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1. 发明授权

US06235738B1 Diphenyl-substituted heterocycles with 6-membered ring, processes for the preparation thereof and the use thereof as medicaments 有权
标题翻译：具有6元环的二苯基取代的杂环，其制备方法及其作为药物的用途
公开(公告)号：US06235738B1
公开(公告)日：2001-05-22
申请号：US09290335
申请日：1999-04-12
申请人： Michael Brenner , Rainer Palluk , Marion Wienrich , Thomas Weiser , Enzo Cereda , Maura Bignotti , Carlo Maria Pellegrini , Giovanni Battista Schiavi , Raffaele Cesana
发明人： Michael Brenner , Rainer Palluk , Marion Wienrich , Thomas Weiser , Enzo Cereda , Maura Bignotti , Carlo Maria Pellegrini , Giovanni Battista Schiavi , Raffaele Cesana
IPC分类号： A61K3153
CPC分类号： C07D239/26 , C07D239/36 , C07D251/16 , C07D253/065
摘要： The invention relates to novel diphenyl-substituted heterocycles with 6-membered ring of general formula (I) in which A, X and the residues R1, R2, R3, R4 and R5 are as defined in the claims, processes for the preparation thereof and the use thereof as medicaments.
摘要翻译：本发明涉及具有通式（I）的6-元环的新型二苯基取代的杂环，其中A，X和残基R1，R2，R3，R4和R5如权利要求中所定义，其制备方法和其作为药物的用途。

2. 发明授权

US06255327B1 Diphenyl-substituted heterocycles, processes for preparing them and their use as pharmaceutical compositions 有权
标题翻译：二苯基取代的杂环，其制备方法及其作为药物组合物的用途
公开(公告)号：US06255327B1
公开(公告)日：2001-07-03
申请号：US09290931
申请日：1999-04-13
申请人： Michael Brenner , Wolf-Dietrich Bechtel , Rainer Palluk , Marion Wienrich , Thomas Weiser , Enzo Cereda , Maura Bignotti , Carlo Maria Pellegrini
发明人： Michael Brenner , Wolf-Dietrich Bechtel , Rainer Palluk , Marion Wienrich , Thomas Weiser , Enzo Cereda , Maura Bignotti , Carlo Maria Pellegrini
IPC分类号： C07D27106
CPC分类号： C07D207/333 , C07D231/12 , C07D231/22 , C07D233/64 , C07D249/08 , C07D261/08 , C07D263/32
摘要： The invention relates to new diphenyl-substituted 5-ring heterocycles of general formula (I) wherein A, X and the groups R1, R2, R3, R4 and R5 are defined as in the claims, processes for preparing them and their use as pharmaceutical compositions.
摘要翻译：本发明涉及通式（I）的新的二苯基取代的5-环杂环，其中A，X和R 1，R 2，R 3，R 4和R 5基团如权利要求中所定义，其制备方法及其作为药物组合物。

3. 发明授权

US06277872B1 Oxadiazoles, processes for their preparation and their use as medicaments 有权
标题翻译：恶二唑，其制备方法及其用作药物
公开(公告)号：US06277872B1
公开(公告)日：2001-08-21
申请号：US09284382
申请日：1999-07-26
申请人： Michael Brenner , Roland Maier , Marion Wienrich , Thomas Weiser , Rainer Palluk , Wolf-Dietrich Bechtel , Angelo Sagrada , Helmut Ensinger , Uwe Pschorn , Raffaele Cesana
发明人： Michael Brenner , Roland Maier , Marion Wienrich , Thomas Weiser , Rainer Palluk , Wolf-Dietrich Bechtel , Angelo Sagrada , Helmut Ensinger , Uwe Pschorn , Raffaele Cesana
IPC分类号： C07D27106
CPC分类号： C07D271/06 , C07D413/04
摘要： The invention relates to oxadiazole derivatives of general formula (I) wherein X, Y, Z and R1 are defined as described in the specification and claims, processes for preparing them and their use as pharmaceutical compositions.
摘要翻译：本发明涉及通式（I）的恶二唑衍生物，其中X，Y，Z和R 1如说明书和权利要求书中所述定义，其制备方法及其作为药物组合物的用途。

4. 发明授权

US06492407B2 Pharmaceutical compositions containing triazolones and methods of treating neurodegenerative disease using triazolones 有权
标题翻译：含有三唑酮的药物组合物和使用三唑酮治疗神经变性疾病的方法
公开(公告)号：US06492407B2
公开(公告)日：2002-12-10
申请号：US09840281
申请日：2001-04-23
申请人： Michael Brenner , Wolf-Dietrich Bechtel , Rainer Palluk , Marion Wienrich , Thomas Weiser
发明人： Michael Brenner , Wolf-Dietrich Bechtel , Rainer Palluk , Marion Wienrich , Thomas Weiser
IPC分类号： A61K3141
CPC分类号： C07D401/04 , C07D249/12
摘要： A method for treating a neurodegenerative disease or cerebral ischemia arising from conditions selected from the group consisting of Status epilepticus, hypoglycaemia, hypoxia, anoxia, brain trauma, brain oedema, amyotropic lateral sclerosis, Huntington's disease, Alzheimer's disease, hypotonia, cardiac infarction, brain pressure (elevated intracranial pressure), ischaemic and haemorrhagic stroke, global cerebral ischaemia with heart stoppage, diabetic polyneuropathy, tinnitus, perinatal asphyxia, psychosis, schizophrenia, depression, and Parkinson's disease, the method of treatment comprising administering to a host in need of such treatment a therapeutic amount of a compound of formula (I) wherein R1, R2, R3, R4, R5, R6, and R7 are as defined herein, or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions containing a compound of formula (I).
摘要翻译：一种用于治疗由选自癫痫持续状态，低血糖，缺氧，缺氧，脑外伤，脑水肿，肌萎缩性侧索硬化，亨廷顿舞蹈病，阿尔茨海默氏病，低张力，心肌梗死，脑中的病症引起的神经变性疾病或脑缺血的方法压力（颅内压升高），缺血性和出血性中风，心脏停止的全球性脑缺血，糖尿病性多发性神经病，耳鸣，围产期窒息，精神病，精神分裂症，抑郁症和帕金森病，治疗方法包括向需要这种治疗治疗量的式（I）化合物，其中R 1，R 2，R 3，R 4，R 5，R 6和R 7如本文所定义，或其药学上可接受的盐，以及含有式（I）化合物的药物组合物，。

5. 发明授权

US06051583A 2,3,3a,4,9,9a-hexahydro-8-hydroxy-1H-benz[f]indoles, processes for preparing them and their use as pharmaceutical compositions 有权
标题翻译： 2,3,3a，4,9,9a-六氢-8-羟基-1H-苯并[f]吲哚，其制备方法及其作为药物组合物的用途
公开(公告)号：US06051583A
公开(公告)日：2000-04-18
申请号：US365064
申请日：1999-07-30
申请人： Matthias Grauert , Christoph Hoenke , Adrian Carter , Wolf-Dietrich Bechtel , Thomas Weiser , Rainer Palluk , Uwe Pschorn
发明人： Matthias Grauert , Christoph Hoenke , Adrian Carter , Wolf-Dietrich Bechtel , Thomas Weiser , Rainer Palluk , Uwe Pschorn
IPC分类号： A61K31/403 , A61P3/08 , A61P9/00 , A61P9/06 , A61P9/10 , A61P11/00 , A61P23/02 , A61P25/04 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/28 , A61P43/00 , C07D209/60 , A61K31/40 , C07D209/56 , C07D215/00 , C07D215/16 , C07D401/00
CPC分类号： C07D209/60
摘要： The present invention relates to new substituted 2,3,3a,4,9,9a-hexahydro-8-hydroxy-1H-benz[f]indole derivatives, processes for preparing them and their use as pharmaceutical compositions. The indole derivatives according to the invention correspond to general formula 1:
摘要翻译：本发明涉及新的取代的2,3,3a，4,9,9a-六氢-8-羟基-1H-苯并[f]吲哚衍生物，其制备方法及其作为药物组合物的用途。根据本发明的吲哚衍生物对应于通式1：

6. 发明授权

US06245777B1 N-(5-phenyl-tetrahydrofuranyl)methyl- and N-(6-phenyl-tetrahydropyranyl)methyl-substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-ols 有权
标题翻译： N-（5-苯基 - 四氢呋喃基）甲基和N-（6-苯基 - 四氢吡喃基）甲基取代的1,2,3,4,5,6-六氢-2,6-亚甲基-3-苯并吖辛因-10- ols
公开(公告)号：US06245777B1
公开(公告)日：2001-06-12
申请号：US09510555
申请日：2000-02-22
申请人： Matthias Grauert , Hans Briem , Matthias Hoffmann , Adrian Carter , Thomas Weiser , Wolf-Dietrich Bechtel , Rainer Palluk
发明人： Matthias Grauert , Hans Briem , Matthias Hoffmann , Adrian Carter , Thomas Weiser , Wolf-Dietrich Bechtel , Rainer Palluk
IPC分类号： A61K314748
CPC分类号： C07D405/06
摘要： The present invention relates to N-(5-phenyl-tetrahydrofuranyl)methyl- and N-(6-phenyl-tetrahydropyranyl)methyl-substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-ols of general formula 1, processes for preparing such compounds, pharmaceutical compositions containing such compounds and methods for using such compounds for the treatment of various diseases caused by a functional disorder resulting from overstimulation.
摘要翻译：本发明涉及N-（5-苯基 - 四氢呋喃基）甲基和N-（6-苯基 - 四氢吡喃基）甲基取代的1,2,3,4,5,6-六氢-2,6-亚甲基-3 - 苯扎佐星-10-ols，通式1的制备方法，制备这些化合物的方法，含有这些化合物的药物组合物和使用这些化合物治疗由过度刺激引起的功能障碍引起的各种疾病的方法。

7. 发明授权

US06455538B1 1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocin-10-ols 有权
标题翻译： 1,2,3,4,5,6-六氢-2,6-亚甲基-3-苯并吖庚因-10-ols
公开(公告)号：US06455538B1
公开(公告)日：2002-09-24
申请号：US09523473
申请日：2000-03-10
申请人： Matthias Grauert , Adrian Carter , Wolf-Dietrich Bechtel , Thomas Weiser , Rainer Palluk , Uwe Pschorn
发明人： Matthias Grauert , Adrian Carter , Wolf-Dietrich Bechtel , Thomas Weiser , Rainer Palluk , Uwe Pschorn
IPC分类号： A61K31439
CPC分类号： C07D221/26
摘要： Compounds of general formula I wherein X is a single bond, —O—, C-C4-alkylene, or an alkylene bridge having 1 to 8 carbon atoms which may be branched or unbranched and optionally have one or two oxygen atom(s) anywhere in the bridge; R1 is hydrogen, methyl, ethyl, or phenyl; R2 is hydrogen or methyl; R3 is hydrogen, fluorine, chlorine, bromine, hydroxy, methyl, or methoxy; R4 is hydrogen, methyl, or ethyl; R5 is hydrogen, methyl, or ethyl; R6 is hydrogen, methyl, or ethyl; R7 is tert-butyl, cyclohexyl, phenyl optionally substituted by R9 and R10, which may be identical or different, or; R8 is hydrogen or C1-C4-alkyl; Z is oxygen, NH, or sulfur; R9 is hydrogen, methyl, fluorine, chlorine, bromine, or methoxy; R10 is hydrogen, methyl, fluorine, chlorine, bromine, or methoxy; optionally in the form of the individual optical isomers, mixtures of the individual enantiomers or racemates as well as in the form of the free bases or the corresponding acid addition salts with pharmaceutically acceptable acids.
摘要翻译：通式I的化合物，其中X是单键，-O-，C-C4-亚烷基或具有1至8个碳原子的亚烷基桥，其可以是支链或非支链的，并且任选地在一个或多个氧原子中具有一个或两个氧原子桥梁 R1是氢，甲基，乙基或苯基; R2是氢或甲基; R3是氢，氟，氯，溴，羟基，甲基或甲氧基; R4是氢，甲基或乙基; R5是氢，甲基或乙基; R6是氢，甲基或乙基; R 7是叔丁基，环己基，任选被R 9和R 10取代的苯基，其可以相同或不同，或者R 8是氢或C 1 -C 4 - 烷基; Z是氧，NH或硫; R9是氢，甲基，氟，氯，溴或甲氧基; R 10为氢，甲基，氟，氯，溴或甲氧基; 任选以各种旋光异构体的形式，各个对映异构体或外消旋体的混合物，以及游离碱的形式或与药学上可接受的酸的相应的酸加成盐。

8. 发明授权

US06441237B1 Substituted 3-phenoxy- and 3-phenylalkyloxy-2-phenyl-propylamines 有权
标题翻译：取代的3-苯氧基 - 和3-苯基烷氧基-2-苯基 - 丙胺
公开(公告)号：US06441237B1
公开(公告)日：2002-08-27
申请号：US09507992
申请日：2000-02-18
申请人： Werner Stransky , Matthias Grauert , Adrian Carter , Thomas Weiser , Wolf-Dietrich Bechtel , Helmut Ensinger , Ralf Richard H. Lotz , Rainer Palluk , Uwe Pschorn
发明人： Werner Stransky , Matthias Grauert , Adrian Carter , Thomas Weiser , Wolf-Dietrich Bechtel , Helmut Ensinger , Ralf Richard H. Lotz , Rainer Palluk , Uwe Pschorn
IPC分类号： C07C21500
CPC分类号： C07D295/088 , C07C217/48 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/66 , C07D233/48 , C07D307/52 , C07D309/14
摘要： The present patent application relates to new substituted 3-phenoxy- or 3-phenylalkyloxy-2-phenyl-propylamines of general formula 1, processes for preparing them and their use as pharmaceutical compositions.
摘要翻译：本专利申请涉及通式1的新的取代的3-苯氧基或3-苯基烷氧基-2-苯基 - 丙胺，其制备方法及其作为药物组合物的用途。

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