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1. 发明申请

US20110020882A1 AMINOTRANSFERASE AND OXIDOREDUCTASE NUCLEIC ACIDS AND POLYPEPTIDES AND METHODS OF USING 有权
标题翻译：氨基转移酶和氧化还原酶核酸和多肽及其使用方法
公开(公告)号：US20110020882A1
公开(公告)日：2011-01-27
申请号：US12811491
申请日：2008-12-31
申请人： Mervyn L. de Souza , Paula M. Hicks , Sherry R. Kollmann , Jose Laplaza , Joshua M. Lundorff , Sara C. McFarlan , Erin Marasco , Wei Niu , Fernando A. Sanchez-Riera , Christopher Solheid , David P. Weiner , Ellen Burke , Peter Luginbuhl , Analia Bueno , Joslin Cuenca
发明人： Mervyn L. de Souza , Paula M. Hicks , Sherry R. Kollmann , Jose Laplaza , Joshua M. Lundorff , Sara C. McFarlan , Erin Marasco , Wei Niu , Fernando A. Sanchez-Riera , Christopher Solheid , David P. Weiner , Ellen Burke , Peter Luginbuhl , Analia Bueno , Joslin Cuenca
IPC分类号： C12P17/10
CPC分类号： C12P13/227 , C12N9/0004 , C12N9/1096 , C12P17/10
摘要： The invention provides for aminotransferase and oxidoreductase polypeptides and nucleic acids encoding such polypeptides. Also provided are methods of using such aminotransferase and oxidoreductase nucleic acids and polypeptides.
摘要翻译：本发明提供氨基转移酶和氧化还原酶多肽以及编码这种多肽的核酸。还提供了使用这种氨基转移酶和氧化还原酶核酸和多肽的方法。

2. 发明授权

US08785162B2 Aminotransferase and oxidoreductase nucleic acids and polypeptides and methods of using 有权
标题翻译：氨基转移酶和氧化还原酶核酸和多肽及其使用方法
公开(公告)号：US08785162B2
公开(公告)日：2014-07-22
申请号：US12811491
申请日：2008-12-31
申请人： Mervyn L. De Souza , Paula M. Hicks , Sherry R. Kollmann , Jose Laplaza , Joshua M. Lundorff , Sara C. McFarlan , Erin Marasco , Wei Niu , Fernando A. Sanchez-Riera , Christopher Solheid , David P. Weiner , Peter Luginbuhl , Analia Bueno , Joslin Cuenca
发明人： Mervyn L. De Souza , Paula M. Hicks , Sherry R. Kollmann , Jose Laplaza , Joshua M. Lundorff , Sara C. McFarlan , Erin Marasco , Wei Niu , Fernando A. Sanchez-Riera , Christopher Solheid , David P. Weiner , Peter Luginbuhl , Analia Bueno , Joslin Cuenca
IPC分类号： C12P17/10 , C12P13/22 , C12P13/04 , C12N9/10 , C12P21/06 , C12P19/34 , C12N1/20 , C07H21/04 , C07K1/00
CPC分类号： C12P13/227 , C12N9/0004 , C12N9/1096 , C12P17/10
摘要： The invention provides for aminotransferase and oxidoreductase polypeptides and nucleic acids encoding such polypeptides. Also provided are methods of using such aminotransferase and oxidoreductase nucleic acids and polypeptides.
摘要翻译：本发明提供氨基转移酶和氧化还原酶多肽以及编码这种多肽的核酸。还提供了使用这种氨基转移酶和氧化还原酶核酸和多肽的方法。

3. 发明申请

US20110045547A1 ISOMERASES AND EPIMERASES AND METHODS OF USING 审中-公开
标题翻译：异构体和硫化物及其使用方法
公开(公告)号：US20110045547A1
公开(公告)日：2011-02-24
申请号：US12828714
申请日：2010-07-01
申请人： Mervyn L. de Souza , Wei Niu , Jose Laplaza , Christopher Solheid , Sherry R. Kollmann , Joshua M. Lundorff , Paula M. Hicks , Sara C. McFarlan , Fernando A. Sanchez-Riera , David P. Weiner , Ellen Burke , Peter Luginbuhl , Analia Bueno , Joslin Cuenca
发明人： Mervyn L. de Souza , Wei Niu , Jose Laplaza , Christopher Solheid , Sherry R. Kollmann , Joshua M. Lundorff , Paula M. Hicks , Sara C. McFarlan , Fernando A. Sanchez-Riera , David P. Weiner , Ellen Burke , Peter Luginbuhl , Analia Bueno , Joslin Cuenca
IPC分类号： C12P13/22 , C12P17/10
CPC分类号： C12N9/90 , C12P13/06 , C12P13/22 , C12P17/10
摘要： The invention provides for isomerase (e.g., racemase) and epimerase polypeptides and nucleic acids encoding such polypeptides. Also provided are methods of using such isomerase (e.g., racemase) and epimerase nucleic acids and polypeptides.
摘要翻译：本发明提供异构酶（例如消旋酶）和差向异构酶多肽以及编码这种多肽的核酸。还提供了使用这种异构酶（例如消旋酶）和差向异构酶核酸和多肽的方法。

4. 发明授权

US07582455B2 Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors 有权
标题翻译：用于生产莫纳甜及其前体的立体异构体的多肽和生物合成途径
公开(公告)号：US07582455B2
公开(公告)日：2009-09-01
申请号：US11411229
申请日：2006-04-26
申请人： Brian J. Brazeau , Ellen Burke , Mervyn DeSouza , Steven J. Gort , Paula M. Hicks , Sherry R. Kollmann , Peter Luginbuhl , Sara C. McFarlan , Toby Richardson , Fernando A. Sanchez-Riera , Christopher Solheid , David Weiner , Lishan Zhao
发明人： Brian J. Brazeau , Ellen Burke , Mervyn DeSouza , Steven J. Gort , Paula M. Hicks , Sherry R. Kollmann , Peter Luginbuhl , Sara C. McFarlan , Toby Richardson , Fernando A. Sanchez-Riera , Christopher Solheid , David Weiner , Lishan Zhao
IPC分类号： C12P17/10
CPC分类号： C12P17/10 , C12N9/1096 , C12N9/90
摘要： Monatin and certain stereoisomers of monatin, such as R,R monatin and S,R monatin, as well as salts thereof, are produced using polypeptides and biosynthetic pathways. These polypeptides and biosynthetic pathways are also useful in the production of R-2-hydroxy-2-(indoly-3-ylmethyl)-4-keto glutaric acid, an intermediate that is formed in certain monatin synthesis pathways, including some biosynthetic pathways.
摘要翻译：使用多肽和生物合成途径产生莫纳甜和莫纳甜的某些立体异构体，例如R，R莫纳甜和S，R莫纳甜及其盐。这些多肽和生物合成途径也可用于生产在特定莫纳甜合成途径中形成的包括一些生物合成途径的中间体R-2-羟基-2-（吲哚-3-基甲基）-4-酮戊二酸。

5. 发明授权

US08975046B2 Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors 有权
公开(公告)号：US08975046B2
公开(公告)日：2015-03-10
申请号：US13287900
申请日：2011-11-02
申请人： Brian J. Brazeau , Mervyn L. De Souza , Steven J. Gort , Paula M. Hicks , Sherry R. Kollmann , Jose M. Laplaza , Sara C. McFarlan , Fernando A. Sanchez-Riera , Christopher Solheid
发明人： Brian J. Brazeau , Mervyn L. De Souza , Steven J. Gort , Paula M. Hicks , Sherry R. Kollmann , Jose M. Laplaza , Sara C. McFarlan , Fernando A. Sanchez-Riera , Christopher Solheid
IPC分类号： C12P17/10 , C12P13/22 , C12N9/10 , C12N9/90
CPC分类号： C12N9/1096 , C12N9/90 , C12P17/10
摘要： Monatin and certain stereoisomers of monatin, such as R,R monatin and S,R monatin, as well as salts thereof, are produced using polypeptides and biosynthetic pathways. These polypeptides and biosynthetic pathways are also useful in the production of R-2-hydroxy-2-(indoly-3-ylmethyl)-4-keto glutaric acid, an intermediate that is formed in certain monatin synthesis pathways, including some biosynthetic pathways.

6. 发明授权

US08076108B2 Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors 有权
标题翻译：用于生产莫纳甜及其前体的立体异构体的多肽和生物合成途径
公开(公告)号：US08076108B2
公开(公告)日：2011-12-13
申请号：US11714279
申请日：2007-03-06
申请人： Brian J. Brazeau , Mervyn L. De Souza , Steven J. Gort , Paula M. Hicks , Sherry R. Kollmann , Jose M. Laplaza , Sara C. McFarlan , Fernando A. Sanchez-Riera , Christopher Solheid
发明人： Brian J. Brazeau , Mervyn L. De Souza , Steven J. Gort , Paula M. Hicks , Sherry R. Kollmann , Jose M. Laplaza , Sara C. McFarlan , Fernando A. Sanchez-Riera , Christopher Solheid
IPC分类号： C12P17/10
CPC分类号： C12N9/1096 , C12N9/90 , C12P17/10
摘要： Monatin and certain stereoisomers of monatin, such as R,R monatin and S,R monatin, as well as salts thereof, are produced using polypeptides and biosynthetic pathways. These polypeptides and biosynthetic pathways are also useful in the production of R-2-hydroxy-2-(indoly-3-ylmethyl)-4-keto glutaric acid, an intermediate that is formed in certain monatin synthesis pathways, including some biosynthetic pathways.
摘要翻译：使用多肽和生物合成途径产生莫纳甜和莫纳甜的某些立体异构体，例如R，R莫纳甜和S，R莫纳甜及其盐。这些多肽和生物合成途径也可用于生产在特定莫纳甜合成途径中形成的包括一些生物合成途径的中间体R-2-羟基-2-（吲哚-3-基甲基）-4-酮戊二酸。

7. 发明授权

US09005938B2 Aldolases, nucleic acids encoding them and methods for making and using them 有权
标题翻译：醛缩酶，编码它们的核酸和制备和使用它们的方法
公开(公告)号：US09005938B2
公开(公告)日：2015-04-14
申请号：US13235107
申请日：2011-09-16
申请人： Ellen Burke , Steven John Gort , Paula M. Hicks , Peter Luginbuhl , Sara C. McFarlan , Toby Richardson , Christopher Solheid , David Weiner , Lishan Zhao
发明人： Ellen Burke , Steven John Gort , Paula M. Hicks , Peter Luginbuhl , Sara C. McFarlan , Toby Richardson , Christopher Solheid , David Weiner , Lishan Zhao
IPC分类号： C12P17/10 , C12P13/22 , C12N9/10 , C12P21/06 , C12P19/34 , C07H21/04 , C12N9/88 , C12P13/00
CPC分类号： C12P17/10 , C12N9/88 , C12P13/001 , Y02P20/52
摘要： This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In some embodiments, the invention is directed to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides in accordance with the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts. In some embodiments, the invention provides polypeptides and biosynthetic pathways that are useful in the production of R-2-hydroxy 2-(indol-3ylmethyl)-4-keto glutaric acid (R-MP) and certain stereoisomers of monatin, such as R,R and S,R monatin, and salts thereof, as well as certain stereoisomers of monatin derivatives, such as the R,R and S,R configurations, and salts thereof.
摘要翻译：本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如但不限于HMG和/或KHG醛缩酶活性，编码这些多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。在一些实施方案中，本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如但不限于HMG和/或KHG醛缩酶活性，包括耐热和耐热活性，以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。根据本发明的多肽可以用于各种药物，农业和工业环境。在一些实施方案中，本发明提供了可用于制备R-2-羟基2-（吲哚-3-基甲基）-4-酮戊二酸（R-MP）和莫纳甜的某些立体异构体的多肽和生物合成途径，例如R ，R和S，R莫纳甜及其盐，以及莫纳甜衍生物的某些立体异构体，例如R，R和S，R构型及其盐。

8. 发明申请

US20120009634A1 ALDOLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 有权
标题翻译：阿尔法，核酸编码方法及其使用方法
公开(公告)号：US20120009634A1
公开(公告)日：2012-01-12
申请号：US13235107
申请日：2011-09-16
申请人： Ellen BURKE , Steven John Gort , Paula M. Hicks , Peter Luginbuhl , Sara C. McFarlan , Toby Richardson , Christopher Solheid , David Weiner , Lishan Zhao
发明人： Ellen BURKE , Steven John Gort , Paula M. Hicks , Peter Luginbuhl , Sara C. McFarlan , Toby Richardson , Christopher Solheid , David Weiner , Lishan Zhao
IPC分类号： C12P17/10
CPC分类号： C12P17/10 , C12N9/88 , C12P13/001 , Y02P20/52
摘要： This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In some embodiments, the invention is directed to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides in accordance with the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts. In some embodiments, the invention provides polypeptides and biosynthetic pathways that are useful in the production of R-2-hydroxy 2-(indol-3ylmethyl)-4-keto glutaric acid (R-MP) and certain stereoisomers of monatin, such as R,R and S, R monatin, and salts thereof, as well as certain stereoisomers of monatin derivatives, such as the R,R and S,R configurations, and salts thereof.
摘要翻译：本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如但不限于HMG和/或KHG醛缩酶活性，编码这些多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。在一些实施方案中，本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如但不限于HMG和/或KHG醛缩酶活性，包括耐热和耐热活性，以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。根据本发明的多肽可以用于各种药物，农业和工业环境。在一些实施方案中，本发明提供了可用于制备R-2-羟基2-（吲哚-3-基甲基）-4-酮戊二酸（R-MP）和莫纳甜的某些立体异构体的多肽和生物合成途径，例如R ，R和S，R莫纳甜及其盐，以及莫纳甜衍生物的某些立体异构体，例如R，R和S，R构型及其盐。

9. 发明授权

US08043837B2 Aldolases, nucleic acids encoding them and methods for making and using them 有权
标题翻译：醛缩酶，编码它们的核酸和制备和使用它们的方法
公开(公告)号：US08043837B2
公开(公告)日：2011-10-25
申请号：US11714909
申请日：2007-03-07
申请人： Ellen Burke , Steven John Gort , Paula M. Hicks , Peter Luginbuhl , Sara C. McFarlan , Toby Richardson , Christopher Solheid , David Weiner , Lishan Zhao
发明人： Ellen Burke , Steven John Gort , Paula M. Hicks , Peter Luginbuhl , Sara C. McFarlan , Toby Richardson , Christopher Solheid , David Weiner , Lishan Zhao
IPC分类号： C12P17/10 , C12P13/22 , C12P21/06 , C12N9/10 , C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： C12P17/10 , C12N9/88 , C12P13/001 , Y02P20/52
摘要： This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In some embodiments, the invention is directed to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides in accordance with the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts. In some embodiments, the invention provides polypeptides and biosynthetic pathways that are useful in the production of R-2-hydroxy 2-(indol-3ylmethyl)-4-keto glutaric acid (R-MP) and certain stereoisomers of monatin, such as R,R and S,R monatin, and salts thereof, as well as certain stereoisomers of monatin derivatives, such as the R,R and S,R configurations, and salts thereof.
摘要翻译：本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如但不限于HMG和/或KHG醛缩酶活性，编码这些多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。在一些实施方案中，本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如但不限于HMG和/或KHG醛缩酶活性，包括耐热和耐热活性，以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。根据本发明的多肽可以用于各种药物，农业和工业环境。在一些实施方案中，本发明提供了可用于制备R-2-羟基2-（吲哚-3-基甲基）-4-酮戊二酸（R-MP）和莫纳甜的某些立体异构体的多肽和生物合成途径，例如R ，R和S，R莫纳甜及其盐，以及莫纳甜衍生物的某些立体异构体，例如R，R和S，R构型及其盐。

10. 发明授权

US07888081B2 Methods and systems for increasing production of equilibrium reactions 失效
标题翻译：增加平衡反应产生的方法和系统
公开(公告)号：US07888081B2
公开(公告)日：2011-02-15
申请号：US11752492
申请日：2007-05-23
申请人： Anil Bhagwan Khare , Brent H. Hilbert , Christopher Solheid , Sara C. McFarlan , Fernando A. Sanchez-Riera , Kent Floy , Paula M. Hicks
发明人： Anil Bhagwan Khare , Brent H. Hilbert , Christopher Solheid , Sara C. McFarlan , Fernando A. Sanchez-Riera , Kent Floy , Paula M. Hicks
IPC分类号： C12P13/22 , C12N1/21
CPC分类号： C07D209/20 , B01D15/34 , B01D15/362 , B01D15/363 , B01D15/3804 , C12P17/10
摘要： Methods and systems for increasing the production of equilibrium reactions are described. In some embodiments, a method comprises removing enzymes from a reaction mixture once equilibrium is achieved, selectively re-adding enzymes and reactants for driving the product-forming reaction to product, and optionally recycling stabilized intermediates, by-products and/or co-products back into the reaction mixture. In some embodiments, a method comprises purifying the desired product from a reaction mixture and selectively recycling one or more components of the reaction mixture, such as original reactants, intermediates, co-products or by-products back into the reaction mixture as desired to improve titer. Systems for implementing the methods are also provided. In some embodiments the methods and systems are implemented for increasing the production of monatin and monatin derivatives, produced in multi-step equilibrium pathways.
摘要翻译：描述了用于增加平衡反应生成的方法和系统。在一些实施方案中，一种方法包括一旦达到平衡即从反应混合物中除去酶，选择性地重新加入用于将产物形成反应驱动到产物中的酶和反应物，以及任选地再循环稳定的中间体，副产物和/或副产物回到反应混合物中。在一些实施方案中，方法包括从反应混合物中纯化所需产物，并根据需要选择性地将反应混合物中的一种或多种组分（例如原始反应物，中间体，副产物或副产物）循环回到反应混合物中，以改善滴度。还提供了实现方法的系统。在一些实施方案中，实施方法和系统用于增加在多步平衡途径中产生的莫纳甜和莫纳甜衍生物的产生。

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