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    • 6. 发明申请
    • Apparatus for Systematic Single Cell Tracking of Distinctive Cellular Events
    • 用于系统性单细胞跟踪特异性细胞事件的装置
    • US20130217061A1
    • 2013-08-22
    • US13880793
    • 2011-10-07
    • Masahiko SatoSachiko Sato
    • Masahiko SatoSachiko Sato
    • C12Q1/02
    • G01N33/5091C12M41/46C12Q1/02G01N33/5017G02B21/367
    • An apparatus for quantitative identification of distinctive cellular events occurring in a cell population using a non-fluorescence approach. The apparatus comprises an image acquisition unit having a Differential Interference Contrast microscope with a camera, a light source, an environmental chamber allowing carrying out cell culture of at least one cell in a cell population; the image acquisition unit acquiring images of the cell population, at predetermined time points; a cell tracker for individually tracking the at least one cell of the cell population in the images; a distinctive cellular event detector for detecting an occurrence of a distinctive cellular event; a report generator; wherein the distinctive cellular event is selected from the group consisting of: tripolar, tetrapolar, quadpolar cell division, cell fusion, cell death, impaired cell division, cell shape alteration, nuclear shape alteration, inner cellular material accumulation, cell enlargement, engulfing, hyper-mobilization, hypo-mobilization and prolonged doubling time.
    • 用于使用非荧光方法定量鉴定发生在细胞群体中的特异性细胞事件的装置。 该装置包括具有相机的差分干涉对比显微镜的图像获取单元,光源,允许在细胞群体中进行至少一个细胞的细胞培养的环境室; 所述图像获取单元在预定时间点获取所述细胞群体的图像; 用于单独跟踪图像中的细胞群体的至少一个细胞的细胞跟踪器; 用于检测特征性细胞事件的发生的特征性细胞事件检测器; 报告生成器 其中特征性细胞事件选自:三极,四极,四极细胞分裂,细胞融合,细胞死亡,细胞分裂受损,细胞形状改变,核形态改变,内细胞物质积累,细胞增殖,吞噬,超 - 动员不足,延长倍增时间。
    • 9. 发明申请
    • OPTICAL SENSOR UNIT AND IMAGE-FORMING APPARATUS
    • 光学传感器单元和图像形成装置
    • US20130004189A1
    • 2013-01-03
    • US13533640
    • 2012-06-26
    • Masafumi HashiguchiToshio YanataMasahiko SatoMasataka AkaishiSohichiroh Naka
    • Masafumi HashiguchiToshio YanataMasahiko SatoMasataka AkaishiSohichiroh Naka
    • G03G15/00G01D5/34
    • G03G15/5058G03G15/0131G03G2215/0132
    • An optical sensor unit includes: a light-emitting device; a light-receiving device that receives light which is emitted from the light-emitting device and reflected from an object to be detected, and outputs an output value in accordance with the light; a shutter member that openably and closably covers an incident/exit plane having an exit part where light of the light-emitting device is emitted to the object to be detected and an incident part where light reflected from the object to be detected enters, and has a facing surface facing the incident/exit plane that is an inclined surface inclined to the incident/exit plane; and a corrector that corrects an output value of the light-receiving device when receiving light reflected from the object to be detected, based on an output value of the light-receiving device obtained by emitting light to the inclined surface of the shutter member.
    • 光学传感器单元包括:发光装置; 光接收装置,其接收从所述发光装置发射并从被检测物体反射的光,并且根据所述光输出输出值; 开闭构件,其可开闭地覆盖具有出射部的入射/出射面,所述出射部将发光装置的光发射到被检测体,并且从被检测体反射的光入射到入射部,并且具有 面对入射/出射平面的面向表面,倾斜表面倾斜于入射/出射平面; 以及校正器,其基于通过将光发射到所述活门构件的倾斜表面而获得的光接收装置的输出值来校正从所述待检测物体反射的光的光接收装置的输出值。