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1. 发明授权

US08003315B2 TAOJIKs as modifiers of the beta-catenin pathway and methods of use 失效
标题翻译： TAOJIKs作为β-连环蛋白途径的修饰剂和使用方法
公开(公告)号：US08003315B2
公开(公告)日：2011-08-23
申请号：US10317835
申请日：2002-12-12
申请人： Michael A. Costa , Steven Brian Gendreau , Emery G. Dora, III , Monique Nicoll , Lenore Urbani , Jeffrey S. Larson
发明人： Michael A. Costa , Steven Brian Gendreau , Emery G. Dora, III , Monique Nicoll , Lenore Urbani , Jeffrey S. Larson
IPC分类号： C12Q1/68 , C12Q1/48 , G01N33/53
CPC分类号： G01N33/57484 , C12Q1/6886 , C12Q2600/136 , G01N33/5011 , G01N2333/4706 , G01N2500/00
摘要： Human TAOJIK genes are identified as modulators of the beta-catenin pathway, and thus are therapeutic targets for disorders associated with defective beta-catenin function. Methods for identifying modulators of beta-catenin, comprising screening for agents that modulate the activity of TAOJIK are provided.
摘要翻译：人TAOJIK基因被鉴定为β-连环蛋白途径的调节剂，因此是与β-连环蛋白功能不良相关的疾病的治疗靶点。提供了鉴定β-连环蛋白调节剂的方法，包括筛选调节TAOJIK活性的药剂。

2. 发明授权

US06247879B1 Hand held drill press 失效
标题翻译：手持钻床
公开(公告)号：US06247879B1
公开(公告)日：2001-06-19
申请号：US09383685
申请日：1999-08-26
申请人： Michael A. Costa
发明人： Michael A. Costa
IPC分类号： B23B4514
CPC分类号： B25H1/0078 , Y10T408/564 , Y10T408/5653
摘要： A new hand held drill press for enabling a power hand drill to be converted into a drill press. The inventive device includes a hollow cylindrical sleeve having an open upper end, an open lower end and a cylindrical side wall therebetween. An interior of the cylindrical side wall has an inwardly extending cylindrical wall disposed on a lower half portion thereof. The open lower end of the sleeve has an annular recess formed on an interior surface thereof. A cylindrical drill engagement collar is provided. The cylindrical drill engagement collar is dimensioned for coupling with a nose of a hand held drill. The collar is slidably received within the open upper end of the hollow cylindrical sleeve. A spring member is disposed interiorly of an upper half portion of the cylindrical side wall of the hollow cylindrical sleeve. The spring member has a lower portion secured to an upper end of the inwardly extending cylindrical wall. An upper end of the spring member is disposed inwardly of the cylindrical drill engagement collar for upward biasing thereof.
摘要翻译：一种新的手持式钻床，用于使电动手钻能够转换成钻床。本发明的装置包括中空的圆柱形套筒，其具有敞开的上端，敞开的下端和它们之间的圆柱形侧壁。圆柱形侧壁的内部具有设置在其下半部分上的向内延伸的圆柱形壁。套筒的敞开的下端具有形成在其内表面上的环形凹部。提供一个圆柱形钻头接合套环。圆柱形钻头接合轴环的尺寸适于与手持钻头的鼻子相连接。轴环可滑动地容纳在中空圆柱形套筒的敞开的上端内。弹簧构件设置在中空圆柱形套筒的圆柱形侧壁的上半部的内部。弹簧构件具有固定到向内延伸的圆柱形壁的上端的下部。弹簧构件的上端设置在圆柱形钻头接合环的内侧，用于向上偏置。

3. 发明授权

US06911330B1 Recombinant secoisolariciciresinol dehydrogensase, and methods of use 有权
标题翻译：重组分裂异丝氨酸脱氢酶，以及使用方法
公开(公告)号：US06911330B1
公开(公告)日：2005-06-28
申请号：US09673918
申请日：1999-04-23
申请人： Zhi-Qiang Xia , Michael A. Costa , Laurence B. Davin , Norman G. Lewis
发明人： Zhi-Qiang Xia , Michael A. Costa , Laurence B. Davin , Norman G. Lewis
IPC分类号： C12N15/09 , C07H21/04 , C12N1/15 , C12N1/19 , C12N1/20 , C12N1/21 , C12N5/00 , C12N5/10 , C12N9/04 , C12N15/00 , C12P21/02 , C12Q1/68
CPC分类号： C12N9/0006
摘要： A secoisolanciresinol dehydrogenase protein has been isolated from Forsythia intermedia, together with cDNAs encoding secoisolariciresinol dehydrogenase from this species. Accordingly, isolated DNA sequences are provided which code for the expression of secoisolariciresinol dehydrogenase. In other aspects, the present invention is directed to replicable recombinant cloning vehicles comprising a nucleic acid sequence which codes for a secoisolariciresinol dehydrogenase protein, or to a base sequence sufficiently complementary to at least a portion of a secoisolariciresinol dehydrogenase DNA or RNA to enable hybridization therewith. Thus, systems and methods are provided for the recombinant expression of secoisolariciresinol dehydrogenases that may be used to facilitate the production, isolation and purification of significant quantities of recombinant secoisolariciresinol dehydrogenase for subsequent use, to obtain expression or enhanced expression of secoisolariciresinol dehydrogenase in plants in order to enhance, or otherwise alter, lignan biosynthesis, or may be otherwise employed for the regulation or expression of secoisolariciresinol dehydrogenase.
摘要翻译：从间叶连翘中分离出一种异恶唑烷醇脱氢酶蛋白，以及来自该物种的编码分离异硫氰酸脱氢酶的cDNA。因此，提供了分离的DNA序列，其编码表达了二异硫氰酸脱氢酶。在其他方面，本发明涉及可复制的重组克隆载体，其包含编码一种间歇异硫氰菊酯脱氢酶蛋白的核酸序列，或与至少一部分间位异辛烯脱氢酶DNA或RNA充分互补的碱基序列，以使其能够与其进行杂交。因此，提供系统和方法用于重组表达的二硫代亚铁氰菊醇脱氢酶，其可用于促进大量的重组分离异硫辛烯醇脱氢酶的生产，分离和纯化用于随后的使用，以顺序获得在植物中的顺式表达或增强的表达，以增强或以其它方式改变木脂素生物合成，或者可以另外用于调节或表达分离异癸烯醇脱氢酶。

4. 发明授权

US08996671B1 Method of providing service-provider-specific support link data to a client in a storage context 有权
标题翻译：在存储环境中向客户端提供特定于服务提供商的支持链接数据的方法
公开(公告)号：US08996671B1
公开(公告)日：2015-03-31
申请号：US13435737
申请日：2012-03-30
申请人： Seth B. Horan , Mark Parenti , Michael A. Costa
发明人： Seth B. Horan , Mark Parenti , Michael A. Costa
IPC分类号： H04L29/06 , H04L12/54
CPC分类号： H04L12/569 , G06F17/30289 , H04L47/10
摘要： A method of providing service-provider-specific link data to a client computer includes (a) at a storage management server (SMS), the SMS being configured to provide management services for a data storage system, sending an identification number of the SMS to a database application, (b) at the SMS, receiving, from the database application, a set of link descriptors, the set of link descriptors identifying a set of link addresses (LAs) to a particular remote storage support server (RMSS) of a plurality of RMSSs, the particular RMSS being associated with the identification number, (c) at the SMS, integrating system-specific status information into the LAs of the set of LAs, thereby generating the service-provider-specific link data, and (d) at the SMS, sending the service-provider-specific link data to the client computer to allow the client computer to display links to a user which allow the user to receive service-provider-specific support services from the service-provider.
摘要翻译：向客户端计算机提供服务提供者专用链接数据的方法包括：（a）在存储管理服务器（SMS）中，SMS被配置为提供数据存储系统的管理服务，将SMS的识别号码发送到数据库应用程序，（b）在SMS处，从数据库应用程序接收一组链接描述符，该组链接描述符将一组链接地址（LAs）标识到特定的远程存储支持服务器（RMSS）多个RMSS，特定RMSS与识别号码相关联，（c）在SMS处，将系统特定的状态信息集成到该组的LAs中，由此生成服务提供商特定链路数据，并且（d ），将服务提供商特定的链接数据发送到客户端计算机，以允许客户端计算机显示到用户的链接，允许用户从服务提供商接收服务提供商特定的支持服务。

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