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1. 发明申请

US20080213574A1 Amphiphilic Fibers and Membranes and Processes for Preparing Them 审中-公开
标题翻译：两亲纤维和膜及其制备方法
公开(公告)号：US20080213574A1
公开(公告)日：2008-09-04
申请号：US11830934
申请日：2007-07-31
申请人： Matthew G. McKee , John M. Layman , Matthew T. Hunley , Matthew P. Cashion , Timothy E. Long
发明人： Matthew G. McKee , John M. Layman , Matthew T. Hunley , Matthew P. Cashion , Timothy E. Long
IPC分类号： B32B7/02 , H05B6/00
CPC分类号： D01D5/38 , B01D69/02 , B01D2323/39 , B01D2325/34 , D01D5/0038 , D01D5/0053 , D01D10/00 , Y10T428/26
摘要： The present invention relates to the fields of chemistry and biology and more particularly to the field of biomaterials. The present invention includes amphiphilic fibers and membranes, which can be used for biomembranes and biocompatible devices. The present invention also relates to processes for preparing amphiphilic fibers and membranes from solutions comprising amphiphilic molecules. More particularly, the present invention relates to processes for preparing fibers and membranes from electrospinning solutions comprising amphiphilic molecules. The present invention further provides fibers and nonwoven membranes comprising amphiphilic fibers chosen from anionic surfactants, cationic surfactants, nonionic surfactants, phospholipids, sulfobetaines, lyotropic liquid crystalline molecules, and/or block copolymers. Electrospun fibers offer the potential for direct fabrication of biologically based, high-surface-area membranes without the use of multiple synthetic steps, complicated electrospinning designs, or post-processing surface treatments. Polymeric phospholipids, for example, have been shown to be attractive candidates for blood purification membranes, artificial heart valves and organs, and other prosthetics, including other biocompatible devices.
摘要翻译：本发明涉及化学和生物学领域，更具体地涉及生物材料领域。本发明包括两亲纤维和膜，其可用于生物膜和生物相容性装置。本发明还涉及由包含两亲性分子的溶液制备两亲性纤维和膜的方法。更具体地说，本发明涉及由包含两亲分子的静电纺丝溶液制备纤维和膜的方法。本发明还提供了包含选自阴离子表面活性剂，阳离子表面活性剂，非离子表面活性剂，磷脂，磺基甜菜碱，溶致液晶分子和/或嵌段共聚物的两亲纤维的纤维和非织造膜。电纺纤维提供直接制造基于生物的高表面积膜的潜力，而不使用多个合成步骤，复杂的电纺丝设计或后处理表面处理。例如，聚合磷脂已被证明是血液净化膜，人造心脏瓣膜和器官以及其他假肢（包括其他生物相容性装置）的有吸引力的候选者。

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