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    • 5. 发明申请
    • PROCESS FOR THE PREPARATION OF ASYMMETRICALLY SUBSTITUTED BIARYLDIPHOSPHINES
    • 制备不对称取代的二异氰尿嘧啶的方法
    • US20090105505A1
    • 2009-04-23
    • US11630109
    • 2005-06-06
    • Hanspeter MettlerFrederic LerouxManfred Schlosser
    • Hanspeter MettlerFrederic LerouxManfred Schlosser
    • C07F9/50
    • C07F9/5027C07F9/5068
    • A process for the preparation of asymmetrically substituted biaryldiphosphine ligands of the formula: wherein R1 is C1-6-alkyl or C3-10-cycloalkyl optionally being substituted with one or more halogen atoms, and R2 and R3 are equal and are C5-10-cycloalkyl and C1-6-alkyl, or R2 is C5-10-cycloalkyl or C1-6-alkyl, and R3 is aryl optionally substituted with one or more substituents selected from the group consisting of halogen atoms, nitro, amino, C1-6-alkyl, C1-6-akoxy and di-C1-6-alkylamino groups,2 and each C1-6-alkyl, C1-6-alkoxy, di-C1-6-alkylamino and C5-10-cycloalkyl group in R2 and R3 is optionally substituted with one or more halogen atoms, from 2,2′,6,6′-tetrabromobiphenyl by a sequence of bromine-metal exchanges and subsequent reactions.
    • 一种用于制备下式的不对称取代的联芳基二膦配体的方法:其中R 1是任选被一个或多个卤素原子取代的C 1-6 - 烷基或C 3-10 - 环烷基,R 2和R 3相同,为C 5-10 - 环烷基和C 1-6 - 烷基,或者R 2是C 5-10 - 环烷基或C 1-6 - 烷基,并且R 3是任选地被一个或多个选自以下的取代基取代的芳基:卤素原子,硝基,氨基,C 1-6 - 烷基,C 1-6 - 烷氧基和二-C 1-6 - 烷基氨基,R2和C 1-6 - 烷基,C 1-6 - 烷氧基,二-C 1-6 - 烷基氨基和C 5-10 - 环烷基, R 3任选地被一个或多个卤素原子,2,2',6,6'-四溴联苯取代,通过溴 - 金属交换和后续反应的顺序。