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1. 发明授权

US08552221B2 Process for the manufacture of halogenated precursors of alkenones under specific conditions 有权
标题翻译：在特定条件下制造烯酮卤化前体的方法
公开(公告)号：US08552221B2
公开(公告)日：2013-10-08
申请号：US12999730
申请日：2010-07-05
申请人： Max Josef Braun , Stefan Palsherm , Uta Claassen
发明人： Max Josef Braun , Stefan Palsherm , Uta Claassen
IPC分类号： C07C45/65
CPC分类号： C07C45/65 , C07C45/41 , C07C49/175 , C07C49/255
摘要： A process for preparing a halogenated precursor of an alkenone, which comprises reacting a carboxylic acid halide with a vinyl ether in a liquid reaction medium under turbulent conditions and a process for preparing an alkenone, by eliminating hydrogen halide from said precursor to form the alkenone.
摘要翻译：一种制备烯酮的卤化前体的方法，其包括在湍流条件下在液体反应介质中使羧酸卤化物与乙烯基醚反应，以及通过从所述前体中除去卤化氢以形成烯酮，制备烯酮的方法。

2. 发明申请

US20130317251A1 Process for the manufacture of fluoromethoxymalonic acid derivatives 审中-公开
标题翻译：氟代甲氧基丙二酸衍生物的制备方法
公开(公告)号：US20130317251A1
公开(公告)日：2013-11-28
申请号：US13984179
申请日：2012-02-07
申请人： Max Josef Braun , Uta Claassen
发明人： Max Josef Braun , Uta Claassen
IPC分类号： C07C67/287 , C07C41/01
CPC分类号： C07C67/287 , C07C41/01 , C07C67/307 , C07C69/708
摘要： Process for the manufacture of a compound of formula R1OOC—CH(OCH2F)—COOR, (I) or R3HNOC—CH(OCH2F)—CONHR4(II) wherein R1, R2, R3, R4 are equal or different from each other and are independently selected from H; an alkyl group having from 1 to 10 carbon atoms which is optionally substituted by at least one halogen atom; an aralkyl group; or an aryl group, comprising reacting a compound of formula R1OOC—CH(OCH2X)—COOR2 (III) or R3HNOC—CH(OCH2X)—CONHR4(IV) wherein X is a leaving group that can be substituted by nucleophilic substitution, and wherein R1, R2, R3, R4 have the same meaning as above, with at least one source of nucleophilic fluorine.
摘要翻译：制备式R1OOC-CH（OCH2F）-COOR，（I）或R3HNOC-CH（OCH2F）-CONHR4（Ⅱ）化合物的方法，其中R 1，R 2，R 3，R 4彼此相同或不同，为独立地选自H; 任选被至少一个卤素原子取代的具有1至10个碳原子的烷基; 芳烷基; 包括使式R 1 OOC-CH（OCH 2 X）-COOR 2（III）或R 3 HNOC-CH（OCH 2 X）-CONHR 4（IV）的化合物与其中X是可被亲核取代取代的离去基团反应，其中 R1，R2，R3，R4具有与上述相同的含义，至少有一个亲核氟源。

3. 发明申请

US20120116128A1 Process For The Manufacture Of Halogenated Precursors Of Alkenones In The Presence Of A Solvent 有权
标题翻译：烯烃酮在溶剂存在下制备卤代前体的方法
公开(公告)号：US20120116128A1
公开(公告)日：2012-05-10
申请号：US12999714
申请日：2010-07-05
申请人： Max Braun , Stefan Palsherm , Uta Claassen
发明人： Max Braun , Stefan Palsherm , Uta Claassen
IPC分类号： C07C45/70 , C07C45/65
CPC分类号： C07C45/455 , C07C45/41 , C07C45/65 , C07C49/255 , C07C49/175
摘要： A process for preparing a halogenated precursor of an alkenone, which comprises reacting a carboxylic acid halide with a vinyl ether in a liquid reaction medium comprising an alkenone or a halogenated precursor of the alkenone, and a process for preparing an alkenone, which comprises (a) reacting a carboxylic acid halide with a vinyl ether by introducing vinyl ether into a liquid reaction medium containing carboxylic acid halide to form a halogenated precursor of the alkenone and (b) eliminating hydrogen halide from said precursor to form the alkenone.
摘要翻译：一种制备烯酮的卤化前体的方法，其包括在包含烯酮的烯酮或卤代前体的液体反应介质中使羧酸卤化物与乙烯基醚反应，以及制备烯酮的方法，其包含（a ）通过将乙烯基醚引入到含有羧酸卤化物的液体反应介质中以形成烯酮的卤化前体，和（b）从所述前体中除去卤化氢以形成烯酮，使羧酸卤化物与乙烯基醚反应。

4. 发明授权

US08440865B2 Process for the manufacture of alkenones 有权
标题翻译：制备烯酮的方法
公开(公告)号：US08440865B2
公开(公告)日：2013-05-14
申请号：US12999750
申请日：2010-07-05
申请人： Max Braun , Stefan Palsherm , Uta Claassen , Alain Lambert
发明人： Max Braun , Stefan Palsherm , Uta Claassen , Alain Lambert
IPC分类号： C07C45/64
CPC分类号： C07C45/65 , C07C45/41 , C07C49/255 , C07C49/175
摘要： Process for preparing an alkenone, which comprises the following steps: (a) providing a halogenated precursor of the alkenone; and (b) eliminating the hydrogen halide from said precursor to form the alkenone by a thermolysis treatment selected from the group consisting of flash thermolysis, vacuum thermolysis, and thermolysis under stripping with inert gas.
摘要翻译：制备烯酮的方法，其包括以下步骤：（a）提供烯酮的卤化前体; 和（b）通过热分解处理从所述前体中消除卤化氢以形成烯酮，所述热分解选自闪蒸热解，真空热解和用惰性气体汽提的热解。

5. 发明申请

US20120116127A1 Process for the manufacture of alkenones 有权
标题翻译：制备烯酮的方法
公开(公告)号：US20120116127A1
公开(公告)日：2012-05-10
申请号：US12999750
申请日：2010-07-05
申请人： Max Braun , Stefan Palsherm , Uta Claassen , Alain Lambert
发明人： Max Braun , Stefan Palsherm , Uta Claassen , Alain Lambert
IPC分类号： C07C45/64
CPC分类号： C07C45/65 , C07C45/41 , C07C49/255 , C07C49/175
摘要： Process for preparing an alkenone, which comprises the following steps: (a) providing a halogenated precursor of the alkenone; and (b) eliminating the hydrogen halide from said precursor to form the alkenone by a thermolysis treatment selected from the group consisting of flash thermolysis, vacuum thermolysis, and thermolysis under stripping with inert gas.
摘要翻译：制备烯酮的方法，其包括以下步骤：（a）提供烯酮的卤化前体; 和（b）通过热分解处理从所述前体中消除卤化氢以形成烯酮，所述热分解选自闪蒸热解，真空热解和用惰性气体汽提的热解。

6. 发明授权

US08957254B2 Process for chemical synthesis from an alkenone made from a halogenated precursor 有权
标题翻译：由卤化前体制成的烯酮进行化学合成的方法
公开(公告)号：US08957254B2
公开(公告)日：2015-02-17
申请号：US14046171
申请日：2013-10-04
申请人： Max Braun , Stefan Palsherm , Uta Claassen , Alain Lambert
发明人： Max Braun , Stefan Palsherm , Uta Claassen , Alain Lambert
IPC分类号： C07C45/41 , C07D211/02 , C07D213/64 , C07D401/00 , C07C45/65
CPC分类号： C07C45/41 , C07C45/65 , C07C49/175 , C07C49/255
摘要： Process for synthesizing a chemical, in particular an agriculturally or pharmaceutically active compound, including: a first step comprising reacting a carboxylic acid halide with a vinyl ether to prepare a halogenated precursor of an alkenone; a second step comprising eliminating hydrogen halide from such precursor to form an alkenone, preferably by thermolysis under specific conditions; and a third step which uses the formed alkenone as a building block to synthesize the chemical. First step may be done in a liquid reaction medium comprising an alkenone or a halogenated alkenone precursor, or in a liquid reaction medium in turbulent state, specifically by creation of gas bubbles of the carboxylic acid halide herein. Second step may include a flash thermolysis, vacuum thermolysis, thermolysis under stripping with inert gas, and/or a thermolysis at a temperature from >90° C. to 120° C. Third step preferably comprises reacting the alkenone with a nitrogen-containing compound.
摘要翻译：用于合成化学品，特别是农业或药学活性化合物的方法，包括：第一步，包括使羧酸卤化物与乙烯基醚反应以制备烯酮的卤化前体; 第二步，包括从这种前体消除卤化氢以形成烯酮，优选通过在特定条件下的热解; 和使用形成的烯酮作为结构单元合成化学品的第三步骤。第一步可以在包含烯酮或卤代烯酮前体的液体反应介质中或在湍流状态的液体反应介质中，特别是通过产生本文中的羧酸卤化物的气泡进行。第二步骤可以包括闪蒸热解，真空热解，用惰性气体汽提时的热解，和/或在> 90℃至120℃的温度下的热解。第三步优选包括使烯酮与含氮化合物。

7. 发明授权

US08426650B2 Process for the manufacture of halogenated precursors of alkenones in the presence of a solvent 有权
标题翻译：在溶剂存在下制备烯酮卤化前体的方法
公开(公告)号：US08426650B2
公开(公告)日：2013-04-23
申请号：US12999714
申请日：2010-07-05
申请人： Max Braun , Stefan Palsherm , Uta Claassen
发明人： Max Braun , Stefan Palsherm , Uta Claassen
IPC分类号： C07C45/70 , C07C45/65 , C07C45/66
CPC分类号： C07C45/455 , C07C45/41 , C07C45/65 , C07C49/255 , C07C49/175
摘要： A process for preparing a halogenated precursor of an alkenone, which comprises reacting a carboxylic acid halide with a vinyl ether in a liquid reaction medium comprising an alkenone or a halogenated precursor of the alkenone, and a process for preparing an alkenone, which comprises (a) reacting a carboxylic acid halide with a vinyl ether by introducing vinyl ether into a liquid reaction medium containing carboxylic acid halide to form a halogenated precursor of the alkenone and (b) eliminating hydrogen halide from said precursor to form the alkenone.
摘要翻译：一种制备烯酮的卤化前体的方法，其包括在包含烯酮的烯酮或卤代前体的液体反应介质中使羧酸卤化物与乙烯基醚反应，以及制备烯酮的方法，其包含（a ）通过将乙烯基醚引入到含有羧酸卤化物的液体反应介质中以形成烯酮的卤化前体，和（b）从所述前体中除去卤化氢以形成烯酮，使羧酸卤化物与乙烯基醚反应。

8. 发明申请

US20050070716A1 Method of synthesizing alkenone compounds 失效
标题翻译：烯酮化合物的合成方法
公开(公告)号：US20050070716A1
公开(公告)日：2005-03-31
申请号：US10912587
申请日：2004-08-06
申请人： Max Braun , Uta Claassen
发明人： Max Braun , Uta Claassen
IPC分类号： C07C45/41 , C07B61/00 , C07C45/45 , C07C49/255 , C07D213/18 , C07D213/46 , C07C45/46
CPC分类号： C07D213/18 , C07C45/455 , C07C49/255
摘要： A method of producing a halogen alkenone ether by attaching carboxylic acid halogenides or carboxylic acid anhydrides to a vinyl ether. According to the invention the method is carried out in the presence of an onium salt of a carbonic acid which can be regenerated. The resulting product is obtained in high yields. Alternatively, pyridine which is substituted by one, two or three C1-C3 alkyl groups or other onium salts can be used.
摘要翻译：通过将羧酸卤化物或羧酸酐连接到乙烯基醚上制备卤素烯酮醚的方法。根据本发明，该方法在可再生的碳酸的鎓盐存在下进行。得到的产物以高收率获得。或者，可以使用被一个，两个或三个C 1 -C 3烷基或其它鎓盐取代的吡啶。

9. 发明授权

US07057079B2 Method of synthesizing alkenone compounds 失效
标题翻译：烯酮化合物的合成方法
公开(公告)号：US07057079B2
公开(公告)日：2006-06-06
申请号：US10912587
申请日：2004-08-06
申请人： Max Braun , Uta Claassen
发明人： Max Braun , Uta Claassen
IPC分类号： C07C45/45
CPC分类号： C07D213/18 , C07C45/455 , C07C49/255
摘要： A method of producing a halogen alkenone ether by attaching carboxylic acid halogenides or carboxylic acid anhydrides to a vinyl ether. According to the invention the method is carried out in the presence of an onium salt of a carbonic acid which can be regenerated. The resulting product is obtained in high yields. Alternatively, pyridine which is substituted by one, two or three C1–C3 alkyl groups or other onium salts can be used.
摘要翻译：通过将羧酸卤化物或羧酸酐连接到乙烯基醚上制备卤素烯酮醚的方法。根据本发明，该方法在可再生的碳酸的鎓盐存在下进行。得到的产物以高收率获得。或者，可以使用被一个，两个或三个C 1 -C 3烷基或其它鎓盐取代的吡啶。

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