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1. 发明授权

US11541017B2 Fortified micronutrient salt formulations 有权
公开(公告)号：US11541017B2
公开(公告)日：2023-01-03
申请号：US15484892
申请日：2017-04-11
申请人： Massachusetts Institute of Technology , Tokitae LLC
发明人： Ana Jaklenec , Xian Xu , Lowell L. Wood, Jr. , Philip A. Welkhoff , William Gates , Boris Nikolic , Robert S. Langer
IPC分类号： A61K9/50 , A23L33/15 , A23L33/155 , A23L33/16 , A23P10/30 , A61K31/375 , A61K31/593 , A61K31/714 , A61K31/18 , A61K31/26 , A61K31/30 , A61K31/519 , A61K47/26 , A61K47/36 , A61K31/295 , A61K33/30 , A61K31/07 , A61K33/18 , A23L27/00 , A23L33/10 , A61K9/48 , A61K31/23 , A61K33/26 , A61K45/06
摘要： Salt formulations, which are resistant to moisture and cooking conditions, are described herein. The formulations provide particles of micronutrients and vitamins encapsulated within heat resistant pH-sensitive water-insoluble polymers, which are packaged within a salt shell. The pH-sensitive, water-insoluble, thermally stable materials stabilize the micronutrients, particularly at high temperatures, such as during food preparation and cooking, and release the micronutrients at the desired locations such as the stomach, small intestine, etc. Preferred pH-sensitive polymers release at a low pH, less than the pH present in the stomach. The particles can be used to deliver daily-recommended doses of micronutrients simultaneously with salt, eliminating the need for vitamin pills. This is particularly important in populations suffering from severe malnutrition.

2. 发明申请

US20210205444A1 MICROMOLDED OR 3-D PRINTED PULSATILE RELEASE VACCINE FORMULATIONS 有权
公开(公告)号：US20210205444A1
公开(公告)日：2021-07-08
申请号：US17143871
申请日：2021-01-07
申请人： Massachusetts Institute of Technology , Tokitae LLC
发明人： Ana Jaklenec , William Gates , Philip A. Welkhoff , Boris Nikolic , Lowell L. Wood, JR. , Robert S. Langer , Thanh Duc Nguyen , Stephany Yi Tzeng , James J. Norman , Kevin McHugh
IPC分类号： A61K39/39 , A61K39/00 , A61K39/12
摘要： Emulsion-based and micromolded (“MM”) or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.

3. 发明授权

US10960073B2 Micromolded or 3-D printed pulsatile release vaccine formulations 有权
公开(公告)号：US10960073B2
公开(公告)日：2021-03-30
申请号：US16401476
申请日：2019-05-02
申请人： Massachusetts Institute of Technology , Tokitae LLC
发明人： Ana Jaklenec , William Gates , Philip A. Welkhoff , Boris Nikolic , Lowell L. Wood, Jr. , Robert S. Langer , Thanh Duc Nguyen , Stephany Yi Tzeng , James J. Norman , Kevin McHugh
IPC分类号： A61K39/39 , A61K39/00 , A61K39/12
摘要： Emulsion-based and micromolded (“MM”) or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.

4. 发明申请

US20170216216A1 FORTIFIED MICRONUTRIENT SALT FORMULATIONS 审中-公开
公开(公告)号：US20170216216A1
公开(公告)日：2017-08-03
申请号：US15484892
申请日：2017-04-11
申请人： Massachusetts Institute of Technology , Tokitae LLC
发明人： Ana Jaklenec , Xian Xu , Lowell L. Wood, JR. , Philip A. Eckhoff , William Gates , Boris Nikolic , Robert S. Langer
IPC分类号： A61K9/50 , A61K31/714 , A61K33/30 , A61K31/295 , A61K33/26 , A61K31/23 , A61K31/519 , A61K31/593 , A61K33/18 , A61K31/375 , A61K45/06 , A23L27/00 , A23L33/10 , A23L33/15 , A23L33/155 , A23L33/16 , A23P10/30 , A61K9/48
CPC分类号： A61K9/5026 , A23L27/72 , A23L27/74 , A23L33/10 , A23L33/15 , A23L33/155 , A23L33/16 , A23P10/30 , A23V2002/00 , A61K9/4866 , A61K9/501 , A61K9/5073 , A61K31/07 , A61K31/23 , A61K31/295 , A61K31/375 , A61K31/519 , A61K31/593 , A61K31/714 , A61K33/18 , A61K33/26 , A61K33/30 , A61K45/06 , A61K47/26 , A61K47/36
摘要： Salt formulations, which are resistant to moisture and cooking conditions, are described herein. The formulations provide particles of micronutrients and vitamins encapsulated within heat resistant pH-sensitive water-insoluble polymers, which are packaged within a salt shell. The pH-sensitive, water-insoluble, thermally stable materials stabilize the micronutrients, particularly at high temperatures, such as during food preparation and cooking, and release the micronutrients at the desired locations such as the stomach, small intestine, etc. Preferred pH-sensitive polymers release at a low pH, less than the pH present in the stomach. The particles can be used to deliver daily-recommended doses of micronutrients simultaneously with salt, eliminating the need for vitamin pills. This is particularly important in populations suffering from severe malnutrition.

5. 发明申请

US20190328871A1 MICROMOLDED OR 3-D PRINTED PULSATILE RELEASE VACCINE FORMULATIONS 审中-公开
公开(公告)号：US20190328871A1
公开(公告)日：2019-10-31
申请号：US16401476
申请日：2019-05-02
申请人： Massachusetts Institute of Technology , Tokitae LLC
发明人： Ana Jaklenec , William Gates , Philip A. Welkhoff , Boris Nikolic , Lowell L. Wood, JR. , Robert S. Langer , Thanh Duc Nguyen , Stephany Yi Tzeng , James J. Norman , Kevin McHugh
IPC分类号： A61K39/39 , A61K39/00 , A61K39/12
摘要： Emulsion-based and micromolded (“MM”) or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.

6. 发明授权

US09649279B2 Fortified micronutrient salt formulations 有权
公开(公告)号：US09649279B2
公开(公告)日：2017-05-16
申请号：US14572346
申请日：2014-12-16
申请人： Massachusetts Institute of Technology , Tokitae LLC
发明人： Ana Jaklenec , Xian Xu , Lowell L. Wood, Jr. , Philip A. Eckhoff , William Gates , Boris Nikolic , Robert S. Langer
IPC分类号： A23L1/304 , A23L1/00 , A61K47/00 , A61K9/50 , A61K31/519 , A61K47/26 , A61K47/36 , A61K31/295 , A61K33/30 , A61K31/07 , A61K31/714 , A61K31/375 , A61K31/593 , A61K33/18 , A23P10/30 , A23L27/00 , A23L33/10 , A23L33/15 , A23L33/155 , A23L33/16
CPC分类号： A61K9/5026 , A23L27/72 , A23L27/74 , A23L33/10 , A23L33/15 , A23L33/155 , A23L33/16 , A23P10/30 , A23V2002/00 , A61K9/4866 , A61K9/501 , A61K9/5073 , A61K31/07 , A61K31/23 , A61K31/295 , A61K31/375 , A61K31/519 , A61K31/593 , A61K31/714 , A61K33/18 , A61K33/26 , A61K33/30 , A61K45/06 , A61K47/26 , A61K47/36
摘要： Salt formulations, which are resistant to moisture and cooking conditions, are described herein. The formulations provide particles of micronutrients and vitamins encapsulated within heat resistant pH-sensitive water-insoluble polymers, which are packaged within a salt shell. The pH-sensitive, water-insoluble, thermally stable materials stabilize the micronutrients, particularly at high temperatures, such as during food preparation and cooking, and release the micronutrients at the desired locations such as the stomach, small intestine, etc. Preferred pH-sensitive polymers release at a low pH, less than the pH present in the stomach. The particles can be used to deliver daily-recommended doses of micronutrients simultaneously with salt, eliminating the need for vitamin pills. This is particularly important in populations suffering from severe malnutrition.

7. 发明授权

US10300136B2 Micromolded or 3-D printed pulsatile release vaccine formulations 有权
公开(公告)号：US10300136B2
公开(公告)日：2019-05-28
申请号：US14572631
申请日：2014-12-16
申请人： Massachusetts Institute of Technology , Tokitae LLC
发明人： Ana Jaklenec , William Gates , Philip A. Welkhoff , Boris Nikolic , Lowell L. Wood , Robert S. Langer , Thanh Duc Nguyen , Stephany Yi Tzeng , James J. Norman , Kevin McHugh
IPC分类号： A61K39/39 , A61K39/00 , A61K39/12
摘要： Emulsion-based and micromolded (“MM”) or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.

8. 发明申请

US20150164816A1 FORTIFIED MICRONUTRIENT SALT FORMULATIONS 有权
标题翻译：经过微生物的盐制剂
公开(公告)号：US20150164816A1
公开(公告)日：2015-06-18
申请号：US14572346
申请日：2014-12-16
申请人： Massachusetts Institute of Technology , Tokitae LLC
发明人： Ana Jaklenec , Xian Xu , Lowell L. Wood, JR. , Philip A. Eckhoff , William Gates , Boris Nikolic , Robert S. Langer
IPC分类号： A61K9/50 , A61K47/26 , A61K47/36 , A61K31/295 , A61K33/30 , A61K31/07 , A61K31/714 , A61K31/375 , A61K31/593 , A61K33/18 , A23L1/304 , A23L1/303 , A23L1/302 , A23L1/30 , A23L1/00 , A61K31/519
CPC分类号： A61K9/5026 , A23L27/72 , A23L27/74 , A23L33/10 , A23L33/15 , A23L33/155 , A23L33/16 , A23P10/30 , A23V2002/00 , A61K9/4866 , A61K9/501 , A61K9/5073 , A61K31/07 , A61K31/23 , A61K31/295 , A61K31/375 , A61K31/519 , A61K31/593 , A61K31/714 , A61K33/18 , A61K33/26 , A61K33/30 , A61K45/06 , A61K47/26 , A61K47/36
摘要： Salt formulations, which are resistant to moisture and cooking conditions, are described herein. The formulations provide particles of micronutrients and vitamins encapsulated within heat resistant pH-sensitive water-insoluble polymers, which are packaged within a salt shell. The pH-sensitive, water-insoluble, thermally stable materials stabilize the micronutrients, particularly at high temperatures, such as during food preparation and cooking, and release the micronutrients at the desired locations such as the stomach, small intestine, etc. Preferred pH-sensitive polymers release at a low pH, less than the pH present in the stomach. The particles can be used to deliver daily-recommended doses of micronutrients simultaneously with salt, eliminating the need for vitamin pills. This is particularly important in populations suffering from severe malnutrition.
摘要翻译：本文描述了耐湿度和烹饪条件的盐制剂。该制剂提供包封在耐热pH值敏感的水不溶性聚合物中的微量营养素和维生素颗粒，其被包装在盐壳内。 pH敏感的水不溶性的热稳定材料稳定微量营养素，特别是在高温下，例如在食物制备和烹饪期间，并且在所需位置例如胃，小肠等释放微量营养素。优选的pH- 敏感的聚合物在低pH下释放，小于胃中存在的pH。颗粒可用于与盐同时递送每日推荐剂量的微量营养素，从而消除维生素丸的需要。这在遭受严重营养不良的人群中特别重要。

9. 发明申请

US20150165020A1 MICROMOLDED OR 3-D PRINTED PULSATILE RELEASE VACCINE FORMULATIONS 审中-公开
标题翻译：微型或三维印刷的流感疫苗制剂
公开(公告)号：US20150165020A1
公开(公告)日：2015-06-18
申请号：US14572631
申请日：2014-12-16
申请人： Massachussetts Institute of Technology , Tokitae LLC
发明人： Ana Jaklenec , William Gates , Philip A. Eckhoff , Boris Nikolic , Lowell L. Wood, JR. , Robert S. Langer
IPC分类号： A61K39/39
CPC分类号： A61K39/39 , A61K39/00 , A61K39/12 , A61K2039/545 , A61K2039/55555 , A61K2039/55566 , A61K2039/6093 , C12N2770/32634 , Y02A50/466
摘要： Emulsion-based and micromolded (“MM”) or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.
摘要翻译：已经开发了用于单次注射抗原的乳液基和微成型（“MM”）或三维印刷（“3DP”）聚合物制剂，优选在两个或更多个时间段内释放。制剂优选由生物相容的可生物降解的聚合物形成。单独或与其他抗原，佐剂，稳定剂和释放调节剂组合的包封抗原的离散区域存在于制剂中。抗原优选在给药时或赋形剂的表面存在于赋形剂中，用于立即释放，并且在初始释放抗原后10至45天，任选地以10至90天的间隔，并入引发至制剂内以释放在一个或多个额外的时间段内释放抗原。抗原可以通过使用稳定剂例如海藻糖玻璃来稳定。在针对小儿麻痹症免疫的优选实施方案中，抗原在给药时释放，其后两个，四个月和六个月。

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