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1. 发明授权

US08957064B2 Fused pyrimidines 有权
标题翻译：融合嘧啶
公开(公告)号：US08957064B2
公开(公告)日：2015-02-17
申请号：US13201277
申请日：2010-02-02
申请人： Matthias Vennemann , Thomas Bär , Thomas Maier , Swen Hölder , Gerrit Beneke , Florian Dehmel , Armin Zülch , Andreas Strub , Stuart Ince , Hartmut Rehwinkel , Ningshu Liu , Ulf Bömer , Barbara Beckers
发明人： Matthias Vennemann , Thomas Bär , Thomas Maier , Swen Hölder , Gerrit Beneke , Florian Dehmel , Armin Zülch , Andreas Strub , Thomas Beckers , Stuart Ince , Hartmut Rehwinkel , Ningshu Liu , Ulf Bömer
IPC分类号： A61K31/495 , A61K31/519 , A61K31/505 , C07D401/12 , C07D487/04 , A61K45/06 , C07D471/04
CPC分类号： A61K31/519 , A61K31/495 , A61K31/505 , A61K45/06 , C07D401/12 , C07D471/04 , C07D487/04
摘要： Compounds of formula (I) or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer, wherein ring B and the pyrimidine to which it is fused, R4, R5, R6, R7, m and n have the meanings as given in the description and the claims, which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals.
摘要翻译：式（I）化合物或所述化合物的N-氧化物，盐，互变异构体或立体异构体，或所述N-氧化物，互变异构体或立体异构体的盐，其中环B和与其稠合的嘧啶，R4 R5，R6，R7，m和n具有在描述和权利要求中给出的含义，它们是Pi3K / Akt途径的有效抑制剂，其生产方法及其作为药物的用途。

2. 发明授权

US07790710B2 Imidazopyridine derivatives useful as iNOS inhibitors 失效
标题翻译：可用作iNOS抑制剂的咪唑并吡啶衍生物
公开(公告)号：US07790710B2
公开(公告)日：2010-09-07
申请号：US11886785
申请日：2006-03-29
申请人： Thomas Fuchss , Andreas Strub , Wolf-Rüdiger Ulrich , Christian Hesslinger , Martin Lehner , Raimund Külzer , Rainer Boer , Manfrid Eltze
发明人： Thomas Fuchss , Andreas Strub , Wolf-Rüdiger Ulrich , Christian Hesslinger , Martin Lehner , Raimund Külzer , Rainer Boer , Manfrid Eltze
IPC分类号： A01N43/00 , A61K31/55 , A01N43/46 , A01N43/90 , A61K31/519 , C07D413/00 , C07D415/00 , C07D417/00 , C07D419/00 , C07D513/02 , C07D515/02 , C07D403/02
CPC分类号： C07D471/04
摘要： The compounds of formula (I) in which R1, R11 and A have the meanings as given in the description are novel effective iNOS inhibitors.
摘要翻译：其中R1，R11和A具有如本说明书中给出的含义的式（I）化合物是新的有效的iNOS抑制剂。

3. 发明申请

US20130317002A1 FUSED PYRIMIDINES 有权
标题翻译：熔融吡啶
公开(公告)号：US20130317002A1
公开(公告)日：2013-11-28
申请号：US13201277
申请日：2010-02-02
申请人： Barbara Beckers
发明人： Matthias Vennemann , Thomas Bär , Thomas Maier , Swen Hölder , Gerrit Beneke , Florian Dehmel , Armin Zülch , Andreas Strub , Thomas Beckers , Stuart Ince , Hartmut Rehwinkel , Ningshu Liu , Ulf Bömer
IPC分类号： A61K31/519 , A61K45/06 , C07D471/04 , C07D487/04
CPC分类号： A61K31/519 , A61K31/495 , A61K31/505 , A61K45/06 , C07D401/12 , C07D471/04 , C07D487/04
摘要： Compounds of formula (I) or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer, wherein ring B and the pyrimidine to which it is fused, R4, R5, R6, R7, m and n have the meanings as given in the description and the claims, which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals.
摘要翻译：式（I）化合物或所述化合物的N-氧化物，盐，互变异构体或立体异构体，或所述N-氧化物，互变异构体或立体异构体的盐，其中环B和与其稠合的嘧啶，R4 R5，R6，R7，m和n具有在描述和权利要求中给出的含义，它们是Pi3K / Akt途径的有效抑制剂，其生产方法及其作为药物的用途。

4. 发明申请

US20130310362A1 FUSED PYRIMIDINES 审中-公开
标题翻译：熔融吡啶
公开(公告)号：US20130310362A1
公开(公告)日：2013-11-21
申请号：US13201227
申请日：2010-02-05
申请人： Barbara Beckers
发明人： Matthias Vennemann , Thomas Bär , Thomas Maier , Swen Hölder , Gerrit Beneke , Florian Dehmel , Armin Zülch , Andreas Strub , Thomas Beckers , Stuart Ince , Hartmut Rehwinkel , Ningshu Liu , Ulf Bömer
IPC分类号： A61K31/519 , A61K45/06 , C07D487/04
CPC分类号： A61K31/519 , A61K45/06 , C07D487/04
摘要： The present invention relates to compounds of formula (I), a N-oxide or tautomer or stereoisomer thereof, or a salt thereof, wherein ring B and the imidazole to which it is fused, R4, R6, R7, R10, m and n have the meanings as given in the description and the claims, which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals.
摘要翻译：本发明涉及式（I）化合物，其N-氧化物或互变异构体或其立体异构体或其盐，其中环B和与其稠合的咪唑R4，R6，R7，R10，m和n 具有在描述和权利要求中给出的含义，其是Pi3K / Akt通路的有效抑制剂，其生产方法及其作为药物的用途。

5. 发明授权

US09291485B2 Sensor module measuring and/or monitoring parameters of media flowing in pipelines and measuring system formed therewith 有权
标题翻译：传感器模块测量和/或监测在管道中流动的介质和与其形成的测量系统的参数
公开(公告)号：US09291485B2
公开(公告)日：2016-03-22
申请号：US14237960
申请日：2012-07-17
申请人： Dominique Wiederkehr , Andreas Strub
发明人： Dominique Wiederkehr , Andreas Strub
IPC分类号： G01F1/32 , G01F5/00
CPC分类号： G01F1/3218 , G01F5/005
摘要： A sensor module serves for registering a flow velocity and/or a volume flow rate, of a fluid flowing in a pipeline. The sensor module comprises a platform (PS) having, extending therein from an inlet opening to a drain opening remote therefrom and communicating with the lumen of the pipeline, a flow path for guiding a fluid volume portion branched from the fluid flowing in the pipeline and a transducer element for producing at least one sensor signal influenced by the fluid guided in the flow path. The flow path is additionally so embodied that an imaginary central axis (LB) of the intermediate region is not parallel to an imaginary central axis of the intake region and/or not parallel to an imaginary central axis of the drain region.
摘要翻译：传感器模块用于记录在管道中流动的流体的流速和/或体积流量。所述传感器模块包括平台（PS），所述平台（PS）从入口开口延伸到远离其的排水开口并与所述管道的内腔连通，用于引导从在管道中流动的流体分支的流体体积部分的流动路径，换能器元件，用于产生受在流动路径中引导的流体影响的至少一个传感器信号。流动路径另外如此体现为中间区域的假想中心轴线（LB）不平行于进气区域的假想中心轴线和/或不平行于漏极区域的假想中心轴线。

6. 发明申请

US20140174197A1 SENSOR MODULE MEASURING AND/OR MONITORING PARAMETERS OF MEDIA FLOWING IN PIPELINES AND MEASURING SYSTEM FORMED THEREWITH 有权
标题翻译：传感器模块测量和/或监测管道中流动的介质参数和形成的测量系统
公开(公告)号：US20140174197A1
公开(公告)日：2014-06-26
申请号：US14237960
申请日：2012-07-17
申请人： Dominique Wiederkehr , Andreas Strub
发明人： Dominique Wiederkehr , Andreas Strub
IPC分类号： G01F1/32
CPC分类号： G01F1/3218 , G01F5/005
摘要： A sensor module serves for registering a flow velocity and/or a volume flow rate, of a fluid flowing in a pipeline. The sensor module comprises a platform (PS) having, extending therein from an inlet opening to a drain opening remote therefrom and communicating with the lumen of the pipeline, a flow path for guiding a fluid volume portion branched from the fluid flowing in the pipeline and a transducer element for producing at least one sensor signal influenced by the fluid guided in the flow path. The flow path is additionally so embodied that an imaginary central axis (LB) of the intermediate region is not parallel to an imaginary central axis of the intake region and/or not parallel to an imaginary central axis of the drain region.
摘要翻译：传感器模块用于记录在管道中流动的流体的流速和/或体积流量。所述传感器模块包括平台（PS），所述平台（PS）从入口开口延伸到远离其的排水开口并与所述管道的内腔连通，用于引导从在管道中流动的流体分支的流体体积部分的流动路径，换能器元件，用于产生受在流动路径中引导的流体影响的至少一个传感器信号。流动路径另外如此体现为中间区域的假想中心轴线（LB）不平行于进气区域的假想中心轴线和/或不平行于漏极区域的假想中心轴线。

7. 发明申请

US20090131399A1 Imidazopyridine Derivatives Useful as iNOS Inhibitors 失效
标题翻译：可用作iNOS抑制剂的咪唑并吡啶衍生物
公开(公告)号：US20090131399A1
公开(公告)日：2009-05-21
申请号：US11886785
申请日：2006-03-29
申请人： Thomas Fuchss , Andreas Strub , Wolf-Rudiger Ulrich , Christian Hesslinger , Martin Lehner , Raimund Kulzer , Rainer Boer , Manfrid Eltze
发明人： Thomas Fuchss , Andreas Strub , Wolf-Rudiger Ulrich , Christian Hesslinger , Martin Lehner , Raimund Kulzer , Rainer Boer , Manfrid Eltze
IPC分类号： A61K31/397 , C07D223/02 , A61P29/00 , A61K31/55
CPC分类号： C07D471/04
摘要： The compounds of formula (I) in which R1, R11 and A have the meanings as given in the description are novel effective iNOS inhibitors.
摘要翻译：其中R1，R11和A具有如本说明书中给出的含义的式（I）化合物是新的有效的iNOS抑制剂。

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