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1. 发明授权

US09115061B2 Naphthalene-based inhibitors of anti-apoptotic proteins 有权
标题翻译：基于萘的抗凋亡蛋白抑制剂
公开(公告)号：US09115061B2
公开(公告)日：2015-08-25
申请号：US12253918
申请日：2008-10-17
申请人： Maurizio Pellecchia , John C. Reed
发明人： Maurizio Pellecchia , John C. Reed
IPC分类号： C07C239/00 , C07C39/14 , C07C47/575 , C07C49/83 , C07C49/84 , C07C235/66 , C07C311/29 , C07D277/64
CPC分类号： C07C39/14 , C07C47/575 , C07C49/83 , C07C49/84 , C07C235/66 , C07C311/29 , C07C2601/08 , C07C2601/14 , C07D277/64
摘要： Methods of using apogossypol and its derivatives for treating inflammation is disclosed. Also, there is described a group of compounds having structure A, or a pharmaceutically acceptable salt, hydrate, N-oxide, or solvate thereof are provided: wherein each R is independently selected from the group consisting of H, C(O)X, C(O)NHX, NH(CO)X, SO2NHX, and NHSO2X, wherein X is selected from the group consisting of an alkyl, a substituted alkyl, an aryl, a substituted aryl, an alkylaryl, and a heterocycle. Compounds of group A may be used for treating various diseases or disorders, such as cancer.
摘要翻译：公开了使用果糖酚及其衍生物治疗炎症的方法。此外，提供了一组具有结构A的化合物或其药学上可接受的盐，水合物，N-氧化物或溶剂合物：其中每个R独立地选自H，C（O）X， C（O）NHX，NH（CO）X，SO2NHX和NHSO2X，其中X选自烷基，取代的烷基，芳基，取代的芳基，烷基芳基和杂环。 A组的化合物可用于治疗各种疾病或病症，例如癌症。

2. 发明申请

US20120269901A1 Methods and Compounds Useful to Induce Apoptosis in Cancer Cells 审中-公开
标题翻译：用于诱导癌细胞凋亡的方法和化合物
公开(公告)号：US20120269901A1
公开(公告)日：2012-10-25
申请号：US13329611
申请日：2011-12-19
申请人： John C. Reed , Maurizio Pellecchia
发明人： John C. Reed , Maurizio Pellecchia
IPC分类号： A61K31/11 , A61K31/12 , A61K31/453 , A61K31/704 , A61P35/00 , A61K31/337 , A61K33/24 , G01N21/64 , G01N27/72 , A61K31/352 , A61K31/335
CPC分类号： A61K31/05 , A61K31/02 , A61K31/075 , A61K31/11 , A61K31/216 , A61K31/225 , A61K31/352 , A61K31/52 , A61K45/06 , G01N2500/02 , Y02A50/471 , A61K2300/00
摘要： The present invention provides a method for treating cancer in a mammal comprising contacting the cancer cells with a compound which is a apogossypol, derivative.
摘要翻译：本发明提供了一种用于治疗哺乳动物癌症的方法，包括使癌细胞与作为脱乙酰壳多糖衍生物的化合物接触。

3. 发明申请

US20110111057A1 Methods and Compounds Useful to Induce Apoptosis in Cancer Cells 有权
标题翻译：用于诱导癌细胞凋亡的方法和化合物
公开(公告)号：US20110111057A1
公开(公告)日：2011-05-12
申请号：US12900319
申请日：2010-10-07
申请人： John C. Reed , Maurizio Pellecchia
发明人： John C. Reed , Maurizio Pellecchia
IPC分类号： A61K31/05 , A61K31/11 , A61K31/353 , A61K31/122 , A61P35/00 , A61K31/453 , A61K31/65 , A61K31/357 , A61K31/337 , A61K33/24 , G01N33/68
CPC分类号： A61K31/05 , A61K31/02 , A61K31/075 , A61K31/11 , A61K31/216 , A61K31/225 , A61K31/352 , A61K31/52 , A61K45/06 , G01N2500/02 , Y02A50/471 , A61K2300/00
摘要： The present invention provides a method for treating cancer in a mammal comprising contacting the cancer cells with a compound which is a apogossypol, derivative.
摘要翻译：本发明提供了一种用于治疗哺乳动物癌症的方法，包括使癌细胞与作为脱乙酰壳多糖衍生物的化合物接触。

4. 发明授权

US07741521B2 Inhibition of bid-induced cell-death using small organic molecules 有权
标题翻译：使用小有机分子抑制招标诱导的细胞死亡
公开(公告)号：US07741521B2
公开(公告)日：2010-06-22
申请号：US11645239
申请日：2006-12-22
申请人： John C. Reed , Maurizio Pellecchia
发明人： John C. Reed , Maurizio Pellecchia
IPC分类号： C07C233/05 , C07C233/65 , A61K31/16
CPC分类号： C07C323/41 , G01N2500/04
摘要： Various phenylamine derivatives are described as well as the use of compounds to inhibit BID protein for controlling apoptotic cascade.
摘要翻译：描述了各种苯胺衍生物以及化合物用于抑制BID蛋白以控制凋亡级联的用途。

5. 发明授权

US07812058B2 Methods and compounds useful to induce apoptosis in cancer cells 有权
标题翻译：用于诱导癌细胞凋亡的方法和化合物
公开(公告)号：US07812058B2
公开(公告)日：2010-10-12
申请号：US10877781
申请日：2004-06-25
申请人： John C. Reed , Maurizio Pellecchia
发明人： John C. Reed , Maurizio Pellecchia
IPC分类号： A01N29/00 , A01N43/00 , A61K31/655
CPC分类号： A61K31/05 , A61K31/02 , A61K31/075 , A61K31/11 , A61K31/216 , A61K31/225 , A61K31/352 , A61K31/52 , A61K45/06 , G01N2500/02 , Y02A50/471 , A61K2300/00
摘要： The present invention provides a method for treating cancer in a mammal comprising contacting the cancer cells with a compound which is a apogossypol, derivative.
摘要翻译：本发明提供了一种用于治疗哺乳动物癌症的方法，包括使癌细胞与作为脱乙酰壳多糖衍生物的化合物接触。

6. 发明授权

US08367644B2 Methods and compounds useful to induce apoptosis in cancer cells 有权
标题翻译：用于诱导癌细胞凋亡的方法和化合物
公开(公告)号：US08367644B2
公开(公告)日：2013-02-05
申请号：US12900319
申请日：2010-10-07
申请人： John C. Reed , Maurizio Pellecchia
发明人： John C. Reed , Maurizio Pellecchia
IPC分类号： A01N37/18 , A61K33/24
CPC分类号： A61K31/05 , A61K31/02 , A61K31/075 , A61K31/11 , A61K31/216 , A61K31/225 , A61K31/352 , A61K31/52 , A61K45/06 , G01N2500/02 , Y02A50/471 , A61K2300/00
摘要： The present invention provides a method for treating cancer in a mammal comprising contacting the cancer cells with a compound which is a apogossypol, derivative.
摘要翻译：本发明提供了一种用于治疗哺乳动物癌症的方法，包括使癌细胞与作为脱乙酰壳多糖衍生物的化合物接触。

7. 发明申请

US20100261788A1 Inhibition of Bid-Induced Cell-Death Using Small Organic Molecules 审中-公开
标题翻译：使用小有机分子抑制诱导的细胞死亡
公开(公告)号：US20100261788A1
公开(公告)日：2010-10-14
申请号：US12821097
申请日：2010-06-22
申请人： John C. Reed , Maurizio Pellecchia
发明人： John C. Reed , Maurizio Pellecchia
IPC分类号： A61K31/27 , C07C237/52 , A61K31/167 , A61P1/16 , A61P9/10 , A61P25/28 , A61P25/16 , C07C323/41 , C07C237/04 , C07C311/29 , G01N33/53 , A61K31/18
CPC分类号： C07C323/41 , G01N2500/04
摘要： Various phenylamine derivatives are described as well as the use of compounds to inhibit BID protein for controlling apoptotic cascade.
摘要翻译：描述了各种苯胺衍生物以及化合物用于抑制BID蛋白以控制凋亡级联的用途。

8. 发明申请

US20090105319A1 NAPHTHALENE-BASED INHIBITORS OF ANTI-APOPTOTIC PROTEINS 有权
标题翻译：基于萘基的抗微生物蛋白抑制剂
公开(公告)号：US20090105319A1
公开(公告)日：2009-04-23
申请号：US12253918
申请日：2008-10-17
申请人： Maurizio Pellecchia , John C. Reed
发明人： Maurizio Pellecchia , John C. Reed
IPC分类号： A61K31/05 , C07C49/345 , C07C39/14 , C07D417/10 , C07C235/66 , A61K31/428 , A61P29/00 , A61K31/18 , C07C311/29 , A61P35/00 , A61K31/166 , A61K31/12
CPC分类号： C07C39/14 , C07C47/575 , C07C49/83 , C07C49/84 , C07C235/66 , C07C311/29 , C07C2601/08 , C07C2601/14 , C07D277/64
摘要： Methods of using apogossypol and its derivatives for treating inflammation is disclosed. Also, there is described a group of compounds having structure A, or a pharmaceutically acceptable salt, hydrate, N-oxide, or solvate thereof are provided: wherein each R is independently selected from the group consisting of H, C(O)X, C(O)NHX, NH(CO)X, SO2NHX, and NHSO2X, wherein X is selected from the group consisting of an alkyl, a substituted alkyl, an aryl, a substituted aryl, an alkylaryl, and a heterocycle. Compounds of group A may be used for treating various diseases or disorders, such as cancer.
摘要翻译：公开了使用果糖酚及其衍生物治疗炎症的方法。此外，提供了一组具有结构A的化合物或其药学上可接受的盐，水合物，N-氧化物或溶剂合物：其中每个R独立地选自H，C（O）X， C（O）NHX，NH（CO）X，SO2NHX和NHSO2X，其中X选自烷基，取代的烷基，芳基，取代的芳基，烷基芳基和杂环。组A的化合物可用于治疗各种疾病或病症，例如癌症。

9. 发明申请

US20130224182A1 BCL-G POLYPEPTIDES, ENCODING NUCLEIC ACIDS AND METHODS OF USE 审中-公开
标题翻译： BCL-G多肽，编码核酸和使用方法
公开(公告)号：US20130224182A1
公开(公告)日：2013-08-29
申请号：US13247882
申请日：2011-09-28
申请人： John C. Reed , Adam Godzik
发明人： John C. Reed , Adam Godzik
IPC分类号： C07K7/08 , C07K7/06
CPC分类号： C07K7/08 , C07K7/06 , C07K14/4747 , C07K2319/00
摘要： The invention provides Bcl-G polypeptides and encoding nucleic acids. Bcl-G polypeptides include Bcl-GL and Bcl-GS. The invention also provides mouse Bcl-G. The invention also provides vectors containing Bcl-G nucleic acids, host cells containing such vectors, Bcl-G anti-sense nucleic acids and related compositions. The invention additionally provides Bcl-G oligonucleotides that can be used to hybridize to or amplify a Bcl-G nucleic acid. Anti-Bcl-G specific antibodies are also provided. Further provided are kits containing Bcl-G nucleic acids or Bcl-G specific antibodies. Such kits and reagents can be used to diagnose cancer, monitor response to therapy, or predict the prognosis of a cancer patient. The invention additionally provides methods of modulating apoptosis using Bcl-G polypeptides, encoding nucleic acids, or compounds that modulate the activity or expression of Bcl-G polypeptides. The methods for modulating apoptosis can be used to treat diseases such as cancer.
摘要翻译：本发明提供了Bcl-G多肽和编码核酸。 Bcl-G多肽包括Bcl-GL和Bcl-GS。本发明还提供了小鼠Bcl-G。本发明还提供含有Bcl-G核酸的载体，含有这些载体的宿主细胞，Bcl-G反义核酸和相关组合物。本发明另外提供可用于与Bcl-G核酸杂交或扩增的Bcl-G寡核苷酸。还提供抗Bcl-G特异性抗体。还提供了含有Bcl-G核酸或Bcl-G特异性抗体的试剂盒。这样的试剂盒和试剂可用于诊断癌症，监测对治疗的反应或预测癌症患者的预后。本发明另外提供了使用调节Bcl-G多肽的活性或表达的Bcl-G多肽，编码核酸或化合物来调节凋亡的方法。调节凋亡的方法可用于治疗癌症等疾病。

10. 发明申请

US20110318362A1 NOVEL CARD PROTEINS INVOLVED IN CELL DEATH REGULATION 审中-公开
标题翻译：参与细胞死亡调控的新型卡片蛋白质
公开(公告)号：US20110318362A1
公开(公告)日：2011-12-29
申请号：US13205566
申请日：2011-08-08
申请人： John C. Reed
发明人： John C. Reed
IPC分类号： A61K39/395 , C12N5/10 , C12N1/21 , C12N1/19 , A61K38/45 , A61P29/00 , C12N5/071 , G01N33/574 , C12N9/96 , C07K14/47 , C07K19/00 , A61P35/00 , C07K16/40 , G01N33/566
CPC分类号： C07K14/4747 , A01K2217/05 , A61K38/00 , A61K2039/505 , C07K2319/00
摘要： The present invention provides NB-ARC and CARD-containing proteins (NACs), nucleic acid molecules encoding NACs and antibodies specific for at least one NAC. The invention further provides chimeric NAC proteins. The invention also provides screening assays for identifying an agent that can effectively alter the association of a NAC with a NAC-associated protein. The invention further provides methods of modulating apoptosis in a cell by introducing into the cell a nucleic acid molecule encoding a NAC or an antisense nucleotide sequence. The invention also provides a method of using a reagent that can specifically bind to a NAC to diagnose a pathology that is characterized by an increased or decreased level of apoptosis in a cell.
摘要翻译：本发明提供NB-ARC和含CARD蛋白（NAC），编码NAC的核酸分子和对至少一种NAC特异的抗体。本发明还提供了嵌合NAC蛋白。本发明还提供用于鉴定可有效改变NAC与NAC相关蛋白的缔合的试剂的筛选试验。本发明还提供了通过将编码NAC或反义核苷酸序列的核酸分子引入细胞来调节细胞凋亡的方法。本发明还提供了使用可以特异性结合NAC的试剂来诊断细胞凋亡水平升高或降低的病理学的方法。

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