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1. 发明授权

US08507280B2 Method of normalizing surface tension of a sample fluid 有权
标题翻译：标准样品液体的表面张力的方法
公开(公告)号：US08507280B2
公开(公告)日：2013-08-13
申请号：US11838576
申请日：2007-08-14
申请人： Merrit Jacobs , Ed Graham , Karen Vavra , Chuck Noeson , Susan Danielson , Terri Fazio
发明人： Merrit Jacobs , Ed Graham , Karen Vavra , Chuck Noeson , Susan Danielson , Terri Fazio
IPC分类号： G01N35/00 , G01N1/00
CPC分类号： B01L3/0275 , B01L3/5082 , B01L2300/041 , G01N35/025 , G01N2035/1058 , G01N2035/1062 , Y10T436/107497 , Y10T436/11 , Y10T436/114998 , Y10T436/25 , Y10T436/2575
摘要： A method of normalizing surface tension of a sample fluid on a clinical analyzer is disclosed. The method comprises aspirating a portion of a sample fluid into a metering tip, the metering tip having a lower end through which the sample fluid is aspirated and an upper end; sealing the lower end of the metering tip, forming a cuvette for the portion of the sample fluid; pre-treating a micro-tip with a surface tension-normalizing agent, and then dispensing the surface tension-normalizing agent into the sample fluid in the cuvette; mixing the surface tension-normalizing agent and the sample fluid in the cuvette using the micro-tip to create a mixture of the sample fluid and the surface tension-normalizing agent, the mixture having a normalized surface tension; and using the mixture for testing on the clinical analyzer.
摘要翻译：公开了一种使临床分析仪上的样品流体的表面张力正常化的方法。该方法包括将一部分样品流体抽吸到计量尖端中，计量尖端具有下端，样品流体通过该下端吸入，上端; 密封计量尖端的下端，形成样品流体部分的比色皿; 用表面张力归一化剂预处理微尖端，然后将表面张力归一化剂分配到试管中的样品流体中; 使用微尖端将表面张力归一化剂和样品流体混合在比色杯中，以产生样品流体和表面张力归一化剂的混合物，该混合物具有归一化的表面张力; 并在临床分析仪上使用混合物进行测试。

2. 发明申请

US20080044908A1 Method of Normalizing Surface Tension of a Sample Fluid 有权
标题翻译：标准样品液体表面张力的方法
公开(公告)号：US20080044908A1
公开(公告)日：2008-02-21
申请号：US11838576
申请日：2007-08-14
申请人： Merrit Jacobs , Ed Graham , Karen Vavra , Chuck Noeson , Susan Denisison , Terri Fazio
发明人： Merrit Jacobs , Ed Graham , Karen Vavra , Chuck Noeson , Susan Denisison , Terri Fazio
IPC分类号： G01N33/48
CPC分类号： B01L3/0275 , B01L3/5082 , B01L2300/041 , G01N35/025 , G01N2035/1058 , G01N2035/1062 , Y10T436/107497 , Y10T436/11 , Y10T436/114998 , Y10T436/25 , Y10T436/2575
摘要： A method of normalizing surface tension of a sample fluid on a clinical analyzer is disclosed. The method comprises aspirating a portion of a sample fluid into a metering tip, the metering tip having a lower end through which the sample fluid is aspirated and an upper end; sealing the lower end of the metering tip, forming a cuvette for the portion of the sample fluid; pre-treating a micro-tip with a surface tension-normalizing agent, and then dispensing the surface tension-normalizing agent into the sample fluid in the cuvette; mixing the surface tension-normalizing agent and the sample fluid in the cuvette using the micro-tip to create a mixture of the sample fluid and the surface tension-normalizing agent, the mixture having a normalized surface tension; and using the mixture for testing on the clinical analyzer.
摘要翻译：公开了一种使临床分析仪上的样品流体的表面张力正常化的方法。该方法包括将一部分样品流体抽吸到计量尖端中，计量尖端具有下端，样品流体通过该下端吸入，上端; 密封计量尖端的下端，形成样品流体部分的比色皿; 用表面张力归一化剂预处理微尖端，然后将表面张力归一化剂分配到试管中的样品流体中; 使用微尖端将表面张力归一化剂和样品流体混合在比色杯中，以产生样品流体和表面张力归一化剂的混合物，该混合物具有归一化的表面张力; 并在临床分析仪上使用混合物进行测试。

3. 发明申请

US20050014284A1 IMPROVED FLUID MIXING IN A DIAGNOSTIC ANALYZER 审中-公开
标题翻译：改进的液体混合在诊断分析仪
公开(公告)号：US20050014284A1
公开(公告)日：2005-01-20
申请号：US10622258
申请日：2003-07-18
申请人： Merrit Jacobs , Ed Graham
发明人： Merrit Jacobs , Ed Graham
IPC分类号： B01F11/00 , G01N33/92 , G01N35/00 , G01N35/10 , G01N1/10
CPC分类号： B01F11/0071 , B01F11/0074 , G01N33/92 , G01N35/10 , G01N2035/106 , Y10T436/25 , Y10T436/2575
摘要： A method for mixing a liquid in a container in a diagnostic analyzer that includes: (a) providing a probe having a probe tip for aspirating and dispensing the liquid in the container; (b) providing the container containing one or more liquid(s) to be mixed; (c) inserting the probe into a first location of the container; (d) aspirating the one or more liquid(s) into the probe; (e) repositioning the probe or container to place the probe at a second location in the container; and (f) dispensing the one or more liquid(s) with the probe. A method of determining the amount of an analyte in a sample, includes the steps of: providing a sample containing an analyte in a container; providing a first reagent in the container; mixing the first reagent and sample as described above; optionally incubating the combined sample and reagent; optionally adding a second reagent to the container and mixing the second reagent and sample and first reagent as described above; and analyzing the sample for an analyte.
摘要翻译：一种用于在诊断分析仪中将容器中的液体混合的方法，包括：（a）提供具有用于吸入和分配容器中的液体的探针尖端的探针; （b）提供含有一种或多种待混合液体的容器; （c）将探针插入容器的第一位置; （d）将一种或多种液体吸入探针中; （e）重新定位探针或容器以将探针放置在容器中的第二位置; 和（f）用探针分配一种或多种液体。确定样品中分析物的量的方法包括以下步骤：在容器中提供含有分析物的样品; 在容器中提供第一试剂; 如上所述混合第一试剂和样品; 任选地孵化组合的样品和试剂; 任选地向容器中加入第二试剂并如上所述混合第二试剂和样品和第一试剂; 并分析样品中的分析物。

4. 发明授权

US07457686B2 Robotic arm alignment 有权
标题翻译：机器臂对齐
公开(公告)号：US07457686B2
公开(公告)日：2008-11-25
申请号：US11685854
申请日：2007-03-14
申请人： Zhong Ding , Ed Graham
发明人： Zhong Ding , Ed Graham
IPC分类号： G06F19/00
CPC分类号： B25J9/1692 , G01N35/0099 , G01N2035/0491
摘要： A method for aligning the position of a movable arm includes: providing an alignment element on the apparatus projecting a distance above the apparatus in the z-direction and having a surface lying in a plane formed by an x and y axis; providing a movable arm having a tool at the free end; positioning the object such that the surface of the element faces the tool; moving the tool in a direction towards the surface of the element; sensing when the tool reaches a predetermined point on or above the surface of the element, whereby the position of the tool in the z-direction is determined based on the relationship between the measured response of the tool and the height of the tool above the surface of the alignment element; placing the tool on or at a distance in the z-direction from the surface; moving the tool in the x-direction while sensing the surface of the element; moving the tool in the x-direction until an edge of the element is sensed; determining the center in the x-direction based on the known distance the tool has moved and the known dimensions of the element in the x-direction; placing the tool on or at a distance in the z-direction from the surface; moving the tool in the y-direction while sensing the surface of the element; moving the tool in the y-direction until an edge of the element is sensed; determining the center in the y-direction based on the known distance the tool has moved and the known dimensions of the element in the y-direction. In a preferred embodiment, the tool is a metering probe having a disposable tip on the end thereof. In another preferred embodiment, the measured response is the air pressure in the probe and the metering probe has a source of compressed air for expelling air out of the end of the probe and a pressure transducer for measuring the air pressure inside the metering probe.
摘要翻译：用于对准可动臂的位置的方法包括：在所述设备上设置对准元件，所述对准元件在所述设备上在z方向上突出一定距离，并且具有位于由x和y轴形成的平面中的表面; 提供在自由端具有工具的可动臂; 定位物体使得元件的表面面向工具; 沿着朝向元件表面的方向移动工具; 当工具到达元件表面上或上方的预定点时，检测工具在z方向上的位置是基于测量的工具响应与工具在表面上方的高度之间的关系来确定的的对准元件; 将工具放置在距离表面的z方向上或距离一定距离处; 在检测元件表面的同时沿x方向移动工具; 在x方向上移动工具直到检测到元件的边缘; 基于工具已经移动的已知距离和元素在x方向上的已知尺寸来确定x方向上的中心; 将工具放置在距离表面的z方向上或距离一定距离处; 在检测元件表面的同时沿y方向移动工具; 在y方向上移动工具直到检测到元件的边缘; 基于工具已经移动的距离以及元素在y方向上的已知尺寸来确定y方向上的中心。在优选实施例中，该工具是在其端部上具有一次性尖端的计量探针。在另一个优选实施例中，测量的响应是探针中的空气压力，并且计量探针具有用于将空气排出探针末端的压缩空气源和用于测量计量探针内部的空气压力的压力传感器。

5. 发明申请

US20080228319A1 ROBOTIC ARM ALIGNMENT 有权
标题翻译：机械臂对准
公开(公告)号：US20080228319A1
公开(公告)日：2008-09-18
申请号：US11685854
申请日：2007-03-14
申请人： Zhong Ding , Ed Graham
发明人： Zhong Ding , Ed Graham
IPC分类号： G01D18/00
CPC分类号： B25J9/1692 , G01N35/0099 , G01N2035/0491
摘要： A method for aligning the position of a movable arm includes: providing an alignment element on the apparatus projecting a distance above the apparatus in the z-direction and having a surface lying in a plane formed by an x and y axis; providing a movable arm having a tool at the free end; positioning the object such that the surface of the element faces the tool; moving the tool in a direction towards the surface of the element; sensing when the tool reaches a predetermined point on or above the surface of the element, whereby the position of the tool in the z-direction is determined based on the relationship between the measured response of the tool and the height of the tool above the surface of the alignment element; placing the tool on or at a distance in the z-direction from the surface; moving the tool in the x-direction while sensing the surface of the element; moving the tool in the x-direction until an edge of the element is sensed; determining the center in the x-direction based on the known distance the tool has moved and the known dimensions of the element in the x-direction; placing the tool on or at a distance in the z-direction from the surface; moving the tool in the y-direction while sensing the surface of the element; moving the tool in the y-direction until an edge of the element is sensed; determining the center in the y-direction based on the known distance the tool has moved and the known dimensions of the element in the y-direction. In a preferred embodiment, the tool is a metering probe having a disposable tip on the end thereof. In another preferred embodiment, the measured response is the air pressure in the probe and the metering probe has a source of compressed air for expelling air out of the end of the probe and a pressure transducer for measuring the air pressure inside the metering probe.
摘要翻译：用于对准可动臂的位置的方法包括：在所述设备上设置对准元件，所述对准元件在所述设备上在z方向上突出一定距离，并且具有位于由x和y轴形成的平面中的表面; 提供在自由端具有工具的可动臂; 定位物体使得元件的表面面向工具; 沿着朝向元件表面的方向移动工具; 当工具到达元件表面上或上方的预定点时，检测工具在z方向上的位置是基于测量的工具响应与工具在表面上方的高度之间的关系来确定的的对准元件; 将工具放置在距离表面的z方向上或距离一定距离处; 在检测元件表面的同时沿x方向移动工具; 在x方向上移动工具直到检测到元件的边缘; 基于工具已经移动的已知距离和元素在x方向上的已知尺寸来确定x方向上的中心; 将工具放置在距离表面的z方向上或距离一定距离处; 在检测元件表面的同时沿y方向移动工具; 在y方向上移动工具直到检测到元件的边缘; 基于工具已经移动的距离以及元素在y方向上的已知尺寸来确定y方向上的中心。在优选实施例中，该工具是在其端部上具有一次性尖端的计量探针。在另一个优选实施例中，测量的响应是探针中的空气压力，并且计量探针具有用于将空气排出探针末端的压缩空气源和用于测量计量探针内部的空气压力的压力传感器。

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