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1. 发明申请

US20060078537A1 Mono-and dual chemokine/cytokine constructs 审中-公开
标题翻译：单 - 和双趋化因子/细胞因子构建体
公开(公告)号：US20060078537A1
公开(公告)日：2006-04-13
申请号：US10499151
申请日：2002-12-20
申请人： Matthias Mack , Detlef Schloendorff
发明人： Matthias Mack , Detlef Schloendorff
IPC分类号： A61K38/19 , A61K48/00 , C07H21/04 , C12P21/02 , C07K14/52
CPC分类号： C07K16/2866 , A61K2039/505 , C07K14/523 , C07K16/2812 , C07K2317/34 , C07K2317/622 , C07K2317/77 , C07K2319/00
摘要： The present invention relates to a chemokine construct comprising a scFV anti-CD4 and a RANTES chemokine or a functional fragment thereof, whereby said chemokine construct has the structural domain form of (a) RANTES-linker-(VH) anti-CD4-linker-(VL) anti-CD4; or (b) (VL) anti-CD4-linker-(VH) anti-CD4-linker-RANTES, or (c) (VH) anti-CD4-linker-(VL) anti-CD4-linker-RANTES, whereby in the alternatives (b) and (c), the linker between (VH) anti-CD4 and RANTES or between (VL) anti-CD4 and RANTES does not terminally comprise a methionine, a lysine or an isoleucine directly adjacent to the first amino add of RANTES. Furthermore, polynucleotides encoding these chemokine constructs as well as vectors comprising these polynucleotides are disclosed. The invention also relates to specific uses of these constructs and to pharmaceutical compositions.
摘要翻译：本发明涉及包含scFV抗CD4和RANTES趋化因子或其功能片段的趋化因子构建体，其中所述趋化因子构建体具有结构域形式（a）RANTES-接头 - （VH）抗CD4-连接子 - （VL）抗CD4; 或（b）（VL）抗CD4-接头 - （VH）抗CD4连接体RANTES或（c）（VH）抗CD4-连接体 - （VL）抗CD4-连接体RANTES，其中替代方案（b）和（c）中，（VH）抗CD4和RANTES之间或（VL）抗CD4和RANTES之间的连接体不终止包含与第一个氨基酸直接相邻的甲硫氨酸，赖氨酸或异亮氨酸的RANTES。此外，公开了编码这些趋化因子构建体的多核苷酸以及包含这些多核苷酸的载体。本发明还涉及这些构建体和药物组合物的具体用途。

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