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1. 发明授权

US5928633A Material for elimination or detoxification of super antigens 失效
标题翻译：超抗原消除或解毒的物质
公开(公告)号：US5928633A
公开(公告)日：1999-07-27
申请号：US645452
申请日：1996-05-13
申请人： Mayumi Fukuyama , Keishi Miwa , Kazuo Ishikawa
发明人： Mayumi Fukuyama , Keishi Miwa , Kazuo Ishikawa
IPC分类号： A61K31/17 , A61K31/717 , A61K31/722 , A61K31/74 , A61L15/42 , B01J20/32 , A61K31/73
CPC分类号： A61K31/17 , A61K31/717 , A61K31/722 , A61K31/74 , A61L15/42 , B01J20/24 , B01J20/261 , B01J20/262 , B01J20/28004 , B01J20/28023 , B01J20/3092 , B01J20/321 , B01J20/3212 , B01J20/3251 , B01J20/3253 , C08G18/3275 , B01J2220/4825 , B01J2220/58
摘要： A material with excellent selective absorption of super antigens. Said material contains urea bonds or thiourea bonds and remains active even in a high protein concentration solution in the neutral region, Activity remains after sterilization. Also provided is a body fluid purifying column for eliminating or detoxification of super antigens. In addition to that, this invention provides a wound dressing material with super antigen adsorbing properties.
摘要翻译：具有优异选择性吸收超抗原的物质。所述材料含有脲键或硫脲键，即使在中性区域的高蛋白质浓度溶液中也保持活性，灭菌后仍保持活性。还提供了用于消除或解毒超抗原的体液净化柱。另外，本发明提供具有超抗原吸附性能的伤口敷料材料。

2. 发明授权

US06190688B1 Material for elimination or detoxification of super antigens 有权
标题翻译：超抗原消除或解毒的物质
公开(公告)号：US06190688B1
公开(公告)日：2001-02-20
申请号：US09259679
申请日：1999-03-01
申请人： Mayumi Fukuyama , Keishi Miwa , Kazuo Ishikawa
发明人： Mayumi Fukuyama , Keishi Miwa , Kazuo Ishikawa
IPC分类号： A61F1300
CPC分类号： A61K31/17 , A61K31/717 , A61K31/722 , A61K31/74 , A61L15/42 , B01J20/24 , B01J20/261 , B01J20/262 , B01J20/28004 , B01J20/28023 , B01J20/3092 , B01J20/321 , B01J20/3212 , B01J20/3251 , B01J20/3253 , B01J2220/4825 , B01J2220/58 , C08G18/3275
摘要： A material with excellent selective absorption of super antigens. Said material contains urea bonds or thiourea bonds and remains active even in a high protein concentration solution in the neutral region, Activity remains after sterilization. Also provided is a body fluid purifying column for eliminating or detoxification of super antigens. In addition to that, this invention provides a wound dressing material with super antigen adsorbing properties.
摘要翻译：具有优异选择性吸收超抗原的物质。所述材料含有脲键或硫脲键，即使在中性区域的高蛋白质浓度溶液中也保持活性，灭菌后仍保持活性。还提供了用于消除或解毒超抗原的体液净化柱。另外，本发明提供具有超抗原吸附性能的伤口敷料材料。

3. 发明授权

US06630315B1 Process for preparing major histocompatibility antigen class II protein and materials in which the same is bound 失效
标题翻译：制备主要组织相容性抗原II类蛋白质的方法及其相同结合的材料
公开(公告)号：US06630315B1
公开(公告)日：2003-10-07
申请号：US08929157
申请日：1997-09-11
申请人： Keishi Miwa , Mayumi Fukuyama , Takehiko Uchiyama
发明人： Keishi Miwa , Mayumi Fukuyama , Takehiko Uchiyama
IPC分类号： B01D1508
CPC分类号： C07K14/70539 , C07K14/47
摘要： This invention provides a process for producing major histocompatibility antigen class II protein (hereinafter referred to as “MHC class II” for short) which occurs on the surfaces of antigen-presenting cells and the like, and MHC class II-bound materials in which MHC class II, &agr; and/or &bgr; subunit of MHC class II, or a part thereof is bound to a carrier such as beads, fibers and hollow fibers via covalent bond, as well as a module for removing superantigen using the same. This invention also provides a method for detecting or quantifying superantigens using MHC class II or a part thereof having an affinity to the superantigens, as well as an assay kit therefor.
摘要翻译：本发明提供了在抗原呈递细胞等表面发生的主要组织相容性抗原II类蛋白（以下简称为“MHC类II”）和MHC II类结合材料的制备方法，其中MHC II类MHC II类的α和/或β亚基，或其一部分通过共价键与载体如珠，纤维和中空纤维结合，以及使用其的去除超抗原的模块。本发明还提供了使用对超级抗原具有亲和力的MHC II类或其一部分以及其测定试剂盒来检测或定量超级抗原的方法。

4. 发明授权

US06461517B1 Bacterial-derived component removal material 有权
标题翻译：细菌衍生成分去除材料
公开(公告)号：US06461517B1
公开(公告)日：2002-10-08
申请号：US09622219
申请日：2000-08-15
申请人： Keishi Miwa , Mayumi Fukuyama , Rumiko Ishii
发明人： Keishi Miwa , Mayumi Fukuyama , Rumiko Ishii
IPC分类号： A61M136
CPC分类号： B01D15/00 , B01D15/3804 , B01J20/24 , B01J20/26 , B01J20/261 , B01J20/262 , B01J20/265 , B01J20/267 , B01J20/28004 , B01J20/28023 , B01J20/3092 , B01J20/321 , B01J20/3212 , B01J20/3248 , B01J20/3251 , B01J20/3253 , B01J20/3255 , B01J2220/445 , B01J2220/58
摘要： A material having affinity for LTA and/or PrA and/or aHL and/or proteinase is prepared by introducing functional groups capable of hydrogen bond formation into a substrate. Using this material, LTA and/or PrA and/or aHL and/or proteinase in blood, plasma or other solution of high protein concentration can be rapidly detoxified or removed. Articles for LTA and/or PrA and/or aHL and/or proteinase removal of detoxification using this material are described, in particular a body fluid purification column for LTA and/or PrA and/or aHL and/or proteinase removal and an LTA and/or PrA and/or aHL and/or proteinase-adsorptive dressing.
摘要翻译：对LTA和/或PrA和/或aHL和/或蛋白酶具有亲和力的材料通过将能够形成氢键的官能团引入底物来制备。使用这种材料，高蛋白浓度的血液，血浆或其他溶液中的LTA和/或PrA和/或aHL和/或蛋白酶可以快速解毒或去除。描述了用于使用该材料的LTA和/或PrA和/或aHL和/或蛋白酶去除解毒的制品，特别是用于LTA和/或PrA和/或aHL和/或蛋白酶去除的体液纯化柱和LTA和 /或PrA和/或aHL和/或蛋白酶吸附敷料。

5. 发明授权

US10744768B2 Bonded substrate, liquid discharge head, and liquid discharge apparatus 有权
公开(公告)号：US10744768B2
公开(公告)日：2020-08-18
申请号：US16262247
申请日：2019-01-30
申请人： Keishi Miwa
发明人： Keishi Miwa
IPC分类号： B41J2/14 , B41J2/16
摘要： A bonded substrate includes a first substrate, a second substrate bonded to the first substrate with adhesive applied to the second substrate, and a checking structure disposed on the first substrate and facing the second substrate. The checking structure includes a bonding surface portion to be adhered to the second substrate with the adhesive and an insufficiency detection surface to detect insufficient adhesion, a height of the insufficiency detection surface being lower than a height of the bonding surface portion. The adhesive does not contact the insufficiency detection surface when an adhesion state of the bonding surface portion to the second substrate with the adhesive is insufficient, and the adhesive contacts the insufficiency detection surface when the adhesion state of the bonding surface portion to the second substrate with the adhesive is sufficient.

6. 发明公开

US20240316928A1 PIEZOELECTRIC ACTUATOR, LIQUID DISCHARGE HEAD, AND LIQUID DISCHARGE APPARATUS 审中-公开
公开(公告)号：US20240316928A1
公开(公告)日：2024-09-26
申请号：US18605948
申请日：2024-03-15
申请人： Keishi Miwa
发明人： Keishi Miwa
IPC分类号： B41J2/14 , H10N30/20 , H10N30/87
CPC分类号： B41J2/14233 , H10N30/2047 , H10N30/87 , H10N30/877 , B41J2002/14258
摘要： A piezoelectric actuator includes: a substrate having an opening; a diaphragm: having a first face on one face of the substrate; and facing the opening; and a piezoelectric element including: a lower electrode; a piezoelectric body; and an upper electrode, and the lower electrode, the piezoelectric body, and the upper electrode being sequentially laminated on a second face opposite to the first face of the diaphragm in a lamination direction, wherein the lower electrode includes: a first lower electrode extending in a first direction; and multiple second lower electrodes: each extending in the first direction; on each of both sides of the first lower electrode in a second direction orthogonal to the first direction; and separated from the first lower electrode in the second direction, and the piezoelectric body is interior of both ends of the opening in the second direction.

7. 发明授权

US09362478B2 Method of producing electromechanical transducer element, electromechanical transducer element, liquid droplet discharge head, and image forming apparatus 有权
标题翻译：制造机电换能器元件，机电换能器元件，液滴喷射头和成像装置的方法
公开(公告)号：US09362478B2
公开(公告)日：2016-06-07
申请号：US14572930
申请日：2014-12-17
申请人： Toshiaki Masuda , Keishi Miwa , Keisuke Hayashi , Takahiko Kuroda
发明人： Toshiaki Masuda , Keishi Miwa , Keisuke Hayashi , Takahiko Kuroda
IPC分类号： B41J2/015 , B41J2/045 , B21D53/76 , B23P17/00 , H01L41/22 , H04R17/00 , H01L41/053 , H01L41/23 , H01L41/08 , H01L41/09
CPC分类号： H01L41/0533 , H01L41/0805 , H01L41/0973 , H01L41/23
摘要： A method of producing an electromechanical transducer element includes forming a first, common electrode on one of a substrate and an undercoat layer; forming an electromechanical transducer film on the first electrode; forming a second electrode on the electromechanical transducer film; forming a first protective film on an upper surface of the second electrode, the electromechanical transducer film, and a side wall of the second electrode, and selectively forming a second protective film on a portion of the first protective film protecting the electromechanical transducer film and the side wall of the second electrode.
摘要翻译：一种制造机电换能器元件的方法包括在基底和底涂层之一上形成第一公共电极; 在所述第一电极上形成机电换能器膜; 在所述机电换能器膜上形成第二电极; 在第二电极的上表面，机电换能器膜和第二电极的侧壁上形成第一保护膜，并且在保护机电换能器膜的第一保护膜的一部分上选择性地形成第二保护膜，第二电极的侧壁。

8. 发明授权

US09321263B2 Electromechanical transducer, liquid droplet discharge head, and image forming apparatus 有权
标题翻译：机电换能器，液滴喷射头和图像形成装置
公开(公告)号：US09321263B2
公开(公告)日：2016-04-26
申请号：US14748517
申请日：2015-06-24
申请人： Toshiaki Masuda , Keishi Miwa
发明人： Toshiaki Masuda , Keishi Miwa
IPC分类号： B41J2/045 , B41J2/14 , H01L41/047
CPC分类号： B41J2/14201 , B41J2/14233 , B41J2/161 , B41J2/1628 , B41J2/1631 , B41J2/1642 , B41J2/1645 , H01L41/047 , H01L41/29 , H01L41/332
摘要： An electromechanical transducer includes a substrate; a diaphragm formed on the substrate; and a piezoelectric element that includes a lower electrode; a piezoelectric member; and an upper electrode, in which a lower electrode film to form the lower electrode, a piezoelectric film to form the piezoelectric member, and an upper electrode film to form the upper electrode are laminated in layers on the diaphragm formed on the substrate. The piezoelectric element is formed such that the lower electrode film, the piezoelectric member film, and the upper electrode film are patterned to form the lower electrode, the piezoelectric member, and the upper electrode, each of which has a desired pattern; and corners of the lower electrode are rounded.
摘要翻译：机电换能器包括基板; 形成在所述基板上的隔膜; 以及包括下电极的压电元件; 压电元件; 并且在形成在基板上的隔膜上层叠有形成下电极的下电极膜，形成压电元件的压电膜和形成上电极的上电极膜的上电极。压电元件形成为使得下电极膜，压电元件膜和上电极膜被图案化以形成每个都具有期望图案的下电极，压电元件和上电极; 并且下电极的角部是圆形的。

9. 发明申请

US20080038757A1 Method for Rapidly and Conveniently Detecting Target Substances and Enzyme Immunological Kit Therefor 审中-公开
标题翻译：快速方便地检测目标物质的方法和酶免疫试剂盒
公开(公告)号：US20080038757A1
公开(公告)日：2008-02-14
申请号：US11596385
申请日：2005-05-13
申请人： Naoko Shibayama , Keishi Miwa
发明人： Naoko Shibayama , Keishi Miwa
IPC分类号： G01N33/535 , C12M1/40
CPC分类号： G01N33/54393 , G01N33/543 , G01N33/6869 , G01N2333/5412
摘要： A measurement kit capable of rapidly and conveniently detecting one type or a plurality of types of target substance(s) simultaneously in a sample and a measurement method therefor are provided. Furthermore, with the kit or the measurement method, disease with which a target substance is associated is diagnosed. The enzyme immunological kit comprises: a support upon the surface of which a substance that recognizes a target substance is immobilized; an enzyme-labeled antibody against the target substance; and a substrate whose reaction product is water-insoluble after the enzyme-labeled antibody is caused to undergo color development; with which the target substance in a sample is detected based on color development on the support surface. Alternatively, the measurement method comprises 2 reaction steps: the incubation step and the color development step, by which a target substance in a sample is detected or the concentration of the target substance in the sample is measured through visual determination of color developed on the support surface after the color development reaction.
摘要翻译：本发明提供能够快速方便地检测样品中的一种或多种目标物质同时检测的测定试剂及其测定方法。此外，通过试剂盒或测量方法，诊断出与其相关的目标物质的疾病。酶免疫试剂盒包括：其表面上的支持物，其识别目标物质的物质被固定; 针对靶物质的酶标记抗体; 以及使酶标记的抗体发生显色后，其反应产物为水不溶性的底物; 基于载体表面上的颜色显现来检测样品中的目标物质。或者，测量方法包括2个反应步骤：孵育步骤和显色步骤，通过该步骤检测样品中的目标物质或样品中目标物质的浓度，通过目视确定在载体上显影的颜色表面后发色反应。

10. 发明申请

US20160001556A1 ELECTROMECHANICAL TRANSDUCER, LIQUID DROPLET DISCHARGE HEAD, AND IMAGE FORMING APPARATUS 有权
标题翻译：机电传感器，液体放电头和图像形成装置
公开(公告)号：US20160001556A1
公开(公告)日：2016-01-07
申请号：US14748517
申请日：2015-06-24
申请人： Toshiaki Masuda , Keishi Miwa
发明人： Toshiaki Masuda , Keishi Miwa
IPC分类号： B41J2/14 , H01L41/047
CPC分类号： B41J2/14201 , B41J2/14233 , B41J2/161 , B41J2/1628 , B41J2/1631 , B41J2/1642 , B41J2/1645 , H01L41/047 , H01L41/29 , H01L41/332
摘要： An electromechanical transducer includes a substrate; a diaphragm formed on the substrate; and a piezoelectric element that includes a lower electrode; a piezoelectric member; and an upper electrode, in which a lower electrode film to form the lower electrode, a piezoelectric film to form the piezoelectric member, and an upper electrode film to form the upper electrode are laminated in layers on the diaphragm formed on the substrate. The piezoelectric element is formed such that the lower electrode film, the piezoelectric member film, and the upper electrode film are patterned to form the lower electrode, the piezoelectric member, and the upper electrode, each of which has a desired pattern; and corners of the lower electrode are rounded.
摘要翻译：机电换能器包括基板; 形成在所述基板上的隔膜; 以及包括下电极的压电元件; 压电元件; 并且在形成在基板上的隔膜上层叠有形成下电极的下电极膜，形成压电元件的压电膜和形成上电极的上电极膜的上电极。压电元件形成为使得下电极膜，压电元件膜和上电极膜被图案化以形成每个都具有期望图案的下电极，压电元件和上电极; 并且下电极的角部是圆形的。

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