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1. 发明授权

US5399725A 7-oxabicycloheptane carboxylic acid prostaglandin analog intermediates useful in the preparation of anti-thrombotic and anti-vasospastic compounds and method for preparing same 失效
标题翻译：可用于制备抗血栓形成和抗血管痉挛性化合物的7-氧杂双环庚烷羧酸前列腺素类似物中间体及其制备方法
公开(公告)号：US5399725A
公开(公告)日：1995-03-21
申请号：US226091
申请日：1994-04-20
申请人： Michael A. Poss , Paul D. Pansegrau , Shaopeng Wang , John K. Thottathil , Janak Singh , Richard H. Mueller
发明人： Michael A. Poss , Paul D. Pansegrau , Shaopeng Wang , John K. Thottathil , Janak Singh , Richard H. Mueller
IPC分类号： C07D491/18 , C07D493/08 , C07D493/18 , C07D307/10 , C07D317/12
CPC分类号： C07D493/08
摘要： A method is provided for preparing carboxylic acid intermediates of the structure ##STR1## wherein an aldehyde of the structure ##STR2## is prepared and subjected to a Horner-Emmons reaction to form the ester of the structure ##STR3## and the ester is hydrogenated to the carboxylic acid which may be used in making the final anti-thrombotic--anti-vasospastic compounds.
摘要翻译：提供了一种制备结构“IMAGE”的羧酸中间体的方法，其中制备了结构“醛”的醛，并进行霍纳 - 埃蒙斯反应以形成结构“酯”的酯，并将酯氢化成可用于制备最终抗血栓形成 - 抗血管痉挛型化合物的羧酸。

2. 发明授权

US5512690A 7-oxabicycloheptane carboxylic acid prostaglandin analog intermediates useful in the preparation of anti-thrombotic and anti-basopastic compounds and method for preparing same 失效
标题翻译：可用于制备抗血栓形成和抗血管痉挛性化合物的7-氧杂双环庚烷羧酸前列腺素类似物中间体及其制备方法
公开(公告)号：US5512690A
公开(公告)日：1996-04-30
申请号：US528371
申请日：1995-09-14
申请人： Michael A. Poss , Paul D. Pansegrau , Shaopeng Wang , John K. Thottathil , Janak Singh , Richard H. Mueller
发明人： Michael A. Poss , Paul D. Pansegrau , Shaopeng Wang , John K. Thottathil , Janak Singh , Richard H. Mueller
IPC分类号： C07D491/18 , C07D493/08 , C07D493/18 , C07D407/02
CPC分类号： C07D493/08
摘要： A method is provided for preparing carboxylic acid intermediates of the structure ##STR1##
摘要翻译：提供了一种制备结构“IMAGE”的羧酸中间体的方法

3. 发明授权

US5508445A 7-oxabicycloheptane carboxylic acid protaglandin analog intermediates useful in the preparation of anti-thrombotic and anti-vasospastic compounds and method for preparing same 失效
标题翻译：可用于制备抗血栓形成和抗血管痉挛性化合物的7-氧杂双环庚烷羧酸普洛草灵类似物中间体及其制备方法
公开(公告)号：US5508445A
公开(公告)日：1996-04-16
申请号：US356743
申请日：1994-12-15
申请人： Michael A. Poss , Paul D. Pansegrau , Shaopeng Wang , John K. Thottathil , Janak Singh , Richard H. Mueller
发明人： Michael A. Poss , Paul D. Pansegrau , Shaopeng Wang , John K. Thottathil , Janak Singh , Richard H. Mueller
IPC分类号： C07D491/18 , C07D493/08 , C07D493/18 , C07D307/77
CPC分类号： C07D493/08
摘要： A method is provided for preparing carboxylic acid intermediates of the structure ##STR1##
摘要翻译：提供了一种制备结构“IMAGE”的羧酸中间体的方法

4. 发明授权

US5618946A 7-oxabicycloheptane carboxylic acid prostaglandin analog intermediates useful in the preparation of anti-thrombotic and anti-vasospastic compounds and method for preparing same 失效
标题翻译：可用于制备抗血栓形成和抗血管痉挛性化合物的7-氧杂双环庚烷羧酸前列腺素类似物中间体及其制备方法
公开(公告)号：US5618946A
公开(公告)日：1997-04-08
申请号：US609153
申请日：1996-02-29
申请人： Michael A. Poss , Paul D. Pansegrau , Shaopeng Wang , John K. Thottathil , Janak Singh , Richard H. Mueller
发明人： Michael A. Poss , Paul D. Pansegrau , Shaopeng Wang , John K. Thottathil , Janak Singh , Richard H. Mueller
IPC分类号： C07D491/18 , C07D493/08 , C07D493/18 , C07D491/02 , C07D407/14
CPC分类号： C07D493/08
摘要： The present invention relates to novel 7-oxabicycloheptane carboxylic acid prostaglandin analog intermediates which may be used to prepare a final anti-thrombotic, anti-vasospastic product, and to methods for preparing the same.
摘要翻译：本发明涉及可用于制备最终抗血栓形成，抗血管扩张产物的新型7-氧杂双环庚烷羧酸前列腺素类似物中间体及其制备方法。

5. 发明授权

US5539130A 7-Oxabicycloheotane carboxylic acid prostaglandin analog intermediates useful in the preparation of anti-thrombotic and anti-vasospastic compounds and method for preparing same 失效
标题翻译：可用于制备抗血栓形成和抗血管痉挛性化合物的7-氧化二氮杂环丁烷羧酸前列腺素类似物中间体及其制备方法
公开(公告)号：US5539130A
公开(公告)日：1996-07-23
申请号：US528274
申请日：1995-09-14
申请人： Michael A. Poss , Paul D. Pansegrau , Shaopeng Wang , John K. Thottahil , Janak Singh , Richard H. Mueller
发明人： Michael A. Poss , Paul D. Pansegrau , Shaopeng Wang , John K. Thottahil , Janak Singh , Richard H. Mueller
IPC分类号： C07D491/18 , C07D493/08 , C07D493/18 , C07D311/02
CPC分类号： C07D493/08
摘要： A method is provided for preparing carboxylic acid intermediates of the structure ##STR1##
摘要翻译：提供了一种制备结构“IMAGE”的羧酸中间体的方法

6. 发明申请

US20170038380A1 INTEGRATED MICROARRAY PRINTING AND DETECTION SYSTEM FOR MOLECULAR BINDING ANALYSIS 审中-公开
标题翻译：用于分子结合分析的综合微型打印和检测系统
公开(公告)号：US20170038380A1
公开(公告)日：2017-02-09
申请号：US15204738
申请日：2016-07-07
申请人： Nongjian Tao , Shaopeng Wang
发明人： Nongjian Tao , Shaopeng Wang
IPC分类号： G01N33/557 , G01N21/552
摘要： A method and system for analysis of protein interaction kinetics in microarray or whole-cell based formats includes positioning a sensor chip on a prism. The sensor chip is spotted with a plurality of target molecules. A movable printer head deposits a plurality of analyte droplets on predefined regions of the sensor chip surface. A light source transmits light through the prism to excite surface plasmon resonance on the sensor chip surface, whereby the plurality of target molecules bound to the upper surface are changing the SPR resonance angle and therefore the intensity of the reflected beam. A detector receives reflected light transmitted through the prism from the bottom surface. Signals from the detector are received and processed into kinetic data and microarray labeled data to determine molecular interactions and binding kinetic properties for the plurality of analyte droplets.
摘要翻译：用于分析微阵列或全细胞蛋白质相互作用动力学的方法和系统包括将传感器芯片定位在棱镜上。传感器芯片被多个目标分子点样。可移动打印头将多个分析物液滴沉积在传感器芯片表面的预定区域上。光源通过棱镜透射光以激发传感器芯片表面上的表面等离子体共振，由此结合到上表面的多个靶分子改变SPR谐振角，并因此改变反射光束的强度。检测器从底面接收透过棱镜的反射光。来自检测器的信号被接收并处理成动力学数据和微阵列标记的数据，以确定多个分析物液滴的分子相互作用和结合动力学性质。

7. 发明申请

US20070003595A1 Three dimensional micro-environments and methods of making and using same 审中-公开
标题翻译：三维微环境及其使用方法
公开(公告)号：US20070003595A1
公开(公告)日：2007-01-04
申请号：US11407002
申请日：2006-04-19
申请人： Shaopeng Wang , Nicholas Kotov , Jun Zhang
发明人： Shaopeng Wang , Nicholas Kotov , Jun Zhang
IPC分类号： C12M3/00 , A61K35/12 , A61F2/02
CPC分类号： C12N5/0068 , A61K38/00 , A61L27/52 , A61L27/54 , A61L2300/252 , A61L2300/258 , A61L2300/414 , A61L2300/426 , A61L2300/602 , C12M25/14 , C12N2533/30
摘要： The presently claimed and disclosed invention relates, in general, to three dimensional micro-environments and, in particular, to three dimensional (“3D”) micro-environments found in inverted-opal scaffolds made from hydrogel therein for controlled release of nutrients. Specifically, the scaffolds have exceptionally ordered, three-dimensional organization that provides excellent porosity, permeability, and transportation properties can that are especially well suited for use as a nutrient carrier in the emerging technologies of drug delivery and cell culture. Methods for incorporation of or to control the release of nutrients and other substances from such scaffold materials are also herein disclosed and claimed.
摘要翻译：本发明要求和公开的发明一般涉及三维微环境，特别涉及在其中由其中的水凝胶制成的倒置蛋白石支架中发现的三维（“3D”）微环境，以控制营养物质的释放。具体来说，支架具有非常有序的，提供优异的孔隙率，渗透性和运输性质的三维组织，特别适合用作药物递送和细胞培养的新兴技术中的营养载体。还公开并要求保护并结合或控制营养物质和其他物质从这种支架材料释放的方法。

8. 发明申请

US20070063154A1 Energy-transfer nanocomposite materials and methods of making and using same 失效
标题翻译：能量转移纳米复合材料及其制造和使用方法
公开(公告)号：US20070063154A1
公开(公告)日：2007-03-22
申请号：US11262470
申请日：2005-10-28
申请人： Wei Chen , Shaopeng Wang , Sarah Westcott , Jun Zhang
发明人： Wei Chen , Shaopeng Wang , Sarah Westcott , Jun Zhang
IPC分类号： G01J1/58 , G01T1/10 , G01N21/64 , F21V9/16
CPC分类号： A61B5/0059 , A61B6/00 , G01N21/76 , G01N2021/6495 , G01T1/10 , Y10S436/904 , Y10S977/904 , Y10S977/905
摘要： The presently claimed and disclosed inventions relate, in general, to methods of radiation dosimetry and imaging using scintillation luminescence. More particularly, materials having a scintillation luminescence response to radiation that varies with total radiation dose received can be used for dosimetry monitoring, including, but not limited to nanoparticles for in vivo, real-time dosimetry. Energy-transfer nanocomposite materials as well as methods of making and using such materials in various applications including, but not limited to, in vivo radiation dosimetry and imaging, are disclosed. More particularly, the presently claimed and disclosed inventions relate to nanoparticle scintillation luminescence particles encapsulated in hosts of the general formula BaFX and BaFX:Eu2+ where X=Cl, Br and I.
摘要翻译：目前权利要求和公开的发明一般涉及使用闪烁发光的放射剂量测定法和成像方法。更具体地，具有随所接收的总辐射剂量变化的对辐射的闪烁发光响应的材料可用于剂量测定监测，包括但不限于用于体内实时剂量测定的纳米颗粒。公开了能量转移纳米复合材料以及在各种应用中制备和使用这些材料的方法，包括但不限于体内辐射剂量测定和成像。更具体地说，本发明涉及纳米颗粒闪烁发光颗粒，其包封在通式为BaFX和BaFX：Eu 2+的主体中，其中X = Cl，Br和I.

9. 发明授权

US06353119B1 Preparation of 3-substituted-4-arylquinolin-2-one derivatives 有权
标题翻译： 3-取代-4-芳基喹啉-2-酮衍生物的制备
公开(公告)号：US06353119B1
公开(公告)日：2002-03-05
申请号：US09724056
申请日：2000-11-28
申请人： Gerard A. Crispino , Shaopeng Wang , Jun Li
发明人： Gerard A. Crispino , Shaopeng Wang , Jun Li
IPC分类号： C07D30702
CPC分类号： C07D217/24 , C07D307/30
摘要： The present invention relates to a process for the preparation of 3-substituted-4-arylquinolin-2-one derivatives from a substituted coumarin and using a photochemical cyclization method on a dihydrofuran intermediate.
摘要翻译：本发明涉及从取代香豆素制备3-取代-4-芳基喹啉-2-酮衍生物的方法，并且在二氢呋喃中间体上使用光化学环化法。

10. 发明申请

US20100176343A1 ENERGY-TRANSFER NANOCOMPOSITE MATERIALS AND METHODS OF MAKING AND USING SAME 审中-公开
标题翻译：能量转移纳米复合材料及其制备和使用方法
公开(公告)号：US20100176343A1
公开(公告)日：2010-07-15
申请号：US12435957
申请日：2009-05-05
申请人： Wei Chen , Shaopeng Wang , Sarah L. Westcott , Jun Zhang
发明人： Wei Chen , Shaopeng Wang , Sarah L. Westcott , Jun Zhang
IPC分类号： C09K11/02 , C09K11/54 , C09K11/78 , C09K11/59
CPC分类号： A61B5/0059 , A61B6/00 , A61B6/485 , G01N21/76 , G01N2021/6495 , G01T1/10
摘要： The presently claimed and disclosed inventions relate, in general, to methods of radiation dosimetry and imaging using scintillation luminescence. More particularly, materials having a scintillation luminescence response to radiation that varies with total radiation dose received can be used for dosimetry monitoring, including, but not limited to nanoparticles for in vivo, real-time dosimetry. Energy-transfer nanocomposite materials as well as methods of making and using such materials in various applications including, but not limited to, in vivo radiation dosimetry and imaging, are disclosed. More particularly, the presently claimed and disclosed inventions relate to nanoparticle scintillation luminescence particles encapsulated in hosts of the general formula BaFX and BaFX:Eu2+ where X═Cl, Br and I.
摘要翻译：目前权利要求和公开的发明一般涉及使用闪烁发光的放射剂量测定法和成像方法。更具体地，具有随所接收的总辐射剂量变化的对辐射的闪烁发光响应的材料可用于剂量测定监测，包括但不限于用于体内实时剂量测定的纳米颗粒。公开了能量转移纳米复合材料以及在各种应用中制造和使用这些材料的方法，包括但不限于体内辐射剂量测定和成像。更具体地，本发明涉及通过包封在通式BaFX和BaFX：Eu 2+的主体中的纳米颗粒闪烁发光颗粒，其中X = Cl，Br和I.

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