies are useful by themselves to prevent growth and/or proliferation of prostate cancer cells. The antibodies can also be formulated as chimeric molecules to direct an effector (e.g. a cytotoxin, an imaging reagent, a drug, etc.) to a prostate tumor site.
摘要翻译：本发明提供了新型前列腺癌特异性内化人抗体。抗体本身可用于预防前列腺癌细胞的生长和/或增殖。抗体还可以配制成嵌合分子以将效应物（例如细胞毒素，成像试剂，药物等）引导至前列腺肿瘤部位。

8. 发明申请

US20050037339A1 Methods of selecting internalizing antibodies 审中-公开
标题翻译：选择内化抗体的方法
公开(公告)号：US20050037339A1
公开(公告)日：2005-02-17
申请号：US10855755
申请日：2004-05-26
申请人： James Marks , Marie Poul , Baltazar Becerril
发明人： James Marks , Marie Poul , Baltazar Becerril
IPC分类号： G01N33/68 , A61K38/00 , A61K39/395 , A61K47/48 , A61P37/02 , C07K14/01 , C07K16/28 , C07K16/32 , C12N15/09 , C12N15/10 , C12N15/86 , C12Q1/70 , C40B20/08 , C40B30/04 , C40B40/02 , C40B50/06 , G01N33/15 , G01N33/50 , G01N33/554 , G01N33/566 , C12Q1/68 , G01N33/53
CPC分类号： C12N15/1037 , A61K38/00 , A61K47/6843 , C07K14/005 , C07K16/2863 , C07K16/2881 , C07K16/32 , C07K2317/21 , C07K2317/622 , C07K2317/626 , C07K2317/77 , C07K2319/02 , C12N15/86 , C12N2795/10022
摘要： This invention provides methods of selecting antibodies that are internalized into target cells. The methods generally involve contacting target cells with one or more members of an antibody phage display library. The members of the phage display library are also contacted with cells of a subtractive cell line. The target cells are then washed to remove the subtractive cell line cells and members of the phage display library that are non-specifically bound or weakly bound to the target cells. The target cells are cultured under conditions where members of the phage display library can be internalized if bound to an internalizing marker and internalized members of the phage display library are then identified.
摘要翻译：本发明提供了选择内化于靶细胞中的抗体的方法。所述方法通常涉及使靶细胞与抗体噬菌体展示文库的一个或多个成员接触。噬菌体展示文库的成员也与减数细胞系的细胞接触。然后洗涤靶细胞以除去非特异性结合或弱结合到靶细胞的消减细胞系细胞和噬菌体展示文库的成员。靶细胞在噬菌体展示文库的成员可以内化的条件下培养，如果结合到内化标记物，然后鉴定噬菌体展示文库的内化成员。

9. 发明申请

US20140271478A1 ANTIBODIES THAT BIND INTEGRIN ALPHA-V BETA-8 有权
标题翻译： BIND INTEGRIN ALPHA-V BETA-8的抗体
公开(公告)号：US20140271478A1
公开(公告)日：2014-09-18
申请号：US14239124
申请日：2012-08-17
申请人： Stephen Nishimura , Jianlong Lou , Jody Lynn Baron , James Marks
发明人： Stephen Nishimura , Jianlong Lou , Jody Lynn Baron , James Marks
IPC分类号： C07K16/28 , A61K49/00
CPC分类号： A61K49/00 , A01K2207/15 , A01K2217/075 , A61K2039/505 , C07K14/70546 , C07K16/2839 , C07K2317/24 , C07K2317/30 , C07K2317/34 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： Provided herein are antibodies with high affinity for the β8 subunit of αβ8.
摘要翻译：本文提供了对α＆bgr的8亚基具有高亲和力的抗体; 8。

10. 发明申请

US20060225291A1 Pipe cutting template 失效
标题翻译：管道切割模板
公开(公告)号：US20060225291A1
公开(公告)日：2006-10-12
申请号：US11398781
申请日：2006-04-05
申请人： James Marks
发明人： James Marks
IPC分类号： B43L9/00
CPC分类号： B43L13/20
摘要： A universal reusable template for cutting ends of cylindrical objects such as pipes, in preparation for joining the cylindrical objects to other cylindrical bodies. The template is formed as a flat flexible bendable sheet with magnetic properties allowing the sheet to be temporarily secured on a metal pipe. The front face of the sheet has reference indicia corresponding to contour lines of a desired cut to be made in the end of the cylindrical body. The cut lines represent most conventional types and sizes of lateral-type cuts, eccentric cuts and saddle-type cuts, with pipe diameters ranging from about 3″ to about 24″.
摘要翻译：用于切割诸如管子的圆柱形物体的端部的通用可重用模板，以准备将圆柱形物体接合到其它圆柱体。模板形成为具有磁性能的扁平柔性可弯曲片材，其允许片材临时固定在金属管上。片材的正面具有对应于要在圆柱体的端部制成的期望切口的轮廓线的参考标记。切割线表示大多数常规类型和尺寸的横向切割，偏心切割和鞍形切割，管直径范围为约3“至约24”。

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