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1. 发明申请

US20070192880A1 Horming response element binding transregulators 审中-公开
标题翻译： Horming响应元件结合式跨越器
公开(公告)号：US20070192880A1
公开(公告)日：2007-08-16
申请号：US10574322
申请日：2004-10-04
申请人： Mesut Muyan , Jing Huang
发明人： Mesut Muyan , Jing Huang
IPC分类号： A01K67/027 , A61K48/00 , C07H21/04 , C12P21/06 , C07K14/82
CPC分类号： C12N15/62 , C07K14/4702 , C07K2319/715 , C12N2799/022 , C12N2830/008
摘要： Disclosed are compositions and methods for ERE-binding tansregulators that specifically and potently regulate ERE-containing genes. To accomplish this, we took advantage of the modular nature of ER and initially designed a monomeric ERE binding module by co-joining two DNA binding domains with the hinge domain. Integradon of strong activation or repressor domains from other transcription factors into this module generated constitutively active ERE-binding activators (EBAs) and ERE-binding repressors (EBRs) respectively. These novel transregulators are the basis for the targeted regulation of ERE containing genes, the identification of estrogen reponsive gene networks, and the development of alternative/complementary therapeutic approaches for estrogen target tissue cancers.
摘要翻译：公开了特异性和有效调节含ERE的基因的ERE结合的调节物的组合物和方法。为了实现这一点，我们利用了ER的模块化特性，并最初通过将两个DNA结合结构域与铰链域共同连接来设计单体ERE结合模块。来自其他转录因子的强激活或抑制子结构域的整合体分别产生组成型活性ERE结合激活因子（EBAs）和ERE结合阻遏物（EBRs）。这些新型跨越调控因子是靶向调控含ERE基因，雌激素反应基因网络的鉴定以及雌激素靶组织癌的替代/补充治疗方法的发展的基础。

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