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1. 发明申请

US20080171747A1 Intermediate Compounds for making Dihydropteridinones Useful as Pharmaceutical Compositions 有权
标题翻译：用作制备二氢蝶呤的中间体化合物可用作药物组合物
公开(公告)号：US20080171747A1
公开(公告)日：2008-07-17
申请号：US11941463
申请日：2007-11-16
申请人： Matthias Hoffman , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Juergen Quant , Flavio Solca , Florian Colbatzky
发明人： Matthias Hoffman , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Juergen Quant , Flavio Solca , Florian Colbatzky
IPC分类号： A61K31/525 , C07D475/02
CPC分类号： C07D295/073 , C07D475/00
摘要： Disclosed are new dihydropteridinones of general formula (I) wherein the groups L and R1-R5 have the meanings given in the claims and specification, the isomers thereof, intermediates and processes for preparing these dihydropteridinones and the use thereof as pharmaceutical compositions.
摘要翻译：公开了通式（I）的新的二氢蝶啶酮，其中基团L和R 1 -R 5具有权利要求和说明书中给出的含义，其异构体，中间体和制备这些二氢蝶啶酮的方法及其作为药物组合物的用途。

2. 发明授权

US06861422B2 Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions 有权
标题翻译：二氢蝶啶酮，其制备方法及其作为药物组合物的用途
公开(公告)号：US06861422B2
公开(公告)日：2005-03-01
申请号：US10374876
申请日：2003-02-26
申请人： Matthias Hoffmann , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Juergen Quant , Flavio Solca , Florian Colbatzky
发明人： Matthias Hoffmann , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Juergen Quant , Flavio Solca , Florian Colbatzky
IPC分类号： A61P35/00 , C07D475/00 , C07D519/00 , C07D487/04 , A61K31/4985
CPC分类号： C07D295/073 , C07D475/00
摘要： The present invention relates to new dihydropteridinones of general formula (I): wherein the groups L and R1-R5 have the meanings given in the claims and specification, the isomers thereof, processes for preparing these dihydropteridinones and the use thereof as pharmaceutical compositions.
摘要翻译：本发明涉及通式（I）的新的二氢蝶啶酮：其中基团L和R 1 -R 5具有权利要求书和说明书中给出的含义，其异构体，制备这些二氢蝶啶的方法和用途作为药物组合物。

3. 发明申请

US20080293944A1 Piperazinyl Compounds 有权
标题翻译：哌嗪基化合物
公开(公告)号：US20080293944A1
公开(公告)日：2008-11-27
申请号：US12129728
申请日：2008-05-30
申请人： Matthias Hoffmann , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Juergen Quant , Flavio Solca , Florian Colbatzky
发明人： Matthias Hoffmann , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Juergen Quant , Flavio Solca , Florian Colbatzky
IPC分类号： C07D241/04
CPC分类号： C07D295/073 , C07D475/00
摘要： Disclosed are new dihydropteridinones of general formula (I) wherein the groups L and R1-R5 have the meanings given in the claims and specification, the isomers thereof, intermediates and processes for preparing these dihydropteridinones and the use thereof as pharmaceutical compositions.
摘要翻译：公开了通式（I）的新的二氢蝶啶酮，其中基团L和R 1 -R 5具有权利要求书和说明书中给出的含义，其异构体，制备这些二氢蝶啶烷的中间体和方法及其作为药物组合物的用途。

4. 发明授权

US07750152B2 Intermediate compounds for making dihydropteridinones useful as pharmaceutical compositions and processes of making the same 有权
标题翻译：用作制备二氢蝶啶酮的中间体化合物可用作药物组合物及其制备方法
公开(公告)号：US07750152B2
公开(公告)日：2010-07-06
申请号：US11941463
申请日：2007-11-16
申请人： Matthias Hoffman , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Jurgen Quant , Flavio Solca , Florian Colbatzky
发明人： Matthias Hoffman , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Jurgen Quant , Flavio Solca , Florian Colbatzky
IPC分类号： C07D475/00
CPC分类号： C07D295/073 , C07D475/00
摘要： Disclosed are dihydropteridinones of general formula (I) wherein the groups L and R1-R5 have the meanings given in the claims and specification, the pharmaceutical compositions, isomers, intermediates thereof and processes for preparing these dihydropteridinones. The compounds are useful the treatment and/or prevention of cancer, infections, inflammatory and autoimmune diseases.
摘要翻译：公开了通式（I）的二氢蝶啶酮，其中基团L和R 1 -R 5具有权利要求书和说明书中给出的含义，药物组合物，异构体，中间体和制备这些二氢蝶啶酮的方法。该化合物可用于治疗和/或预防癌症，感染，炎症和自身免疫性疾病。

5. 发明申请

US20050014761A1 Intermediate compounds for making dihydropteridinones useful as pharmaceutical compositions 审中-公开
标题翻译：用作制备二氢蝶啶酮的中间体化合物，可用作药物组合物
公开(公告)号：US20050014761A1
公开(公告)日：2005-01-20
申请号：US10909008
申请日：2004-07-30
申请人： Matthias Hoffmann , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Quant , Flavio Solca , Florian Colbatzky
发明人： Matthias Hoffmann , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Quant , Flavio Solca , Florian Colbatzky
IPC分类号： A61P35/00 , C07D475/00 , C07D519/00 , A61K31/525 , C07D475/02
CPC分类号： C07D295/073 , C07D475/00
摘要： Disclosed are new dihydropteridinones of general formula (I) wherein the groups L and R1-R5 have the meanings given in the claims and specification, the isomers thereof, intermediates and processes for preparing these dihydropteridinones and the use thereof as pharmaceutical compositions.
摘要翻译：公开了通式（I）的新的二氢蝶啶酮，其中基团L和R 1 -R 5具有权利要求书和说明书中给出的含义，其异构体，制备这些二氢蝶呤的中间体和方法及其用途药物组合物。

6. 发明申请

US20050014760A1 Methods of treating diseases or conditions using dihydropteridinone compounds 审中-公开
标题翻译：使用二氢蝶啶酮化合物治疗疾病或病症的方法
公开(公告)号：US20050014760A1
公开(公告)日：2005-01-20
申请号：US10903807
申请日：2004-07-30
申请人： Matthias Hoffmann , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Quant , Flavio Solca , Florian Colbatzky
发明人： Matthias Hoffmann , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Quant , Flavio Solca , Florian Colbatzky
IPC分类号： A61P35/00 , C07D475/00 , C07D519/00 , A61K31/525
CPC分类号： C07D295/073 , C07D475/00
摘要： Disclosed are new dihydropteridinones of general formula (I) wherein the groups L and R1-R5 have the meanings given in the claims and specification, the isomers thereof, intermediates and processes for preparing these dihydropteridinones and the use thereof as pharmaceutical compositions.
摘要翻译：公开了通式（I）的新的二氢蝶啶酮，其中基团L和R 1 -R 5具有权利要求书和说明书中给出的含义，其异构体，制备这些二氢蝶呤的中间体和方法及其用途药物组合物。

7. 发明授权

US07332491B2 Dihydropteridione derivatives, process for their manufacture and their use as medicament 有权
标题翻译：二氢丙啶衍生物，其制备方法及其作为药物的用途
公开(公告)号：US07332491B2
公开(公告)日：2008-02-19
申请号：US11210951
申请日：2005-08-24
申请人： Matthias Grauert , Matthias Hoffmann , Martin Steegmaier , Christian Eickmeier , Gisela Schnapp , Norbert Redemann , Flavio Solca , Jens Juergen Quant
发明人： Matthias Grauert , Matthias Hoffmann , Martin Steegmaier , Christian Eickmeier , Gisela Schnapp , Norbert Redemann , Flavio Solca , Jens Juergen Quant
IPC分类号： A61K31/541 , A61K31/5025 , A61K31/4985 , C07D273/01 , C07D471/04 , C07D487/04 , C07D491/04 , C07D475/12 , A61P19/02
CPC分类号： C07D487/04 , C07D475/00 , Y02P20/55
摘要： Disclosed are new dihydropteridinones of general formula (I) whereby the groups L, R1, R2, R3, R4 and R5 have the meanings given in the claims and specification, the isomers thereof, processes for preparing these dihydropteridinones and their use as pharmaceutical compositions.
摘要翻译：公开了通式（I）的新的二氢蝶啶酮，其中基团L，R 1，R 2，R 3，R 4，＆lt; 5＆gt;和＆lt; 5＆gt;具有权利要求书和说明书中给出的含义，其异构体，制备这些二氢蝶啶的方法及其作为药物组合物的用途。

8. 发明申请

US20060052383A1 New dihydropteridione derivatives, process for their manufacture and their use as medicament 有权
标题翻译：新的二氢二萜衍生物，其制备方法及其作为药物的用途
公开(公告)号：US20060052383A1
公开(公告)日：2006-03-09
申请号：US11210951
申请日：2005-08-24
申请人： Matthias Grauert , Matthias Hoffmann , Martin Steegmaier , Christian Eickmeier , Gisela Schnapp , Norbert Redemann , Flavio Solca , Jens Quant
发明人： Matthias Grauert , Matthias Hoffmann , Martin Steegmaier , Christian Eickmeier , Gisela Schnapp , Norbert Redemann , Flavio Solca , Jens Quant
IPC分类号： A61K31/525 , C07D475/02
CPC分类号： C07D487/04 , C07D475/00 , Y02P20/55
摘要： Disclosed are new dihydropteridinones of general formula (I) whereby the groups L, R1, R2, R3, R4 and R5 have the meanings given in the claims and specification, the isomers thereof, processes for preparing these dihydropteridinones and their use as pharmaceutical compositions.
摘要翻译：公开了通式（I）的新的二氢蝶啶酮，

9. 发明授权

US06806272B2 Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions 有权
标题翻译：二氢蝶啶酮，其制备方法及其作为药物组合物的用途
公开(公告)号：US06806272B2
公开(公告)日：2004-10-19
申请号：US10226710
申请日：2002-08-23
申请人： Eckhart Bauer , Steffen Breitfelder , Christian Eickmeier , Matthias Grauert , Matthias Hoffmann , Thorsten Lehmann-Lintz , Gerald Pohl , Jens Quant , Norbert Redemann , Gisela Schnapp , Martin Steegmaier
发明人： Eckhart Bauer , Steffen Breitfelder , Christian Eickmeier , Matthias Grauert , Matthias Hoffmann , Thorsten Lehmann-Lintz , Gerald Pohl , Jens Quant , Norbert Redemann , Gisela Schnapp , Martin Steegmaier
IPC分类号： C07D48704
CPC分类号： C07D487/04 , C07D475/00
摘要： The present invention relates to new dihydropteridinones of the formula (I) wherein the groups X, R1, R2, R3, R4, R5 and R7 have the meanings given in the claims and the specification, the isomers thereof, processes and intermediates for preparing these dihydropteridinones as well as the use thereof as pharmaceutical compositions.
摘要翻译：本发明涉及式（I）的新的二氢蝶啶酮，其中基团X，R 1，R 2，R 3，R 4，R 5和R 7具有如下含义：权利要求书和说明书中给出的其异构体，用于制备这些二氢蝶啶烷酮的方法和中间体以及其作为药物组合物的用途。

10. 发明授权

US06696462B2 Anticholinergics, processes for the preparation thereof, and pharmaceutical compositions 有权
标题翻译：抗胆碱能药，其制备方法和药物组合物
公开(公告)号：US06696462B2
公开(公告)日：2004-02-24
申请号：US10345911
申请日：2003-01-16
申请人： Christian Eickmeier , Sabine Germeyer , Matthias Grauert , Sabine Pestel , Michael P. Pieper , Georg Speck , Steffen Breitfelder
发明人： Christian Eickmeier , Sabine Germeyer , Matthias Grauert , Sabine Pestel , Michael P. Pieper , Georg Speck , Steffen Breitfelder
IPC分类号： A61K31439
CPC分类号： C07D451/06 , C07D451/10
摘要： A compound of formula 1 wherein: X- is an anion with a single negative charge; A and B, which are identical or different, are each —O—, —S—, —NH—, —CH2—, —CH═CH—, or —N(C1-C4-alkyl)—; R is hydrogen, hydroxy, —C1-C4-alkyl, —C1-C4-alkyloxy, —C1-C4-alkylene-halogen, —0—C1-C4-alkylene-halogen, —C1-C4-alkylene-OH, —CF3, —CHF2, —C1-C4-alkylene-C1-C4-alkyloxy, —0—COC1-C4-alkyl, —0—COC1-C4-alkylene-halogen, —C1-C4-alkylene-C3-C6-cycloalkyl, —0—COCF3, or halogen; R1 and R2, which are identical or different, are each —C1-C5-alkyl, which is optionally substituted by —C3-C6-cycloalkyl, hydroxy, or halogen, or R1 and R2 together are a —C3-C5-alkylene bridge; R3, R4, R3′, and R4′, which are identical or different, are each hydrogen, C1-C4-alkyl, C1-C4-alkyloxy, hydroxy, —CF3, —CHF2, —CN, —NO2, or halogen; RX and RX′, which are identical or different, are each hydrogen, C1-C4-alkyl, C1-C4-alkyloxy, hydroxy, —CF3, —CHF2, —CN, —NO2, or halogen, or RX and RX′ together are a single bond or a bridging group selected from —O—, —S—, —NH—, —CH2—, —CH2—CH2—, —N(C1-C4-alkyl)—, —CH(C1-C4-alkyl)—, and —C(C1-C4-alkyl)2—, or a pharmacologically acceptable acid addition salt thereof, processes for preparing, them and their use in pharmaceutical compositions.
摘要翻译：式1的化合物，其中X 1是具有单个负电荷的阴离子; A和B相同或不同，各自为-O - ， - S - ， - NH-， - CH 2 - ， - CH = CH-或-N（C 1 -C 4 - 烷基） - ; R是氢，羟基，-C 1 -C 4 - 烷基，-C 1 -C 4 - 烷氧基，-C 1 -C 4 - 亚烷基 - 卤素，-O-C 1 -C 4 - 亚烷基 - 卤素，-C 1 -C 4 - 亚烷基-OH，-CF 3，-CHF 2，-C 1 -C 4 - 亚烷基-C 1 -C 4 - 烷氧基，-O-CCl-C 4 - 烷基，-O-CCl- - 卤素，-C 1 -C 4 - 亚烷基-C 3 -C 6 - 环烷基，-O-COCF 3或卤素; R 1和R 2各自为-C 1 -C 5 - 烷基，任选被-C 3 -C 6 - 环烷基，羟基或卤素取代，或R 1和R 2一起是-C 3 -C 5亚烷基桥; R 3，R 4，R 3' R 1，R 2，R 3，R 4，R 4，R 4，R 4，R 4， X，R 1，R 2，R 2，R 2，R 2，R 3，R 3，R 3，R 3，R 3， X>和R X'一起是单键或选自-O - ， - S - ， - NH - ， - CH 2 - ， - CH 2 -CH 2 - ， - N（C 1 -C 4 - 烷基） - ， - CH（C 1 -C 4烷基）和-C（C 1 -C 4 - 烷基）2-或其药理学上可接受的酸加成盐，用于制备它们及其在药物组合物中的用途。

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