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1. 发明授权

US07437193B2 Microstimulator employing improved recharging reporting and telemetry techniques 有权
标题翻译：微型激光器采用改进的充电报告和遥测技术
公开(公告)号：US07437193B2
公开(公告)日：2008-10-14
申请号：US10607963
申请日：2003-06-27
申请人： Jordi Parramon , Goran N. Marnfeldt , Kelly H. McClure , Matthew I. Haller
发明人： Jordi Parramon , Goran N. Marnfeldt , Kelly H. McClure , Matthew I. Haller
IPC分类号： A61N1/08
CPC分类号： A61N1/37276 , A61N1/36007 , A61N1/3605 , A61N1/37205 , A61N1/37217 , A61N1/37223 , A61N1/37229 , A61N1/37235 , A61N1/3727 , A61N1/375 , A61N1/3787 , H01L2224/45144 , H01L2224/45147 , H01L2224/48465 , H01L2224/49175 , H01L2924/00011 , H01L2924/1461 , H01L2924/19105 , H01L2924/19107 , H01L2924/3011 , H01L2924/30111 , H02J7/025 , H02J7/345 , H04B5/0037 , H04B5/0081 , H04L27/02 , H04L27/10 , Y10T29/4902 , Y10T29/49071 , Y10T29/49073 , Y10T29/49128 , Y10T29/4913 , Y10T29/49155 , Y10T29/49169 , Y10T29/49826 , Y10T29/49945 , Y10T29/49968 , Y10T428/12264 , Y10T428/12271 , Y10T428/12347 , Y10T428/12375 , Y10T428/12396 , Y10T428/12535 , Y10T428/12806 , H01L2924/00 , H01L2924/01005 , H01L2924/01033
摘要： An implantable microstimulator configured to be implanted beneath a patient's skin for tissue stimulation to prevent and/or treat various disorders, e.g., neurological disorders, uses a self-contained power source such as a primary battery, a rechargeable battery, or other energy sources. For the rechargeable battery, and other energy sources that may require a periodic or occasional replenishment, such recharging or replenishment is accomplished, for example, by inductive coupling with an external device. A suitable bidirectional telemetry link allows the microstimulator system to inform the patient or clinician regarding the status of the system, including the charge level of the power source, and stimulation parameter states. Processing circuitry within the microstimulator automatically controls the applied stimulation pulses to match a set of programmed stimulation parameters established for a particular patient. The microstimulator preferably has a cylindrical hermetically sealed case having a length no greater than about 27 mm and a diameter no greater than about 3.3 mm. A reference electrode is located on one end of the case and an active electrode is located on the other end of the case. Further, the case is externally coated on selected areas with conductive and non-conductive materials.
摘要翻译：被配置为植入在患者皮肤下面用于组织刺激以防止和/或治疗各种疾病（例如神经障碍）的可植入微刺激器使用诸如一次电池，可再充电电池或其他能量源的独立电源。对于可充电电池和可能需要定期或偶尔的补充的其他能量源，例如通过与外部设备的电感耦合来实现这种再充电或补充。合适的双向遥测链路允许微刺激器系统通知患者或临床医生关于系统的状态，包括电源的充电水平和刺激参数状态。微刺激器内的处理电路自动控制所施加的刺激脉冲，以匹配为特定患者建立的一组编程刺激参数。微型激励器优选具有圆柱形气密密封的外壳，其长度不大于约27mm，直径不大于约3.3mm。参考电极位于壳体的一端，有源电极位于壳体的另一端。此外，外壳在导电和非导电材料的外围涂覆在选定的区域上。

2. 发明授权

US07379775B2 Voltage converter for implantable microstimulator using RF-powering coil 有权
标题翻译：使用RF供电线圈的可植入微型激励器的电压转换器
公开(公告)号：US07379775B2
公开(公告)日：2008-05-27
申请号：US11047052
申请日：2005-01-31
申请人： Jordi Parramon , Matthew I. Haller
发明人： Jordi Parramon , Matthew I. Haller
IPC分类号： A61N1/378
CPC分类号： A61N1/08 , A61N1/37205 , A61N1/3787
摘要： A combination, voltage converter circuit for use within an implantable device, such as a microstimulator, uses a coil, instead of capacitors, to provide a voltage step up and step down conversion functions. The output voltage is controlled, or adjusted, through duty-cycle modulation. In accordance with one aspect of the invention, applicable to implantable devices having an existing RF coil through which primary or charging power is provided, the existing RF coil is used in a time-multiplexing scheme to provide both the receipt of the RF signal and the voltage conversion function. This minimizes the number of components needed within the device, and thus allows the device to be packaged in a smaller housing or frees up additional space within an existing housing for other circuit components. In accordance with another aspect of the invention, the voltage up/down converter circuit is controlled by a pulse width modulation (PWM) low power control circuit. Such operation allows high efficiencies over a wide range of output voltages and current loads.
摘要翻译：在可植入装置（例如微型激励器）内使用的组合电压转换器电路使用线圈代替电容器来提供升压和降压转换功能。通过占空比调制来控制或调节输出电压。根据本发明的一个方面，可应用于具有通过其提供初级或充电功率的现有RF线圈的可植入装置，现有的RF线圈用于时间复用方案以提供RF信号的接收和电压转换功能。这使得器件中所需的部件的数量最小化，并因此允许将器件封装在较小的外壳中，或释放现有外壳内用于其他电路元件的额外空间。根据本发明的另一方面，电压上/下变频器电路由脉宽调制（PWM）低功率控制电路控制。这种操作允许在宽范围的输出电压和电流负载下实现高效率。

3. 发明授权

US08175717B2 Ultracapacitor powered implantable pulse generator with dedicated power supply 有权
标题翻译：具有专用电源的超级电容器动力植入脉冲发生器
公开(公告)号：US08175717B2
公开(公告)日：2012-05-08
申请号：US11221095
申请日：2005-09-06
申请人： Matthew I. Haller , Jordi Parramon , Emanuel Feldman
发明人： Matthew I. Haller , Jordi Parramon , Emanuel Feldman
IPC分类号： A61N1/00
CPC分类号： A61N1/3787 , A61N1/37247 , A61N1/37258 , A61N1/37264
摘要： A stimulator includes an implantable pulse generator comprising circuit elements, a first power source, such as an ultracapacitor, that provides operating power for the circuit elements of the pulse generator. The pulse generator can also have a memory associated therewith, such as a volatile memory for storing programming data. A second power source that has higher voltage retention than the first power source can also be included. The second power source can be dedicated to the volatile memory and can provide operating power for the volatile memory.
摘要翻译：刺激器包括可植入脉冲发生器，其包括电路元件，第一电源，例如超级电容器，其为脉冲发生器的电路元件提供工作电力。脉冲发生器还可以具有与其相关联的存储器，诸如用于存储编程数据的易失性存储器。还可以包括比第一电源具有更高的电压保持的第二电源。第二个电源可以专用于易失性存储器，并且可以为易失性存储器提供工作电源。

4. 发明授权

US07904171B2 Voltage converter for implantable microstimulator using RF-powering coil 有权
标题翻译：使用RF供电线圈的可植入微型激励器的电压转换器
公开(公告)号：US07904171B2
公开(公告)日：2011-03-08
申请号：US12099474
申请日：2008-04-08
申请人： Jordi Parramon , Matthew I Haller
发明人： Jordi Parramon , Matthew I Haller
IPC分类号： A61N1/00
CPC分类号： A61N1/08 , A61N1/37205 , A61N1/3787
摘要： A combination, voltage converter circuit for use within an implantable device, such as a microstimulator, uses a coil, instead of capacitors, to provide a voltage step up and step down conversion functions. The output voltage is controlled, or adjusted, through duty-cycle modulation. In accordance with one aspect of the invention, applicable to implantable devices having an existing RF coil through which primary or charging power is provided, the existing RF coil is used in a time-multiplexing scheme to provide both the receipt of the RF signal and the voltage conversion function. This minimizes the number of components needed within the device, and thus allows the device to be packaged in a smaller housing or frees up additional space within an existing housing for other circuit components. In accordance with another aspect of the invention, the voltage up/down converter circuit is controlled by a pulse width modulation (PWM) low power control circuit. Such operation allows high efficiencies over a wide range of output voltages and current loads.
摘要翻译：在可植入装置（例如微型激励器）内使用的组合电压转换器电路使用线圈代替电容器来提供升压和降压转换功能。通过占空比调制来控制或调节输出电压。根据本发明的一个方面，可应用于具有通过其提供初级或充电功率的现有RF线圈的可植入装置，现有的RF线圈用于时间复用方案以提供RF信号的接收和电压转换功能。这使得器件中所需的部件的数量最小化，并因此允许将器件封装在较小的外壳中，或释放现有外壳内用于其他电路元件的额外空间。根据本发明的另一方面，电压上/下变频器电路由脉宽调制（PWM）低功率控制电路控制。这种操作允许在宽范围的输出电压和电流负载下实现高效率。

5. 发明授权

US07177698B2 Telemetry system for use with microstimulator 有权
标题翻译：用于微型激励器的遥测系统
公开(公告)号：US07177698B2
公开(公告)日：2007-02-13
申请号：US10607962
申请日：2003-06-27
申请人： Daniel J. Klosterman , Kelly H. McClure , Goran N. Marnfeldt , Jordi Parramon , Matthew I. Haller , Rudolph V. Park
发明人： Daniel J. Klosterman , Kelly H. McClure , Goran N. Marnfeldt , Jordi Parramon , Matthew I. Haller , Rudolph V. Park
IPC分类号： A61N1/00
CPC分类号： A61N1/37276 , A61N1/36007 , A61N1/3605 , A61N1/37205 , A61N1/37217 , A61N1/37223 , A61N1/37229 , A61N1/37235 , A61N1/3727 , A61N1/375 , A61N1/3787 , H01L2224/45144 , H01L2224/45147 , H01L2224/48465 , H01L2224/49175 , H01L2924/00011 , H01L2924/1461 , H01L2924/19105 , H01L2924/19107 , H01L2924/3011 , H01L2924/30111 , H02J7/025 , H02J7/345 , H04B5/0037 , H04B5/0081 , H04L27/02 , H04L27/10 , Y10T29/4902 , Y10T29/49071 , Y10T29/49073 , Y10T29/49128 , Y10T29/4913 , Y10T29/49155 , Y10T29/49169 , Y10T29/49826 , Y10T29/49945 , Y10T29/49968 , Y10T428/12264 , Y10T428/12271 , Y10T428/12347 , Y10T428/12375 , Y10T428/12396 , Y10T428/12535 , Y10T428/12806 , H01L2924/00 , H01L2924/01005 , H01L2924/01033
摘要： An implantable microstimulator configured to be implanted beneath a patient's skin for tissue stimulation employs a bi-directional RF telemetry link for allowing data-containing signals to be sent to and from the implantable microstimulator from at least two external devices. Further, a separate electromagnetic inductive telemetry link allows data containing signals to be sent to the implantable microstimulator from at least one of the two external devices. The RF bidirectional telemetry link allows the microstimulator to inform the patient or clinician regarding the status of the microstimulator device, including the charge level of a power source, and stimulation parameter states. The microstimulator has a cylindrical hermetically sealed case having a length no greater than about 27 mm and a diameter no greater than about 3.3 mm. A reference electrode is located on one end of the case and an active electrode is located on the other end of the case.
摘要翻译：被配置为植入在患者皮肤下方进行组织刺激的可植入微型刺激器使用双向RF遥测链路，用于允许从至少两个外部设备向可植入微型激励器发送含数据信号。此外，单独的电磁感应遥测链路允许从两个外部设备中的至少一个将包含信号的数据发送到可植入微型激励器。 RF双向遥测链路允许微刺激器通知患者或临床医生关于微刺激器装置的状态，包括电源的充电水平和刺激参数状态。微型激励器具有圆柱形密封的外壳，其长度不大于约27mm，直径不大于约3.3mm。参考电极位于壳体的一端，有源电极位于壳体的另一端。

6. 发明授权

US07120992B2 Method of making an electronic module 有权
标题翻译：制作电子模块的方法
公开(公告)号：US07120992B2
公开(公告)日：2006-10-17
申请号：US10609452
申请日：2003-06-27
申请人： Tom Xiaohai He , Matthew I. Haller , Jordi Parramon , Goran N. Marnfeldt
发明人： Tom Xiaohai He , Matthew I. Haller , Jordi Parramon , Goran N. Marnfeldt
IPC分类号： H01F7/06
CPC分类号： A61N1/37276 , A61N1/36007 , A61N1/3605 , A61N1/37205 , A61N1/37217 , A61N1/37223 , A61N1/37229 , A61N1/37235 , A61N1/3727 , A61N1/375 , A61N1/3787 , H01L2224/45144 , H01L2224/45147 , H01L2224/48465 , H01L2224/49175 , H01L2924/00011 , H01L2924/1461 , H01L2924/19105 , H01L2924/19107 , H01L2924/3011 , H01L2924/30111 , H02J7/025 , H02J7/345 , H04B5/0037 , H04B5/0081 , H04L27/02 , H04L27/10 , Y10T29/4902 , Y10T29/49071 , Y10T29/49073 , Y10T29/49128 , Y10T29/4913 , Y10T29/49155 , Y10T29/49169 , Y10T29/49826 , Y10T29/49945 , Y10T29/49968 , Y10T428/12264 , Y10T428/12271 , Y10T428/12347 , Y10T428/12375 , Y10T428/12396 , Y10T428/12535 , Y10T428/12806 , H01L2924/00 , H01L2924/01005 , H01L2924/01033
摘要： Compact electronic modules, which may be used with implantable microstimulators and other medical and non-medical devices, and manufacture/assembly of such modules are described. Component and circuitry designs utilize unique redistribution techniques and attachment methods. A number of component designs and packaging configurations maximize the volume efficiency of electronic modules. Also included are improved processes and systems enabling the manufacture and assembly of such compact packages.
摘要翻译：描述了可与可植入微型刺激器和其他医疗和非医疗装置一起使用的紧凑型电子模块以及这种模块的制造/组装。组件和电路设计采用独特的再分配技术和附件方法。许多组件设计和封装配置使电子模块的体积效率最大化。还包括改进的工艺和系统，能够制造和组装这些紧凑型封装。

7. 发明授权

US08655451B2 Telemetry system for use with microstimulator 有权
标题翻译：用于微型激励器的遥测系统
公开(公告)号：US08655451B2
公开(公告)日：2014-02-18
申请号：US13016246
申请日：2011-01-28
申请人： Daniel J. Klosterman , Kelly H. McClure , Goran N. Marnfeldt , Jordi Parramon , Matthew I. Haller , Rudolph V. Park
发明人： Daniel J. Klosterman , Kelly H. McClure , Goran N. Marnfeldt , Jordi Parramon , Matthew I. Haller , Rudolph V. Park
IPC分类号： A61N1/00
CPC分类号： A61N1/37276 , A61N1/36007 , A61N1/3605 , A61N1/37205 , A61N1/37217 , A61N1/37223 , A61N1/37229 , A61N1/37235 , A61N1/3727 , A61N1/375 , A61N1/3787 , H01L2224/45144 , H01L2224/45147 , H01L2224/48465 , H01L2224/49175 , H01L2924/00011 , H01L2924/1461 , H01L2924/19105 , H01L2924/19107 , H01L2924/3011 , H01L2924/30111 , H02J7/025 , H02J7/345 , H04B5/0037 , H04B5/0081 , H04L27/02 , H04L27/10 , Y10T29/4902 , Y10T29/49071 , Y10T29/49073 , Y10T29/49128 , Y10T29/4913 , Y10T29/49155 , Y10T29/49169 , Y10T29/49826 , Y10T29/49945 , Y10T29/49968 , Y10T428/12264 , Y10T428/12271 , Y10T428/12347 , Y10T428/12375 , Y10T428/12396 , Y10T428/12535 , Y10T428/12806 , H01L2924/00 , H01L2924/01005 , H01L2924/01033
摘要： An implantable microstimulator configured to be implanted beneath a patient's skin for tissue stimulation employs a bi-directional RF telemetry link for allowing data-containing signals to be sent to and from the implantable microstimulator from at least two external devices. Further, a separate electromagnetic inductive telemetry link allows data containing signals to be sent to the implantable microstimulator from at least one of the two external devices. The RF bidirectional telemetry link allows the microstimulator to inform the patient or clinician regarding the status of the microstimulator device, including the charge level of a power source, and stimulation parameter states. The microstimulator has a cylindrical hermetically sealed case having a length no greater than about 27 mm and a diameter no greater than about 3.3 mm. A reference electrode is located on one end of the case and an active electrode is located on the other end of the case.
摘要翻译：被配置为植入在患者皮肤下方进行组织刺激的可植入微型刺激器使用双向RF遥测链路，用于允许从至少两个外部设备向可植入微型激励器发送含数据信号。此外，单独的电磁感应遥测链路允许从两个外部设备中的至少一个将包含信号的数据发送到可植入微型激励器。 RF双向遥测链路允许微刺激器通知患者或临床医生关于微刺激器装置的状态，包括电源的充电水平和刺激参数状态。微型激励器具有圆柱形密封的外壳，其长度不大于约27mm，直径不大于约3.3mm。参考电极位于壳体的一端，有源电极位于壳体的另一端。

8. 发明授权

US07890182B2 Current steering for an implantable stimulator device involving fractionalized stimulation pulses 有权
$Current steering for an implantable stimulator device involving fractionalized stimulation pulses$
标题翻译：用于涉及分数化刺激脉冲的可植入刺激器装置的电流转向
公开(公告)号：US07890182B2
公开(公告)日：2011-02-15
申请号：US12121281
申请日：2008-05-15
申请人： Jordi Parramon , Rafael Carbunaru , Matthew I. Haller
发明人： Jordi Parramon , Rafael Carbunaru , Matthew I. Haller
IPC分类号： A61N1/36
CPC分类号： A61N1/36171 , A61N1/05 , A61N1/0551 , A61N1/36 , A61N1/36071 , A61N1/36125 , A61N1/36175 , A61N1/36178 , A61N1/37235
摘要： A method for configuring stimulation pulses in an implantable stimulator device having a plurality of electrodes is disclosed, which method is particularly useful in adjusting the electrodes by current steering during initialization of the device. In one aspect, a set of ideal pulses for patient therapy is determined, in which at least two of the ideal pulses are of the same polarity and are intended to be simultaneous applied to corresponding electrodes on the implantable stimulator device during an initial duration. These pulses are reconstructed into fractionalized pulses, each comprised of pulse portions. The fractionalized pulses are applied to the corresponding electrodes on the device during a final duration, but the pulse portions of the fractionalized pulses are not simultaneously applied during the final duration.
摘要翻译：公开了一种用于在具有多个电极的可植入刺激器装置中配置刺激脉冲的方法，该方法在装置的初始化期间通过电流转向来调节电极特别有用。在一个方面，确定用于患者治疗的一组理想脉冲，其中至少两个理想脉冲具有相同的极性并且旨在在初始持续时间期间同时施加到可植入刺激器装置上的对应电极。这些脉冲被重建成分数脉冲，每个脉冲包括脉冲部分。分数脉冲在最后的持续时间内施加到器件上的对应电极，但分数脉冲的脉冲部分在最后的持续时间内不被同时施加。

9. 发明授权

US07729758B2 Magnetically coupled microstimulators 失效
标题翻译：磁耦合微型激励器
公开(公告)号：US07729758B2
公开(公告)日：2010-06-01
申请号：US11291464
申请日：2005-11-30
申请人： Matthew I. Haller , Jordi Parramon
发明人： Matthew I. Haller , Jordi Parramon
IPC分类号： A61N1/36
CPC分类号： A61N1/37205 , A61N1/36036 , A61N1/3605 , A61N1/3756
摘要： Disclosed are implantable electronic devices and systems including a pair of microstimulators. The microstimulators include coils that are energized to generate magnetic fields aligned along a common axis.
摘要翻译：公开了包括一对微型激励器的可植入电子设备和系统。微型激励器包括被激励以产生沿公共轴对准的磁场的线圈。

10. 发明申请

US20110137378A1 Telemetry System for Use With Microstimulator 有权
标题翻译：用于微型激励器的遥测系统
公开(公告)号：US20110137378A1
公开(公告)日：2011-06-09
申请号：US13016246
申请日：2011-01-28
申请人： Daniel J. Klosterman , Kelly H. McClure , Goran N. Marnfeldt , Jordi Parramon , Matthew I. Haller , Rudolph V. Park
发明人： Daniel J. Klosterman , Kelly H. McClure , Goran N. Marnfeldt , Jordi Parramon , Matthew I. Haller , Rudolph V. Park
IPC分类号： A61N1/36
CPC分类号： A61N1/37276 , A61N1/36007 , A61N1/3605 , A61N1/37205 , A61N1/37217 , A61N1/37223 , A61N1/37229 , A61N1/37235 , A61N1/3727 , A61N1/375 , A61N1/3787 , H01L2224/45144 , H01L2224/45147 , H01L2224/48465 , H01L2224/49175 , H01L2924/00011 , H01L2924/1461 , H01L2924/19105 , H01L2924/19107 , H01L2924/3011 , H01L2924/30111 , H02J7/025 , H02J7/345 , H04B5/0037 , H04B5/0081 , H04L27/02 , H04L27/10 , Y10T29/4902 , Y10T29/49071 , Y10T29/49073 , Y10T29/49128 , Y10T29/4913 , Y10T29/49155 , Y10T29/49169 , Y10T29/49826 , Y10T29/49945 , Y10T29/49968 , Y10T428/12264 , Y10T428/12271 , Y10T428/12347 , Y10T428/12375 , Y10T428/12396 , Y10T428/12535 , Y10T428/12806 , H01L2924/00 , H01L2924/01005 , H01L2924/01033
摘要： An implantable microstimulator configured to be implanted beneath a patient's skin for tissue stimulation employs a bi-directional RF telemetry link for allowing data-containing signals to be sent to and from the implantable microstimulator from at least two external devices. Further, a separate electromagnetic inductive telemetry link allows data containing signals to be sent to the implantable microstimulator from at least one of the two external devices. The RF bidirectional telemetry link allows the microstimulator to inform the patient or clinician regarding the status of the microstimulator device, including the charge level of a power source, and stimulation parameter states. The microstimulator has a cylindrical hermetically sealed case having a length no greater than about 27 mm and a diameter no greater than about 3.3 mm. A reference electrode is located on one end of the case and an active electrode is located on the other end of the case.
摘要翻译：被配置为植入在患者皮肤下方进行组织刺激的可植入微型刺激器使用双向RF遥测链路，用于允许从至少两个外部设备向可植入微型激励器发送含数据信号。此外，单独的电磁感应遥测链路允许从两个外部设备中的至少一个将包含信号的数据发送到可植入微型激励器。 RF双向遥测链路允许微刺激器通知患者或临床医生关于微刺激器装置的状态，包括电源的充电水平和刺激参数状态。微型激励器具有圆柱形密封的外壳，其长度不大于约27mm，直径不大于约3.3mm。参考电极位于壳体的一端，有源电极位于壳体的另一端。

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