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1. 发明申请

US20060102935A1 Transistor-based biosensors having gate electrodes coated with receptor molecules 审中-公开
标题翻译：基于晶体管的生物传感器具有涂覆有受体分子的栅电极
公开(公告)号：US20060102935A1
公开(公告)日：2006-05-18
申请号：US10534455
申请日：2003-11-11
申请人： Shlomo Yitzchaik , Micha Spira , Joseph Shappir
发明人： Shlomo Yitzchaik , Micha Spira , Joseph Shappir
IPC分类号： H01L23/58
CPC分类号： C07K17/14 , C12Q1/001 , G01N27/4145 , G01N33/551 , H01L2924/0002 , H01L2924/00
摘要： A device and method are presented for detecting analyte molecules in a medium. At least one FET (Field Effect Transistor) is provided being formed by at least one pair of source-drain electrodes and at least one gate electrode. The gate electrode is coated with a layer of receptor molecules that in the presence of said analytes catalyze a reaction that causes release of ions in a medium surrounding said receptor molecules. A monolayer of linker molecules is provided for linking said receptor molecules to said at least one gate such that a distance between the receptor molecules layer and the surface of the coated gate is smaller than 15A. In the prefered embodiments, the receptor molecules are enzymes (e.g. acetylcholine estarase) or peptides, and the analyte molecules are pesticides, herbicides and chemical pollutants of industrial origin.
摘要翻译：提出了用于检测介质中的分析物分子的装置和方法。至少一个FET（场效应晶体管）被提供由至少一对源 - 漏电极和至少一个栅极电极形成。栅电极涂覆有一层受体分子，所述受体分子在所述分析物存在下催化引起离子在所述受体分子周围的介质中释放的反应。提供单层连接分子用于将所述受体分子与所述至少一个栅极连接，使得受体分子层与涂覆的栅极的表面之间的距离小于15A。在优选的实施方案中，受体分子是酶（例如乙酰胆碱雌酮酶）或肽，分析物分子是工业起源的农药，除草剂和化学污染物。

2. 发明授权

US07795039B2 Electronic device for communication with living cells 有权
标题翻译：用于与活细胞通讯的电子设备
公开(公告)号：US07795039B2
公开(公告)日：2010-09-14
申请号：US10560315
申请日：2004-06-10
申请人： Micha Spira , Shlomo Yitzchaik , Joseph Shappir
发明人： Micha Spira , Shlomo Yitzchaik , Joseph Shappir
IPC分类号： G01N33/543
CPC分类号： C07K17/14 , B82Y10/00 , B82Y15/00 , B82Y30/00 , C12Q1/001 , G01N27/4146 , G01N33/48728 , G01N2333/918 , H01L29/788
摘要： The present invention provides a surface-substrate for adherence of cells thereto. The surface-substrate comprises at least one micronail structure protruding from the surface, at least a region of the micronail having cellular-internalization promoting properties. The invention also provides an electronic device comprising a transistor structure, in which a gate electrode is formed with the at least one micronail protruding from the surface thereof.
摘要翻译：本发明提供了一种用于将细胞附着于其上的表面基质。表面基材包括从表面突出的至少一个微米结构，至少一个具有细胞内化促进性质的微米的区域。本发明还提供了一种包括晶体管结构的电子器件，其中栅电极形成有从其表面突出的至少一个微米。

3. 发明申请

US20070099173A1 Electronic device for communication with living cells 有权
标题翻译：用于与活细胞通讯的电子设备
公开(公告)号：US20070099173A1
公开(公告)日：2007-05-03
申请号：US10560315
申请日：2004-06-10
申请人： Micha Spira , Shlomo Yitzchaik , Joseph Shappir
发明人： Micha Spira , Shlomo Yitzchaik , Joseph Shappir
IPC分类号： C12Q1/00 , C12M1/34 , C07K1/26
CPC分类号： C07K17/14 , B82Y10/00 , B82Y15/00 , B82Y30/00 , C12Q1/001 , G01N27/4146 , G01N33/48728 , G01N2333/918 , H01L29/788
摘要： The present invention provides a surface-substrate for adherence of cells thereto. The surface-substrate comprises at least one micronail structure protruding from the surface, at least a region of the micronail having cellular-internalization promoting properties. The invention also provides an electronic device comprising a transistor structure, in which a gate electrode is formed with the at least one micronail protruding from the surface thereof.
摘要翻译：本发明提供了一种用于将细胞附着于其上的表面基质。表面基材包括从表面突出的至少一个微米结构，至少一个具有细胞内化促进性质的微米的区域。本发明还提供了一种包括晶体管结构的电子器件，其中栅电极形成有从其表面突出的至少一个微米。

4. 发明授权

US06703660B2 Hybrid electrical device with biological components 失效
标题翻译：具有生物成分的混合电气装置
公开(公告)号：US06703660B2
公开(公告)日：2004-03-09
申请号：US09933873
申请日：2001-08-22
申请人： Shlomo Yitzchaik , Joseph Shappir , Micha Spira
发明人： Shlomo Yitzchaik , Joseph Shappir , Micha Spira
IPC分类号： H01L29758
CPC分类号： H01L51/0595 , B82Y10/00 , G01N33/48728 , H01L27/11517 , H01L27/11526 , H01L29/66825 , H01L29/788
摘要： The present invention concerns an electrical junction between one transistor and at least one voltage sensitive cell such as a neuron. The invention further concerns transistors to be used in said junction and methods for their preparation. By another aspect the invention concerns “an artificial chemical synapse” i.e. a junction between a cell, which secretes an agent, and a transistor bearing receptors for the agent, wherein binding of the agent to the receptor changes an electrical property off the transistor.
摘要翻译：本发明涉及一个晶体管与诸如神经元的至少一个电压敏感单元之间的电连接。本发明还涉及要在所述连接处使用的晶体管及其制备方法。另一方面，本发明涉及“人造化学突触”，即分泌药剂的细胞与承载药剂的晶体管之间的结，其中药剂与受体的结合改变晶体管的电性质。

5. 发明申请

US20060121441A1 Methods of determining the effect of an agent on diploid cells and/or on the pattern of expression of polypeptides expressed therewith 审中-公开
标题翻译：确定试剂对二倍体细胞的影响和/或用其表达的多肽的表达模式的方法
公开(公告)号：US20060121441A1
公开(公告)日：2006-06-08
申请号：US10528785
申请日：2003-09-24
申请人： Micha Spira
发明人： Micha Spira
IPC分类号： C12Q1/00 , C12Q1/68 , C12N5/08 , C12N15/87
CPC分类号： C12N15/89 , C12Q1/68
摘要： A method of determining the effect of an agent on a diploid cell and/or on an expression or activity of a polypeptide expressed within the diploid cell is provided. The method is effected by: (a) administering an exogenous RNA molecule encoding the polypeptide into the diploid cell; (b) contacting the diploid cell with the agent; and (c) monitoring a phenotype of the diploid cell and/or the expression or activity of the polypeptide within the diploid cell, thereby determining the effect of the agent on the diploid cell and/or on the expression or activity of the polypeptide expressed within the diploid cell.
摘要翻译：提供了确定二倍体细胞和/或在二倍体细胞内表达的多肽的表达或活性的作用的方法。该方法通过：（a）将编码该多肽的外源RNA分子施用于二倍体细胞; （b）将二倍体细胞与该药剂接触; 和（c）监测二倍体细胞的表型和/或多肽在二倍体细胞内的表达或活性，从而确定药剂对二倍体细胞的作用和/或表达的多肽的表达或活性二倍体细胞。

6. 发明申请

US20140171774A1 BIOMOLECULAR ELECTRONIC DEVICE AND PROCESS OF USE 有权
标题翻译：生物分子电子器件及其使用过程
公开(公告)号：US20140171774A1
公开(公告)日：2014-06-19
申请号：US14122580
申请日：2012-05-24
申请人： Micha Spira , Oded Shoseyov
发明人： Micha Spira , Oded Shoseyov
IPC分类号： A61N1/05 , A61B5/04 , G01N27/327
CPC分类号： A61N1/0543 , A61B5/04001 , A61N1/05 , A61N1/0541 , C07K14/47 , G01N27/327 , G01N33/4836 , Y10T428/31681
摘要： Provided is a biological membrane including at least one ring-like polypeptide, where the at least one of the ring-like polypeptide is not a membrane protein, a surface being associated with at least one ring-like polypeptide capable of integration into a cell membrane, an electrode including said surface and electronically and biomedical devices including the electrodes for recording and stimulating cell activity.
摘要翻译：提供了包括至少一种环状多肽的生物膜，其中至少一种环状多肽不是膜蛋白，表面与至少一种能够整合到细胞膜中的环状多肽相关联，包括所述表面的电极和电子和生物医学装置，其包括用于记录和刺激细胞活性的电极。

7. 发明授权

US09629995B2 Biomolecular electronic device and process of use 有权
公开(公告)号：US09629995B2
公开(公告)日：2017-04-25
申请号：US14122580
申请日：2012-05-24
申请人： Micha Spira , Oded Shoseyov
发明人： Micha Spira , Oded Shoseyov
IPC分类号： A61N1/05 , C07K14/415 , G01N27/327 , C07K14/47 , G01N33/483 , A61B5/04
CPC分类号： A61N1/0543 , A61B5/04001 , A61N1/05 , A61N1/0541 , C07K14/47 , G01N27/327 , G01N33/4836 , Y10T428/31681
摘要： Provided is a biological membrane including at least one ring-like polypeptide, where the at least one of the ring-like polypeptide is not a membrane protein, a surface being associated with at least one ring-like polypeptide capable of integration into a cell membrane, an electrode including said surface and electronically and biomedical devices including the electrodes for recording and stimulating cell activity.

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