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1. 发明授权

US10357537B2 Cyclotides as immunosuppressive agents 有权
公开(公告)号：US10357537B2
公开(公告)日：2019-07-23
申请号：US16174428
申请日：2018-10-30
申请人： Medizinische Universitat Wien , Universitatsklinikum Freiburg
发明人： Christian Werner Gruber , Carsten Gruendemann
IPC分类号： A61K39/00 , A61K38/16 , A61K38/12 , C07K14/415 , A61K45/06 , A61K51/08 , C07K14/00 , G01N33/50 , A61P37/06
摘要： The present invention relates to a pharmaceutical composition comprising a cyclotide for use in immune suppression as well as to a method for immune suppression comprising the step of administering an effective amount of a pharmaceutical composition comprising such a cyclotide to a subject in need thereof. The present invention also relates to a pharmaceutical composition comprising a cyclotide for use in treating or preventing a disorder selected from the group consisting of (i) an autoimmune disorder; (ii) a hypersensitivity disorder; and (iii) a lymphocyte-mediated inflammation. Likewise, the present invention also relates to a method for treating or preventing a disorder selected from the group consisting of (i) an autoimmune disorder; (ii) a hypersensitivity disorder; and (iii) a lymphocyte-mediated inflammation. The present invention further relates to a method of screening for and/or selecting an immunosuppressive cyclotide or a mutation which results in a mutated cyclotide having an induced or enhanced immunosuppressive activity. The present invention further relates to a method of producing an immunosuppressive cyclotide or an immunosuppressive pharmaceutical composition. The present invention further relates to a mutated cyclotide having immunosuppressive activity and a pharmaceutical composition comprising the same.

2. 发明授权

US09453052B2 Cyclotides as immunosuppressive agents 有权
标题翻译：茜素作为免疫抑制剂
公开(公告)号：US09453052B2
公开(公告)日：2016-09-27
申请号：US14366427
申请日：2012-12-21
申请人： Medizinische Universitat Wien , Universitatsklinikum Freiburg
发明人： Christian Werner Gruber , Carsten Gruendemann
IPC分类号： A61K38/00 , C07K9/00 , C07K14/00 , A61K38/12 , C07K14/415 , A61K38/16 , A61K45/06 , A61K51/08 , G01N33/50
CPC分类号： A61K38/168 , A61K38/12 , A61K38/16 , A61K45/06 , A61K51/08 , C07K14/00 , C07K14/415 , G01N33/5023
摘要： The present invention relates to a pharmaceutical composition comprising a cyclotide for use in immune suppression as well as to a method for immune suppression comprising the step of administering an effective amount of a pharmaceutical composition comprising such a cyclotide to a subject in need thereof. The present invention also relates to a pharmaceutical composition comprising a cyclotide for use in treating or preventing a disorder selected from the group consisting of (i) an autoimmune disorder; (ii) a hypersensitivity disorder; and (iii) a lymphocyte-mediated inflammation. Likewise, the present invention also relates to a method for treating or preventing a disorder selected from the group consisting of (i) an autoimmune disorder; (ii) a hypersensitivity disorder; and (iii) a lymphocyte-mediated inflammation. The present invention further relates to a method of screening for and/or selecting an immunosuppressive cyclotide or a mutation which results in a mutated cyclotide having an induced or enhanced immunosuppressive activity. The present invention further relates to a method of producing an immunosuppressive cyclotide or an immunosuppressive pharmaceutical composition. The present invention further relates to a mutated cyclotide having immunosuppressive activity and a pharmaceutical composition comprising the same.
摘要翻译：本发明涉及包含用于免疫抑制的环肽的药物组合物以及免疫抑制方法，包括向有需要的受试者施用有效量的包含这种环肽的药物组合物的步骤。本发明还涉及一种药物组合物，其包含用于治疗或预防选自以下的病症的环肽：（i）自身免疫性疾病; （ii）超敏反应障碍; 和（iii）淋巴细胞介导的炎症。同样，本发明还涉及治疗或预防选自以下的病症的方法：（i）自身免疫性疾病; （ii）超敏反应障碍; 和（iii）淋巴细胞介导的炎症。本发明还涉及一种筛选和/或选择免疫抑制性环肽或突变，其导致具有诱导或增强的免疫抑制活性的突变的环肽。本发明还涉及产生免疫抑制性环肽或免疫抑制药物组合物的方法。本发明进一步涉及具有免疫抑制活性的突变型环肽，以及包含其的药物组合物。

3. 发明申请

US20190046607A1 CYCLOTIDES AS IMMUNOSUPPRESSIVE AGENTS 审中-公开
公开(公告)号：US20190046607A1
公开(公告)日：2019-02-14
申请号：US16174428
申请日：2018-10-30
申请人： Medizinische Universitat Wien , Universitatsklinikum Freiburg
发明人： Christian Werner Gruber , Carsten Gruendemann
IPC分类号： A61K38/16 , G01N33/50 , C07K14/415 , C07K14/00 , A61K38/12 , A61K45/06 , A61K51/08
CPC分类号： A61K38/168 , A61K38/12 , A61K38/16 , A61K45/06 , A61K51/08 , A61P37/06 , C07K14/00 , C07K14/415 , G01N33/5023
摘要： The present invention relates to a pharmaceutical composition comprising a cyclotide for use in immune suppression as well as to a method for immune suppression comprising the step of administering an effective amount of a pharmaceutical composition comprising such a cyclotide to a subject in need thereof. The present invention also relates to a pharmaceutical composition comprising a cyclotide for use in treating or preventing a disorder selected from the group consisting of (i) an autoimmune disorder; (ii) a hypersensitivity disorder; and (iii) a lymphocyte-mediated inflammation. Likewise, the present invention also relates to a method for treating or preventing a disorder selected from the group consisting of (i) an autoimmune disorder; (ii) a hypersensitivity disorder; and (iii) a lymphocyte-mediated inflammation. The present invention further relates to a method of screening for and/or selecting an immunosuppressive cyclotide or a mutation which results in a mutated cyclotide having an induced or enhanced immunosupressive activity. The present invention further relates to a method of producing an immunosuppressive cyclotide or an immunosuppressive pharmaceutical composition. The present invention further relates to a mutated cyclotide having immunosuppressive activity and a pharmaceutical composition comprising the same.

4. 发明申请

US20170239327A9 CYCLOTIDES AS IMMUNOSUPPRESSIVE AGENTS 审中-公开
公开(公告)号：US20170239327A9
公开(公告)日：2017-08-24
申请号：US15244244
申请日：2016-08-23
申请人： Medizinische Universitat Wien , Universitatsklinikum Freiburg
发明人： Christian Werner Gruber , Carsten Gruendemann
IPC分类号： A61K38/16 , G01N33/50
CPC分类号： A61K38/168 , A61K38/12 , A61K38/16 , A61K45/06 , A61K51/08 , A61P37/06 , C07K14/00 , C07K14/415 , G01N33/5023
摘要： The present invention relates to a pharmaceutical composition comprising a cyclotide for use in immune suppression as well as to a method for immune suppression comprising the step of administering an effective amount of a pharmaceutical composition comprising such a cyclotide to a subject in need thereof. The present invention also relates to a pharmaceutical composition comprising a cyclotide for use in treating or preventing a disorder selected from the group consisting of (i) an autoimmune disorder; (ii) a hypersensitivity disorder; and (iii) a lymphocyte-mediated inflammation. Likewise, the present invention also relates to a method for treating or preventing a disorder selected from the group consisting of (i) an autoimmune disorder; (ii) a hypersensitivity disorder; and (iii) a lymphocyte-mediated inflammation. The present invention further relates to a method of screening for and/or selecting an immunosuppressive cyclotide or a mutation which results in a mutated cyclotide having an induced or enhanced immunosuppressive activity. The present invention further relates to a method of producing an immunosuppressive cyclotide or an immunosuppressive pharmaceutical composition. The present invention further relates to a mutated cyclotide having immunosuppressive activity and a pharmaceutical composition comprising the same.

5. 发明授权

US10159710B2 Cyclotides as immunosuppressive agents 有权
公开(公告)号：US10159710B2
公开(公告)日：2018-12-25
申请号：US15244244
申请日：2016-08-23
申请人： Medizinische Universitat Wien , Universitatsklinikum Freiburg
发明人： Christian Werner Gruber , Carsten Gruendemann
IPC分类号： A61K38/00 , A61K38/16 , A61K38/12 , C07K14/415 , A61K45/06 , A61K51/08 , C07K14/00 , G01N33/50
摘要： The present invention relates to a pharmaceutical composition comprising a cyclotide for use in immune suppression as well as to a method for immune suppression comprising the step of administering an effective amount of a pharmaceutical composition comprising such a cyclotide to a subject in need thereof. The present invention also relates to a pharmaceutical composition comprising a cyclotide for use in treating or preventing a disorder selected from the group consisting of (i) an autoimmune disorder; (ii) a hypersensitivity disorder; and (iii) a lymphocyte-mediated inflammation. Likewise, the present invention also relates to a method for treating or preventing a disorder selected from the group consisting of (i) an autoimmune disorder; (ii) a hypersensitivity disorder; and (iii) a lymphocyte-mediated inflammation. The present invention further relates to a method of screening for and/or selecting an immunosuppressive cyclotide or a mutation which results in a mutated cyclotide having an induced or enhanced immunosuppressive activity. The present invention further relates to a method of producing an immunosuppressive cyclotide or an immunosuppressive pharmaceutical composition. The present invention further relates to a mutated cyclotide having immunosuppressive activity and a pharmaceutical composition comprising the same.

6. 发明申请

US20160367626A1 CYCLOTIDES AS IMMUNOSUPPRESSIVE AGENTS 审中-公开
标题翻译：作为免疫抑制剂的CYCLOTIDES
公开(公告)号：US20160367626A1
公开(公告)日：2016-12-22
申请号：US15244244
申请日：2016-08-23
申请人： Medizinische Universitat Wien , Universitatsklinikum Freiburg
发明人： Christian Werner Gruber , Carsten Gruendemann
IPC分类号： A61K38/16 , G01N33/50
CPC分类号： A61K38/168 , A61K38/12 , A61K38/16 , A61K45/06 , A61K51/08 , A61P37/06 , C07K14/00 , C07K14/415 , G01N33/5023
摘要： The present invention relates to a pharmaceutical composition comprising a cyclotide for use in immune suppression as well as to a method for immune suppression comprising the step of administering an effective amount of a pharmaceutical composition comprising such a cyclotide to a subject in need thereof. The present invention also relates to a pharmaceutical composition comprising a cyclotide for use in treating or preventing a disorder selected from the group consisting of (i) an autoimmune disorder; (ii) a hypersensitivity disorder; and (iii) a lymphocyte-mediated inflammation. Likewise, the present invention also relates to a method for treating or preventing a disorder selected from the group consisting of (i) an autoimmune disorder; (ii) a hypersensitivity disorder; and (iii) a lymphocyte-mediated inflammation. The present invention further relates to a method of screening for and/or selecting an immunosuppressive cyclotide or a mutation which results in a mutated cyclotide having an induced or enhanced immunosuppressive activity. The present invention further relates to a method of producing an immunosuppressive cyclotide or an immunosuppressive pharmaceutical composition. The present invention further relates to a mutated cyclotide having immunosuppressive activity and a pharmaceutical composition comprising the same.
摘要翻译：本发明涉及包含用于免疫抑制的环肽的药物组合物以及免疫抑制方法，包括向有需要的受试者施用有效量的包含这种环肽的药物组合物的步骤。本发明还涉及一种药物组合物，其包含用于治疗或预防选自以下的病症的环肽：（i）自身免疫性疾病; （ii）超敏反应障碍; 和（iii）淋巴细胞介导的炎症。同样，本发明还涉及治疗或预防选自以下的病症的方法：（i）自身免疫性疾病; （ii）超敏反应障碍; 和（iii）淋巴细胞介导的炎症。本发明还涉及一种筛选和/或选择免疫抑制性环肽或突变，其导致具有诱导或增强的免疫抑制活性的突变的环肽。本发明还涉及产生免疫抑制性环肽或免疫抑制药物组合物的方法。本发明进一步涉及具有免疫抑制活性的突变型环肽，以及包含其的药物组合物。

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