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    • 1. 发明申请
    • Knowledge discovery tool navigation
    • 知识发现工具导航
    • US20060179069A1
    • 2006-08-10
    • US11127776
    • 2005-05-11
    • Michael BechtelSanjay MathurJordi Arago
    • Michael BechtelSanjay MathurJordi Arago
    • G06F17/30
    • G06N5/022G06F16/20
    • A system including a knowledge model is provided. The system includes an interface for presenting a relationship between two entities of a knowledge model. The interface includes a method that accepts a first input representative of a selection of a first interface item, the first interface item associated with an entity of the knowledge model. The method also includes presenting, in response to the acceptance, a second interface item, the second interface item associated with a second entity of the knowledge model, wherein the second entity has a relationship with the selected entity and the relationship has a relationship type selected from the group consisting of a direct relationship type or a derived relationship type. Finally, the method also includes presenting a relationship indicia representative of the relationship between the first entity and the second entity.
    • 提供了包括知识模型的系统。 该系统包括用于呈现知识模型的两个实体之间的关系的界面。 接口包括一种方法,该方法接受代表第一接口项的选择的第一输入,第一接口项与知识模型的实体相关联。 该方法还包括响应于接受而呈现第二接口项,与知识模型的第二实体相关联的第二接口项,其中第二实体与所选择的实体具有关系,并且关系具有所选择的关系类型 从由直接关系类型或派生关系类型组成的组中。 最后,该方法还包括呈现代表第一实体和第二实体之间的关系的关系标记。
    • 2. 发明申请
    • Knowledge discovery tool relationship generation
    • 知识发现工具关系生成
    • US20060179027A1
    • 2006-08-10
    • US11128427
    • 2005-05-11
    • Michael BechtelSanjay MathurJordi Arago
    • Michael BechtelSanjay MathurJordi Arago
    • G06N5/00
    • G06F17/30731
    • A system for managing a knowledge model defining a plurality of entities is provided. The system includes an extraction tool for extracting data items from disparate data sources that determines if the data item has been previously integrated into the knowledge model. The system also includes an integration tool for integrating the data item into the knowledge model that integrates the data item into the knowledge model only if the data item has not been previously integrated into the knowledge model. Additionally, a relationship tool for identifying, automatically, a plurality of relationships between the plurality of entities may also be provided. The system may also include a data visualization tool for presenting the plurality of entities and the plurality of relationships.
    • 提供了一种用于管理定义多个实体的知识模型的系统。 该系统包括用于从不同数据源提取数据项的提取工具,该数据项确定数据项是否已经被预先集成到知识模型中。 该系统还包括一个集成工具,用于将数据项整合到知识模型中,只有数据项以前未被集成到知识模型中才将数据项集成到知识模型中。 此外,还可以提供用于识别多个实体之间的多个关系的关系工具。 系统还可以包括用于呈现多个实体和多个关系的数据可视化工具。
    • 8. 发明申请
    • REGULATORY PROTEIN PKE#83 FROM HUMAN KERATINOCYTES
    • 人类KERATINOCYTES的调节蛋白PKE#83
    • US20070154911A1
    • 2007-07-05
    • US11566115
    • 2006-12-01
    • Michael KramerMichael BechtelJeanette ReinartzBirgit SchaeferReinhard Wallich
    • Michael KramerMichael BechtelJeanette ReinartzBirgit SchaeferReinhard Wallich
    • C12Q1/68C07H21/04C12P21/06C07K14/78
    • C07K16/18C07K14/4702
    • The invention relates to an isolated polypeptide which is the same as or similar to (i.e., has the same function and effect as) a protein which occurs naturally in human keratinocytes and is more strongly expressed when the keratinocytes are in their activated state. The invention also relates to an isolated nucleic acid which codes a polypeptide or protein of this type that is typical for human keratinocytes and to the use of said polypeptide and said nucleic acid for detection, especially diagnostic purposes and/or for therapeutic purposes or the use of reagents, especially recombinant vector molecules and antibodies, against molecules of this type. The inventive protein has the amino acid sequence shown in sequence protocol SEQ ID NO:3 or an allele or derivative of this amino acid sequence produced therefrom by amino acid substitution, deletion, insertion, or inversion, and the inventive nucleic acid has either the amino acid sequence shown in sequence protocol SEQ ID NO:1 or a nucleotide sequence complementary thereto or a partial sequence of one of these two nucleotide sequences or a nucleotide sequence which is completely or partially hybridizable one of these two nucleotide sequences.
    • 本发明涉及与角质形成细胞处于其活化状态时天然存在的蛋白质相同或相似(即具有与之相同的功能和作用)的分离多肽。 本发明还涉及编码这种类型的多肽或蛋白质的分离的核酸,其是人角质形成细胞的典型特征,以及使用所述多肽和所述核酸进行检测,特别是诊断目的和/或用于治疗目的或使用 的试剂,特别是重组载体分子和抗体。 本发明的蛋白质具有序列方案SEQ ID NO:3所示的氨基酸序列或通过氨基酸取代,缺失,插入或倒位从其产生的该氨基酸序列的等位基因或衍生物,并且本发明的核酸具有氨基酸 序列方案SEQ ID NO:1所示的酸序列或其互补的核苷酸序列或这两个核苷酸序列之一的部分序列或这两个核苷酸序列之一完全或部分杂交的核苷酸序列。