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1. 发明申请

US20200147298A1 SELF-RIGHTING SYSTEMS AND RELATED COMPONENTS AND METHODS 审中-公开
公开(公告)号：US20200147298A1
公开(公告)日：2020-05-14
申请号：US16613766
申请日：2018-05-17
申请人： Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc. , Novo Nordisk A/S
发明人： Carlo Giovanni Traverso , Alex G. Abramson , Ester Caffarel Salvador , Niclas Roxhed , Minsoo Khang , Taylor Bensel , Robert S. Langer , Jorrit Jeroen Water , Morten Revsgaard Frederiksen , Bo Uldall Kristiansen , Mikkel Oliver Jespersen , Mette Poulsen , Peter Herskind , Brian Jensen
IPC分类号： A61M5/142 , A61M37/00 , A61B10/02 , A61N1/36 , A61N1/32 , A61B5/145
摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

2. 发明申请

US20230050912A1 SELF-RIGHTING SYSTEMS AND RELATED COMPONENTS AND METHODS 有权
公开(公告)号：US20230050912A1
公开(公告)日：2023-02-16
申请号：US17826799
申请日：2022-05-27
申请人： Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc. , Novo Nordisk A/S
发明人： Carlo Giovanni Traverso , Alex G. Abramson , Ester Caffarel Salvador , Niclas Roxhed , Minsoo Khang , Taylor Bensel , Robert S. Langer , Jorrit Jeroen Water , Morten Revsgaard Frederiksen , Bo Uldall Kristiansen , Mikkel Oliver Jespersen , Mette Poulsen , Peter Herskind , Brian Jensen
IPC分类号： A61K9/48 , A61J3/07 , A61N1/36 , A61K9/00 , A61N1/32 , A61M5/32 , A61B5/145 , A61B10/02 , A61M5/20 , A61M31/00 , A61M5/142 , A61M5/158 , A61M37/00 , A61K38/28 , A61N1/05
摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

3. 发明授权

US12036324B2 Self-righting systems and related components and methods 有权
公开(公告)号：US12036324B2
公开(公告)日：2024-07-16
申请号：US17826799
申请日：2022-05-27
申请人： Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc. , Novo Nordisk A/S
发明人： Carlo Giovanni Traverso , Alex G. Abramson , Ester Caffarel Salvador , Niclas Roxhed , Minsoo Khang , Taylor Bensel , Robert S. Langer , Jorrit Jeroen Water , Morten Revsgaard Frederiksen , Bo Uldall Kristiansen , Mikkel Oliver Jespersen , Mette Poulsen , Peter Herskind , Brian Jensen
IPC分类号： A61K9/48 , A61B5/145 , A61B10/02 , A61J3/07 , A61K9/00 , A61K38/28 , A61M5/142 , A61M5/145 , A61M5/158 , A61M5/20 , A61M5/32 , A61M31/00 , A61M37/00 , A61N1/32 , A61N1/36 , A61B10/06 , A61N1/05
CPC分类号： A61K9/4808 , A61B5/14503 , A61B5/14539 , A61B10/02 , A61J3/07 , A61K9/0002 , A61K9/0012 , A61K9/0021 , A61K9/0065 , A61K9/0092 , A61K9/4866 , A61K38/28 , A61M5/14276 , A61M5/1454 , A61M5/158 , A61M5/2033 , A61M5/329 , A61M5/3295 , A61M31/002 , A61M37/0015 , A61M37/0069 , A61N1/325 , A61N1/36007 , A61B2010/0208 , A61B10/0233 , A61B10/06 , A61M2005/14284 , A61M2005/1581 , A61M2005/1585 , A61M2037/0023 , A61M2037/0053 , A61M2205/0238 , A61M2205/21 , A61M2210/1053 , A61M2210/106 , A61N1/0509
摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

4. 发明授权

US11771829B2 Systems and methods for liquid injection 有权
公开(公告)号：US11771829B2
公开(公告)日：2023-10-03
申请号：US16778152
申请日：2020-01-31
申请人： Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc. , Novo Nordisk A/S
发明人： Robert S. Langer , Carlo Giovanni Traverso , Alex G. Abramson , Morten Revsgaard Frederiksen , Mikkel Oliver Jespersen , Brian Mouridsen , Jesper Windum , Mette Poulsen , Brian Jensen , Jorrit Jeroen Water , Mikkel Wennemoes Hvitfeld Ley , Xiaoya Lu , Andreas Vegge
IPC分类号： A61M5/20 , A61K9/00 , A61M5/30
CPC分类号： A61M5/2033 , A61K9/0024 , A61M5/30 , A61M2005/202 , A61M2202/0007 , A61M2202/30 , A61M2210/1042
摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject) such as a liquid pharmaceutical agent. In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article.

5. 发明授权

US11607390B2 Self-righting systems and related components and methods 有权
公开(公告)号：US11607390B2
公开(公告)日：2023-03-21
申请号：US16691579
申请日：2019-11-21
申请人： Massachusetts Institute of Technology , Novo Nordisk A/S , The Brigham and Women's Hospital, Inc.
发明人： Alex G. Abramson , Morten Revsgaard Frederiksen , Brian Jensen , Mikkel Oliver Jespersen , Carlo Giovanni Traverso
IPC分类号： A61K9/48 , A61K9/00 , A61M5/142 , A61M37/00 , A61N1/36 , A61M31/00 , A61M5/158 , A61J3/07 , A61B5/145 , A61B10/02 , A61N1/32 , A61M5/20 , A61M5/32 , A61K38/28 , A61N1/05
摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface. The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage with a surface. In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components.

6. 发明授权

US11369574B2 Self-righting systems and related components and methods 有权
公开(公告)号：US11369574B2
公开(公告)日：2022-06-28
申请号：US16613766
申请日：2018-05-17
申请人： Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc. , Novo Nordisk A/S
发明人： Carlo Giovanni Traverso , Alex G. Abramson , Ester Caffarel Salvador , Niclas Roxhed , Minsoo Khang , Taylor Bensel , Robert S. Langer , Jorrit Jeroen Water , Morten Revsgaard Frederiksen , Bo Uldall Kristiansen , Mikkel Oliver Jespersen , Mette Poulsen , Peter Herskind , Brian Jensen
IPC分类号： A61K9/48 , A61J3/07 , A61K9/00 , A61M5/142 , A61M37/00 , A61M5/20 , A61M5/32 , A61M31/00 , A61M5/158 , A61B5/145 , A61B10/02 , A61N1/32 , A61N1/36 , A61K38/28 , A61N1/05
摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

7. 发明申请

US20200246545A1 SYSTEMS AND METHODS FOR LIQUID INJECTION 审中-公开
公开(公告)号：US20200246545A1
公开(公告)日：2020-08-06
申请号：US16778152
申请日：2020-01-31
申请人： Massachusetts Institute of Technology , The Brigham and Women's Hospital Inc. , Novo Nordisk A/S
发明人： Robert S. Langer , Carlo Giovanni Traverso , Alex G. Abramson , Morten Revsgaard Frederiksen , Mikkel Oliver Jespersen , Brian Mouridsen , Jesper Windum , Mette Poulsen , Brian Jensen , Jorrit Jeroen Water , Mikkel Wennemoes Hvitfeld Ley , Xiaoya Lu
IPC分类号： A61M5/20 , A61M5/30 , A61K9/00
摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject) such as a liquid pharmaceutical agent. In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article.

8. 发明申请

US20220023546A1 DRUG DELIVERY ASSEMBLY WITH SENSOR SAMPLING FEATURE 有权
公开(公告)号：US20220023546A1
公开(公告)日：2022-01-27
申请号：US17291306
申请日：2019-11-06
申请人： Novo Nordisk A/S
发明人： Mikkel Oliver Jespersen , Kim Ejholm Hansen , Laurits Hoejgaard Olesen
IPC分类号： A61M5/315 , A61M5/28
摘要： A drug delivery assembly comprising a sensor system in combination with an indicator arranged to rotate, the amount of rotation being indicative of the size of an expelled dose amount. The sensor system comprises a sensor assembly adapted to measure a rotational position and/or a rotational movement of the indicator, the sensor assembly comprising a sensor element adapted to be operated at a non-constant sampling frequency. A processor is configured to determine on the basis of measured values from the sensor element rotational position(s) and/or amount of rotational movement of the indicator, as well as rotational speed of the indicator. To optimize energy consumption the processor is configured to dynamically control the sampling frequency in response to the determined rotational speed.

9. 发明申请

US20220313967A1 INGESTIBLE DEVICE WITH DELIVERY MEMBER DETACHMENT 有权
公开(公告)号：US20220313967A1
公开(公告)日：2022-10-06
申请号：US17616386
申请日：2020-06-07
申请人： Novo Nordisk A/S
发明人： Morten Revsgaard Frederiksen , Brian Jensen , Mikkel Oliver Jespersen , Mette Poulsen
IPC分类号： A61M31/00 , A61M5/20 , A61M5/28 , A61M5/32
摘要： An ingestible device is disclosed suitable for swallowing into a lumen of a gastrointestinal tract of a patient, the lumen having a lumen wall. The ingestible device (100, 200) comprises: a capsule (110, 120), a delivery member (130) being shaped to penetrate tissue of a lumen wall and having a tissue penetrating end and a trailing end, the delivery member (130) comprising a therapeutic payload, a ram (150) attached relative to the delivery member (130) at the trailing end; and an actuator (140) coupled to the ram (150) and having a first configuration and a second configuration, the delivery member (130) being retained by the ram (150) within the capsule (110, 120) when the actuator (140) is in the first configuration, wherein the delivery member (130) is configured to be advanced from the capsule (110, 120) and into the lumen wall by movement of the actuator (140) from the first configuration to the second configuration such that the delivery member (130) moves along a predefined trajectory. The ram (150) is configured for being tilted relative to the predefined trajectory upon the actuator (140) moving into the second configuration to detach at least a portion of the delivery member (130) from the ram (150) such that the detached portion of the delivery member (130) remains within the lumen wall to release therapeutic payload.

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