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1. 发明授权

US08987263B2 Basic esters of fatty alcohols and their use as anti-inflammatory or immunomodulatory agents 有权
标题翻译：脂肪醇的基础酯及其作为抗炎或免疫调节剂的用途
公开(公告)号：US08987263B2
公开(公告)日：2015-03-24
申请号：US10530776
申请日：2003-10-09
申请人： Meir Shinitzky , Irun R. Cohen , Raanan Margalit , Yaacov Herzig , Jeffrey Sterling , Gyorgy Toth , Istvan Miskolczi , Ferenc Rantal , Tivadar Tamas
发明人： Meir Shinitzky , Irun R. Cohen , Raanan Margalit , Yaacov Herzig , Jeffrey Sterling , Gyorgy Toth , Istvan Miskolczi , Ferenc Rantal , Tivadar Tamas
IPC分类号： A61K31/5377 , A61K31/495 , A61K31/131 , C07D295/00 , C07C211/01 , A61K31/195 , A61K31/22 , A61K31/221 , A61K31/222 , A61K31/223 , A61K31/44 , A61K31/4425 , A61K45/06
CPC分类号： A61K31/195 , A61K31/22 , A61K31/221 , A61K31/222 , A61K31/223 , A61K31/44 , A61K31/4425 , A61K45/06
摘要： Basic esters of fatty alcohols of the general formula: R1-O—CO-A or pharmaceutically acceptable salts thereof, wherein R1 is C12-C24 alkyl or C10-C24 alkenyl, and A is a residue containing at least one acyclic or cyclic amino group and/or at least one heteroaromatic ring containing a tertiary or quaternary nitrogen atom, are anti-inflammatory and immunomodulatory agents, useful in the treatment of immunologically-mediated inflammation, as adjuvants for antigens involved in both cellular and humoral responses.
摘要翻译：脂肪醇的基本酯，其通式为：R 1 -O-CO-A或其药学上可接受的盐，其中R 1为C 12 -C 24烷基或C 10 -C 24烯基，A为含有至少一个无环或环状氨基的残基和/或含有叔或季氮原子的至少一个杂芳环是用于治疗免疫介导的炎症的抗炎和免疫调节剂，作为参与细胞和体液应答的抗原的佐剂。

2. 发明授权

US4634590A Cell membrane proteins, compositions containing them and procedure for their preparation 失效
标题翻译：细胞膜蛋白，含有它们的组合物及其制备方法
公开(公告)号：US4634590A
公开(公告)日：1987-01-06
申请号：US648802
申请日：1984-09-07
申请人： Irun R. Cohen , Meir Shinitzky
发明人： Irun R. Cohen , Meir Shinitzky
IPC分类号： A61K39/00 , A61K35/12 , A61K35/26 , A61K38/00 , A61K38/16 , C07K14/705 , C07K3/28
CPC分类号： C07K14/705 , A61K38/00 , Y10S424/81 , Y10S435/82 , Y10S435/948 , Y10S530/806
摘要： Compositions for the prevention of, and for the treatment of autoimmune diseases which comprise as active ingredient membrane material shed from autoimmune T lymphocytes, or T lymphocytes activated by a pressure application and release process. There is also provided a process for obtaining such active materials and for preparing pharmaceutical compositions for these.
摘要翻译：用于预防和治疗自身免疫性疾病的组合物，其包含作为活性成分从自身免疫T淋巴细胞脱落的膜材料或通过压力施用和释放过程激活的T淋巴细胞。还提供了获得这种活性物质和制备这些活性物质的药物组合物的方法。

3. 发明授权

US06488933B2 Preparations for the treatment of T cell mediated diseases 失效
标题翻译：用于治疗T细胞介导的疾病的制剂
公开(公告)号：US06488933B2
公开(公告)日：2002-12-03
申请号：US08981861
申请日：1998-04-19
申请人： Irun R. Cohen , Dana Elias , Meir Shinitzky
发明人： Irun R. Cohen , Dana Elias , Meir Shinitzky
IPC分类号： A61K3900
CPC分类号： C07K16/18 , A61K9/0029 , A61K38/1709 , A61K39/0008 , A61K39/39 , A61K2039/55566 , A61K2039/57 , C07K14/4713
摘要： Metabolizable lipid emulsions, such as Intralipid and Lipofundin, are excellent vehicles for peptide therapy of autoimmune diseases and of other TH1 T cell mediated diseases or conditions, as it promotes a TH1 to TH2 cytokine shift. Such emulsions may be used in conjunction with an antigen recognized by inflammatory T cells associated with the pathogenesis of a T cell mediated disease or condition for the therapeutic treatment of such
摘要翻译：可代谢的脂质乳剂，如Intralipid和Lipofundin，是自身免疫疾病和其他TH1 T细胞介导的疾病或病症的肽治疗的优良载体，因为它促进TH1至TH2细胞因子转移。这样的乳剂可以与由与T细胞介导的疾病或病症有关的炎性T细胞识别的抗原结合使用，用于治疗这些

4. 再颁专利

USRE35277E Cell membrane proteins, compositions containing them and procedure for their preparation 失效
公开(公告)号：USRE35277E
公开(公告)日：1996-06-18
申请号：US242961
申请日：1988-09-06
申请人： Irun R. Cohen , Meir Shinitzky
发明人： Irun R. Cohen , Meir Shinitzky
IPC分类号： A61K38/00 , C07K14/705 , C07K14/725
CPC分类号： C07K14/705 , A61K38/00
摘要： Compositions for the prevention of, and for the treatment of autoimmune diseases which comprise as active ingredient membrane material shed from autoimmune T lymphocytes, or T lymphocytes activated by a pressure application and release process. There is also provided a process for obtaining such active materials and for preparing pharmaceutical compositions for these.

5. 发明授权

US5114721A Preparation of T-cell and T-cell membrane for use in prevention and treatment of autoimmune diseases 失效
标题翻译： T细胞和T细胞膜的制备用于预防和治疗自身免疫性疾病
公开(公告)号：US5114721A
公开(公告)日：1992-05-19
申请号：US323705
申请日：1989-03-15
申请人： Irun R. Cohen , Meir Shinitzky , Richard L. Edelson
发明人： Irun R. Cohen , Meir Shinitzky , Richard L. Edelson
IPC分类号： A61K35/12 , A61K35/14 , A61K35/26 , A61K39/00 , A61P37/00
CPC分类号： A61K39/0008 , Y10S514/825 , Y10S514/866 , Y10S514/885 , Y10S514/903
摘要： Pharmaceutical preparations are provided for preventing or treating autoimmune diseases in which the active principle is activated T-lymphocyte cells, specific for the autoimmune disease to be treated, which cells have been treated by incubation with a photoactivatable psoralen cross-linking agent, such as 8-methoxypsoralen, and then photoactivated. The active principle may also be the membrane fraction of such cells. Such preparations may be formulated into pharmaceutical compositions and administered to prevent or treat autoimmune disesases.

6. 发明授权

US4996194A Pressure treated autoimmune specific T cell compositions 失效
标题翻译：压力治疗的自身免疫特异性T细胞组合物
公开(公告)号：US4996194A
公开(公告)日：1991-02-26
申请号：US910876
申请日：1986-09-23
申请人： Irun R. Cohen , Meir Shinitzky
发明人： Irun R. Cohen , Meir Shinitzky
IPC分类号： A61K39/00 , A61K35/12 , A61K35/26 , A61K38/00 , A61K38/16 , C07K14/705
CPC分类号： C07K14/705 , A61K38/00 , Y10S424/81 , Y10S435/82 , Y10S435/948 , Y10S530/806
摘要： Composition for the prevention and treatment of autoimmune diseases are provided which comprise as an active ingredient membrane material shed from autoimmune T lymphocytes, or activated T lymphocytes which are treated by a pressure application and releases process. There is also provided processes for obtaining such active materials and for preparing pharmaceutical compositions containing them.
摘要翻译：提供了用于预防和治疗自身免疫性疾病的组合物，其包含作为活性成分从自身免疫性T淋巴细胞脱落的膜材料或通过压力施加和释放过程处理的活化T淋巴细胞。还提供了获得这种活性物质和制备含有它们的药物组合物的方法。

7. 发明授权

US4931275A Anti-tumor vaccines and their preparation 失效
标题翻译：抗肿瘤疫苗及其制备
公开(公告)号：US4931275A
公开(公告)日：1990-06-05
申请号：US198691
申请日：1988-05-24
申请人： Meir Shinitzky , Irun R. Cohen
发明人： Meir Shinitzky , Irun R. Cohen
IPC分类号： A61K39/00 , C07K2/00
CPC分类号： C07K2/00 , A61K39/00 , Y10S530/806 , Y10S530/828
摘要： There are provided anti-tumor vaccines which contain as active ingredient tumor cells which have been pressure treated so as to augment their antigenic properties, tumor cells treated with cholesteryl hemisuccinate (CHS) and subsequently pressure treated, or plasma membranes from either of, or membrane proteins shed from either of these cells, or a combination of any of these. According to another embodiment, tumor cells are treated with cholesteryl hemisuccinate or by the application and release of pressure, and subsequently with a cross-linking agent. Such cells, plasma membranes obtained from these and proteins shed from the surface of these are effective active ingredients in anti-tumor vaccines.
摘要翻译：提供抗肿瘤疫苗，其包含作为活性成分的肿瘤细胞，其已经被加压处理以增强其抗原性质，用胆固醇半琥珀酸盐（CHS）处理的肿瘤细胞并随后进行压力处理，或从任何一个或多个膜从这些细胞中的任一个中分离的蛋白质，或这些细胞的组合。根据另一个实施方案，用胆固醇基半琥珀酸盐或通过施加和释放压力，随后用交联剂处理肿瘤细胞。这些细胞，从这些获得的质膜和从其表面脱落的蛋白质是抗肿瘤疫苗中的有效活性成分。

8. 发明授权

US5861382A Methods for regulation of active TNF-.alpha. 失效
标题翻译：调节活性TNF-α的方法
公开(公告)号：US5861382A
公开(公告)日：1999-01-19
申请号：US436330
申请日：1995-06-29
申请人： Irun R. Cohen , Ofer Lider , Liora Cahalon , Oded Shoseyov , Raanan Margalit
发明人： Irun R. Cohen , Ofer Lider , Liora Cahalon , Oded Shoseyov , Raanan Margalit
IPC分类号： A61K31/70 , C07H11/00 , A01N43/16 , C07K14/525 , C08B37/10
CPC分类号： A61K31/7024 , A61K31/70 , A61K31/7016 , C07H11/00 , Y10S514/822 , Y10S514/825 , Y10S514/826 , Y10S514/885 , Y10S514/886 , Y10S530/868
摘要： Substances comprising disaccharides and substances comprising carboxylated and/or sulfated oligosaccharides in substantially purified form, and methods of using same, are disclosed for the regulation of cytokine activity in a host. For instance, the secretion of active Tumor Necrosis Factor Alpha (TNF-.alpha.) can be either inhibited or augmented selectively by administration to the host of an effective amount of a substance of the invention. Thus, the present invention also relates to pharmaceutical compositions and their use for the prevention and/or treatment of pathological processes involving the induction of active cytokine secretion, such as TNF-.alpha.. The invention also relates to the initiation of a desirable immune system-related response by the host to the presence of activators, including pathogens. The substances and pharmaceutical compositions of the present invention may be administered daily, at very low effective doses, typically below 0.1 mg/kg human, or at intervals of tip to about 5-8 days, preferably once a week.
摘要翻译： PCT No.PCT / US93 / 10868 Sec。 371日期：1995年6月29日 102（e）日期1995年6月29日PCT 1993年11月9日PCT公布。公开号WO94 / 11006 日期1994年5月26日包含二糖的物质和包含基本纯化形式的羧化和/或硫酸化寡糖的物质及其使用方法被公开用于调节宿主中的细胞因子活性。例如，活性肿瘤坏死因子α（TNF-α）的分泌可以通过给予宿主有效量的本发明的物质而被选择性地抑制或增强。因此，本发明还涉及药物组合物及其用于预防和/或治疗涉及诱导活性细胞因子分泌的病理过程如TNF-α的用途。本发明还涉及由宿主引起包括病原体在内的活化剂的存在引起所需的免疫系统相关应答。本发明的物质和药物组合物可以以非常低的有效剂量（通常低于0.1mg / kg的人），或以尖端间隔至约5-8天，优选每周一次施用。

9. 发明授权

US06750207B1 Compositions for the regulation of cytokine activity 失效
标题翻译：用于调节细胞因子活性的组合物
公开(公告)号：US06750207B1
公开(公告)日：2004-06-15
申请号：US09495723
申请日：2000-02-01
申请人： Irun R. Cohen , Ofer Lider , Liora Cahalon , Oded Shoseyov , Raanan Margalit
发明人： Irun R. Cohen , Ofer Lider , Liora Cahalon , Oded Shoseyov , Raanan Margalit
IPC分类号： A61K31715
CPC分类号： A61K31/7024 , A61K31/70 , A61K31/7016 , A61K31/727 , C07H11/00
摘要： A pharmaceutical composition for the regulation of cytokine activity in a subject. The composition features an effective amount of an oligosaccharide to inhibit the cytokine activity, preferably through inhibition of TNF-alpha activity. The oligosaccharide is more preferably up to four saccharide units in length, and optionally and more preferably, is N-sulfated with at least one other sulfur moeity. The compositions are useful for the treatment of various pathological conditions related to, caused by or promoted through, cytokine activity.
摘要翻译：用于调节受试者中细胞因子活性的药物组合物。组合物特征在于有效量的寡糖以抑制细胞因子活性，优选通过抑制TNF-α活性。寡糖更优选长达四个糖单元，并且任选地并且更优选的是用至少一种其它的硫醇的N-硫酸化。该组合物可用于治疗与由细胞因子活性引起或促进的各种病理状况。

10. 发明授权

US6020323A Compositions and methods for regulation of active TNF-.alpha. 失效
标题翻译：用于调节活性TNF-α的组合物和方法
公开(公告)号：US6020323A
公开(公告)日：2000-02-01
申请号：US486127
申请日：1995-06-07
申请人： Irun R. Cohen , Ofer Lider , Liora Cahalon , Oded Shoseyov , Raanan Margalit
发明人： Irun R. Cohen , Ofer Lider , Liora Cahalon , Oded Shoseyov , Raanan Margalit
IPC分类号： A61K31/70 , C07H11/00 , A01N43/04 , A61K39/00 , A61K45/05 , C07H15/00
CPC分类号： A61K31/7024 , A61K31/70 , A61K31/7016 , C07H11/00 , Y10S514/822 , Y10S514/825 , Y10S514/826 , Y10S514/885 , Y10S514/886 , Y10S530/868
摘要： Substances comprising disaccharides and substances comprising carboxylated and/or sulfated oligosaccharides in substantially purified form, and methods of using same, are disclosed for the regulation of cytokine activity in a host. For instance, the secretion of active Tumor Necrosis Factor Alpha (TNF-.alpha.) can be either inhibited or augmented selectively by administration to the host of an effective amount of a substance of the invention. Thus, the present invention also relates to pharmaceutical compositions and their use for the prevention and/or treatment of pathological processes involving the induction of active cytokine secretion, such as TNF-.alpha.. The invention also relates to the initiation of a desirable immune system-related response by the host to the presence of activators, including pathogens. The substances and pharmaceutical compositions of the present invention may be administered daily, at very low effective doses, typically below 0.1 mg/kg human, or at intervals of up to about 5-8 days, preferably once a week.
摘要翻译：公开了包含二糖的物质和包含基本纯化形式的羧化和/或硫酸化寡糖的物质及其使用方法，用于调节宿主中的细胞因子活性。例如，活性肿瘤坏死因子α（TNF-α）的分泌可以通过给予宿主有效量的本发明的物质而被选择性地抑制或增强。因此，本发明还涉及药物组合物及其用于预防和/或治疗涉及诱导活性细胞因子分泌的病理过程如TNF-α的用途。本发明还涉及由宿主引起包括病原体在内的活化剂的存在引起所需的免疫系统相关应答。本发明的物质和药物组合物可以以非常低的有效剂量（通常低于0.1mg / kg的人）或以至多约5-8天，优选每周一次的间隔施用。

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