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1. 发明申请

US20090204318A1 METHOD FOR CHECKING THE PLAUSIBILITY OF AN ASCERTAINED VEHICLE MASS 审中-公开
标题翻译：检查汽车质量可靠性的方法
公开(公告)号：US20090204318A1
公开(公告)日：2009-08-13
申请号：US12158353
申请日：2006-11-15
申请人： Matthew Nimmo , Laszlo Boros , Michael Wommer
发明人： Matthew Nimmo , Laszlo Boros , Michael Wommer
IPC分类号： G01G19/08
CPC分类号： G01G19/086 , B60G17/0162 , B60G2400/61 , B60G2800/012 , B60G2800/24 , B60G2800/915 , G01M1/122
摘要： In a method for detecting the loading state of a motor vehicle, first wheel loads of all wheels are ascertained in the absence of cornering, second wheel loads of at least the rear wheel which is on the inside of the curve and of the front wheel which is on the inside of the curve are ascertained when cornering, and information relating to the loading state of the motor vehicle is ascertained on the basis of the first and second wheel loads of the wheels which are on the inside of the curve.
摘要翻译：在用于检测机动车辆的装载状态的方法中，在没有转弯的情况下确定所有车轮的第一车轮负载，至少在曲线内侧的后轮和前轮的第二轮负载在转弯时确定曲线内侧，并且基于在曲线内侧的车轮的第一和第二轮负载来确定与机动车辆的装载状态有关的信息。

2. 发明申请

US20060228301A1 Methods and compositions for determining targeted drug sensitivity and resistance in a cancer subject 审中-公开
标题翻译：用于确定癌症受试者中靶向药物敏感性和抗性的方法和组合物
公开(公告)号：US20060228301A1
公开(公告)日：2006-10-12
申请号：US11100069
申请日：2005-04-06
申请人： Laszlo Boros
发明人： Laszlo Boros
IPC分类号： A61K49/00 , A61K31/70
CPC分类号： G01N33/574 , G01N33/5011 , G01N2800/52
摘要： Diagnostic and therapeutic methods of cancer treatment and prevention using metabolic profiling compounds that contain [1,2-13C2]-D-glucose, and kits for using such metabolic profiling compounds.
摘要翻译：使用含有[1,2--12β-D-葡萄糖]的代谢构象化合物进行癌症治疗和预防的诊断和治疗方法，以及使用这种代谢分析的试剂盒化合物。

3. 发明申请

US20050281745A1 Stable isotope based dynamic metabolic profiling of living organisms for characterization of metabolic diseases, drug testing and drug development 审中-公开
标题翻译：用于表征代谢疾病，药物测试和药物开发的生物体的稳定同位素的动态代谢分析
公开(公告)号：US20050281745A1
公开(公告)日：2005-12-22
申请号：US11184546
申请日：2005-07-18
申请人： Wai-Nang Lee , Laszlo Boros
发明人： Wai-Nang Lee , Laszlo Boros
IPC分类号： A61K49/00 , C12N13/00 , G01N33/60
CPC分类号： G01N33/58 , A61K49/10 , A61K51/0491 , G01N2500/00
摘要： The metabolic processes involved in the formation of any glucose-based metabolite of a metabolic network are determined. A precursor molecule is labeled with a stable carbon (13C) isotope at specific positions. The label is allowed to distribute and rearrange in the system. Metabolites are recovered and analyzed against a control system to determine a set of metabolic pathway substrate fluxes caused by changes to the test system relative to the control system such as the addition of compound being tested as a potential drug.
摘要翻译：确定代谢网络中形成任何基于葡萄糖的代谢物的代谢过程。前体分子在特定位置用稳定的碳（“13 C”）同位素标记。允许标签在系统中分发和重新排列。根据对照系统回收和分析代谢物以确定由测试系统相对于对照系统的变化引起的一组代谢途径底物通量，例如加入待测试的化合物作为潜在药物。

4. 发明申请

US20060100903A1 Method of enhancing the efficiency of a pharmaceutical business 审中-公开
标题翻译：提高制药业务效率的方法
公开(公告)号：US20060100903A1
公开(公告)日：2006-05-11
申请号：US11106031
申请日：2005-04-13
申请人： Wai-Nang Lee , Laszlo Boros
发明人： Wai-Nang Lee , Laszlo Boros
IPC分类号： A61K49/00 , G06Q10/00 , G06Q50/00
CPC分类号： A61K51/0491 , G06Q50/22
摘要： A method of doing business is disclosed whereby the process for selecting drug candidates is improved. The method involves the application of a technology which makes it possible to determine metabolic processes involved in the formation of any glucose-based metabolite. A precursor molecule is labeled with a stable carbon (13C) isotope at specific positions. The label is allowed to distribute and rearrange in the system. Metabolites are recovered and analyzed against a control system or known biochemical reactions and/or cycles to determine information such as metabolic pathway substrate flux caused by a compound acting on the system.
摘要翻译：公开了一种做生意的方法，从而提高了候选药物的选择过程。该方法涉及应用可以确定涉及形成任何基于葡萄糖的代谢物的代谢过程的技术。前体分子在特定位置用稳定的碳（“13 C”）同位素标记。允许标签在系统中分发和重新排列。根据对照系统或已知的生物化学反应和/或循环来回收和分析代谢物，以确定由作用在系统上的化合物引起的代谢途径底物通量的信息。

5. 发明授权

US4608340A Immobilized aminoacylase enzyme 失效
标题翻译：固定化氨酰基酶
公开(公告)号：US4608340A
公开(公告)日：1986-08-26
申请号：US675265
申请日：1984-11-27
申请人： Bela Szajani , Janosne Kiss , Jozsefne Ivony , Iren Huber , Laszlo Boros , Ivan Daroczi
发明人： Bela Szajani , Janosne Kiss , Jozsefne Ivony , Iren Huber , Laszlo Boros , Ivan Daroczi
IPC分类号： C12N9/78 , C12N9/80 , C12N11/08 , C12P13/12 , C12P41/00 , C12N11/06
CPC分类号： C12N11/08 , C12N9/78 , C12N9/80 , C12P13/12 , C12P41/007
摘要： Immobilized aminoacylase having high specific activity is obtained by covalent bonding of aminoacylase to a partially hydrolyzed Akrilex P type acrylamide-N,N.sup.1 -methylene-bis (acrylamide) copolymer. Covalent bonding is carried out by partially hydrolyzing the copolymer with a base or an acid to form carboxy groups, activating the carboxy groups with a carbodiimide and coupling aminoacylase to the activated carboxy groups. The aminoacylase may be isolated from mammal kidneys by forming an aqueous kidney extract, heat treating the extract and isolating aminoacylase from the heat treated extract.
摘要翻译：通过氨基酰化酶与部分水解的Akrilex P型丙烯酰胺-N，N 1 - 亚甲基 - 双（丙烯酰胺）共聚物的共价键合获得具有高比活性的固定氨基酰化酶。通过用碱或酸部分水解共聚物以形成羧基，用碳二亚胺和偶联氨基酰化酶与活化的羧基偶联羧基来进行共价键。通过形成水性肾提取物，热处理提取物和从热处理的提取物中分离氨基酰化酶，可以从哺乳动物的肾脏中分离出氨基酰化酶。

6. 发明授权

US4532214A Method for isolation of aminoacylase 失效
标题翻译：分离氨基酰化酶的方法
公开(公告)号：US4532214A
公开(公告)日：1985-07-30
申请号：US384766
申请日：1982-06-03
申请人： Bela Szajani , Janosne Kiss , Jozsefne Ivony , Iren Huber , Laszlo Boros , Ivan Daroczi
发明人： Bela Szajani , Janosne Kiss , Jozsefne Ivony , Iren Huber , Laszlo Boros , Ivan Daroczi
IPC分类号： C12N9/80 , C12N11/08 , C12P13/12 , C12P41/00
CPC分类号： C12P41/007 , C12N11/08 , C12N9/80 , C12P13/12 , Y10S435/814 , Y10S435/815 , Y10S435/816
摘要： Aminoacylase is isolated from mammal kidneys by comminuting and homogenizing mammal kidney in water, centrifuging to form an aqueous extract, heating the aqueous extract at 60.degree. to 80.degree. C. for 5 to 15 minutes, centrifuging, adding a salt such as ammonium sulfate to the resultant supernatant, centrifuging to separate solids, dissolving the solids in water, dialyzing and recovering active aminoacylase from the dialyzed solution. The process produces aminoacylase with high specific activity and the process requires fewer purification steps. The aminoacylase obtained may be utilized directly without any subsequent purification to produce immonobilized aminoacylase. Immobilization can be carried out by covalent bonding of the aminoacylase to a partially hydrolyzed Akrilex P type acryl amide-N,N'-methylene-bis(arylamide) copolymer. The recovered aminoacylase can be subjected to two chromatographic purification steps to produce a very pure aminoacylase.
摘要翻译：通过在哺乳动物肾脏中粉碎和匀浆哺乳动物肾脏，离心分离出氨基酰化酶，离心分离形成水提取物，将其在60-80℃加热5〜15分钟，离心分离，加入硫酸铵等盐生成的上清液，离心分离固体，将固体溶解在水中，透析并从透析溶液中回收活性氨基酰化酶。该方法产生具有高比活性的氨基酰化酶，该方法需要较少的纯化步骤。所获得的氨基酰化酶可以直接使用而无需任何后续的纯化以产生单克隆的氨基酰化酶。可以通过氨基酰化酶与部分水解的Akrilex P型丙烯酰胺-N，N'-亚甲基 - 双（芳基酰胺）共聚物共价键来进行固定。回收的氨基酰化酶可以进行两个色谱纯化步骤以产生非常纯的氨基酰化酶。

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