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1. 发明公开

US20240352098A1 ANTIBODY DIRECTED AGAINST S. AUREUS CLUMPING FACTOR A (ClfA) 审中-公开
公开(公告)号：US20240352098A1
公开(公告)日：2024-10-24
申请号：US18621921
申请日：2024-03-29
申请人： MedImmune, LLC , Humabs BioMed SA
发明人： Christine TKACZYK , Bret SELLMAN , Martin BORROK, III , Davide CORTI , Andrea MINOLA
IPC分类号： C07K16/12
CPC分类号： C07K16/1271 , C07K2317/31 , C07K2317/34 , C07K2317/51 , C07K2317/515
摘要： The present disclosure is directed to a monoclonal antibody, or antigen-binding fragment thereof, that specifically binds to a Staphylococcus aureus clumping factor A protein (ClfA), as well as compositions comprising the monoclonal antibody. The disclosure also is directed to methods of treating a Staphylococcus aureus infection by administering the anti-ClfA monoclonal antibody alone, or in combination with a monoclonal antibody that specifically binds to S. aureus alpha toxin (AT) protein to a subject. Bispecific monoclonal antibodies that specifically bind to both ClfA and AT and methods of using the same also are provided.

2. 发明申请

US20220073595A1 ANTIBODY DIRECTED AGAINST S. AUREUS CLUMPING FACTOR A (ClfA) 有权
公开(公告)号：US20220073595A1
公开(公告)日：2022-03-10
申请号：US17483162
申请日：2021-09-23
申请人： MedImmune, LLC , Humabs BioMed SA
发明人： Christine TKACZYK , Bret SELLMAN , Martin BORROK, III , Davide CORTI , Andrea MINOLA
IPC分类号： C07K16/12
摘要： The present disclosure is directed to a monoclonal antibody, or antigen-binding fragment thereof, that specifically binds to a Staphylococcus aureus clumping factor A protein (ClfA), as well as compositions comprising the monoclonal antibody. The disclosure also is directed to methods of treating a Staphylococcus aureus infection by administering the anti-ClfA monoclonal antibody alone, or in combination with a monoclonal antibody that specifically binds to S. aureus alpha toxin (AT) protein to a subject. Bispecific monoclonal antibodies that specifically bind to both ClfA and AT and methods of using the same also are provided.

3. 发明申请

US20210363229A1 ANTIBODIES DIRECTED AGAINST STAPHYLOCOCCUS AUREUS LEUKOTOXINS 有权
公开(公告)号：US20210363229A1
公开(公告)日：2021-11-25
申请号：US17340622
申请日：2021-06-07
申请人： MedImmune, LLC , Humabs BioMed SA
发明人： Christine TKACZYK , Bret SELLMAN , Qun DU , Melissa DAMSCHRODER , Davide CORTI , Andrea MINOLA
IPC分类号： C07K16/12 , A61P31/04 , G01N33/569
摘要： The present disclosure is directed to leukotoxin-binding antibodies and antigen-binding fragments thereof. The antibodies and fragments can be used, for example, to detect leukotoxin and/or in methods of treating and preventing Staphylococcus aureus infections.

4. 发明申请

US20190016787A1 ANTIBODIES TO S. AUREUS SURFACE DETERMINANTS 审中-公开
公开(公告)号：US20190016787A1
公开(公告)日：2019-01-17
申请号：US15880157
申请日：2018-01-25
申请人： MEDIMMUNE, LLC
发明人： Bret SELLMAN , Christine TKACZYK , Partha S. CHOWDHURY , Lei HUA , Peter PAVLIK , Rebecca BUONPANE , Chew-Shun CHANG
IPC分类号： C07K16/12 , G01N33/569 , A61K39/40 , A61K45/06
摘要： Antibodies and antigen binding fragments thereof directed against Staphylococcus aureus (S. aureus) surface determinant antigens and secreted toxins are disclosed. Methods of detecting, diagnosing and treating S. aureus using the antibodies and antigen binding fragments thereof are also provided.

5. 发明申请

US20220089699A1 COMBINATIONS OF ANTI-STAPHYLOCOCCUS AUREUS ANTIBODIES 有权
公开(公告)号：US20220089699A1
公开(公告)日：2022-03-24
申请号：US17491889
申请日：2021-10-01
申请人： MedImmune, LLC
发明人： Christine TKACZYK , Bret SELLMAN , Qun DU , Melissa DAMSCHRODER , Taylor COHEN
IPC分类号： C07K16/12
摘要： The present disclosure is directed to anti-Staphylococcus aureus antibody combinations including combinations of antibodies that bind to S. aureus alpha toxin (AT) protein, clumping factor A protein (ClfA), and/or at least one leukotoxin protein. Methods of treating and preventing infections comprising administering the antibody combinations are also provided herein.

6. 发明申请

US20190002540A1 METHODS OF TREATING S. AUREUS-ASSOCIATED DISEASES 审中-公开
公开(公告)号：US20190002540A1
公开(公告)日：2019-01-03
申请号：US15845701
申请日：2017-12-18
申请人： MedImmune, LLC
发明人： Brett R. SELLMAN , Christine TKACZYK , Melissa HAMILTON , Lei HUA
IPC分类号： C07K16/12 , A61K39/085
摘要： The present invention provides for methods of preventing and/or treating S. aureus-associated bacteremia and sepsis, and methods for preventing and/or treating S. aureus-associated pneumonia in immunocompromised patients using anti-S. aureus alpha-toxin (anti-AT) antibodies. Also provided are methods of reducing S. aureus bacterial load in the bloodstream or heart of a mammalian subject comprising administering to the subject an effective amount of an isolated anti-S. aureus alpha toxin (anti-AT) antibody or antigen-binding fragment thereof. Methods of reducing S. aureus bacterial agglutination and/or thromboembolic lesion formation in a mammalian subject comprising administering to the subject an effective amount of an isolated anti-S. aureus alpha toxin (anti-AT) antibody or antigen-binding fragment thereof, are also provided. Also provided are methods of preventing or reducing the severity of S. aureus associated pneumonia in an immunocompromised mammalian subject.

7. 发明申请

US20200109191A1 METHODS OF TREATING S. AUREUS-ASSOCIATED DISEASES 审中-公开
公开(公告)号：US20200109191A1
公开(公告)日：2020-04-09
申请号：US16599595
申请日：2019-10-11
申请人： MedImmune, LLC
发明人： Brett R. SELLMAN , Christine TKACZYK , Melissa HAMILTON , Lei HUA
IPC分类号： C07K16/12 , A61K39/085
摘要： The present invention provides for methods of preventing and/or treating S. aureus-associated bacteremia and sepsis, and methods for preventing and/or treating S. aureus-associated pneumonia in immunocompromised patients using anti-S. aureus alpha-toxin (anti-AT) antibodies. Also provided are methods of reducing S. aureus bacterial load in the bloodstream or heart of a mammalian subject comprising administering to the subject an effective amount of an isolated anti-S. aureus alpha toxin (anti-AT) antibody or antigen-binding fragment thereof. Methods of reducing S. aureus bacterial agglutination and/or thromboembolic lesion formation in a mammalian subject comprising administering to the subject an effective amount of an isolated anti-S. aureus alpha toxin (anti-AT) antibody or antigen-binding fragment thereof, are also provided. Also provided are methods of preventing or reducing the severity of S. aureus associated pneumonia in an immunocompromised mammalian subject.

8. 发明申请

US20160257733A1 METHODS OF TREATING S. AUREUS-ASSOCIATED DISEASES 有权
标题翻译：治疗金黄色葡萄球菌相关疾病的方法
公开(公告)号：US20160257733A1
公开(公告)日：2016-09-08
申请号：US14440749
申请日：2013-11-05
申请人： MEDIMMUNE, LLC
发明人： Brett SELLMAN , Christine TKACZYK , Melissa HAMILTON , Lei HUA
IPC分类号： C07K16/12
CPC分类号： C07K16/1271 , A61K39/085 , A61K2039/505 , C07K2317/52 , C07K2317/565 , C07K2317/76
摘要： The present invention provides for methods of preventing and/or treating S. aureus-associated bacteremia and sepsis, and methods for preventing and/or treating S. aureus-associated pneumonia in immunocompromised patients using anti-S. aureus alpha-toxin (anti-AT) antibodies. Also provided are methods of reducing S. aureus bacterial load in the bloodstream or heart of a mammalian subject comprising administering to the subject an effective amount of an isolated anti-S. aureus alpha toxin (anti-AT) antibody or antigen-binding fragment thereof. Methods of reducing S. aureus bacterial agglutination and/or thromboembolic lesion formation in a mammalian subject comprising administering to the subject an effective amount of an isolated anti-S. aureus alpha toxin (anti-AT) antibody or antigen-binding fragment thereof, are also provided. Also provided are methods of preventing or reducing the severity of S. aureus-associated pneumonia in an immunocompromised mammalian subject.
摘要翻译：本发明提供了预防和/或治疗金黄色葡萄球菌相关菌血症和败血症的方法，以及在使用抗-S的免疫受损患者中预防和/或治疗金黄色葡萄球菌相关性肺炎的方法。金黄色葡萄球菌α-毒素（抗AT）抗体。还提供了降低哺乳动物受试者的血液或心脏中的金黄色葡萄球菌细菌负荷的方法，包括向受试者施用有效量的分离的抗S。金黄色葡萄球菌α毒素（抗AT）抗体或其抗原结合片段。在哺乳动物受试者中降低金黄色葡萄球菌细菌凝集和/或血栓栓塞损伤形成的方法，包括向受试者施用有效量的分离的抗S。还提供了金黄色葡萄球菌α毒素（抗AT）抗体或其抗原结合片段。还提供了在免疫受损的哺乳动物受试者中预防或降低金黄色葡萄球菌相关性肺炎的严重性的方法。

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