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1. 发明授权

US09550750B2 Indoline compounds as aldosterone synthase inhibitors 有权
标题翻译：二氢吲哚化合物作为醛固酮合酶抑制剂
公开(公告)号：US09550750B2
公开(公告)日：2017-01-24
申请号：US14433441
申请日：2013-10-02
申请人： Merck Sharp & Dohme Corp. , ElexoPharm GmbH , Amjad Ali , Michael Man-Chu Lo , Edward Metzger , Lina Yin , Rolf Hartmann , Qingzhong Hu , Ralf Heim , Christina Zimmer
发明人： Amjad Ali , Michael Man-Chu Lo , Edward Metzger , Lina Yin , Rolf Hartmann , Qingzhong Hu , Ralf Heim , Christina Zimmer
IPC分类号： C07D401/04 , A61K31/4439 , A61K45/06 , A61K31/4709 , C07D409/14
CPC分类号： C07D401/04 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K45/06 , C07D409/14 , A61K2300/00
摘要： This invention relates to indo line compounds of the structural formula I, or their pharmaceutically acceptable salts, wherein the variables are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.
摘要翻译：本发明涉及结构式I的吲哚类化合物或其药学上可接受的盐，其中变量在本文中定义。本发明化合物选择性地抑制醛固酮合酶。本发明还提供包含式I化合物或其盐的药物组合物，以及潜在的治疗改善或预防可通过抑制醛固酮合酶治疗的病症的方法。

2. 发明申请

US20150225365A1 INDOLINE COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS 有权
标题翻译：吲哚酚化合物作为醛固酮合成酶抑制剂
公开(公告)号：US20150225365A1
公开(公告)日：2015-08-13
申请号：US14433441
申请日：2013-10-02
申请人： Amjad ALI , Man-Chu Michael , Edward METZGER , Lina YIN , Rolf HARTMANN , Qingzhong HU , Ralf HEIM , Christina ZIMMER , MERCK SHARP & DOHME CORP. , ELEXOPHARM GMBH
发明人： Amjad Ali , Michael Man-Chu Lo , Edward Metzger , Lina Yin , Rolf Hartmann , Qingzhong Hu , Ralf Heim , Christina Zimmer
IPC分类号： C07D401/04 , C07D409/14
CPC分类号： C07D401/04 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K45/06 , C07D409/14 , A61K2300/00
摘要： This invention relates to indo line compounds of the structural formula I, or their pharmaceutically acceptable salts, wherein the variables are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.
摘要翻译：本发明涉及结构式I的吲哚类化合物或其药学上可接受的盐，其中变量在本文中定义。本发明化合物选择性地抑制醛固酮合酶。本发明还提供包含式I化合物或其盐的药物组合物，以及潜在的治疗改善或预防可通过抑制醛固酮合酶治疗的病症的方法。

3. 发明授权

US09073929B2 Aldosterone synthase inhibitors 有权
标题翻译：醛固酮合酶抑制剂
公开(公告)号：US09073929B2
公开(公告)日：2015-07-07
申请号：US14112945
申请日：2012-04-20
申请人： Scott B. Hoyt , Whitney Lane Petrilli , Clare London , Yusheng Xiong , Jerry Andrew Taylor , Amjad Ali , Michael Man-Chu Lo , Timothy J. Henderson , Qingzhong Hu , Rolf Hartmann , Lina Yin , Ralf Heim , Emmanuel Bey , Rohit Saxena , Swapan Kumar Samanta , Bheemashankar A. Kulkarni
发明人： Scott B. Hoyt , Whitney Lane Petrilli , Clare London , Yusheng Xiong , Jerry Andrew Taylor , Amjad Ali , Michael Man-Chu Lo , Timothy J. Henderson , Qingzhong Hu , Rolf Hartmann , Lina Yin , Ralf Heim , Emmanuel Bey , Rohit Saxena , Swapan Kumar Samanta , Bheemashankar A. Kulkarni
IPC分类号： C07D471/04 , C07D487/04 , C07D519/00 , A61K31/41 , A61K45/06
CPC分类号： C07D487/04 , A61K31/41 , A61K45/06 , C07D471/04 , C07D519/00 , A61K2300/00
摘要： This invention relates to tricyclic triazole analogs of the formula I or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthetase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthetase.
摘要翻译：本发明涉及式I的三环三唑类似物或其药学上可接受的盐，其中该变量在本文中定义。本发明化合物选择性地抑制醛固酮合成酶。本发明还提供包含式I化合物或其盐的药物组合物，以及用于治疗，改善或预防可通过抑制醛固酮合成酶治疗的病症的方法。

4. 发明申请

US20140045819A1 ALDOSTERONE SYNTHASE INHIBITORS 有权
公开(公告)号：US20140045819A1
公开(公告)日：2014-02-13
申请号：US14112945
申请日：2012-04-20
申请人： Scott B. Hoyt , Whitney Lane Petrilli , Clare London , Yusheng Xiong , Jerry Andrew Taylor , Amjad Ali , Michael Man-Chu Lo , Timothy J. Henderson , Qingzhong Hu , Rolf Hartmann , Lina Yin , Ralf Heim , Emmanuel Bey , Rohit Saxena , Swapan Kumar Samanta , Bheemashankar A. Kulkarni
发明人： Scott B. Hoyt , Whitney Lane Petrilli , Clare London , Yusheng Xiong , Jerry Andrew Taylor , Amjad Ali , Michael Man-Chu Lo , Timothy J. Henderson , Qingzhong Hu , Rolf Hartmann , Lina Yin , Ralf Heim , Emmanuel Bey , Rohit Saxena , Swapan Kumar Samanta , Bheemashankar A. Kulkarni
IPC分类号： C07D487/04 , C07D471/04
CPC分类号： C07D487/04 , A61K31/41 , A61K45/06 , C07D471/04 , C07D519/00 , A61K2300/00
摘要： This invention relates to tricyclic triazole analogues of the formula I or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthetase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthetase.
摘要翻译：本发明涉及式I的三环三唑类似物或其药学上可接受的盐，其中该变量在本文中定义。本发明化合物选择性地抑制醛固酮合成酶。本发明还提供包含式I化合物或其盐的药物组合物，以及用于治疗，改善或预防可通过抑制醛固酮合成酶治疗的病症的方法。

5. 发明授权

US09745282B2 Indoline compounds as aldosterone synthase inhibitors 有权
公开(公告)号：US09745282B2
公开(公告)日：2017-08-29
申请号：US15197957
申请日：2016-06-30
申请人： Merck Sharp & Dohme Corp. , ElexoPharm GmbH
发明人： Amjad Ali , Michael Man-Chu Lo , Edward Metzger , Lina Yin , Rolf Hartmann , Qingzhong Hu , Ralf Heim , Christina Zimmer
IPC分类号： C07D401/04 , A61K31/4709 , A61K31/4439 , A61K45/06 , C07D409/14 , A61K31/4725
CPC分类号： C07D401/04 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K45/06 , C07D409/14 , A61K2300/00
摘要： This invention relates to indoline compounds of the structural formula: or their pharmaceutically acceptable salts, wherein the variables are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.

6. 发明申请

US20160304486A1 INDOLINE COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS 审中-公开
标题翻译：吲哚酚化合物作为醛固酮合成酶抑制剂
公开(公告)号：US20160304486A1
公开(公告)日：2016-10-20
申请号：US15197957
申请日：2016-06-30
申请人： Merck Sharp & Dohme Corp. , ElexoPharm GmbH
发明人： Amjad Ali , Michael Man-Chu Lo , Edward Metzger , Lina Yin , Rolf Hartmann , Qingzhong Hu , Ralf Heim , Christina Zimmer
IPC分类号： C07D401/04 , A61K31/4439 , C07D409/14 , A61K31/4725
CPC分类号： C07D401/04 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K45/06 , C07D409/14 , A61K2300/00
摘要： This invention relates to indoline compounds of the structural formula: or their pharmaceutically acceptable salts, wherein the variables are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.
摘要翻译：或其药学上可接受的盐，其中变量在本文中定义。本发明化合物选择性地抑制醛固酮合酶。本发明还提供包含式I化合物或其盐的药物组合物，以及潜在的治疗，改善或预防可通过抑制醛固酮合酶治疗的病症的方法。

7. 发明申请

US20110118241A1 6-Pyridin-3-YL-3,4-Dihydro-1H-Quinolin-2-One Derivatives and Related Compounds as Inhibitors of the Human Aldosterone Synthase CYP11B2 有权
标题翻译： 6-吡啶-3-基-L-3,4-二氢-1H-喹啉-2-酮衍生物和相关化合物作为人醛固酮合酶CYP11B2的抑制剂
公开(公告)号：US20110118241A1
公开(公告)日：2011-05-19
申请号：US12990909
申请日：2009-05-05
申请人： Rolf W. Hartmann , Ralf Heim , Simon Lucas
发明人： Rolf W. Hartmann , Ralf Heim , Simon Lucas
IPC分类号： A61K31/5415 , C07D401/10 , C07D471/06 , C07D417/10 , C07D413/10 , A61K31/4709 , A61K31/4439 , A61K31/4725 , A61K31/4745 , A61K31/506 , A61K31/538 , A61K31/498 , A61K31/536 , A61P9/12 , A61P5/40 , A61P9/04 , A61P13/12 , A61P9/10 , A61P9/00 , A61P3/04 , A61P29/00
CPC分类号： C07D401/04 , C07D215/227 , C07D221/06 , C07D401/14 , C07D471/04
摘要： The invention provides compounds of the general formula (I) which are inhibitors of the human aldosterone synthase, and also pharmaceutical compositions containing these compounds, and the use of these compounds and other heteroaryl substituted quinolinone derivatives for the treatment of hyperaldosteronism and/or disorders or diseases that are mediated by 11 β-hydroxylase (CYP11 B1).
摘要翻译：本发明提供了作为人醛固酮合酶抑制剂的通式（I）化合物，以及含有这些化合物的药物组合物，以及这些化合物和其它杂芳基取代的喹啉酮衍生物用于治疗醛固酮增多症和/或病症或由11β-羟化酶（CYP11B1）介导的疾病。

8. 发明授权

US08403009B2 Method and device for filling containers 有权
标题翻译：填充容器的方法和装置
公开(公告)号：US08403009B2
公开(公告)日：2013-03-26
申请号：US12538523
申请日：2009-08-10
申请人： Joachim Noe , Thomas Ruelker , Ralf Heim
发明人： Joachim Noe , Thomas Ruelker , Ralf Heim
IPC分类号： B65B3/04
CPC分类号： B65B5/103 , B65B43/52 , B65B43/56 , B65G47/082 , B65G47/5127
摘要： A method for filling a plurality of containers in cycles at a predetermined number of stationary filling units arranged in a row with a first spacing from each other. The method includes providing a plurality of positively guided containers in a row, one-by-one, wherein the containers have a uniform second spacing from each other, wherein the first spacing of the individual filling units is a whole-number multiple of the second spacing of the containers, and filling a predetermined number of the containers simultaneously at the filling units. The containers are shifted in cycles along the filling units in a transport direction by a step length, which is a whole-number multiple of the second spacing of the containers and which is shorter than a third spacing between a first filling unit and a last filling unit steps of filling and shifting are repeated over a predetermined number of iterations.
摘要翻译：一种用于以预定数量的固定填充单元周期地填充多个容器的方法，所述预定数量的固定填充单元彼此排列成一行。所述方法包括一排一列地提供一排一排的带正导向的容器，其中容器彼此具有均匀的第二间隔，其中各个填充单元的第一间隔是第二间隔的整数倍容器的间隔，以及在填充单元处同时填充预定数量的容器。容器沿着输送方向沿着填充单元沿循环移动步长，其是容器的第二间距的整数倍，并且比第一填充单元和最后填充物之间的第三间隔短在预定次数的迭代中重复填充和移位的单元步骤。

9. 发明申请

US20110112067A1 Inhibitors of the Human Aldosterone Sythase CYP11B2 有权
标题翻译：人醛固酮相关CYP11B2抑制剂
公开(公告)号：US20110112067A1
公开(公告)日：2011-05-12
申请号：US12938581
申请日：2010-11-03
申请人： Rolf W. Hartmann , Ralf Heim , Simon Lucas
发明人： Rolf W. Hartmann , Ralf Heim , Simon Lucas
IPC分类号： A61K31/4709 , C07D401/10 , C07D417/10 , C07D413/10 , C07D471/06 , A61K31/4439 , A61K31/4725 , A61K31/55 , A61K31/4745 , A61K31/553 , A61K31/554 , A61P9/12 , A61P9/04 , A61P9/10 , A61P9/00 , A61P29/00 , A61P3/04 , A61P7/00
CPC分类号： C07D401/10 , C07D413/10 , C07D417/10 , C07D471/06
摘要： The invention provides compounds of the general formula (I) which are inhibitors of the human aldosterone synthase, and also pharmaceutical compositions containing these compounds, and a method of treating of hyperaldosteronism and/or disorders or diseases that are mediated by 11β-hydroxylase (CYP11B1) with these compounds.
摘要翻译：本发明提供了作为人醛固酮合酶抑制剂的通式（I）化合物，以及含有这些化合物的药物组合物，以及治疗醛固酮增多症和/或由11β-羟化酶介导的疾病或疾病的方法（ CYP11B1）与这些化合物。

10. 发明申请

US20080307757A1 Device for Conveying Tablets 审中-公开
标题翻译：输送片剂装置
公开(公告)号：US20080307757A1
公开(公告)日：2008-12-18
申请号：US12134599
申请日：2008-06-06
申请人： Ralf Heim , Wolfgang Krahl , Michael Kronawitter , Rolf Armbruster , Bernd Geiselhardt , Joachim Noe
发明人： Ralf Heim , Wolfgang Krahl , Michael Kronawitter , Rolf Armbruster , Bernd Geiselhardt , Joachim Noe
IPC分类号： B65B1/08 , B65B1/30
CPC分类号： B65G27/16 , B65G27/04 , B65G27/34 , B65G2201/027
摘要： A device for conveying tablets has a lower part, an upper part with at least one guide channel for holding and conveying the tablets, and several elastic elements, arranged a certain distance apart, on each of which at least one piezoelectric vibratory element is mounted, wherein the elastic elements are arranged between the upper part and the lower part and connect the two parts together. In addition, the device has at least one control unit for exciting the piezoelectric vibratory elements and thus the elastic elements and a sorting device installed in the area of the guide channel to separate the good tablets from the bad.
摘要翻译：用于输送片剂的装置具有下部，具有用于保持和输送片剂的至少一个引导通道的上部和布置成一定距离的几个弹性元件，每个弹性元件安装有至少一个压电振动元件，其中所述弹性元件布置在所述上部和下部之间并将所述两个部分连接在一起。此外，该装置具有至少一个用于激发压电振动元件和因此弹性元件的控制单元，以及安装在引导通道的区域中的分类装置，以将好的片剂与坏的分离。

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