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    • 1. 发明申请
    • Method and apparatus for improving ventricular status using the force interval relationship
    • 使用力间隔关系改善心室状态的方法和装置
    • US20040220639A1
    • 2004-11-04
    • US10426730
    • 2003-04-30
    • Medtronic, Inc.
    • Lawrence J. MulliganMichael R.S. HillJohn E. Burnes
    • A61N001/37
    • A61N1/36514A61N1/3627
    • Methods and devices for improving ventricular contractile status of a patient suitably exploit changes in ventricular pressure and/or dP/dtmax to provide and/or optimize a response to a patient. The ventricular pressure may be appropriately correlated to intracellular calcium regulation, which is indicative of contractile status. To assess ventricular contractile status, the device suitably observes a cardiac perturbation of the patient and measures force interval potentiation following the perturbation. The contractile potentiation can then be stored and/or quantified in the implantable medical device to determine the ventricular contractile status of the patient, and an appropriate response may be provided to the patient as a function of the ventricular contractile status. Examples of responses may include administration of drug or neuro therapies, modification of a pacing rate, or the like. Force interval potentiation may also be used to optimize or improve a parameter for a response provided by the implantable medical device.
    • 用于改善患者的心室收缩状态的方法和装置适当地利用心室压力和/或dP / dtmax的变化,以提供和/或优化对患者的反应。 心室压力可以适当地与细胞内钙调节相关,细胞内钙调节指示收缩状态。 为了评估心室收缩状态,该装置适当地观察患者的心脏摄动,并测量扰动后的力间隔增强作用。 收缩增强能随后在可植入的医疗装置中被储存和/或定量,以确定患者的心室收缩状态,并且作为心室收缩状态的函数可以向患者提供适当的响应。 反应的实例可包括药物或神经疗法的施用,起搏速率的改变等。 力间隔增强也可用于优化或改善由可植入医疗装置提供的响应的参数。
    • 2. 发明申请
    • Method and device for electronically controlling the beating of a heart
    • 用于电子控制心脏跳动的方法和装置
    • US20020026221A1
    • 2002-02-28
    • US09897630
    • 2001-07-02
    • Medtronic, Inc.
    • Michael R.S. HillKenneth R. Jonkman
    • A61N001/362
    • A61N1/36114A61B17/3417A61B2017/00243A61B2017/00969A61B2017/0243A61B2017/3445A61B2017/3449A61N1/056A61N1/362A61N1/385A61N1/3962
    • An electro-stimulation device includes a pair of electrodes for connection to at least one location in the body that affects or regulates the heartbeat. The electro-stimulation device both electrically arrests the heartbeat and stimulates the heartbeat. A pair of electrodes are provided for connection to at least one location in the body that affects or regulates the heartbeat. The pair of electrodes may be connected to an intravenous catheter for transvenous stimulation of the appropriate nerve. A first switch is connected between a power supply and the electrodes for selectively supplying current from the power supply to the electrodes to augment any natural stimuli to the heart and thereby stop the heart from beating. A second switch is connected between the power supply and the electrodes for selectively supplying current from the power supply to the electrodes to provide an artificial stimulus to initiate heartbeating. In another aspect, the invention is directed to a method for arresting the beat of a heart in a living body comprising the steps of connecting the pair of electrodes to at least one location in the body that affects or regulates the heartbeat and supplying an electrical current to the electrodes of sufficient amplitude and duration to arrest the heartbeat. The device may also serve to still the lungs by input to a respirator or by stimulation of the phrenic nerve during surgical procedures.
    • 电刺激装置包括一对电极,用于连接到体内至少一个影响或调节心跳的位置。 电刺激装置既电气阻止心跳并刺激心跳。 提供一对电极用于连接到体内至少一个影响或调节心跳的位置。 该对电极可以连接到静脉导管,用于适当神经的经静脉刺激。 第一开关连接在电源和电极之间,用于选择性地从电源向电极提供电流,以增加对心脏的任何自然刺激,从而阻止心脏跳动。 第二开关连接在电源和电极之间,用于选择性地从电源向电极提供电流以提供人造刺激以启动心跳。 另一方面,本发明涉及一种用于在生物体中阻止心脏的搏动的方法,包括以下步骤:将一对电极连接到体内至少一个位置,其影响或调节心跳并提供电流 到足够的幅度和持续时间的电极以阻止心跳。 该装置还可以通过输入呼吸器或在外科手术期间刺激膈神经而服用于肺。