专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06169074A Peptide inhibitors of neurotransmitter secretion by neuronal cells 失效
标题翻译：神经递质分泌神经元细胞的肽抑制剂
公开(公告)号：US06169074A
公开(公告)日：2001-01-02
申请号：US08819286
申请日：1997-03-18
申请人： Mauricio Montal , Jaume M. Canaves , Antonio V. Ferrer-Monteil
发明人： Mauricio Montal , Jaume M. Canaves , Antonio V. Ferrer-Monteil
IPC分类号： C07K708
CPC分类号： C07K14/33 , A61K38/00 , C07K2319/00 , Y02A50/469
摘要： The invention consists of peptides which inhibit the secretion of neurotransmitters from synaptic vesicles. The peptides of the invention are believed to mimic the activity of neurotoxins produced by Clostridium botulinum and tetani (including botulinum serotypes A, B, C, D, E, F and G). Structurally, the peptides are comprised of amino acid fragments from the substrate binding domains selected from three proteins which bind to form a receptor for docking of synaptic vesicles to the plasma membranes of neuronal cells; i.e., SNAP-25, VAMP-2 and syntaxin. Certain of the inventive peptides exhibit strong inhibitory activity; e.g., 50% or greater decline in neurotransmitter release is obtained at even nanomolar concentrations. The peptides are suited for use as substitutes for Clostridium neurotoxins in clinical applications and in compounds for targeted delivery of drugs into neural cells.
摘要翻译：本发明由抑制神经递质从突触小泡分泌的肽组成。据信本发明的肽模拟肉毒杆菌和破伤风（包括肉毒杆菌血清型A，B，C，D，E，F和G）产生的神经毒素的活性。结构上，肽由选自三种蛋白质的底物结合结构域的氨基酸片段组成，三种蛋白质结合形成突触小泡对接神经元细胞的质膜的受体; 即SNAP-25，VAMP-2和syntaxin。某些本发明的肽表现出强的抑制活性; 例如在甚至纳摩尔浓度下获得神经递质释放的50％或更大的下降。这些肽适合用作临床应用中的Clostridium神经毒素的替代物和用于将药物靶向递送至神经细胞的化合物。

IPRDB

热门服务

关于我们

友情链接

联系方式