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1. 发明申请

US20110281347A1 Multivalent vaccines comprising recombinant viral vectors 有权
标题翻译：包含重组病毒载体的多价疫苗
公开(公告)号：US20110281347A1
公开(公告)日：2011-11-17
申请号：US13134190
申请日：2011-05-31
申请人： Menzo Jans Emco Havenga , Ronald Vogels , Jerald C. Sadoff , David Hone , Yasir Abdul Wahid Skeiky , Katarina Radosevic
发明人： Menzo Jans Emco Havenga , Ronald Vogels , Jerald C. Sadoff , David Hone , Yasir Abdul Wahid Skeiky , Katarina Radosevic
IPC分类号： C12N15/63
CPC分类号： A61K39/04 , A61K35/761 , A61K2039/523 , A61K2039/5256 , A61K2039/53 , A61K2039/55544 , C07K14/35 , C07K2319/00 , C12N2710/10343
摘要： Described are vaccines comprising recombinant vectors, such as recombinant adenoviruses. The vectors comprise heterologous nucleic acids encoding at least two antigens from one or more tuberculosis-causing bacilli. Also described is the use of specific protease recognition sites linking antigens through which the encoded antigens are separated upon cleavage. After cleavage, the antigens contribute to the immune response in a separate manner. The recombinant vectors may comprise a nucleic acid encoding the protease cleaving the linkers and separating the antigens. Also described is the use of genetic adjuvants encoded by the recombinant vectors, wherein such genetic adjuvants may also be cleaved through the presence of the cleavable linkers and the specific protease.
摘要翻译：描述了包含重组载体例如重组腺病毒的疫苗。载体包含编码来自一种或多种结核分枝杆菌的至少两种抗原的异源核酸。还描述了连接抗原的特异性蛋白酶识别位点的使用，通过该抗原，编码的抗原在切割时被分离。在切割后，抗原以单独的方式有助于免疫应答。重组载体可以包含编码切割接头并分离抗原的蛋白酶的核酸。还描述了由重组载体编码的遗传佐剂的用途，其中这种遗传佐剂也可以通过可切割接头和特异性蛋白酶的存在来切割。

2. 发明申请

US20090123438A1 Multivalent Vaccines Comprising Recombinant Viral Vectors 有权
标题翻译：包含重组病毒载体的多价疫苗
公开(公告)号：US20090123438A1
公开(公告)日：2009-05-14
申请号：US11667975
申请日：2005-11-15
申请人： Menzo Jans Emco Havenga , Ronald Vogels , Jerald C. Sadoff , David Hone , Yasir Abdul Wahid Skeiky , Katarina Radosevic
发明人： Menzo Jans Emco Havenga , Ronald Vogels , Jerald C. Sadoff , David Hone , Yasir Abdul Wahid Skeiky , Katarina Radosevic
IPC分类号： A61K48/00 , A61K39/04 , C12N15/861 , C12N7/01
CPC分类号： A61K39/04 , A61K35/761 , A61K2039/523 , A61K2039/5256 , A61K2039/53 , A61K2039/55544 , C07K14/35 , C07K2319/00 , C12N2710/10343
摘要： The invention relates to vaccines comprising recombinant vectors, such as recombinant adenoviruses. The vectors comprise heterologous nucleic acids encoding for at least two antigens from one or more tuberculosis-causing bacilli. The invention also relates to the use of specific protease recognition sites linking antigens through which the encoded antigens are separated upon cleavage. After cleavage, the antigens contribute to the immune response in a separate manner. The recombinant vectors may comprise a nucleic acid encoding the protease cleaving the linkers and separating the antigens. The invention furthermore relates to the use of genetic adjuvants encoded by the recombinant vectors, wherein such genetic adjuvants may also be cleaved through the presence of the cleavable linkers and the specific protease.
摘要翻译：本发明涉及包含重组载体例如重组腺病毒的疫苗。载体包含编码来自一种或多种结核分枝杆菌的至少两种抗原的异源核酸。本发明还涉及连接抗原的特异性蛋白酶识别位点的用途，通过该抗原将经编码的抗原在切割后分离。在切割后，抗原以单独的方式有助于免疫应答。重组载体可以包含编码切割接头并分离抗原的蛋白酶的核酸。本发明还涉及由重组载体编码的遗传佐剂的用途，其中这种遗传佐剂也可以通过存在可切割接头和特异性蛋白酶来切割。

3. 发明申请

US20110256166A1 Multivalent vaccines comprising recombinant viral vectors 有权
标题翻译：包含重组病毒载体的多价疫苗
公开(公告)号：US20110256166A1
公开(公告)日：2011-10-20
申请号：US13134206
申请日：2011-05-31
申请人： Menzo Jans Emco Havenga , Ronald Vogels , Jerald C. Sadoff , David Hone , Yasir Abdul Wahid Skeiky , Katarina Radosevic
发明人： Menzo Jans Emco Havenga , Ronald Vogels , Jerald C. Sadoff , David Hone , Yasir Abdul Wahid Skeiky , Katarina Radosevic
IPC分类号： A61K39/04 , C12N15/63 , A61P31/06 , C12N15/62
CPC分类号： A61K39/04 , A61K35/761 , A61K2039/523 , A61K2039/5256 , A61K2039/53 , A61K2039/55544 , C07K14/35 , C07K2319/00 , C12N2710/10343
摘要： The invention relates to vaccines comprising recombinant vectors, such as recombinant adenoviruses. The vectors comprise heterologous nucleic acids encoding for at least two antigens from one or more tuberculosis-causing bacilli. Also described is the use of specific protease recognition sites linking antigens through which the encoded antigens are separated upon cleavage. After cleavage, the antigens contribute to the immune response in a separate manner. The recombinant vectors may comprise a nucleic acid encoding the protease cleaving the linkers and separating the antigens. Further described is the use of genetic adjuvants encoded by the recombinant vectors, wherein such genetic adjuvants may also be cleaved through the presence of the cleavable linkers and the specific protease.
摘要翻译：本发明涉及包含重组载体例如重组腺病毒的疫苗。载体包含编码来自一种或多种结核分枝杆菌的至少两种抗原的异源核酸。还描述了连接抗原的特异性蛋白酶识别位点的使用，通过该抗原，编码的抗原在切割时被分离。在切割后，抗原以单独的方式有助于免疫应答。重组载体可以包含编码切割接头并分离抗原的蛋白酶的核酸。进一步描述了由重组载体编码的遗传佐剂的用途，其中此类遗传佐剂也可通过存在可切割连接子和特异性蛋白酶来切割。

4. 发明授权

US08012467B2 Multivalent vaccines comprising recombinant viral vectors 有权
标题翻译：包含重组病毒载体的多价疫苗
公开(公告)号：US08012467B2
公开(公告)日：2011-09-06
申请号：US11667975
申请日：2005-11-15
申请人： Menzo J. E. Havenga , Ronald Vogels , Jerald Sadoff , David Hone , Yasir A. W. Skeiky , Katarina Radosevic
发明人： Menzo J. E. Havenga , Ronald Vogels , Jerald Sadoff , David Hone , Yasir A. W. Skeiky , Katarina Radosevic
IPC分类号： A61K39/00 , A61K39/04 , A61K39/235 , C12N15/31
CPC分类号： A61K39/04 , A61K35/761 , A61K2039/523 , A61K2039/5256 , A61K2039/53 , A61K2039/55544 , C07K14/35 , C07K2319/00 , C12N2710/10343
摘要： The invention relates to vaccines comprising recombinant vectors, such as recombinant adenoviruses. The vectors comprise heterologous nucleic acids encoding for at least two antigens from one or more tuberculosis-causing bacilli. The invention also relates to the use of specific protease recognition sites linking antigens through which the encoded antigens are separated upon cleavage. After cleavage, the antigens contribute to the immune response in a separate manner. The recombinant vectors may comprise a nucleic acid encoding the protease cleaving the linkers and separating the antigens. The invention furthermore relates to the use of genetic adjuvants encoded by the recombinant vectors, wherein such genetic adjuvants may also be cleaved through the presence of the cleavable linkers and the specific protease.
摘要翻译：本发明涉及包含重组载体例如重组腺病毒的疫苗。载体包含编码来自一种或多种结核分枝杆菌的至少两种抗原的异源核酸。本发明还涉及连接抗原的特异性蛋白酶识别位点的用途，通过该抗原将经编码的抗原在切割后分离。在切割后，抗原以单独的方式有助于免疫应答。重组载体可以包含编码切割接头并分离抗原的蛋白酶的核酸。本发明还涉及由重组载体编码的遗传佐剂的用途，其中这种遗传佐剂也可以通过存在可切割接头和特异性蛋白酶来切割。

5. 发明授权

US09168292B2 Heterologous prime boost vaccination regimen against malaria 有权
标题翻译：针对疟疾的异源初次加强免疫接种方案
公开(公告)号：US09168292B2
公开(公告)日：2015-10-27
申请号：US13823581
申请日：2011-09-07
申请人： Ariane Rodriguez-Munoz , Katarina Radosevic , Angelique Alida Corina Lemckert
发明人： Ariane Rodriguez-Munoz , Katarina Radosevic , Angelique Alida Corina Lemckert
IPC分类号： F16K31/62 , A61K39/015 , C12N15/86 , A61K39/00
CPC分类号： A61K39/015 , A61K2039/5256 , A61K2039/545 , A61K2039/55555 , A61K2039/55566 , A61K2039/55577 , C12N15/86 , C12N2710/10343 , C12N2710/10362 , C12N2710/10371 , C12N2799/022 , Y02A50/412
摘要： Described are methods for inducing an immune response in a subject against an antigen from a malaria-causing parasite, preferably P. falciparum, the method comprising: (i) administering to a subject a priming composition comprising adjuvanted proteinaceous antigen-comprising circumsporozoite (CS) protein or an immunogenic part thereof from a malaria-causing parasite; (ii) administering to the subject a first boosting composition comprising a recombinant adenovirus vector that comprises nucleic acid encoding CS protein or immunogenic part thereof from a malaria-causing parasite; and (iii) administering to the subject a second boosting composition comprising a recombinant adenovirus vector that comprises nucleic acid encoding CS protein or an immunogenic part thereof from a malaria-causing parasite, wherein either the first boosting composition comprises a recombinant adenovirus vector of serotype 35 (Ad35) and the second boosting composition comprises a recombinant adenovirus of Ad26, or wherein the first boosting composition comprises a recombinant adenovirus vector of Ad26 and the second boosting composition comprises a recombinant adenovirus of Ad35.
摘要翻译：描述了在受试者中针对来自引起疟疾的寄生虫，优选恶性疟原虫的抗原诱导免疫应答的方法，所述方法包括：（i）向受试者施用包含佐剂化蛋白质抗原的环子孢子（CS）的引发组合物，蛋白质或其免疫原性部分来自引起疟疾的寄生虫; （ii）向所述受试者施用包含重组腺病毒载体的第一加强组合物，所述重组腺病毒载体包含编码来自疟原虫寄生虫的CS蛋白或其免疫原性部分的核酸; 和（iii）向所述受试者施用包含重组腺病毒载体的第二增强组合物，所述重组腺病毒载体包含编码CS蛋白或其免疫原性部分的来自引起疟疾的寄生虫的核酸，其中所述第一加强组合物包含血清型35的重组腺病毒载体（Ad35），第二增强组合物包含Ad26的重组腺病毒，或其中第一促进组合物包含Ad26的重组腺病毒载体，第二加强组合物包含Ad35的重组腺病毒。

6. 发明申请

US20130216580A1 HETEROLOGOUS PRIME BOOST VACCINATION REGIMEN AGAINST MALARIA 有权
标题翻译：异位妊娠加强疟疾疫苗
公开(公告)号：US20130216580A1
公开(公告)日：2013-08-22
申请号：US13823581
申请日：2011-09-07
申请人： Ariane Rodriguez-Munoz , Katarina Radosevic , Angelique Alida Corina Lemckert
发明人： Ariane Rodriguez-Munoz , Katarina Radosevic , Angelique Alida Corina Lemckert
IPC分类号： A61K39/015
CPC分类号： A61K39/015 , A61K2039/5256 , A61K2039/545 , A61K2039/55555 , A61K2039/55566 , A61K2039/55577 , C12N15/86 , C12N2710/10343 , C12N2710/10362 , C12N2710/10371 , C12N2799/022 , Y02A50/412
摘要： Described are methods for inducing an immune response in a subject against an antigen from a malaria-causing parasite, preferably P. falciparum, the method comprising: (i) administering to a subject a priming composition comprising adjuvanted proteinaceous antigen-comprising circumsporozoite (CS) protein or an immunogenic part thereof from a malaria-causing parasite; (ii) administering to the subject a first boosting composition comprising a recombinant adenovirus vector that comprises nucleic acid encoding CS protein or immunogenic part thereof from a malaria-causing parasite; and (iii) administering to the subject a second boosting composition comprising a recombinant adenovirus vector that comprises nucleic acid encoding CS protein or an immunogenic part thereof from a malaria-causing parasite, wherein either the first boosting composition comprises a recombinant adenovirus vector of serotype 35 (Ad35) and the second boosting composition comprises a recombinant adenovirus of Ad26, or wherein the first boosting composition comprises a recombinant adenovirus vector of Ad26 and the second boosting composition comprises a recombinant adenovirus of Ad35.
摘要翻译：描述了在受试者中针对来自引起疟疾的寄生虫，优选恶性疟原虫的抗原诱导免疫应答的方法，所述方法包括：（i）向受试者施用包含佐剂化蛋白质抗原的环子孢子（CS）的引发组合物，蛋白质或其免疫原性部分来自引起疟疾的寄生虫; （ii）向所述受试者施用包含重组腺病毒载体的第一加强组合物，所述重组腺病毒载体包含编码来自疟原虫寄生虫的CS蛋白或其免疫原性部分的核酸; 和（iii）向所述受试者施用包含重组腺病毒载体的第二增强组合物，所述重组腺病毒载体包含编码CS蛋白或其免疫原性部分的来自引起疟疾的寄生虫的核酸，其中所述第一加强组合物包含血清型35的重组腺病毒载体（Ad35），第二增强组合物包含Ad26的重组腺病毒，或其中第一促进组合物包含Ad26的重组腺病毒载体，第二加强组合物包含Ad35的重组腺病毒。

7. 发明申请

US20090110695A1 Compositions Comprising a Recombinant Adenovirus and an Adjuvant 审中-公开
标题翻译：包含重组腺病毒和佐剂的组合物
公开(公告)号：US20090110695A1
公开(公告)日：2009-04-30
申请号：US12225673
申请日：2007-03-26
申请人： Menzo Jans Emko Havenga , Katarina Radosevic
发明人： Menzo Jans Emko Havenga , Katarina Radosevic
IPC分类号： A61K39/00
CPC分类号： A61K39/235 , A61K39/12 , A61K2039/55505 , A61K2039/55566 , A61K2039/57 , C12N7/00 , C12N15/86 , C12N2710/10334 , C12N2710/10343 , Y02A50/412
摘要： The invention relates to pharmaceutical compositions comprising replication-defective adenoviruses, said adenoviruses generally comprising an adenoviral genome wherein a heterologous nucleic acid of interest is incorporated, and wherein said nucleic acid typically encodes an antigen. Such compositions are suitable for vaccination purposes. The pharmaceutical compositions of the present invention further comprise an adjuvant, which stimulates and increases the immune response towards the antigen encoded by the heterologous nucleic acid. Preferred adjuvants are oil-emulsion based adjuvants and aluminium-based adjuvants.
摘要翻译：本发明涉及包含复制缺陷型腺病毒的药物组合物，所述腺病毒通常包含腺病毒基因组，其中并入有感兴趣的异源核酸，并且其中所述核酸通常编码抗原。这种组合物适用于疫苗接种目的。本发明的药物组合物还包含佐剂，其刺激并增加针对由异源核酸编码的抗原的免疫应答。优选的佐剂是基于油乳液的佐剂和铝基助剂。

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