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1. 发明授权

US09149369B2 Methods and devices for delivering and affixing tissue scaffolds 有权
标题翻译：用于递送和固定组织支架的方法和装置
公开(公告)号：US09149369B2
公开(公告)日：2015-10-06
申请号：US13542004
申请日：2012-07-05
申请人： Mehmet Z. Sengun , Kristian Dimatteo
发明人： Mehmet Z. Sengun , Kristian Dimatteo
IPC分类号： A61F2/46 , A61F2/30
CPC分类号： A61F2/4618 , A61F2002/30766 , A61F2002/4627
摘要： Methods and devices are provided for delivering and affixing tissue replacements. In one embodiment, a tissue scaffold can be delivered into a patient through a cannula to a cavity formed at a defect site in tissue, e.g., cartilage. A delivery shaft can be used to deliver the scaffold through the cannula, and a loading device can help load the scaffold onto the delivery shaft. A delivery guide device can position and temporarily hold the scaffold within the cavity. The delivery guide device can guide one or more surgical instruments to the scaffold to affix the scaffold within the cavity, e.g., to bone underlying the scaffold, using at least one securing mechanism.
摘要翻译：提供了用于递送和贴附组织替代物的方法和装置。在一个实施例中，组织支架可以通过套管递送到患者体内，形成在组织例如软骨中的缺损部位。输送轴可用于通过套管递送支架，并且装载装置可以帮助将支架装载到输送轴上。输送引导装置可以将支架放置并暂时保持在腔内。输送引导装置可以使用至少一个固定机构将一个或多个外科器械引导至支架以将支架固定在腔内，例如骨架下面的骨骼上。

2. 发明授权

US09186169B2 Snare with loop made of heat shrinkable shape memory material and method of use thereof 有权
标题翻译：具有由热收缩形状记忆材料制成的圈圈的圈圈及其使用方法
公开(公告)号：US09186169B2
公开(公告)日：2015-11-17
申请号：US12766054
申请日：2010-04-23
申请人： William J. Shaw , Kristian Dimatteo
发明人： William J. Shaw , Kristian Dimatteo
IPC分类号： A61B17/24 , A61B17/3205 , A61B17/00
CPC分类号： A61B17/32056 , A61B2017/00867 , A61B2017/00871
摘要： A tissue snare comprises an elongated member having a distal end and a loop formed of a shape memory material, the loop including a tissue receiving interior opening and being connected to the distal end of the elongated member, properties of the shape memory material being selected so that, when a temperature of the loop exceeds a critical temperature thereof, the loop constricts from an expanded state to a constricted state. A method of treating tissue comprises placing a loop of a snare around a portion of tissue to be treated while the loop is in an expanded configuration, the loop being formed of a shape memory material having a critical temperature so that, when a temperature of the loop is above the critical temperature, the loop transitions from the expanded configuration to a constricted configuration in combination with transitioning, after the loop has been placed around the portion of tissue to be treated, the loop from the expanded configuration to the constricted configuration to tighten the loop around the portion of tissue to be treated.
摘要翻译：组织圈套包括具有远端的细长构件和由形状记忆材料形成的环，所述环包括组织容纳内部开口并连接到细长构件的远端，形状记忆材料的特性被选择为当环路的温度超过其临界温度时，环路从膨胀状态收缩到收缩状态。一种治疗组织的方法包括将环圈环绕在待处理组织的一部分上，同时循环处于膨胀构型，该环由具有临界温度的形状记忆材料形成，使得当循环高于临界温度，循环在放置在待处理组织的部分周围，从膨胀构型到收缩构型的环状收缩之后，循环从扩张构型转变为结合转变的收缩构型围绕待处理组织部分的环。

3. 发明申请

US20060241661A1 Devices and methods for fastening tissue layers 有权
公开(公告)号：US20060241661A1
公开(公告)日：2006-10-26
申请号：US11471513
申请日：2006-06-21
申请人： Robert DeVries , William Shaw , Kristian Dimatteo , Gerhard Buess , Daniel Kalanovic , Marc Schurr , Roy Sullivan , Marc Tassy , John Griego , Patrick Gutileus , Paul DiCesare
发明人： Robert DeVries , William Shaw , Kristian Dimatteo , Gerhard Buess , Daniel Kalanovic , Marc Schurr , Roy Sullivan , Marc Tassy , John Griego , Patrick Gutileus , Paul DiCesare
IPC分类号： A61B17/08
CPC分类号： A61B17/08 , A61B1/2736 , A61B17/0401 , A61B17/0469 , A61B17/0487 , A61B17/06109 , A61B17/0643 , A61B17/068 , A61B17/10 , A61B17/29 , A61B2017/00827 , A61B2017/0404 , A61B2017/0417 , A61B2017/0419 , A61B2017/0445 , A61B2017/0458 , A61B2017/0461 , A61B2017/0462 , A61B2017/0464 , A61B2017/061 , A61B2017/081 , A61B2017/306
摘要： Endoscopic devices and methods used for fastening multiple tissue layers, such as, for example, an endoscopic fundoplication procedure, are disclosed. The device may include, for example, an elongated tubular member having a proximal end for extending outside of the body and a distal end for positioning proximate the multiple tissue layers, a grasper configured for positioning proximate the distal end of the tubular member and for grasping at least one of the multiple tissue layers, a device coupled to the distal end of the tubular member for folding the multiple tissue layers together, a tissue fastener configured to be inserted into the tissue layers to hold the tissue layers together, and a fastener head for inserting the tissue fastener into the tissue layers.

4. 发明申请

US20060058867A1 Elastomeric radiopaque adhesive composite and prosthesis 审中-公开
标题翻译：弹性不透射线粘合剂复合材料和假体
公开(公告)号：US20060058867A1
公开(公告)日：2006-03-16
申请号：US10941189
申请日：2004-09-15
申请人： Robert Thistle , Kristian Dimatteo
发明人： Robert Thistle , Kristian Dimatteo
IPC分类号： A61F2/06
CPC分类号： C08J5/124 , A61B17/12022 , A61B17/12118 , A61B17/12131 , A61F2/06 , A61F2/07 , A61F2002/072 , A61L24/0089 , A61L24/02 , A61L27/427 , A61L27/48 , A61L27/507 , A61L31/128 , A61L31/129 , C08J2327/18 , C09J11/04
摘要： An elastomeric radiopaque adhesive composition which includes a biocompatible elastomeric matrix and a radiopaque material distributed therein in sufficient amounts to produce a radiopaque image. Further, a hybrid vascular prosthesis including a PTFE structure, a textile structure and a cured elastomeric bonding agent adhesively secures the PTFE to the textile. The elastomeric agent having radiopaque material impregnated therein in sufficient amounts to produce a radiopaque image.
摘要翻译：一种弹性不透射线粘合剂组合物，其包含生物相容的弹性体基质和分布在其中的不透射线材料，其量足以产生不透射线的图像。此外，包括PTFE结构，纺织结构和固化的弹性粘合剂的混合血管假体将PTFE粘合地固定到纺织品上。具有浸透在其中的不透射线材料的弹性体剂量足以产生不透射线的图像。

5. 发明申请

US20060020256A1 Reinforced venous access catheter 有权
标题翻译：强化静脉导管
公开(公告)号：US20060020256A1
公开(公告)日：2006-01-26
申请号：US10894992
申请日：2004-07-20
申请人： Barbara Bell , George Bourne , Raymond Lareau , Kristian Dimatteo
发明人： Barbara Bell , George Bourne , Raymond Lareau , Kristian Dimatteo
IPC分类号： A61M25/00
CPC分类号： A61M25/0045 , A61M25/0052 , A61M25/0069 , A61M2025/0031 , A61M2025/0037 , A61M2025/0059 , A61M2025/0063
摘要： A catheter for medical procedures comprises a shaft portion having a distal end insertable into a body lumen, the shaft portion having a wall defining a working lumen extending therewithin and a first strengthening element coupled to the wall to increase a burst pressure of the shaft portion, wherein the first strengthening element cooperates with a base material of the wall to define a flexible region of the shaft portion allowing the shaft portion to be atraumatically inserted into the body lumen.
摘要翻译：用于医疗程序的导管包括轴部分，其具有可插入体腔的远端，所述轴部分具有限定在其中延伸的工作腔的壁和连接到所述壁的第一加强元件，以增加所述轴部的爆裂压力，其中所述第一加强元件与所述壁的基底材料配合以限定所述轴部分的柔性区域，从而允许所述轴部分被无损伤地插入到所述体腔内。

6. 发明申请

US20080051736A1 Sterilizable indwelling catheters 有权
标题翻译：可消毒的留置导管
公开(公告)号：US20080051736A1
公开(公告)日：2008-02-28
申请号：US11879537
申请日：2007-07-18
申请人： Robert Rioux , Raymond Lareau , Kristian Dimatteo
发明人： Robert Rioux , Raymond Lareau , Kristian Dimatteo
IPC分类号： A61M25/00
CPC分类号： A61L2/08 , A61L2/084 , A61L2/085 , A61L2/10 , A61L29/04 , A61L29/08 , A61L29/14 , A61M25/0017 , A61M2025/0056
摘要： According to an aspect of the invention, an indwelling catheter is provided which comprises a catheter shaft. The catheter either comprises a light source or is adapted to receive light from a light source, and is configured such that light is transmitted from the light source into the catheter shaft. Moreover, the catheter shaft is formed of a polymeric material that transmits a quantity of light from the light source that is effective to inactivate microorganisms on a surface of the catheter shaft upon activation of the light source. For example, the light may inactivate the microorganisms directly or in conjunction with a photosensitizer. According to another aspect of the invention, a sterilization method is provided, which comprises activating the light source while the catheter is inserted in a subject.
摘要翻译：根据本发明的一个方面，提供了一种留置导管，其包括导管轴。导管包括光源或适于接收来自光源的光，并且被配置为使得光从光源传输到导管轴。此外，导管轴由聚合物材料形成，该聚合物材料在光源激活时透射来自光源的一定量的光，其有效地使导管轴表面上的微生物灭活。例如，光可以直接或与光敏剂结合灭活微生物。根据本发明的另一方面，提供一种杀菌方法，其包括在将导管插入受试者时激活光源。

7. 发明授权

US08556950B2 Sterilizable indwelling catheters 有权
标题翻译：可消毒的留置导管
公开(公告)号：US08556950B2
公开(公告)日：2013-10-15
申请号：US11879537
申请日：2007-07-18
申请人： Robert Rioux , Raymond Lareau , Kristian Dimatteo
发明人： Robert Rioux , Raymond Lareau , Kristian Dimatteo
IPC分类号： A61N5/06
CPC分类号： A61L2/08 , A61L2/084 , A61L2/085 , A61L2/10 , A61L29/04 , A61L29/08 , A61L29/14 , A61M25/0017 , A61M2025/0056
摘要： According to an aspect of the invention, an indwelling catheter is provided which comprises a catheter shaft. The catheter either comprises a light source or is adapted to receive light from a light source, and is configured such that light is transmitted from the light source into the catheter shaft. Moreover, the catheter shaft is formed of a polymeric material that transmits a quantity of light from the light source that is effective to inactivate microorganisms on a surface of the catheter shaft upon activation of the light source. For example, the light may inactivate the microorganisms directly or in conjunction with a photosensitizer. According to another aspect of the invention, a sterilization method is provided, which comprises activating the light source while the catheter is inserted in a subject.
摘要翻译：根据本发明的一个方面，提供了一种留置导管，其包括导管轴。导管包括光源或适于接收来自光源的光，并且被配置为使得光从光源传输到导管轴。此外，导管轴由聚合物材料形成，该聚合材料在光源激活时透过来自光源的一定量的光，其有效地使导管轴表面上的微生物灭活。例如，光可以直接或与光敏剂结合灭活微生物。根据本发明的另一方面，提供一种杀菌方法，其包括在将导管插入受试者时激活光源。

8. 发明申请

US20120004505A1 DEVICES AND METHODS FOR TISSUE INVAGINATION 有权
标题翻译：用于组织引入的装置和方法
公开(公告)号：US20120004505A1
公开(公告)日：2012-01-05
申请号：US13176172
申请日：2011-07-05
申请人： Robert B. DeVRIES , Roy H. Sullivan , Marc Tassy, JR. , Kristian Dimatteo , Tak Kwan , William J. Shaw
发明人： Robert B. DeVRIES , Roy H. Sullivan , Marc Tassy, JR. , Kristian Dimatteo , Tak Kwan , William J. Shaw
IPC分类号： A61B1/00
CPC分类号： A61B1/32 , A61B17/00234 , A61B17/0218 , A61B17/0469 , A61B17/1114 , A61B17/1285 , A61B17/29 , A61B2017/00336 , A61B2017/00557 , A61B2017/00827 , A61B2017/0419 , A61B2017/306 , A61B2017/308
摘要： Surgical devices and methods used for invaginating tissue during, for example, an endoscopic fundoplication procedure, are disclosed. The device includes an elongated tube having a proximal end configured to extend outside of the body and a distal end configured to extend proximate the tissue to be invaginated, and a distal member coupled to the distal end of the tube. The distal member is configured to hold or grasp the tissue to be invaginated. The devices may include a protective distal sleeve.
摘要翻译：公开了在例如内窥镜下眼底切开手术期间用于入侵组织的手术装置和方法。该装置包括细长管，该细长管具有构造成延伸到主体外部的近端，以及被配置为延伸到待入侵的组织附近的远端，以及联接到管的远端的远侧构件。远端构件被构造成保持或抓住要入侵的组织。装置可以包括保护性远端套管。

9. 发明申请

US20110054312A1 Reinforced Venous Access Catheter 审中-公开
标题翻译：强化静脉导管导管
公开(公告)号：US20110054312A1
公开(公告)日：2011-03-03
申请号：US12917964
申请日：2010-11-02
申请人： Barbara Bell , George Bourne , Raymond Lareau , Kristian Dimatteo
发明人： Barbara Bell , George Bourne , Raymond Lareau , Kristian Dimatteo
IPC分类号： A61M25/00 , A61B6/00
CPC分类号： A61M25/0045 , A61M25/0052 , A61M25/0069 , A61M2025/0031 , A61M2025/0037 , A61M2025/0059 , A61M2025/0063
摘要： A catheter for medical procedures comprises a shaft portion having a distal end insertable into a body lumen, the shaft portion having a wall defining a working lumen extending therewithin and a first strengthening element coupled to the wall to increase a burst pressure of the shaft portion, wherein the first strengthening element cooperates with a base material of the wall to define a flexible region of the shaft portion allowing the shaft portion to be atraumatically inserted into the body lumen.
摘要翻译：用于医疗程序的导管包括轴部分，其具有可插入体腔的远端，所述轴部分具有限定在其中延伸的工作腔的壁和连接到所述壁的第一加强元件，以增加所述轴部的爆裂压力，其中所述第一加强元件与所述壁的基底材料配合以限定所述轴部分的柔性区域，从而允许所述轴部分被无损伤地插入到所述体腔内。

10. 发明授权

US07837698B2 Devices and methods for fastening tissue layers 有权
标题翻译：用于固定组织层的装置和方法
公开(公告)号：US07837698B2
公开(公告)日：2010-11-23
申请号：US11471513
申请日：2006-06-21
申请人： Robert DeVries , William J. Shaw , Kristian Dimatteo , Gerhard F. Buess , Daniel Kalanovic , Marc O. Schurr , Roy H. Sullivan , Marc Tassy, Jr. , John Griego , Patrick Gutelius , Paul DiCesare
发明人： Robert DeVries , William J. Shaw , Kristian Dimatteo , Gerhard F. Buess , Daniel Kalanovic , Marc O. Schurr , Roy H. Sullivan , Marc Tassy, Jr. , John Griego , Patrick Gutelius , Paul DiCesare
IPC分类号： A61B17/08
CPC分类号： A61B17/08 , A61B1/2736 , A61B17/0401 , A61B17/0469 , A61B17/0487 , A61B17/06109 , A61B17/0643 , A61B17/068 , A61B17/10 , A61B17/29 , A61B2017/00827 , A61B2017/0404 , A61B2017/0417 , A61B2017/0419 , A61B2017/0445 , A61B2017/0458 , A61B2017/0461 , A61B2017/0462 , A61B2017/0464 , A61B2017/061 , A61B2017/081 , A61B2017/306
摘要： Endoscopic devices and methods used for fastening multiple tissue layers, such as, for example, an endoscopic fundoplication procedure, are disclosed. The device may include, for example, an elongated tubular member having a proximal end for extending outside of the body and a distal end for positioning proximate the multiple tissue layers, a grasper configured for positioning proximate the distal end of the tubular member and for grasping at least one of the multiple tissue layers, a device coupled to the distal end of the tubular member for folding the multiple tissue layers together, a tissue fastener configured to be inserted into the tissue layers to hold the tissue layers together, and a fastener head for inserting the tissue fastener into the tissue layers.
摘要翻译：公开了用于紧固多个组织层的内窥镜装置和方法，例如内窥镜基底层手术。该装置可以包括例如具有用于延伸到身体外部的近端的细长管状构件和用于在多个组织层附近定位的远端，构造成用于靠近管状构件的远端定位并用于抓握所述多个组织层中的至少一个，联接到所述管状构件的远端的装置，用于将所述多个组织层折叠在一起的组织紧固件，被配置为插入所述组织层以将所述组织层保持在一起的组织紧固件，用于将组织紧固件插入组织层中。

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