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1. 发明授权

US5955107A Pharmaceutical suspension tablet compositions 失效
标题翻译：药物悬浮液片剂组合物
公开(公告)号：US5955107A
公开(公告)日：1999-09-21
申请号：US989787
申请日：1997-12-12
申请人： Michael Augello , Sheila M. Dell , George A. Agyilirah , George E. Reier
发明人： Michael Augello , Sheila M. Dell , George A. Agyilirah , George E. Reier
IPC分类号： A61K9/00 , A61K9/20
CPC分类号： A61K9/0095 , A61K9/0056
摘要： Rapidly disintegrating and readily suspendible tablets and their method of preparation are disclosed in which there is a therapeutic amount of a pharmacologically active ingredient, 1 to 6 percent croscarmellose sodium, 10 to 50 percent microcrystalline cellulose, and 10 to 50 percent of a coprocessed additive consisting essentially of 75 to 95 percent microcrystalline cellulose and 5 to 25 percent calcium, sodium alginate complex. The tablets are suitable for oral administration of measured-dose suspensions of either water soluble or water insoluble pharmaceuticals.
摘要翻译：公开了快速崩解和容易悬浮的片剂及其制备方法，其中存在治疗量的药理活性成分，1至6％交联羧甲基纤维素钠，10至50％微晶纤维素和10至50％的协同加工添加剂，基本上为75至95％的微晶纤维素和5至25％的钙，藻酸钠复合物。片剂适合于口服施用水溶性或水不溶性药物的测量剂量悬浮液。

2. 发明授权

US6099865A Croscarmellose taste masking 失效
标题翻译：交联巧克力味掩味
公开(公告)号：US6099865A
公开(公告)日：2000-08-08
申请号：US330445
申请日：1999-06-11
申请人： Michael Augello , Sheila M. Dell , George E. Reier , Howard J. Stamato , Lynn M. DiMemmo
发明人： Michael Augello , Sheila M. Dell , George E. Reier , Howard J. Stamato , Lynn M. DiMemmo
IPC分类号： A61K9/00 , A61K9/16 , A61K9/20 , A61K9/50 , A61K9/62
CPC分类号： A61K9/1652 , A61K9/0056 , A61K9/5047 , A61K9/2054 , A61K9/2077 , A61K9/2081
摘要： The present invention describes the use of croscarmellose sodium to coat bitter-tasting active agents in a manner that will mask the bitter taste of these materials, taste masked pharmaceutical compositions in which the particles of pharmaceutically active agent are coated with croscarmellose sodium, taste masked pharmaceutical tablets made therefrom, in which the rapid disintegration of tablets that is imparted by croscarmellose sodium is preserved, and to a method for preparing such coated particles by preparing them in a fluidized bed coating process.
摘要翻译：本发明描述了使用交联羧甲基纤维素钠以掩蔽这些材料的苦味的方式涂上苦味活性剂，其中药物活性剂颗粒用交联羧甲纤维素钠涂覆的掩味药物组合物，掩味药剂由其制备的片剂，其中保存了由交联羧甲基纤维素钠赋予的片剂的快速崩解，以及通过在流化床包衣方法中制备这些包衣颗粒的方法。

3. 发明授权

US5985323A Microcrystalline cellulose/alginate wet granulation excipient/binder 失效
标题翻译：微晶纤维素/藻酸盐湿法造粒赋形剂/粘合剂
公开(公告)号：US5985323A
公开(公告)日：1999-11-16
申请号：US46359
申请日：1998-03-23
申请人： Michael Augello , George E. Reier
发明人： Michael Augello , George E. Reier
IPC分类号： A61K9/16 , A61K9/20
CPC分类号： A61K9/205 , A61K9/1652 , A61K9/2054
摘要： The present invention discloses an improved excipient composition for use as an excipient/binder for wet granulation of pharmaceuticals, a process for preparing the excipient composition, its use in granular pharmaceutical compositions, and compressed pharmaceutical tablets made from the granular pharmaceutical compositions. The excipient composition comprises a dried aqueous slurry of microcrystalline cellulose wetcake and a low viscosity alginate.
摘要翻译：本发明公开了一种用作药物湿法制粒的赋形剂/粘合剂的改进的赋形剂组合物，制备赋形剂组合物的方法，其在粒状药物组合物中的用途，以及由颗粒状药物组合物制成的压缩药片。赋形剂组合物包含微晶纤维素湿饼和低粘度藻酸盐的干燥水性浆液。

4. 发明申请

US20060127451A1 Coating composition 审中-公开
标题翻译：涂料组成
公开(公告)号：US20060127451A1
公开(公告)日：2006-06-15
申请号：US11232690
申请日：2005-09-22
申请人： Michael Augello , Sharon Ray , Jian-Xin Li , Brian Carlin
发明人： Michael Augello , Sharon Ray , Jian-Xin Li , Brian Carlin
IPC分类号： A61K9/68 , A61K9/20 , A61K31/717
CPC分类号： A61K9/2886 , A61K9/2826 , A61K9/2853 , A61K9/286 , A61K9/2866 , A61K9/7007 , A61K31/717
摘要： The present invention is directed to compositions containing: (i) sugar and/or a sugar substitute and (ii) microcrystalline cellulose present in an amount equal to greater than 41% of the total weight of the composition. The present invention is also directed to compositions containing: (i) sugar and/or a sugar substitute and (ii) microcrystalline cellulose having an average particle size equal to or less than 20 microns and present in an amount equal to or greater than 20% of the total weight of the composition. The compositions of the present invention are useful in coating a wide variety of solid forms such as pharmaceutical dosage forms, veterinary dosage forms, nutraceutical dosage forms, food, industrial material, cosmetic material or oral care material. The compositions of the invention are also useful as films such as cast films. The present invention is also directed to methods of making such compositions, as well as methods of coating such compositions on solid forms.
摘要翻译：本发明涉及含有：（i）糖和/或糖替代物的组合物和（ii）等于大于组合物总重量的41％量的微晶纤维素。本发明还涉及含有：（i）糖和/或糖替代物的组合物和（ii）平均粒度等于或小于20微米并且以等于或大于20％的量存在的微晶纤维素，的组合物的总重量。本发明的组合物可用于涂覆各种固体形式，例如药物剂型，兽用剂型，营养制剂剂型，食品，工业材料，化妆品材料或口腔护理材料。本发明的组合物也可用作薄膜如流延膜。本发明还涉及制备这种组合物的方法，以及在固体形式上涂覆这些组合物的方法。

5. 发明授权

US06723342B1 Edible coating composition 失效
标题翻译：食用涂料组合物
公开(公告)号：US06723342B1
公开(公告)日：2004-04-20
申请号：US09632228
申请日：2000-08-04
申请人： Michael Augello , Sheila M. Dell , Domingo C. Tuason , James J. Modliszewski , Thomas A. Ruszkay , David E. Werner
发明人： Michael Augello , Sheila M. Dell , Domingo C. Tuason , James J. Modliszewski , Thomas A. Ruszkay , David E. Werner
IPC分类号： A61K936
CPC分类号： A61K9/286 , A61K9/284 , A61K9/2866
摘要： An edible, hardenable coating composition containing microcrystalline cellulose and carrageenan and at least one of a strengthening polymer, a plasticizer, a surface active agent or a combination thereof. The coating composition of the present invention may be applied to pharmaceutical and veterinary solid dosage forms, confectionery, seeds, animal feed, fertilizers, pesticide tablets, and foods and provides an elegant prompt release coating which does not retard the release of active ingredients from the coated substrate.
摘要翻译：一种含有微晶纤维素和角叉菜胶的可食用，可硬化的涂料组合物和至少一种强化聚合物，增塑剂，表面活性剂或其组合。本发明的涂料组合物可以应用于药物和兽用固体剂型，糖果，种子，动物饲料，肥料，农药片和食品，并提供优雅的快速释放涂层，其不会阻止活性成分从涂层基材。

6. 发明授权

US06709713B2 Edible coating composition 失效
公开(公告)号：US06709713B2
公开(公告)日：2004-03-23
申请号：US10165022
申请日：2002-06-07
申请人： Michael Augello , Sheila M. Dell , Domingo C. Tuason , James J. Modliszewski , Thomas A. Ruszkay , David E. Werner
发明人： Michael Augello , Sheila M. Dell , Domingo C. Tuason , James J. Modliszewski , Thomas A. Ruszkay , David E. Werner
IPC分类号： A61K936
CPC分类号： A61K9/2866 , A61K9/284 , A61K9/286
摘要： An edible, hardenable coating composition containing microcrystalline cellulose and carrageenan and either a strengthening polymer, a plasticizer or both. The coating composition of the present invention may be applied to pharmaceutical and veterinary solid dosage forms, confectionery, seeds, animal feed, fertilizers, pesticide tablets, and foods and provides an elegant prompt release coating which does not retard the release of active ingredients from the coated substrate.

7. 发明申请

US20070136198A1 Method of facilitating the tracing and/or auditing of operations performed during check image processing 审中-公开
标题翻译：便于在检查图像处理期间执行的操作的跟踪和/或审计的方法
公开(公告)号：US20070136198A1
公开(公告)日：2007-06-14
申请号：US11302814
申请日：2005-12-14
申请人： Thomas Foth , Michael Augello , Jeffrey Pierce , Brian Romansky , Kolleen Dibble-Smith
发明人： Thomas Foth , Michael Augello , Jeffrey Pierce , Brian Romansky , Kolleen Dibble-Smith
IPC分类号： G06Q40/00
CPC分类号： G06Q40/02 , G06Q20/40
摘要： A number of methods of processing checks are provided that enable the various parties involved in processing/clearing the checks to be able to audit the movement of the check, and specifically an image of the check, through the check processing/clearing system. In particular, cryptographic techniques are employed allow the various parties involved in processing/clearing the checks to be able to identify what person and/or process performed an operation on the check, such as scanning the check to create the check image or performing optical character recognition on the check image to obtain data therefrom such as the amount of the
摘要翻译：提供了一些处理检查的方法，使得参与处理/清除检查的各方能够通过检查处理/清除系统来审核检查的移动，特别是检查的图像。特别地，采用加密技术允许涉及处理/清除检查的各方能够识别在检查上执行的操作的人和/或过程，诸如扫描检查以创建检查图像或执行光学字符在检查图像上识别从其获得的数据，例如数量

8. 发明授权

US06881449B2 Edible PGA coating composition 失效
标题翻译：食用PGA涂料组合物
公开(公告)号：US06881449B2
公开(公告)日：2005-04-19
申请号：US10654529
申请日：2003-09-03
申请人： Michael Augello , Eric Bliefernich
发明人： Michael Augello , Eric Bliefernich
IPC分类号： A61K47/36 , A23G3/34 , A23L1/00 , A61K9/20 , A61K9/28 , A61K9/30 , A61K9/36 , A61K47/24 , A61K47/38 , C05G5/00 , C08L1/28 , C08L3/02 , C08L5/00 , C08L71/02 , C09D105/04 , C09D105/06 , B05D1/02 , A23P1/08
CPC分类号： C09D105/06 , A23G3/343 , A23G2200/00 , A23P20/105 , A23V2002/00 , A61K9/2072 , A61K9/282 , A61K9/286 , C08L1/284 , C08L3/02 , C08L5/00 , C08L71/02 , C09D105/04 , C08L2666/26 , C08L2666/02 , A23V2200/22 , A23V2250/5026 , A23V2250/1842 , A23V2250/612 , A23V2250/5114
摘要： An edible, hardenable coating composition is disclosed which comprises high levels of low viscosity propylene glycol alginate and a surfactant, which may additionally contain a filler, a pigment, and optionally a small amount of a secondary film former and/or a strengthening polymer. The coating composition of the present invention may be applied to pharmaceutical and veterinary solid dosage forms, confectionery, seeds, animal feed, fertilizers, pesticide tablets, and foods and provides an elegant prompt release coating which does not retard the release of active ingredients from the coated substrate.
摘要翻译：公开了一种可食用的可硬化涂料组合物，其包含高含量的低粘度丙二醇藻酸盐和表面活性剂，其可以另外含有填料，颜料和任选的少量二次成膜剂和/或强化聚合物。本发明的涂料组合物可以应用于药物和兽用固体剂型，糖果，种子，动物饲料，肥料，农药片和食品，并提供优雅的快速释放涂层，其不会阻止活性成分从涂层基材。

9. 发明授权

US06432448B1 Edible coating composition 失效
标题翻译：食用涂料组合物
公开(公告)号：US06432448B1
公开(公告)日：2002-08-13
申请号：US09491724
申请日：2000-01-27
申请人： Michael Augello , Sheila M. Dell , Domingo C. Tuason , James J. Modliszewski , Thomas A. Ruszkay , David E. Werner
发明人： Michael Augello , Sheila M. Dell , Domingo C. Tuason , James J. Modliszewski , Thomas A. Ruszkay , David E. Werner
IPC分类号： A61K936
CPC分类号： A61K9/2866 , A61K9/284 , A61K9/286
摘要： An edible, hardenable coating composition containing microcrystalline cellulose and carrageenan and either a strengthening polymer, a plasticizer or both. The coating composition of the present invention may be applied to pharmaceutical and veterinary solid dosage forms, confectionery, seeds, animal feed, fertilizers, pesticide tablets, and foods and provides an elegant prompt release coating which does not retard the release of active ingredients from the coated substrate.
摘要翻译：含有微晶纤维素和角叉菜胶以及强化聚合物，增塑剂或两者的可食用，可硬化的涂料组合物。本发明的涂料组合物可以应用于药物和兽用固体剂型，糖果，种子，动物饲料，肥料，农药片和食品，并提供优雅的快速释放涂层，其不会阻止活性成分从涂层基材。

10. 发明申请

US20050196445A1 Edible microcrystalline cellulose and carrageenan coating composition 审中-公开
标题翻译：食用微晶纤维素和角叉菜胶涂料组合物
公开(公告)号：US20050196445A1
公开(公告)日：2005-09-08
申请号：US11070615
申请日：2005-03-02
申请人： Michael Augello
发明人： Michael Augello
IPC分类号： A61K9/24 , A61K9/28 , A61K9/30 , A61K9/36 , A61K31/716 , A61K31/737
CPC分类号： A61K9/286 , A23P20/105 , A23V2002/00 , A61K9/2866 , A23V2200/22 , A23V2250/51084 , A23V2250/5036
摘要： The present invention relates to novel, edible, hardenable, prompt release coatings for pharmaceutical, nutraceutical and veterinary solid dosage forms, confectionery, seeds, animal feed, fertilizers, pesticide tablets, and foods, etc., comprising microcrystalline cellulose and a film forming amount of carrageenan, wherein such coatings do not contain a plasticizer, a strengthening polymer or a surfactant.
摘要翻译：本发明涉及包含微晶纤维素和成膜量的药物，营养保健和兽用固体剂型，糖食，种子，动物饲料，肥料，农药片和食品等的新型可食用，可硬化，的角叉菜胶，其中这样的涂层不含增塑剂，强化聚合物或表面活性剂。

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