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1. 发明授权

US5866709A Process for making aromatic nitriles 失效
标题翻译：制备芳香腈的方法
公开(公告)号：US5866709A
公开(公告)日：1999-02-02
申请号：US982611
申请日：1997-12-02
申请人： Michael C. Hausladen , Bao-Guo Huang , David Y. Tang
发明人： Michael C. Hausladen , Bao-Guo Huang , David Y. Tang
IPC分类号： C07C253/28 , C07C253/00 , C07C253/34 , C07C255/50 , C07C255/00
CPC分类号： C07C253/00
摘要： Disclosed is a process for making an aromatic nitrile by reacting a benzotrichloride with an ammonium halide in the presence of an oxygen-donating initiator at a temperature of about 150.degree. to about 250.degree. C. An optional catalyst of a metal oxide or a metal salt can be used if desired.
摘要翻译：公开了一种在约150至约250℃的温度下，在给氧引发剂存在下，使苯并三氯化物与卤化铵反应制备芳族腈的方法。任选的金属氧化物或金属盐的催化剂如果需要可以使用。

2. 发明授权

US6153810A Highly selective process for making o-arylbenzonitriles 失效
标题翻译：制备邻芳基苯腈的高选择性方法
公开(公告)号：US6153810A
公开(公告)日：2000-11-28
申请号：US70467
申请日：1998-04-30
申请人： Bao-Guo Huang , David Y. Tang
发明人： Bao-Guo Huang , David Y. Tang
IPC分类号： C07C253/30 , C07C255/49 , C07C255/51 , C07C255/00
CPC分类号： C07C253/30
摘要： Disclosed is a method of making an o-arylbenzonitrile by reacting o-chlorobenzonitrile with a substituted phenylzinc halide. The reaction is performed in the presence of a nickel catalyst, an ethereal solvent, and N-methylpyrrolidinone as a cosolvent.
摘要翻译：公开了通过邻氯苄腈与取代的苯基卤化锌反应制备邻 - 芳基苄腈的方法。该反应是在镍催化剂，醚类溶剂和作为助溶剂的N-甲基吡咯烷酮的存在下进行的。

3. 发明授权

US5874606A Process for making o-arylbenzonitriles 失效
标题翻译：制备邻芳基苯腈的方法
公开(公告)号：US5874606A
公开(公告)日：1999-02-23
申请号：US52556
申请日：1998-03-31
申请人： Bao-Guo Huang , David Y. Tang
发明人： Bao-Guo Huang , David Y. Tang
IPC分类号： C07C253/30 , C07C255/50 , C07C255/00
CPC分类号： C07C255/50 , C07C253/30
摘要： Disclosed is a method of making an o-arylbenzonitrile. A mixture is prepared of o-chlorobenzonitrile and about 1.0 to about 2.0 equivalents per equivalent of o-chlorobenzonitrile of a substituted phenylmagnesium halide in about 5 to about 30 mL per gram of o-chlorobenzonitrile of a solvent system of an ethereal solvent and N-methyl pyrrolidinone. The o-chlorobenzonitrile is reacted with the substituted phenylmagnesium halide at a temperature of about 10-.degree. to about 25.degree. C.
摘要翻译：公开了一种制备邻 - 芳基苄腈的方法。制备邻氯苯甲腈和约1.0至约2.0当量/当量邻氯苯甲腈的取代苯基卤化镁在约5至约30mL /克邻苯二甲酰氯溶剂体系的邻氯苄腈中的溶液和N- 甲基吡咯烷酮。邻氯苯甲腈与取代的苯基卤化镁在约10-约25℃的温度下反应。

4. 发明授权

US06417407B1 Method of making 2-bromo-4-chloro substituted phenols 失效
标题翻译：制备2-溴-4-氯取代的酚的方法
公开(公告)号：US06417407B1
公开(公告)日：2002-07-09
申请号：US09502082
申请日：2000-02-10
申请人： Bao-Guo Huang , Lawrence B. Fertel
发明人： Bao-Guo Huang , Lawrence B. Fertel
IPC分类号： C07C4563
CPC分类号： C07C45/63 , C07C47/565
摘要： A 2-bromo-4-chloro substituted phenol is prepared from a first composition of a substituted phenol and benzotrifluoride in a weight ratio to the substituted phenol of about 2 to about 4. Into the first composition is sparged about 1 to about 1.5 equivalents of chlorine gas, whereby the substituted phenol is chlorinated to form a 4-chloro substituted phenol. The first composition is cooled to precipitate the 4-chloro substituted phenol, which can be isolated by filtration. A second composition is formed of the 4-chloro substituted phenol, acetic acid in an weight ratio to the 4-chloro substituted phenol of about 1 to about 2, about 1 to about 2 equivalents of a salt of a strong base and a weak acid, and about 1 to about 5 equivalents of a brominating agent, whereby the 4-chloro substituted phenol is brominated to form a 2-bromo-4-chloro substituted phenol.
摘要翻译：由与取代苯酚重量比为约2至约4的取代苯酚和三氟甲苯的第一组合物制备2-溴-4-氯取代的苯酚。向第一组合物中喷射约1至约1.5当量的氯气，由此将取代的苯酚氯化以形成4-氯取代的苯酚。将第一组合物冷却以沉淀4-氯取代的苯酚，其可以通过过滤分离。第二组合物由4-氯取代的苯酚，与4-氯取代的苯酚的重量比为约1至约2，约1至约2当量的强碱和弱酸的盐形成的乙酸和约1至约5当量的溴化剂，由此将4-氯取代的苯酚溴化以形成2-溴-4-氯取代的苯酚。

5. 发明授权

US08283374B2 Process for preparing (3-oxo-2,3-dihydro-1H-isoindol-1-yl) acetylguanidine derivatives 有权
标题翻译：制备（3-氧代-2,3-二氢-1H-异吲哚-1-基）乙酰基胍衍生物的方法
公开(公告)号：US08283374B2
公开(公告)日：2012-10-09
申请号：US12417179
申请日：2009-04-02
申请人： Gerrit Schubert , Joerg Rieke-Zapp , Johannes Keil , Heinz-Werner Kleemann , Reda Hanna , Bao-Guo Huang , Xiao-Dong Wu , Yves Gouraud
发明人： Gerrit Schubert , Joerg Rieke-Zapp , Johannes Keil , Heinz-Werner Kleemann , Reda Hanna , Bao-Guo Huang , Xiao-Dong Wu , Yves Gouraud
IPC分类号： A61K31/4035 , C07D209/46
CPC分类号： A61K31/4035
摘要： The present invention relates to processes for preparing (3-oxo-2,3-dihydro-1H-isoindol-1-yl)acetylguanidine derivatives of the formula I via 3-hydroxy-2,3-dihydro-1H-isoindol-1-one derivatives or 3-(2-carbamoylphenyl)-acrylic ester derivatives as intermediates, to a process for optical resolution, and to intermediates of the process according to the invention.
摘要翻译：本发明涉及通过3-羟基-2,3-二氢-1H-异吲哚-1-酮制备式I的（3-氧代-2,3-二氢-1H-异吲哚-1-基）乙酰基胍衍生物的方法，一种衍生物或3-（2-氨基甲酰基苯基） - 丙烯酸酯衍生物作为中间体，用于光学拆分的方法，以及根据本发明的方法的中间体。

6. 发明授权

US07626027B2 Substituted 1H-pyrrolo[2,3-c]pyridine-2-carboxamides and related analogs as inhibitors of casein kinase Iε 有权
标题翻译：取代的1H-吡咯并[2,3-c]吡啶-2-甲酰胺和相关类似物作为酪蛋白激酶Iepsilon的抑制剂
公开(公告)号：US07626027B2
公开(公告)日：2009-12-01
申请号：US12106681
申请日：2008-04-21
申请人： William A. Metz, Jr. , Frank Halley , Gilles Dutruc-Rosset , Yong Mi Choi-Sledeski , Gregory Bernard Poli , David Marc Fink , Gilles Doerflinger , Bao-Guo Huang , Ann Marie Gelormini , Juan Anotonio Gamboa , Andrew Giovanni , Joachim E. Roehr , Joseph T. Tsay , Fernando Camacho , William Joseph Hurst , Stephen Wayne Harnish , Yulin Chiang
发明人： William A. Metz, Jr. , Frank Halley , Gilles Dutruc-Rosset , Yong Mi Choi-Sledeski , Gregory Bernard Poli , David Marc Fink , Gilles Doerflinger , Bao-Guo Huang , Ann Marie Gelormini , Juan Anotonio Gamboa , Andrew Giovanni , Joachim E. Roehr , Joseph T. Tsay , Fernando Camacho , William Joseph Hurst , Stephen Wayne Harnish , Yulin Chiang
IPC分类号： C07D471/02
CPC分类号： C07D471/04
摘要： The present invention discloses and claims compounds of formula (I) wherein M is N, and K and L are each C with the remaining substituents further defined herein. These compounds are effective as inhibitors of human casein kinase Iε, and as such are useful in the treatment of central nervous system diseases and disorders including mood disorders and sleep disorders. Pharmaceutical compositions comprising compounds of formula (I) and methods for the preparation of compounds of formula (I) are also disclosed and claimed.
摘要翻译：本发明公开并要求其中M为N的式（I）化合物，并且K和L各自为C，其余取代基进一步定义。这些化合物作为人酪氨酸激酶Iepsilon的抑制剂是有效的，因此可用于治疗中枢神经系统疾病和病症，包括情绪障碍和睡眠障碍。还公开并要求保护包含式（I）化合物和制备式（I）化合物的方法的药物组合物。

7. 发明授权

US07186705B2 Process for the preparation of 3-amino-2-hydroxypropylphosphinic acid derivatives 有权
标题翻译： 3-氨基-2-羟丙基次膦酸衍生物的制备方法
公开(公告)号：US07186705B2
公开(公告)日：2007-03-06
申请号：US10946869
申请日：2004-09-22
申请人： Bao-Guo Huang , Witold Subotkowski , Duane Rudisill
发明人： Bao-Guo Huang , Witold Subotkowski , Duane Rudisill
IPC分类号： A61K31/66 , C07F9/28
CPC分类号： C07F9/306 , C07F9/301
摘要： The present invention relates to a process for the preparation of 3-amino-2-hydroxypropylphosphinic acid derivatives of the formula I, which are valuable pharmaceutical active ingredients and can be used, for example, as antidepressants. The process starts from O-ethyl phosphinates of the formula II into which, after silylation with hexamethyldisilazane, the 3-amino-2-hydroxypropyl moiety is introduced by reactions with epichlorohydrin and ammonia.
摘要翻译：本发明涉及一种制备式I的3-氨基-2-羟丙基次膦酸衍生物的方法，它是有价值的药物活性成分，可用作例如抗抑郁药。该方法从式II的O-乙基次膦酸酯开始，其中在用六甲基二硅氮烷甲硅烷基化之后，通过与表氯醇和氨的反应引入3-氨基-2-羟丙基部分。

8. 发明申请

US20050070507A1 Process for the preparation of 3-amino-2-hydroxypropylphosphinic acid derivatives 有权
标题翻译： 3-氨基-2-羟丙基次膦酸衍生物的制备方法
公开(公告)号：US20050070507A1
公开(公告)日：2005-03-31
申请号：US10946869
申请日：2004-09-22
申请人： Bao-Guo Huang , Witold Subotkowski , Duane Rudisill
发明人： Bao-Guo Huang , Witold Subotkowski , Duane Rudisill
IPC分类号： C07F9/30 , A61K31/66 , C07F9/28
CPC分类号： C07F9/306 , C07F9/301
摘要： The present invention relates to a process for the preparation of 3-amino-2-hydroxypropylphosphinic acid derivatives of the formula I, which are valuable pharmaceutical active ingredients and can be used, for example, as antidepressants. The process starts from O-ethyl phosphinates of the formula II into which, after silylation with hexamethyldisilazane, the 3-amino-2-hydroxypropyl moiety is introduced by reactions with epichlorohydrin and ammonia.
摘要翻译：本发明涉及一种制备式I的3-氨基-2-羟丙基次膦酸衍生物的方法，它是有价值的药物活性成分，可用作例如抗抑郁药。该方法从式II的O-乙基次膦酸酯开始，其中在用六甲基二硅氮烷甲硅烷基化之后，通过与表氯醇和氨的反应引入3-氨基-2-羟丙基部分。

9. 发明授权

US07531569B2 Process for preparing (3-oxo-2,3-dihydro-1H-isoindol-1-yl) acetylguanidine derivatives 有权
标题翻译：制备（3-氧代-2,3-二氢-1H-异吲哚-1-基）乙酰基胍衍生物的方法
公开(公告)号：US07531569B2
公开(公告)日：2009-05-12
申请号：US11001624
申请日：2004-12-01
申请人： Gerrit Schubert , Joerg Rieke-Zapp , Johannes Keil , Heinz-Werner Kleemann , Reda Hanna , Bao-Guo Huang , Xiao-Dong Wu , Yves Gouraud
发明人： Gerrit Schubert , Joerg Rieke-Zapp , Johannes Keil , Heinz-Werner Kleemann , Reda Hanna , Bao-Guo Huang , Xiao-Dong Wu , Yves Gouraud
IPC分类号： A61K31/4035 , C07D209/46 , C07C229/38
CPC分类号： A61K31/4035
摘要： A method and apparatus for preventing board warpage during the application and curing or drying of liquid epoxies, or the like, on printed circuit boards using a clamping fixture assembly, which includes at least one clamping fixture support and at least one clamping fixture overlay. If desired, a plurality of printed circuit boards may be processed using an appropriate clamping fixture assembly. Furthermore, the clamping fixture may be constructed so a slight bow or curvature thereof can counter either a convex or concave bow or curvature of the printed circuit board.In the method, at least one printed circuit board is mounted to a clamping fixture support whereby a clamping fixture overlay is placed on top of the first printed circuit board.
摘要翻译：一种用于在使用夹紧夹具组件的印刷电路板上施加和固化或干燥液体环氧树脂等期间防止板翘曲的方法和装置，其包括至少一个夹紧夹具支架和至少一个夹紧固定盖。如果需要，可以使用适当的夹具组件来处理多个印刷电路板。此外，夹持夹具可以被构造成轻微的弓形或其曲率可以对抗印刷电路板的凸形或凹形弓形或曲率。在该方法中，至少一个印刷电路板安装到夹具固定支架上，由此夹紧夹具覆盖物放置在第一印刷电路板的顶部上。

10. 发明授权

US07402672B2 Substituted 1H-pyrrolo[3,2-b, 3,2-c, and 2,3-c]pyridine-2-carboxamides and related analogs as inhibitors of casein kinase lepsilon 有权
标题翻译：取代的1H-吡咯并[3,2-b，3,2-c和2,3-c]吡啶-2-甲酰胺和相关类似物作为酪蛋白激酶lepsilon的抑制剂
公开(公告)号：US07402672B2
公开(公告)日：2008-07-22
申请号：US11001533
申请日：2004-12-01
申请人： William A. Metz, Jr. , Frank Halley , Gilles Dutruc-Rosset , Yong Mi Choi-Sledeski , Gregory Bernard Poli , David Marc Fink , Gilles Doerflinger , Bao-Guo Huang , Ann Marie Gelormini , Juan Antonio Gamboa , Andrew Giovanni , Joachim E. Roehr , Joseph T. Tsay , Fernando Camacho , William Joseph Hurst , Stephen Wayne Harnish , Yulin Chiang
发明人： William A. Metz, Jr. , Frank Halley , Gilles Dutruc-Rosset , Yong Mi Choi-Sledeski , Gregory Bernard Poli , David Marc Fink , Gilles Doerflinger , Bao-Guo Huang , Ann Marie Gelormini , Juan Antonio Gamboa , Andrew Giovanni , Joachim E. Roehr , Joseph T. Tsay , Fernando Camacho , William Joseph Hurst , Stephen Wayne Harnish , Yulin Chiang
IPC分类号： C07D471/00
CPC分类号： C07D471/04
摘要： The present invention discloses and claims compounds of formula (I) as inhibitors of human casein kinase IF, and methods of using said compounds of formula (I) for treating central nervous system diseases and disorders including mood disorders and sleep disorders. Pharmaceutical compositions comprising compounds of formula (I) and methods for the preparation of compounds of formula (I) are also disclosed and claimed.
摘要翻译：本发明公开并要求作为人酪蛋白激酶IF抑制剂的式（I）化合物，以及使用所述式（I）化合物治疗中枢神经系统疾病和病症（包括情绪障碍和睡眠障碍）的方法。还公开并要求保护包含式（I）化合物和制备式（I）化合物的方法的药物组合物。

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