专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09421242B2 Methods and materials for reducing the severity of viral infections 有权
标题翻译：降低病毒感染严重程度的方法和材料
公开(公告)号：US09421242B2
公开(公告)日：2016-08-23
申请号：US14156275
申请日：2014-01-15
申请人： Mayo Foundation for Medical Education and Research
发明人： Moses Rodriguez , Allan J. Bieber , Arthur E. Warrington, Jr. , Meghan McGee Painter , Eric M. Poeschla
IPC分类号： C12N15/86 , A61K38/16
CPC分类号： A61K38/45 , A61K9/0019 , A61K9/0053 , A61K9/007 , A61K38/162 , A61K48/0075 , C12N7/00 , C12N2740/16043 , C12N2770/32033 , C12N2770/32222 , C12N2770/32232 , C12N2800/22 , C12Y207/07048
摘要： This document relates to methods and materials involved in treating and/or preventing and/or reducing the severity of a viral infection present in a mammal. For example, methods for increasing expression of an Oas gene family polypeptide, an Ifit gene family polypeptide, an Isg15 polypeptide, a Rig-1 polypeptide, a Mda5 polypeptide, and a Mx1 polypeptide in mammals using a lentiviral vector comprising nucleic acid encoding a picornavirus 3Dpol polypeptide (or a fragment thereof) are provided.
摘要翻译：本文件涉及涉及治疗和/或预防和/或降低存在于哺乳动物中的病毒感染的严重性的方法和材料。例如，使用包含编码小核糖核酸病毒核酸的慢病毒载体在哺乳动物中增加Oas基因家族多肽，Ifit基因家族多肽，Isg15多肽，Rig-1多肽，Mda5多肽和Mx1多肽的表达的方法提供3Dpol多肽（或其片段）。

2. 发明授权

US09981019B2 Methods and materials for reducing the severity of viral infections 有权
公开(公告)号：US09981019B2
公开(公告)日：2018-05-29
申请号：US15222048
申请日：2016-07-28
申请人： Mayo Foundation for Medical Education and Research
发明人： Moses Rodriguez , Allan J. Bieber , Arthur E. Warrington, Jr. , Meghan McGee Painter , Eric M. Poeschla
IPC分类号： A61K38/45 , A61K48/00 , A61K9/00 , C12N7/00 , A61K38/16
CPC分类号： A61K38/45 , A61K9/0019 , A61K9/0053 , A61K9/007 , A61K38/162 , A61K48/0075 , C12N7/00 , C12N2740/16043 , C12N2770/32033 , C12N2770/32222 , C12N2770/32232 , C12N2800/22 , C12Y207/07048
摘要： This document relates to methods and materials involved in treating and/or preventing and/or reducing the severity of a viral infection present in a mammal. For example, methods and materials for reducing the severity of a viral infection present in a mammal (e.g., a human) are provided.

3. 发明授权

US08968735B2 Compositions and methods including a recombinant human MAB that promotes CNS remyelination 有权
标题翻译：组合物和方法，包括促进CNS髓鞘再生的重组人MAB
公开(公告)号：US08968735B2
公开(公告)日：2015-03-03
申请号：US13788529
申请日：2013-03-07
申请人： Acorda Therapeutics, Inc. , Mayo Foundation for Medical Education and Research
发明人： Elliot A. Gruskin , Eric Chojnicki , Arthur E. Warrington , Allan J. Bieber , Moses Rodriguez
IPC分类号： A61K39/395 , A61K31/573 , C07K16/18 , A61K39/00
CPC分类号： C07K16/28 , A61K31/573 , A61K39/39533 , A61K39/39541 , A61K2039/505 , A61K2039/545 , C07K16/18 , C07K2317/21 , C07K2317/56 , C07K2317/75 , A61K2300/00
摘要： Antibodies, and particularly human antibodies, are disclosed that demonstrate activity in the treatment of demyelinating diseases as well as other diseases of the central nervous system that are of viral, bacterial or idiopathic origin, including neural dysfunction caused by spinal cord injury. Neuromodulatory agents are set forth that include and comprise a material selected from the group consisting of an antibody capable of binding structures or cells in the central nervous system, a peptide analog, a hapten, active fragments thereof, agonists thereof, mimics thereof, monomers thereof and combinations thereof. Methods are described for treating demyelinating diseases, and diseases of the central nervous system of humans and domestic animals, using polyclonal IgM antibodies and human monoclonal antibodies sHIgm22(LYM 22), sHIgm46(LYM46) ebvHIgM MSI19D10, CB2bG8, AKJR4, CB2iE12, CB2iE7, MSI19E5 and MSI10E10, active fragments thereof and the like. The invention also extends to the use of human antibodies, fragments, peptide derivatives and like materials, and their use in above referenced therapeutic applications, and to pharmaceutical compositions containing them, that may be administered in desirably low doses to treat conditions involving demyelination and to promote remyelination.
摘要翻译：公开了抗体，特别是人抗体，其表现出治疗脱髓鞘疾病以及中枢神经系统的病毒，细菌或特发性起源的其它疾病，包括由脊髓损伤引起的神经功能障碍的活性。阐述神经调节剂，其包括并且包含选自能够结合中枢神经系统结构或细胞的抗体，肽类似物，半抗原，其活性片段，其激动剂，其模拟物，其单体及其组合。描述了使用多克隆IgM抗体和人单克隆抗体sHIgm22（LYM22），sHIgm46（LYM46）ebvHIgM MSI19D10，CB2bG8，AKJR4，CB2iE12，CB2iE7等治疗脱髓鞘疾病和人和家畜的中枢神经系统疾病的方法， MSI19E5和MSI10E10，其活性片段等。本发明还延伸到人抗体，片段，肽衍生物和类似材料及其在上述治疗应用中的用途以及含有它们的药物组合物的使用，其可以以期望的低剂量施用以治疗涉及脱髓鞘的病症，以及促进髓鞘再生。

4. 发明申请

US20200247883A1 COMPOSITIONS AND METHODS INCLUDING A RECOMBINANT HUMAN MAB THAT PROMOTES CNS REMYELINATION 审中-公开
公开(公告)号：US20200247883A1
公开(公告)日：2020-08-06
申请号：US16578649
申请日：2019-09-23
申请人： Mayo Foundation for Medical Education and Research , Acorda Therapeutics, Inc.
发明人： Elliott A. Gruskin , Arthur E. Warrington , Allan J. Bieber , Moses Rodriguez , Eric Walter Theodore Chojnicki
IPC分类号： C07K16/28 , A61K31/573 , A61K39/395 , C07K16/18
摘要： Antibodies, and particularly human antibodies, are disclosed that demonstrate activity in the treatment of demyelinating diseases as well as other diseases of the central nervous system that are of viral, bacterial or idiopathic origin, including neural dysfunction caused by spinal cord injury. Neuromodulatory agents are set forth that include and comprise a material selected from the group consisting of an antibody capable of binding structures or cells in the central nervous system, a peptide analog, a hapten, active fragments thereof, agonists thereof, mimics thereof, monomers thereof and combinations thereof. Methods are described for treating demyelinating diseases, and diseases of the central nervous system of humans and domestic animals, using polyclonal IgM antibodies and human monoclonal antibodies sHIgm22(LYM 22), sHIgm46(LYM46) ebvHIgM MSI19D10, CB2bG8, AKJR4, CB2iE12, CB2iE7, MSI19E5 and MSI10E10, active fragments thereof and the like. The invention also extends to the use of human antibodies, fragments, peptide derivatives and like materials, and their use in above referenced therapeutic applications, and to pharmaceutical compositions containing them, that may be administered in desirably low doses to treat conditions involving demyelination and to promote remyelination.

5. 发明申请

US20170014490A1 METHODS AND MATERIALS FOR REDUCING THE SEVERITY OF VIRAL INFECTIONS 有权
标题翻译：减少病毒感染严重程度的方法和材料
公开(公告)号：US20170014490A1
公开(公告)日：2017-01-19
申请号：US15222048
申请日：2016-07-28
申请人： Mayo Foundation for Medical Education and Research
发明人： Moses Rodriguez , Allan J. Bieber , Arthur E. Warrington, Jr. , Meghan McGee Painter , Eric M. Poeschla
IPC分类号： A61K38/45 , A61K9/00 , A61K48/00 , C12N7/00
CPC分类号： A61K38/45 , A61K9/0019 , A61K9/0053 , A61K9/007 , A61K38/162 , A61K48/0075 , C12N7/00 , C12N2740/16043 , C12N2770/32033 , C12N2770/32222 , C12N2770/32232 , C12N2800/22 , C12Y207/07048
摘要： This document relates to methods and materials involved in treating and/or preventing and/or reducing the severity of a viral infection present in a mammal. For example, methods and materials for reducing the severity of a viral infection present in a mammal (e.g., a human) are provided.
摘要翻译：本文件涉及涉及治疗和/或预防和/或降低存在于哺乳动物中的病毒感染的严重性的方法和材料。例如，提供了用于降低存在于哺乳动物（例如人）中的病毒感染的严重性的方法和材料。

6. 发明申请

US20140206754A1 METHODS AND MATERIALS FOR REDUCING THE SEVERITY OF VIRAL INFECTIONS 有权
标题翻译：减少病毒感染严重程度的方法和材料
公开(公告)号：US20140206754A1
公开(公告)日：2014-07-24
申请号：US14156275
申请日：2014-01-15
申请人： Mayo Foundation for Medical Education and Research
发明人： Moses Rodriguez , Allan J. Bieber , Arthur E. Warrington, JR. , Meghan McGee Painter
IPC分类号： C12N15/86
CPC分类号： A61K38/45 , A61K9/0019 , A61K9/0053 , A61K9/007 , A61K38/162 , A61K48/0075 , C12N7/00 , C12N2740/16043 , C12N2770/32033 , C12N2770/32222 , C12N2770/32232 , C12N2800/22 , C12Y207/07048
摘要： This document relates to methods and materials involved in treating and/or preventing and/or reducing the severity of a viral infection present in a mammal. For example, methods and materials for reducing the severity of a viral infection present in a mammal (e.g., a human) are provided.
摘要翻译：本文件涉及涉及治疗和/或预防和/或降低存在于哺乳动物中的病毒感染的严重性的方法和材料。例如，提供了用于降低存在于哺乳动物（例如人）中的病毒感染的严重性的方法和材料。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式