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1. 发明申请

US20160015444A1 CARDIAC CRYOLIPOLYSIS FOR THE TREATMENT OF CARDIAC ARRHYTHMIA 有权
标题翻译： CARDIAC CRYOLIPOLYSIS FOR CARDAC ARRHYTHMIA的治疗
公开(公告)号：US20160015444A1
公开(公告)日：2016-01-21
申请号：US14334874
申请日：2014-07-18
申请人： Medtronic CryoCath LP
发明人： Dan WITTENBERGER
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2018/00023 , A61B2018/0025 , A61B2018/00351 , A61B2018/00375 , A61B2018/00577 , A61B2018/0212 , A61B2018/0262
摘要： A system, device, and method for the treatment of cardiac arrhythmia by, specifically, cryolipolysis of non-myocardial tissue and cryoablation of myocardial tissue. A system for treating cardiac arrhythmia may include a first thermal treatment device configured for placement within a heart in contact with myocardial tissue, a second thermal treatment device configured for placement in contact with pericardial tissue, an ablation energy source in communication with the first thermal treatment device, and a cooling energy source in communication with the second thermal treatment device, the cooling energy source causing the second thermal treatment device to reach a temperature insufficient for myocardial ablation when the second thermal treatment device is activated. A method of treating cardiac arrhythmia may include introducing a cooling element into a pericardial space proximate pericardial adipose tissue, and activating the cooling element to reduce the temperature of adjacent pericardial adipose tissue to approximately 0° C.
摘要翻译：用于治疗心律失常的系统，装置和方法，特别是非心肌组织的冰冻溶解和心肌组织的冷冻消融。用于治疗心律失常的系统可以包括构造成放置在与心肌组织接触的心脏内的第一热处理装置，被配置为与心包组织接触放置的第二热处理装置，与第一热处理相通的消融能量源装置和与第二热处理装置连通的冷却能源，当第二热处理装置被激活时，导致第二热处理装置的冷却能源达到不足以用于心肌消融的温度。治疗心律失常的方法可以包括将冷却元件引入紧邻心包脂肪组织的心包空间，并激活冷却元件以将相邻的心包脂肪组织的温度降低至约0℃。

2. 发明申请

US20160008049A1 CRYOABLATION METHOD AND SYSTEM 有权
标题翻译： CRYOABLATION方法和系统
公开(公告)号：US20160008049A1
公开(公告)日：2016-01-14
申请号：US14329571
申请日：2014-07-11
申请人： Medtronic CryoCath LP
发明人： Rachid MAHROUCHE , Dan WITTENBERGER
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2018/00011 , A61B2018/00017 , A61B2018/00023 , A61B2018/00041 , A61B2018/0022 , A61B2018/00577 , A61B2018/0212 , A61B2018/0268
摘要： A system and method for providing greater control over the temperature of a thermal treatment element of a medical device, enabling an operator to extend a thawing period of a cryoablation procedure. The system may include a fluid flow path that bypasses a subcooler, giving the operator selective control over the temperature of refrigerant delivered to the treatment element and, therefore, treatment element temperature. Additionally or alternatively, the system may include a fluid delivery conduit that is in communication with a liquid refrigerant and a gaseous refrigerant. Adjustment of the ratio of liquid to gaseous refrigerant also offers control over the treatment element temperature. Additionally or alternatively, the system may include one or more valves and/or heating elements in the fluid delivery and recovery conduits to control the treatment element temperature.
摘要翻译：一种用于提供对医疗装置的热处理元件的温度的更大控制的系统和方法，使得操作者能够延长冷冻消融过程的解冻期。该系统可以包括绕过过冷却器的流体流动路径，使得操作者选择性地控制输送到处理元件的制冷剂的温度，并因此选择性地控制处理元件温度。附加地或替代地，系统可以包括与液体制冷剂和气态制冷剂连通的流体输送导管。液体与气体制冷剂的比例调整也可以控制处理元件的温度。另外或替代地，系统可以包括流体输送和回收管道中的一个或多个阀和/或加热元件，以控制处理元件的温度。

3. 发明申请

US20150216589A1 MEDICAL DEVICE WITH ADJUSTABLE FLEXIBILITY 有权
标题翻译：具有可调节灵活性的医疗装置
公开(公告)号：US20150216589A1
公开(公告)日：2015-08-06
申请号：US14170063
申请日：2014-01-31
申请人： Medtronic CryoCath LP
发明人： Dan WITTENBERGER , George D. MALLIN , Claudia LUECKGE , Mihai-Alexandru IONESCU , Daniel HARVEY-PONCELET
IPC分类号： A61B18/14 , A61M25/01
CPC分类号： A61B18/1492 , A61B2018/00351 , A61B2018/00363 , A61B2018/00577 , A61B2018/0212 , A61M25/0138 , A61M25/0147 , A61M25/0155
摘要： A system and method for the delivery of a medical device to a treatment location. The device may include an elongate body, the elongate body including a plurality of annular segments and a jacket disposed about the plurality of annular segments and defining an interior space, and a vacuum source in fluid communication with the interior space of the jacket. When a vacuum is applied to the interior space of the jacket, the jacket may constrict about the plurality of annular elements, thereby increasing the frictional forces between the plurality of segments and between the plurality of segments and an inner surface of the jacket.
摘要翻译：一种用于将医疗装置递送到治疗位置的系统和方法。该装置可以包括细长主体，细长主体包括多个环形段和围绕多个环形区段设置并限定内部空间的护套以及与护套的内部空间流体连通的真空源。当真空施加到护套的内部空间时，护套可以围绕多个环形元件收缩，从而增加多个段之间以及多个段之间的摩擦力和护套的内表面。

4. 发明申请

US20150164572A1 COOLANT INJECTION TUBE 有权
公开(公告)号：US20150164572A1
公开(公告)日：2015-06-18
申请号：US14632319
申请日：2015-02-26
申请人： Medtronic CryoCath LP
发明人： Jean-Pierre LALONDE , Marwan ABBOUD , Teresa Ann MIHALIK , Jean-Pierre DESMARAIS , Dan WITTENBERGER
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/00318 , A61B2017/22038 , A61B2017/22051 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262
摘要： A medical device includes a steering element defining a passage for a guide wire. A fluid injection tube defining a proximal and a distal end is also included, wherein a portion of the fluid injection tube is contoured about a portion of the steering element. A plurality of injection ports may be disposed in the portion of the fluid injection tube contoured about the steering element.

5. 发明申请

US20140088580A1 METHOD AND SYSTEM FOR PREVENTING NERVE INJURY DURING A MEDICAL PROCEDURE 有权
标题翻译：用于在医疗过程中预防神经损伤的方法和系统
公开(公告)号：US20140088580A1
公开(公告)日：2014-03-27
申请号：US14090819
申请日：2013-11-26
申请人： Medtronic CryoCath LP
发明人： Dan WITTENBERGER , Nicolas COULOMBE
IPC分类号： A61B18/02 , A61B18/18
CPC分类号： A61B18/02 , A61B5/04012 , A61B5/0488 , A61B5/0492 , A61B5/0535 , A61B5/0803 , A61B5/0809 , A61B5/4035 , A61B5/6853 , A61B17/320068 , A61B18/1492 , A61B18/18 , A61B18/1815 , A61B18/20 , A61B2017/22038 , A61B2018/00214 , A61B2018/0022 , A61B2018/0212 , A61B2018/1861 , A61N1/08 , A61N1/36014 , A61N1/3702 , G06F19/00
摘要： A method of treating tissue is provided, including positioning a stimulation device proximate a phrenic nerve; stimulating the phrenic nerve with the stimulation device; measuring a physiological response to the stimulation; defining a threshold physiological response value based at least in part on the measured physiological response; positioning a thermal treatment element proximate to an arrhythmogenic cardiac tissue region; applying a thermal treatment regimen to the cardiac tissue region with the medical device; measuring a physiological parameter during the thermal treatment regimen application; and conveying the measured physiological parameter to a controller, the controller comparing the measured physiological parameter to the defined physiological response value threshold, the controller adjusting the thermal treatment regimen in response to the comparison of the measured physiological parameter to the defined physiological response value threshold.
摘要翻译：提供一种治疗组织的方法，包括将刺激装置定位在膈神经附近; 用刺激装置刺激膈神经; 测量刺激的生理反应; 至少部分地基于所测量的生理反应定义阈值生理反应值; 将热处理元件放置在致心律失常心脏组织区域附近; 用医疗装置将热处理方案应用于心脏组织区域; 在热处理方案应用中测量生理参数; 以及将所测量的生理参数输送到控制器，所述控制器将所测量的生理参数与所述确定的生理响应值阈值进行比较，所述控制器响应于所测量的生理参数与所述生理响应值阈值的比较来调节热处理方案。

6. 发明申请

US20220280217A1 APPARATUS AND METHOD FOR TARGETED BRONCHIAL DENERVATION BY CRYO-ABLATION 有权
公开(公告)号：US20220280217A1
公开(公告)日：2022-09-08
申请号：US17749704
申请日：2022-05-20
申请人： Medtronic CryoCath LP
发明人： Zhongping YANG , Linnea R. LENTZ , Rick D. MCVENES , Dan WITTENBERGER
IPC分类号： A61B18/02
摘要： A method for performing bronchial denervation, the method comprising an electromyography system having a cryoablation device with at least two recording electrodes. The electromyography system being configured to calculate a difference between a first electromyogram signal received from the first recording electrode and a second electromyogram signal received from the second recording electrode to generate a recorded electromyogram and compare the recorded electromyogram to a reference electromyogram.

7. 发明申请

US20180064482A1 VARIABLE GEOMETRY COOLING CHAMBER 审中-公开
公开(公告)号：US20180064482A1
公开(公告)日：2018-03-08
申请号：US15808512
申请日：2017-11-09
申请人： Medtronic CryoCath LP
发明人： Dan WITTENBERGER , Marwan ABBOUD , Ioana DEAC
IPC分类号： A61B18/02 , A61M29/02 , A61M25/10 , A61B17/00 , A61B18/00 , A61B17/22
CPC分类号： A61B18/02 , A61B2017/00256 , A61B2017/00867 , A61B2017/22051 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61M29/02 , A61M2025/1093 , A61M2029/025
摘要： The present invention provides a medical device that may include a catheter body having proximal and distal portions, a fluid injection lumen disposed within elongate body, and a guidewire lumen disposed within the elongate body. A tip portion defining a cavity in fluid communication with the fluid injection lumen may be coupled to the distal end of the guidewire lumen, and an expandable element may be coupled to the distal portion of the catheter body and to the tip portion, such that the expandable element is in fluid communication with the fluid injection lumen. A shaping element may at least partially surround the expandable element, where the shaping element is configurable in a first geometric configuration and a second geometric configuration.

8. 发明申请

US20150080870A1 BALLOON CATHETER WITH DEFORMABLE FLUID DELIVERY CONDUIT 有权
标题翻译：具有可变流体输送管道的气球导管
公开(公告)号：US20150080870A1
公开(公告)日：2015-03-19
申请号：US14549972
申请日：2014-11-21
申请人： Medtronic CryoCath LP
发明人： Dan WITTENBERGER
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2018/00214 , A61B2018/0022 , A61B2018/00345 , A61B2018/00375 , A61B2018/00577 , A61B2018/0212 , A61B2018/0268 , A61M25/0147
摘要： A medical device, including an elongate body having a proximal portion and a distal portion; a shaft at least partially disposed within the elongate body; an expandable element at the distal portion of the elongate body; and a fluid delivery conduit defining a deflectable segment movably coupled to the shaft, the deflectable segment being transitionable from a substantially linear configuration to a substantially curvilinear configuration.
摘要翻译：一种医疗装置，包括具有近端部分和远端部分的细长体; 至少部分地设置在所述细长主体内的轴; 在所述细长体的远端部分处的可膨胀元件; 以及流体输送导管，其限定可移动地联接到所述轴的可偏转段，所述可偏转段可从基本线性构型转变到基本上曲线形状。

9. 发明申请

US20130165927A1 SURGICAL CLAMP HAVING TREATMENT ELEMENTS 审中-公开
标题翻译：具有治疗元素的手术夹
公开(公告)号：US20130165927A1
公开(公告)日：2013-06-27
申请号：US13771314
申请日：2013-02-20
申请人： Medtronic Cryocath LP
发明人： Daniel NAHON , Sean CARROLL , Dan WITTENBERGER , Cristian PETRE , Allan SKANES , Alan H. MENKIS , Réal STE-MARIE
IPC分类号： A61B18/08
CPC分类号： A61B18/02 , A61B2017/00026 , A61B2018/00791 , A61B2018/00839 , A61B2018/00875 , A61B2018/0212 , A61B2018/0225 , A61B2018/0262 , A61B2018/1465
摘要： A medical device is provided having a means for actuating a pair of opposing jaw members. The jaw members are movable relative to one another from a first position, wherein the jaw members are disposed in a spaced apart relation relative to one another, to a second position, wherein the jaw members cooperate to grasp tissue therebetween. An ablation tool is connected to at least one of the jaws members, such that the jaw members are capable of conducting ablation energy through the tissue grasped therebetween.
摘要翻译：提供了具有用于致动一对相对的钳口构件的装置的医疗装置。钳口构件可从第一位置相对于彼此移动，其中钳口构件相对于彼此以间隔开的关系设置到第二位置，其中钳口构件协作以在其间抓握组织。消融工具连接到至少一个夹爪构件，使得钳口构件能够通过夹在其间夹持的组织进行消融能量。

10. 发明申请

US20180214045A1 HIGHLY FLEXIBLE MAPPING AND TREATMENT DEVICE 审中-公开
公开(公告)号：US20180214045A1
公开(公告)日：2018-08-02
申请号：US15418264
申请日：2017-01-27
申请人： Medtronic CryoCath LP
发明人： Dan WITTENBERGER , Claudia LUECKGE
IPC分类号： A61B5/042 , A61B5/00 , A61B5/06
摘要： A device and system for providing mapping and treatment capabilities without increasing stiffness of the device. An embodiment of a device may include a flexible elongate body and at least one mapping element on the distal portion of the elongate body. Each mapping element may be an area of thermally conductive material, such as metallic nanoparticles, that is embedded within, integrated with, or deposited on the elongate body. The flexibility of the areas of thermally conductive material is at least substantially the same as that of the elongate body so the device may include many electrodes without compromising flexibility and maneuverability of the device. Alternatively, the device may include a treatment element coupled to the elongate body, such as a balloon. The mapping elements may be embedded within, integrated with, or deposited on the balloon and may have at least substantially the same flexibility as that of the balloon.

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